Skip to main content

Implantable Biosensors

  • Chapter
  • First Online:

Part of the book series: SpringerBriefs in Applied Sciences and Technology ((BRIEFSAPPLSCIENCES))

Abstract

Implantable biosensors have been recognised for their ability to continuously monitor with minimal patient intervention compared with common procedure in clinical environments, such as introduction of catheters and surgical drains.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Abbotdiabetes. Available: http://www.abbottdiabetescare.com/index.htm [Accessed March 2013

  • Agnesi F, Tye SJ, Bledsoe JM, Griessenauer CJ, Kimble CJ, Sieck GC, Bennet KE, Garris PA, Blaha CD, Lee KH (2009) Wireless Instantaneous Neurotransmitter Concentration System-based amperometric detection of dopamine, adenosine, and glutamate for intraoperative neurochemical monitoring: Laboratory investigation. J Neurosurg 111:701–711

    Article  Google Scholar 

  • Ahmadi MM, Jullien GA (2009) A wireless-implantable microsystem for continuous blood glucose monitoring. IEEE Trans Biomed Circuits Syst 3:169–180

    Article  Google Scholar 

  • Anne ML, Keirsse J, Nazabal V, Hyodo K, Inoue S, Boussard-Pledel C, Lhermite H, Charrier J, Yanakata K, Loreal O, le Person J, Colas F, Compère C, Bureau B (2009) Chalcogenide glass optical waveguides for infrared biosensing. Sensors 9:7398–7411

    Article  Google Scholar 

  • Arntz Y, Seelig JD, Lang HP, Zhang J, Hunziker P, Ramseyer JP, Meyer E, Hegner M, Gerber C (2003) Label-free protein assay based on a nanomechanical cantilever array. Nanotechnology 14:86–90

    Article  Google Scholar 

  • Bahl MI, Hansen LH, Licht TR, Sørensen SJ (2004) In Vivo detection and quantification of tetracycline by use of a whole-cell biosensor in the rat intestine. Antimicrob Agents Chemother 48:1112–1117

    Article  Google Scholar 

  • Ballerstadt R, Evans C, McNichols R, Gowda A (2006) Concanavalin A for in vivo glucose sensing: a biotoxicity review. Biosens Bioelectron 22:275–284

    Article  Google Scholar 

  • Bazzu G, Puggioni GGM, Dedola S, Calia G, Rocchitta G, Migheli R, Desole MS, Lowry JP, O’Neill RD, Serra PA (2009) Real-time monitoring of brain tissue oxygen using a miniaturized biotelemetric device implanted in freely moving rats. Anal Chem 81:2235–2241

    Article  Google Scholar 

  • Bode B, Gross K, Rikalo N, Schwartz S, Wahl T, Page C, Gross T, Mastrototaro J (2004) Alarms based on real-time sensor glucose values alert patients to hypo- and hyperglycemia: the guardian continuous monitoring system. Diab Technol Ther 6:105–113

    Article  Google Scholar 

  • Bode B, Silver M, Weiss R, Martin K (2008) Evaluation of a continuous glucose monitoring system for home-use conditions. Managed, Care 17

    Google Scholar 

  • Bonanno LM, Delouise LA (2007) Whole blood optical biosensor. Biosens Bioelectron 23:444–448

    Article  Google Scholar 

  • Borisov SM, Wolfbeis OS (2008) Optical biosensors. Chem Rev 108:423–461

    Article  Google Scholar 

  • Boss C, Meurville E, Sallese JM, Ryser P (2011) A viscosity-dependent affinity sensor for continuous monitoring of glucose in biological fluids. Biosens Bioelectron 30:223–228

    Article  Google Scholar 

  • Broderick PA, Kolodny EH (2011) Biosensors for brain trauma and dual laser Doppler flowmetry: enoxaparin simultaneously reduces stroke-induced dopamine and blood flow while enhancing serotonin and blood flow in motor neurons of brain, in vivo. Sensors 11:138–161

    Article  Google Scholar 

  • Bryan T, Luo X, Bueno PR, Davis JJ (2013) An optimised electrochemical biosensor for the label-free detection of C-reactive protein in blood. Biosens Bioelectron 39:94–98

    Article  Google Scholar 

  • Campanella L, Favero G, Mastrofini D, Tomassetti M (1996) Toxicity order of cholanic acids using an immobilised cell biosensor. J Pharm Biomed Anal 14:1007–1013

    Article  Google Scholar 

  • Cao Y, Koo YEL, Kopelman R (2004) Poly(decyl methacrylate)-based fluorescent PEBBLE swarm nanosensors for measuring dissolved oxygen in biosamples. Analyst 129:745–750

    Article  Google Scholar 

  • Chang SY, Jay T, Muñoz J, Kim I, Lee KH (2012) Wireless fast-scan cyclic voltammetry measurement of histamine using WINCS—A proof-of-principle study. Analyst 137:2158–2165

    Article  Google Scholar 

  • Chanu A, Martel S (2007) MRI controlled magnetoelastic nano biosensor for in vivo pH monitoring: a preliminary approach. pp 166–170

    Google Scholar 

  • Chikkaveeraiah BV, Bhirde AA, Morgan NY, Eden HS, Chen X (2012) Electrochemical immunosensors for detection of cancer protein biomarkers. ACS Nano 6:6546–6561

    Article  Google Scholar 

  • Chinnayelka S, McShane MJ (2006) Glucose sensors based on microcapsules containing an orange/red competitive binding resonance energy transfer assay. Diab Technol Ther 8:269–278

    Article  Google Scholar 

  • Chua JH, Chee RE, Agarwal A, She MW, Zhang GJ (2009) Label-free electrical detection of cardiac biomarker with complementary metal-oxide semiconductor-compatible silicon nanowire sensor arrays. Anal Chem 81:6266–6271

    Article  Google Scholar 

  • Clark LC, Lyons C (1962) Electrode systems for continuous monitoring in cardiovascular surgery. Ann N Y Acad Sci 102:29–45

    Article  Google Scholar 

  • Daniel KD, Kim GY, Vassiliou CC, Galindo M, Guimaraes AR, Weissleder R, Charest A, Langer R, Cima MJ (2009) Implantable diagnostic device for cancer monitoring. Biosens Bioelectron 24:3252–3257

    Article  Google Scholar 

  • Dardzinski BJ, Schmithorst VJ, Holland SK, Boivin GP, Imagawa T, Watanabe S, Lewis JM, Hirsch R (2001) MR imaging of murine arthritis using ultrasmall superparamagnetic iron oxide particles. Magn Reson Imaging 19:1209–1216

    Article  Google Scholar 

  • Day BK, Pomerleau F, Burmeister JJ, Huettl P, Gerhardt GA (2006) Microelectrode array studies of basal and potassium-evoked release of L-glutamate in the anesthetized rat brain. J Neurochem 96:1626–1635

    Article  Google Scholar 

  • Dolatabadi JEN, Mashinchian O, Ayoubi B, Jamali AA, Mobed A, Losic D, Omidi Y, de la Guardia M (2011) Optical and electrochemical DNA nanobiosensors. TrAC–Trends in Analytical Chemistry 30:459–472

    Article  Google Scholar 

  • D’Orazio P (2011) Biosensors in clinical chemistry—2011 update. Clin Chim Acta 412:1749–1761

    Article  Google Scholar 

  • Dreier JP, Major S, Manning A, Woitzik J, Drenckhahn C, Steinbrink J, Tolias C, Oliveira-Ferreira AI, Fabricius M, Hartings JA, Vajkoczy P, Lauritzen M, Dirnagl U, Bohner G, Strong AJ (2009) Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage. Brain 132:1866–1881

    Article  Google Scholar 

  • Elshafey R, Tlili C, Abulrob A, Tavares AC, Zourob M (2013) Label-free impedimetric immunosensor for ultrasensitive detection of cancer marker Murine double minute 2 in brain tissue. Biosens Bioelectron 39:220–225

    Article  Google Scholar 

  • Eiferman D, Perez-Tamayo RA, Abe K, Okum E, Higgins R (2007) Real-time monitoring of cardiac metabolism using biosensors shows myocardial protection during ischemia-reperfusion injury with glucose-insulin-potassium administration. Surgery 142:150–155

    Article  Google Scholar 

  • Eiferman DS, Nguyen L, Perez-Tamayo RA (2008) Real-time myocardial glucose measurement using biosensors. ASAIO J 54:120–123

    Article  Google Scholar 

  • Ermini ML, Mariani S, Scarano S, Campa D, Barale R Minunni M (2012) Single nucleotide polymorphism detection by optical DNA-based sensing coupled with whole genomic amplification. Anal Bioanal Chem 1–9

    Google Scholar 

  • Feigel IM, Vedala H, Star A (2011) Biosensors based on one-dimensional nanostructures. J Mater Chem 21:8940–8954

    Article  Google Scholar 

  • Franceschini MA, Joseph DK, Huppert TJ, Diamond SG, Boas DA (2006) Diffuse optical imaging of the whole head. J Biomed Optics 11

    Google Scholar 

  • Frey O, Holtzman T, McNamara RM, Theobald DEH, van der Wal PD, de Rooij NF, Dalley JW, Koudelka-Hep M (2010) Enzyme-based choline and l-glutamate biosensor electrodes on silicon microprobe arrays. Biosens Bioelectron 26:477–484

    Article  Google Scholar 

  • Fritz J (2008) Cantilever biosensors. Analyst 133:855–863

    Article  Google Scholar 

  • Gerritsen M, Jansen JA, Lutterman JA (2002) Subcutaneously implantable glucose sensors in patients with diabetes mellitus; still many problems. Subcutaan implanteerbare glucosesensoren voor patiënten met diabetes mellitus; nog veel problemen, 146:1313–1316

    Google Scholar 

  • Gough DA, Kumosa LS, Routh TL, Lin JT Lucisano JY (2010) Function of an implanted tissue glucose sensor for more than 1 year in animals. Sci Trans Med 2

    Google Scholar 

  • Gourine AV, Dale N, Llaudet E, Poputnikov DM, Spyer KM, Gourine VN (2007) Release of ATP in the central nervous system during systemic inflammation: real-time measurement in the hypothalamus of conscious rabbits. J Physiol 585:305–316

    Article  Google Scholar 

  • Guilbault GG, Lubrano GJ (1973) An enzyme electrode for the amperometric determination of glucose. Anal Chim Acta 64:439–455

    Article  Google Scholar 

  • Guiseppi-Elie A (2011) An implantable biochip to influence patient outcomes following trauma-induced hemorrhage. Anal Bioanal Chem 399:403–419

    Article  Google Scholar 

  • Haes AJ, Chang L, Klein WL, van Duyne RP (2005) Detection of a biomarker for Alzheimer’s disease from synthetic and clinical samples using a nanoscale optical biosensor. J Am Chem Soc 127:2264–2271

    Article  Google Scholar 

  • Hashemi P, Walsh PL, Guillot TS, Gras-Najjar J, Takmakov P, Crews FT, Wightman RM (2011) Chronically implanted, nafion-coated Ag/AgCl reference electrodes for neurochemical applications. ACS Chem Neurosci 2:658–666

    Article  Google Scholar 

  • Haun JB, Yoon TJ, Lee H, Weissleder R (2010) Magnetic nanoparticle biosensors. Wiley Interdisc Rev Nanomed Nanobiotechnology 2:291–304

    Article  Google Scholar 

  • Heo YJ, Shibata H, Okitsu T, Kawanishi T, Takeuchi S (2011) Fluorescent hydrogel fibers for long-term in vivo glucose monitoring. pp 2140–2143

    Google Scholar 

  • Hinzman JM, Thomas TC, Burmeister JJ, Quintero JE, Huettl P, Pomerleau F, Gerhardt GA, Lifshitz J (2010) Diffuse brain injury elevates tonic glutamate levels and potassium-evoked glutamate release in discrete brain regions at two days post-injury: an enzyme-based microelectrode array study. J Neurotrauma 27:889–899

    Article  Google Scholar 

  • Hirmo S, Artursson E, Puu G, Wadström T, Nilsson B (1999) Helicobacter pylori interactions with human gastric mucin studied with a resonant mirror biosensor. J Microbiol Methods 37:177–182

    Article  Google Scholar 

  • Ho JAA, Lin YC, Wang LS, Hwang KC, Chou PT (2009) Carbon nanoparticle-enhanced immunoelectrochemical detection for protein tumor marker with cadmium sulfide biotracers. Anal Chem 81:1340–1346

    Article  Google Scholar 

  • Hoehn M, Küstermann E, Blunk J, Wiedermann D, Trapp T, Wecker S, Föcking M, Arnold H, Hescheler J, Fleischmann BK, Schwindt W, Bührle C (2002) Monitoring of implanted stem cell migration in vivo: a highly resolved in vivo magnetic resonance imaging investigation of experimental stroke in rat. Proc Natl Acad Sci USA 99:16267–16272

    Article  Google Scholar 

  • Huang MCY, Mateus CFR, Foley JE, Beatty R, Cunningham BT, Chang-Hasnain CJ (2008) VCSEL optoelectronic biosensor for detection of infectious diseases. IEEE Photonics Technol Lett 20:443–445

    Article  Google Scholar 

  • Ito A, Shinkai M, Honda H, Kobayashi T (2005) Medical application of functionalized magnetic nanoparticles. J Biosci Bioeng 100:1–11

    Article  Google Scholar 

  • Iwuoha E, Ngece R, Klink M, Baker P (2007) Amperometric responses of CYP2D6 drug metabolism nanobiosensor for sertraline: a selective serotonin reuptake inhibitor. IET Nanobiotechnol 1:62–67

    Article  Google Scholar 

  • Jackowska K, Krysinski P (2012) New trends in the electrochemical sensing of dopamine. Anal Bioanal Chem 1–19

    Google Scholar 

  • Jeong HH, Erdene N, Park JH, Jeong DH, Lee HY, Lee SK (2013) Real-time label-free immunoassay of interferon-gamma and prostate-specific antigen using a fiber-optic localized surface plasmon resonance sensor. Biosens Bioelectron 39:346–351

    Article  Google Scholar 

  • Jin XH, Ishii A, Aoki K, Ishida S, Mukasa K, Ohno S (2011) Detection of human adenovirus hexon antigen using carbon nanotube sensors. J Virol Methods 171:405–407

    Article  Google Scholar 

  • Jobst G, Moser I, Varahram M, Svasek P, Aschauer E, Trajanoski Z, Wach P, Kotanko P, Skrabal F, Urban G (1996) Thin-film microbiosensors for glucose-lactate monitoring. Anal Chem 68:3173–3179

    Article  Google Scholar 

  • Joshi A, Solanki S, Chaudhari R, Bahadur D, Aslam M, Srivastava R (2011) Multifunctional alginate microspheres for biosensing, drug delivery and magnetic resonance imaging. Acta Biomater 7:3955–3963

    Article  Google Scholar 

  • Kalish H, Arbab AS, Miller BR, Lewis BK, Zywicke HA, Bulte JWM, Bryant JR LH, Frank JA (2003) Combination of transfection agents and magnetic resonance contrast agents for cellular imaging: Relationship between relaxivities, electrostatic forces, and chemical composition. Magn Reson Med 50:275–282

    Google Scholar 

  • Kirk JT, Brault ND, Baehr-Jones T, Hochberg M, Jiang S, Ratner DM (2013) Zwitterionic polymer-modified silicon microring resonators for label-free biosensing in undiluted human plasma. Biosens Bioelectron 42:100–105

    Article  Google Scholar 

  • Kishida KT, Sandberg SG, Lohrenz T, Comair YG, Sáez I, Phillips PEM, Montague PR (2011) Sub-second dopamine detection in human striatum. PLoS ONE 6

    Google Scholar 

  • Koschwanez HE, Reichert WM (2007) In vitro, in vivo and post explantation testing of glucose-detecting biosensors: current methods and recommendations. Biomaterials 28:3687–3703

    Article  Google Scholar 

  • Kumeria T, Kurkuri MD, Diener KR, Parkinson L, Losic D (2012) Label-free reflectometric interference microchip biosensor based on nanoporous alumina for detection of circulating tumour cells. Biosens Bioelectron 35:167–173

    Article  Google Scholar 

  • Laborla N, Fragoso A, Kemmner W, Latta D, Nllsson O, Botero ML, Drese K, O’Sulllivan CK (2010) Amperometric immunosensor for carcinoembryonic antigen in colon cancer samples based on monolayers of dendritic bipodal scaffolds. Anal Chem 82:1712–1719

    Article  Google Scholar 

  • Lambrecht A, Beyer T, Hebestreit K, Mischler R, Petrich W (2006) Continuous glucose monitoring by means of fiber-based, mid-infrared laser spectroscopy. Appl Spectrosc 60:729–736

    Article  Google Scholar 

  • Lei M, Baldi A, Nuxoll E, Siegel RA, Ziaie B (2006) A hydrogel-based implantable micromachined transponder for wireless glucose measurement. Diab Technol Ther 8:112–122

    Article  Google Scholar 

  • Li C, Ahn CH, Shutter LA, Narayan RK (2009) Toward real-time continuous brain glucose and oxygen monitoring with a smart catheter. Biosens Bioelectron 25:173–178

    Article  Google Scholar 

  • Li CM, Dong H, Cao X, Luong JHT, Zhang X (2007) Implantable electrochemical sensors for biomedical and clinical applications: progress, problems, and future possibilities. Curr Med Chem 14:937–951

    Article  Google Scholar 

  • Ligler F, Taitt C (2008) Optical biosensors: today and tomorrow, Elsevier

    Google Scholar 

  • Long R, McShane M (2010) Three-dimensional, multiwavelength monte Carlo simulations of dermally implantable luminescent sensors. J Biomed Optics 15:027011

    Article  Google Scholar 

  • May KML, Vogt A, Bachas LG, Anderson KW (2005) Vascular endothelial growth factor as a biomarker for the early detection of cancer using a whole cell-based biosensor. Anal Bioanal Chem 382:1010–1016

    Article  Google Scholar 

  • Mastrototaro J (1999) The MiniMed continuous glucose monitoring system (CGMS). J Pediatr Endocrinol Metab 12:751–758

    Google Scholar 

  • McLamore ES, Mohanty S, Shi J, Claussen J, Jedlicka SS, Rickus JL, Porterfield DM (2010) A self-referencing glutamate biosensor for measuring real time neuronal glutamate flux. J Neurosci Methods 189:14–22

    Article  Google Scholar 

  • Mcshane MJ, O’neal DP, Russell RJ, Pishko MV Cote GL (2000) Progress toward implantable fluorescence-based sensors for monitoring glucose levels in interstitial fluid. pp 78–87

    Google Scholar 

  • Medtronic Minimed I. Available: http://www.medtronic.com/for-healthcare-professionals/products-therapies/diabetes/index.htm [Accessed March 2013

  • Moatti-Sirat D, Velho G, Reach G (1992) Evaluating in vitro and in vivo the interference of ascorbate and acetaminophen on glucose detection by a needle-type glucose sensor. Biosens Bioelectron 7:345–352

    Article  Google Scholar 

  • Morales-Villagrán A, Medina-Ceja L, López-Pérez SJ (2008) Simultaneous glutamate and EEG activity measurements during seizures in rat hippocampal region with the use of an electrochemical biosensor. J Neurosci Methods 168:48–53

    Article  Google Scholar 

  • Mukundan H, Kubicek JZ, Holt A, Shively JE, Martinez JS, Grace K, Grace WK, Swanson BI (2009) Planar optical waveguide-based biosensor for the quantitative detection of tumor markers. Sens Actuators, B: Chem 138:453–460

    Article  Google Scholar 

  • Mukundan H, Kumar S, Price DN, Ray SM, Lee YJ, Min S, Eum S, Kubicek-Sutherland J, Resnick JM, Grace WK, Anderson AS, Hwang SH, Cho SN, Via LE, Barry III C, Sakamuri R, Swanson B I (2012) Rapid detection of mycobacterium tuberculosis biomarkers in a sandwich immunoassay format using a waveguide-based optical biosensor. Tuberculosis 92:407–416

    Google Scholar 

  • Njagi J, Chernov MM, Leiter JC, Andreescu S (2010) Amperometric detection of dopamine in vivo with an enzyme based carbon fiber microbiosensor. Anal Chem 82:989–996

    Article  Google Scholar 

  • Obonyo O, Fisher E, Edwards M, Douroumis D (2010) Quantum dots synthesis and biological applications as imaging and drug delivery systems. Crit Rev Biotechnol 30:283–301

    Article  Google Scholar 

  • Paek SH, Cho IH, Kim DH, Jeon JW, Lim GS, Paek SH (2013) Label-free, needle-type biosensor for continuous glucose monitoring based on competitive binding. Biosens Bioelectron 40:38–44

    Article  Google Scholar 

  • Patel BA, Rogers M, Wieder T, O’Hare D, Boutelle MG (2011) ATP microelectrode biosensor for stable long-term in vitro monitoring from gastrointestinal tissue. Biosens Bioelectron 26:2890–2896

    Article  Google Scholar 

  • Pfeiffer D, Möller B, Klimes N, Szeponik J, Fischer S (1997) Amperometric lactate oxidase catheter for real-time lactate monitoring based on thin film technology. Biosens Bioelectron 12:539–550

    Article  Google Scholar 

  • Redshaw N, Dickson SJ, Ambrose V, Horswell J (2007) A preliminary investigation into the use of biosensors to screen stomach contents for selected poisons and drugs. Forensic Sci Int 172:106–111

    Article  Google Scholar 

  • Renard E (2008) Implantable continuous glucose sensors. Current Diabetes Reviews 4:169–174

    Article  Google Scholar 

  • Robinson DL, Hermans A, Seipel AT, Wightman RM (2008) Monitoring rapid chemical communication in the brain. Chem Rev 108:2554–2584

    Article  Google Scholar 

  • Rusling JF, Kumar CV, Gutkind JS, Patel V (2010) Measurement of biomarker proteins for point-of-care early detection and monitoring of cancer. Analyst 135:2496–2511

    Article  Google Scholar 

  • Ryou M, Nemiroski A, Azagury D, Shaikh SN, Ryan MB, Westervelt RM, Thompson CC (2011) An implantable wireless biosensor for the immediate detection of upper GI bleeding: a new fluorescein-based tool for diagnosis and surveillance (with video). Gastrointest Endosc 74:189–194

    Article  Google Scholar 

  • Salazar P, O’Neill RD, Martín M, Roche R, González-Mora JL (2011) Amperometric glucose microbiosensor based on a Prussian Blue modified carbon fiber electrode for physiological applications. Sens Actuators, B: Chem 152:137–143

    Article  Google Scholar 

  • Sandhu A, Handa H, Abe M (2010) Synthesis and applications of magnetic nanoparticles for biorecognition and point of care medical diagnostics. Nanotechnology 21

    Google Scholar 

  • Sarkar P, Pal PS, Ghosh D, Setford SJ, Tothill IE (2002) Amperometric biosensors for detection of the prostate cancer marker (PSA). Int J Pharm 238:1–9

    Article  Google Scholar 

  • Sassolas A, Blum LJ, Leca-Bouvier BD (2011) Optical detection systems using immobilized aptamers. Biosens Bioelectron 26:3725–3736

    Article  Google Scholar 

  • Schröder L (2013) Xenon for NMR biosensing—Inert but alert. Physica Med 29:3–16

    Article  Google Scholar 

  • Speight RE, Cooper MA (2012) A survey of the 2010 quartz crystal microbalance literature. J Mol Recognit 25:451–473

    Article  Google Scholar 

  • Srivastava R, Jayant RD, Chaudhary A, McShane MJ (2011) “Smart tattoo” glucose biosensors and effect of coencapsulated anti-inflammatory agents. J Diab Sci Technol 5:76–85

    Google Scholar 

  • Staples M, Daniel K, Cima MJ, Langer R (2006) Application of micro- and nanoelectromechanical devices to drug delivery. Pharm Res 23:847–863

    Article  Google Scholar 

  • Stephens ML, Pomerleau F, Huettl P, Gerhardt GA, Zhang Z (2010) Real-time glutamate measurements in the putamen of awake rhesus monkeys using an enzyme-based human microelectrode array prototype. J Neurosci Methods 185:264–272

    Article  Google Scholar 

  • Strong AJ, Bezzina EL, Anderson PJB, Boutelle MG, Hopwood SE, Dunn AK (2006) Evaluation of laser speckle flowmetry for imaging cortical perfusion in experimental stroke studies: Quantitation of perfusion and detection of peri-infarct depolarisations. J Cereb Blood Flow Metab 26:645–653

    Article  Google Scholar 

  • Struss AK, Pasini P, Flomenhoft D, Shashidhar H, Daunert S (2012) Investigating the effect of antibiotics on quorum sensing with whole-cell biosensing systems. Anal Bioanal Chem 402:3227–3236

    Article  Google Scholar 

  • Swain CP, Brown GJ, Gong F, Mills TN (1994) An endoscopically deliverable tissue-transfixing device for securing biosensors in the gastrointestinal tract. Gastrointest Endosc 40:730–733

    Google Scholar 

  • Tolosa VM, Wassum KM, Maidment NT, Monbouquette HG (2013) Electrochemically deposited iridium oxide reference electrode integrated with an electroenzymatic glutamate sensor on a multi-electrode array microprobe. Biosens Bioelectron 42:256–260

    Article  Google Scholar 

  • Vaddiraju S, Tomazos I, Burgess DJ, Jain FC, Papadimitrakopoulos F (2010) Emerging synergy between nanotechnology and implantable biosensors: a review. Biosens Bioelectron 25:1553–1565

    Article  Google Scholar 

  • Vadgama P, Spoors J, Tang LX, Battersby C (1989) The needle glucose electrode: In vitro performance and optimisation for implantation. Biomed Biochim Acta 48:935–942

    Google Scholar 

  • Valdastri P, Susilo E, Förster T, Strohhöfer C, Menciassi A, Dario P (2011) Wireless implantable electronic platform for chronic fluorescent-based biosensors. IEEE Trans Biomed Eng 58:1846–1854

    Article  Google Scholar 

  • Vamvakaki V, Fournier D, Chaniotakis NA (2005) Fluorescence detection of enzymatic activity within a liposome based nano-biosensor. Biosens Bioelectron 21:384–388

    Article  Google Scholar 

  • Veetil JV, Jin S, Ye K (2010) A glucose sensor protein for continuous glucose monitoring. Biosens Bioelectron 26:1650–1655

    Article  Google Scholar 

  • Voiculescu I, Nordin AN (2012) Acoustic wave based MEMS devices for biosensing applications. Biosens Bioelectron 33:1–9

    Article  Google Scholar 

  • Wang J (2001) Glucose biosensors: 40 Years of advances and challenges. Electroanalysis 13:983–988

    Article  Google Scholar 

  • Wang J (2008) In vivo glucose monitoring: towards ‘Sense and Act’ feedback-loop individualized medical systems. Talanta 75:636–641

    Article  Google Scholar 

  • Ward WK, Jansen LB, Anderson E, Reach G, Klein JC, Wilson GS (2002) A new amperometric glucose microsensor: In vitro and short-term in vivo evaluation. Biosens Bioelectron 17:181–189

    Article  Google Scholar 

  • Ward WK, Casey HM, Quinn MJ, Federiuk IF, Wood MD (2003) A fully implantable subcutaneous glucose sensor array: enhanced accuracy from multiple sensing units and a median-based algorithm. Diab Technol Ther 5:943–952

    Article  Google Scholar 

  • Wickramasinghe Y, Yang Y, Spencer SA (2004) Current problems and potential techniques in in vivo glucose monitoring. J Fluoresc 14:513–520

    Article  Google Scholar 

  • Woderer S, Henninger N, Garthe CD, Kloetzer HM, Hajnsek M, Kamecke U, Gretz N, Kraenzlin B, Pill J (2007) Continuous glucose monitoring in interstitial fluid using glucose oxidase-based sensor compared to established blood glucose measurement in rats. Anal Chim Acta 581:7–12

    Article  Google Scholar 

  • Xing Y, Xia Z, Rao J (2009) Semiconductor quantum dots for biosensing and in vivo imaging. IEEE Trans Nanobiosci 8:4–12

    Article  Google Scholar 

  • Xu M, Luo X, Davis JJ (2013) The label free picomolar detection of insulin in blood serum. Biosens Bioelectron 39:21–25

    Article  Google Scholar 

  • Yeh TC, Zhang W, Ildstad ST, Ho C (1995) In vivo dynamic MRI tracking of rat T-cells labeled with superparamagnetic iron-oxide particles. Magn Reson Med 33:200–208

    Article  Google Scholar 

  • Yu B, Moussy Y, Moussy F (2005) Coil-type implantable glucose biosensor with excess enzyme loading. Front Biosci J Virtual Libr 10:512–520

    Article  Google Scholar 

  • Yuan J, Duan R, Yang H, Luo X, Xi M (2012) Detection of serum human epididymis secretory protein 4 in patients with ovarian cancer using a label-free biosensor based on localized surface plasmon resonance. Int J Nanomed 7:2921–2928

    Article  Google Scholar 

  • Zhang Y, Chen Y, Jin G (2011) Serum tumor marker detection on PEGylated lipid membrane using biosensor based on total internal reflection imaging ellipsometry. Sens Actuators, B: Chem 159:121–125

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Emma P. Córcoles .

Rights and permissions

Reprints and permissions

Copyright information

© 2013 The Author(s)

About this chapter

Cite this chapter

Córcoles, E.P., Boutelle, M.G. (2013). Implantable Biosensors. In: Biosensors and Invasive Monitoring in Clinical Applications. SpringerBriefs in Applied Sciences and Technology. Springer, Heidelberg. https://doi.org/10.1007/978-3-319-00360-3_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-00360-3_5

  • Published:

  • Publisher Name: Springer, Heidelberg

  • Print ISBN: 978-3-319-00359-7

  • Online ISBN: 978-3-319-00360-3

  • eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics