Protein Contact Prediction by Integrating Joint Evolutionary Coupling Analysis and Supervised Learning
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- Ma J., Wang S., Wang Z., Xu J. (2015) Protein Contact Prediction by Integrating Joint Evolutionary Coupling Analysis and Supervised Learning. In: Przytycka T. (eds) Research in Computational Molecular Biology. RECOMB 2015. Lecture Notes in Computer Science, vol 9029. Springer, Cham
Residue-residue contacts play an important role in maintaining the native fold of a protein and guiding protein folding. However, contact prediction from sequence is very challenging, as indicated by CASP10 , which shows that long-range contact prediction accuracy on hard targets is only ~20%.
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