Abstract
Prostate cancer diagnosis involves the highly subjective and time-consuming Gleason grading process. This paper proposes the use of Max-Margin Conditional Random Fields (CRFs) towards the aim of creating an automatic computer-aided diagnosis system. Unlike previous methods, this approach enables us to fuse information from multiple classifiers while leveraging CRFs to model spatial dependencies. We perform grading on superpixels which reduce redundancy and the size of data. Probabilistic outputs from independent classifiers are passed as input to a Max-Margin CRF, which then performs structured prediction on the biopsy core, segmenting the image into regions of benign tissue, Gleason grade 3 adenocarcinoma and Gleason grade 4 adenocarcinoma. The system achieves an accuracy of 83.0% with accuracies of 83.6%, 86.9% and 77.1% reported for benign, grade 3 and grade 4 classes respectively.
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References
Achanta, R., Shaji, A., Smith, K., Lucchi, A., Fua, P., Süsstrunk, S.: SLIC Superpixels Compared to State-of-the-Art Superpixel Methods. IEEE TPAMI 34(11), 2274–2282 (2012)
Chang, C.C., Lin, C.J.: LIBSVM: A library for support vector machines. ACM TIST 2(3), 27:1–27:27 (2011)
Doyle, S., Feldman, M.D., Tomaszewski, J., Madabhushi, A.: A Boosted Bayesian Multiresolution Classifier for Prostate Cancer Detection From Digitized Needle Biopsies. IEEE TBE 59(5), 1205–1218 (2012)
Epstein, J.I.: An Update of the Gleason Grading System. J. Urology 183(2), 433–440 (2010)
Gorelick, L., Veksler, O., Gaed, M., Gomez, J.A., Moussa, M., Bauman, G., Fenster, A., Ward, A.D.: Prostate Histopathology: Learning Tissue Component Histograms for Cancer Detection and Classification. IEEE TMI 32(10), 1804–1818 (2013)
Lin, H.T., Lin, C.J., Weng, R.C.: A note on Platt’s probabilistic outputs for support vector machines. Mach. Learn. 68(3), 267–276 (2007)
Martins, A.F.T., Figueiredo, M.A.T., Aguiar, P.M.Q., Smith, N.A., Xing, E.P.: An Augmented Lagrangian Approach to Constrained MAP Inference. In: Getoor, L., Scheffer, T. (eds.) ICML 2011, pp. 169–176. Omnipress (2011)
Monaco, J., Tomaszewski, J., Feldman, M.D., Hagemann, I., Moradi, M., Mousavi, P., Boag, A., Davidson, C., Abolmaesumi, P., Madabhushi, A.: High-throughput detection of prostate cancer in histological sections using probabilistic pairwise Markov models. Med. Image Anal. 14(4), 617–629 (2010)
Montironi, R., Mazzuccheli, R., Scarpelli, M., Lopez-Beltran, A., Fellegara, G., Algaba, F.: Gleason grading of prostate cancer in needle biopsies or radical prostatectomy specimens: contemporary approach, current clinical significance and sources of pathology discrepancies. BJU Int. 95(8), 1146–1152 (2005)
Müller, A., Behnke, S.: PyStruct-Structured Prediction in Python. JMLR 15, 2055–2060 (2014)
Nguyen, K., Sarkar, A., Jain, A.K.: Structure and Context in Prostatic Gland Segmentation and Classification. In: Ayache, N., Delingette, H., Golland, P., Mori, K. (eds.) MICCAI 2012, Part I. LNCS, vol. 7510, pp. 115–123. Springer, Heidelberg (2012)
Ojala, T., Pietikäinen, M., Mäenpää, T.: Multiresolution Gray-Scale and Rotation Invariant Texture Classification with Local Binary Patterns. IEEE TPAMI 24(7), 971–987 (2002)
Pedregosa, F., Varoquaux, G., Gramfort, A., Michel, V., Thirion, B., Grisel, O., Blondel, M., Prettenhofer, P., Weiss, R., Dubourg, V., VanderPlas, J., Passos, A., Cournapeau, D., Brucher, M., Perrot, M., Duchesnay, E.: scikit-learn: Machine Learning in Python. JMLR 12, 2825–2830 (2011)
Tabesh, A., Teverovskiy, M., Pang, H.Y., Kumar, V.P., Verbel, D., Kotsianti, A., Saidi, O.: Multifeature Prostate Cancer Diagnosis and Gleason Grading of Histological Images. IEEE TMI 26(10), 1366–1378 (2007)
Tsochantaridis, I., Joachims, T., Hofmann, T., Altun, Y.: Large Margin Methods for Structured and Interdependent Output Variables. JMLR 6, 1453–1484 (2005)
van der Walt, S., Schönberger, J.L., Nunez-Iglesias, J., Boulogne, F., Warner, J.D., Yager, N., Gouillart, E., Yu, T., The scikit-image contributors: scikit-image: image processing in Python. PeerJ 2, e453 (2014)
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Jacobs, J.G., Panagiotaki, E., Alexander, D.C. (2014). Gleason Grading of Prostate Tumours with Max-Margin Conditional Random Fields. In: Wu, G., Zhang, D., Zhou, L. (eds) Machine Learning in Medical Imaging. MLMI 2014. Lecture Notes in Computer Science, vol 8679. Springer, Cham. https://doi.org/10.1007/978-3-319-10581-9_11
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DOI: https://doi.org/10.1007/978-3-319-10581-9_11
Publisher Name: Springer, Cham
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