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Revisiting Complexation Between DNA and Polyethylenimine: The Effect of Length of Free Polycationic Chains on Gene Transfection

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How Free Cationic Polymer Chains Promote Gene Transfection

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Abstract

The gene therapy, considered as the treatment of genetically-caused diseases by transferring exogenous nucleic acids into specific cells of patients, has attracted great interests over the past few decades [1]. It has been gradually realized that the development of safe, efficient and controllable gene-delivery vectors has become a bottleneck in clinical applications. The gene transfection vectors can be generally divided as viral and non-viral ones.

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  1. Department of Chemistry, University of Chicago, 929 E 57th Street, Chicago, IL, 60637, USA

    Yue Yanan

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Yanan, Y. (2013). Revisiting Complexation Between DNA and Polyethylenimine: The Effect of Length of Free Polycationic Chains on Gene Transfection. In: How Free Cationic Polymer Chains Promote Gene Transfection. Springer Theses. Springer, Heidelberg. https://doi.org/10.1007/978-3-319-00336-8_3

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