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Nutrigenomik Regulation der Genexpression Durch Nährstoffe

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Zusammenfassung

Ein Leben unter Steinzeitbedingungen war geprägt durch einen täglichen Existenzkampf am Rande der kalorischen Mindestversorgung. Die in unserer Zeit herrschende Kalorienüberversorgung (hyperkalorische Ernährung) und der damit assoziierte Bewegungsmangel stellt unsere Gesellschaft vor ein ernstes kollektives Gesundheitsproblem und beschert uns u. a. Erkrankungen wie das Metabolische Syndrom. Das Metabolische Syndrom wird oft auch als „tödliches Quartett“ bezeichnet, da es durch erhöhte Triglyzeridwerte, Hypertonie, Insulinresistenz und Hypercholesterinämie definiert ist (IDF Clinical Guidelines Task Force, 2005).

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Literaturverzeichnis

  • Amemiya-Kudo M, Shimano H, Hasty AH, Yahagi N, Yoshikawa T, Matsuzaka T, Okazaki H, Tamura Y, Iizuka Y, Ohashi Y, Osuga J, Harada K, Gotoda T, Sato R, Kimura S, Ishibashi S, Yamada N (2002) Transcriptional activities of nuclear SREBP-1 a,-1 c, and-2 to different target promoters of lipogenic and cholesterogenic genes. J Lipid Res 43: 1220–1235

    CAS  PubMed  Google Scholar 

  • Auboeuf D, Rieusset J, Fajas L, Vallier P, Frering V, Riou JP, Staels B, Auwerx J, Laville M, Vidal H (1997) Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: no alteration in adipose tissue of obese and NIDDM patients. Diabetes 46: 1319–1327

    Article  CAS  PubMed  Google Scholar 

  • Bastien J, Rochette-Egly C (2004) Nuclear retinoid receptors and the transcription of retinoid-target genes, Gene 328: 1–16

    Article  CAS  PubMed  Google Scholar 

  • Bergot MO, Diaz-Guerra MJ, Puzenat N, Raymondjean M, Kahn A (1992) Cis-regulation of the L-type pyruvate kinase gene promoter by glucose, insulin and cyclic AMP. Nucleic Acids Res 20: 1871–1877

    Article  CAS  PubMed  Google Scholar 

  • Blomhoff R, Blomhoff HK (2006) Overview of retinoid metabolism and function. Journal of Neurobiology 66: 606–630

    Article  CAS  PubMed  Google Scholar 

  • Brown MS, Goldstein JL (1997) The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89: 331–340

    Article  CAS  PubMed  Google Scholar 

  • Chen G, Liang G, Ou J, Goldstein JL, Brown MS (2004) Central role for liver X receptor in insulin-mediated activation of Srebp-1 c transcription and stimulation of fatty acid synthesis in liver. Proc Natl Acad Sci USA 101: 11 245–11 250

    CAS  Google Scholar 

  • Chen W, Chen G, Head DL, Mangelsdorf DJ, Russell DW (2007) Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice. Cell Metab 5: 73–79

    Article  CAS  PubMed  Google Scholar 

  • Chen Y, Jimenez AR, Medh JD (2006) Identification and regulation of novel PPAR-gamma splice variants in human THP-1 macrophages. Biochim Biophys Acta 1759: 32–43

    CAS  PubMed  Google Scholar 

  • Conrad ME, Umbreit JN (2002) Pathways of iron absorption. Blood Cells Mol Dis 29: 336–355

    Article  CAS  PubMed  Google Scholar 

  • D’Autréaux B, Toledano MB (2007) ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. Nat Rev Mol Cell Biol 8: 813–824

    Article  PubMed  Google Scholar 

  • Datta S, Osborne TF (2005) Activation domains from both monomers contribute to transcriptional stimulation by sterol regulatory element-binding protein dimers. J Biol Chem 280: 3338–3345

    Article  CAS  PubMed  Google Scholar 

  • DeBusk RM, Fogarty CP, Ordovas JM, Kornman KS (2005) Nutritional genomics in practice: where do we begin J Am Diet Assoc 105: 589–598

    Article  CAS  PubMed  Google Scholar 

  • Denechaud PD, Bossard P, Lobaccaro JM, Millatt L, Staels B, Girard J, Postic C (2008) ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver. J Clin Invest 118: 956–964

    CAS  PubMed  Google Scholar 

  • Desvergne B, Wahli W (1999) Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev 20: 649–688

    Article  CAS  PubMed  Google Scholar 

  • Diradourian C, Girard J, Pegorier JP (2005) Phosphorylation of PPARs: from molecular characterization to physiological relevance. Biochemie 87: 33–38

    Article  CAS  Google Scholar 

  • Dreyer C, Krey G, Keller H, Givel F, Helftenbein G, Wahli W (1992) Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors. Cell 68: 879–887

    Article  CAS  PubMed  Google Scholar 

  • Feder JN, Penny DM, Irrinki A, Lee VK, Lebron JA, Watson N, Tsuchihashi Z, Sigal E, Bjorkman PJ, Schatzman RC (1998) The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Proc Natl Acad Sci USA 95: 1472–1477

    Article  CAS  PubMed  Google Scholar 

  • Galy B, Ferring-Appel D, Kaden S, Gröne HJ, Hentze MW (2008) Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum. Cell Metab 7: 79–85

    Article  CAS  PubMed  Google Scholar 

  • Gidlöf AC, Ocaya P, Krivospitskaya O, Sirsjö A (2008) Vitamin A: a drug for prevention of restenosis/reocclusion after percutaneous coronary intervention. Clin Sci (Lond) 114: 19–25

    Article  PubMed  Google Scholar 

  • Giguere V, Ong ES, Segui P, Evans RM (1987) Identification of a receptor for the morphogen retinoic acid. Nature 330: 624–629

    Article  CAS  PubMed  Google Scholar 

  • Hanselman JC, Vartanian MA, Koester BP, Gray SA, Essenburg AD, Rea TJ, Bisgaier CL, Pape ME (2001) Expression of the mRNA encoding truncated PPAR alpha does not correlate with hepatic insensitivity to peroxisome proliferators. Mol Cell Biochem 217: 91–97

    Article  CAS  PubMed  Google Scholar 

  • Holtzclaw WD, Dinkova-Kostova AT, Talalay P (2004) Protection against electrophile and oxidative stress by induction of phase 2 genes: the quest for the elusive sensor that responds to inducers. Adv Enzyme Regul 44: 335–367

    Article  CAS  PubMed  Google Scholar 

  • Horton JD, Shah NA, Warrington JA, Anderson NN, Park SW, Brown MS, Goldstein JL (2003) Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. Proc Natl Acad Sci USA 100: 12 027–12 032

    Article  CAS  Google Scholar 

  • IDF Clinical Guidelines Task Force (2005) Global guideline for Type 2 diabetes. International Diabetes Federation, Brussels

    Google Scholar 

  • Iizuka K, Bruick RK, Liang G, Horton JD, Uyeda K (2004) Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis. Proc Natl Acad Sci USA 101: 7281–7286

    Article  CAS  PubMed  Google Scholar 

  • Joost HG (2005) Genotyp-basierte Ernährungsempfehlung — Noch im experimentellen Stadium. Deutsches Ärzteblatt 102: 2608–2610

    Google Scholar 

  • Kaput J, Rodriguez RL (2006) Nutritional Genomics, Discovering the path to personalized nutrition. John Wiley and Sons, Hoboken, NJ USA

    Google Scholar 

  • Kobayashi A, Kang MI, Okawa H, Ohtsuji M, Zenke Y, Chiba T, Igarashi K, Yamamoto M (2004) Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol Cell Biol 24: 7130–7139

    Article  CAS  PubMed  Google Scholar 

  • Kussmann M, Raymond F, Affolter M (2006) OMICS-driven biomarker discovery in nutrition and health. J Biotechnol 124(4): 758–787

    Article  CAS  PubMed  Google Scholar 

  • Maestro MA, Cardalda C, Boj SF, Luco RF, Servitja JM, Ferrer J (2007) Distinct roles of HNF1beta, HNF1alpha, and HNF4alpha in regulating pancreas development, beta-cell function and growth. Endocr Dev 12: 33–45

    Article  CAS  PubMed  Google Scholar 

  • Mitro N, Mak PA, Vargas L, Godio C, Hampton E, Molteni V, Kreusch A, Saez E (2007) The nuclear receptor LXR is a glucose sensor. Nature 445: 219–223

    Article  CAS  PubMed  Google Scholar 

  • Müller M, Kersten S (2003) Nutrigenomics: goals and strategies. Nat Rev Genet 4: 315–322

    Article  PubMed  Google Scholar 

  • Na HK, Surh YJ (2008) Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG. Food Chem Toxicol 46: 1271–1278

    Article  CAS  PubMed  Google Scholar 

  • Na SY, Kim HJ, Lee SK, Choi HS, Na DS, Lee MO, Chung M, Moore DD, Lee JW (1998) IkappaBbeta interacts with the retinoid X receptor and inhibits retinoid-dependent transactivation in lipopolysaccharide-treated cells. J Biol Chem 273: 3212–3215

    Article  CAS  PubMed  Google Scholar 

  • Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T (2003) Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 101: 2461–2463

    Article  CAS  PubMed  Google Scholar 

  • Nguyen T, Sherratt PJ, Pickett CB (2003) Regulatory mechanisms controlling gene expression mediated by the antioxidant response element. Annu Rev Pharmacol Toxicol 43: 233–260

    Article  CAS  PubMed  Google Scholar 

  • Nicolas G, Bennoun M, Porteu A, Mativet S, Beaumont C, Grandchamp B, Sirito M, Sawadogo M, Kahn A, Vaulont S (2002) Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci USA 99: 4596–4601

    Article  CAS  PubMed  Google Scholar 

  • Palozza P, Serini S, Maggiano N, Tringali G, Navarra P, Ranelletti FO, Calviello G (2005) beta-Carotene downregulates the steady-state and heregulin-alpha-induced COX-2 pathways in colon cancer cells. J Nutr 135: 129–136

    CAS  PubMed  Google Scholar 

  • Repa JJ, Mangelsdorf DJ (2000) The role of orphan nuclear receptors in the regulation of cholesterol homeostasis. Annu Rev Cell Dev Biol 16: 459–481

    Article  CAS  PubMed  Google Scholar 

  • Shih HM, Liu Z, Towle HC (1995) Two CACGTG motifs with proper spacing dictate the carbohydrate regulation of hepatic gene transcription. J Biol Chem 270: 21 991–21 997

    CAS  Google Scholar 

  • Shiota M, Magnuson MA (2008) Hepatic glucose sensing: does flux matter J Clin Invest 118: 841–844

    Article  CAS  PubMed  Google Scholar 

  • Schmutz J, Wheeler J, Grimwood J, Dickson M, Yang J, Caoile C, Bajorek E, Black S, Chan YM, Denys M, Escobar J, Flowers D, Fotopulos D, Garcia C, Gomez M, Gonzales E, Haydu L, Lopez F, Ramirez L, Retterer J, Rodriguez A, Rogers S, Salazar A, Tsai M, Myers RM (2004) Quality assessment of the human genome sequence. Nature 429: 365–368

    Article  CAS  PubMed  Google Scholar 

  • Schultz JR, Tu H, Luk A, Repa JJ, Medina JC, Li L, Schwendner S, Wang S, Thoolen M, Mangelsdorf DJ, Lustig KD, Shan B (2000). Role of LXRs in control of lipogenesis. Genes Dev 14: 2831–2838

    Article  CAS  PubMed  Google Scholar 

  • Sibley E (2004) Genetic variation and lactose intolerance: detection methods and clinical implications. Am J Pharmacogenomics 4: 239–245

    Article  CAS  PubMed  Google Scholar 

  • Takahashi M, Tsuboyama-Kasaoka N, Nakatani T, Ishii M, Tsutsumi S, Aburatani H, Ezaki O (2002) Fish oil feeding alters liver gene expressions to defend against PPARalpha activation and ROS production. Am J Physiol Gastrointest Liver Physiol 282: G338–G348

    CAS  PubMed  Google Scholar 

  • Tontonoz P, Mangelsdorf DJ (2003) Liver X receptor signaling pathways in cardiovascular disease. Mol Endocrinol 17: 985–993

    Article  CAS  PubMed  Google Scholar 

  • Umbreit, JN, Conrad ME, Hainsworth LN, Simovich M (2002) The ferrireductase paraferritin contains divalent metal transporter as well as mobilferrin. Am J Physiol Gastrointest Liver Physiol 282: G534–G539

    CAS  PubMed  Google Scholar 

  • Uyeda K, Yamashita H, Kawaguchi T (2002) Carbohydrate responsive element-binding protein (ChREBP): a key regulator of glucose metabolism and fat storage. Biochem Pharmacol 63: 2075–2080

    Article  CAS  PubMed  Google Scholar 

  • Wang TT, Tavera-Mendoza LE, Laperriere D, Libby E, MacLeod NB, Nagai Y, Bourdeau V, Konstorum A, Lallemant B, Zhang R, Mader S, White JH (2005) Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol 19: 2685–2695

    Article  CAS  PubMed  Google Scholar 

  • Wisely GB, Miller AB, Davis RG, Thornquest AD Jr, Johnson R, Spitzer T, Sefler A, Shearer B, Moore JT, Miller AB, Willson TM, Williams SP (2002) Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids. Structure 10: 1225–1234

    Article  CAS  PubMed  Google Scholar 

  • Yu L, Hammer RE, Li-Hawkins J, Von Bergmann K, Lutjohann D, Cohen JC, Hobbs HH (2002) Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. Proc Natl Acad Sci USA 99: 16 237–16 242

    CAS  Google Scholar 

  • Zelcer N, Tontonoz P (2006) Liver X receptors as integrators of metabolic and inflammatory signaling. J Clin Invest 116: 607–614

    Article  CAS  PubMed  Google Scholar 

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Wrulich, O.A., Überall, F. (2010). Nutrigenomik Regulation der Genexpression Durch Nährstoffe. In: Ledochowski, M. (eds) Klinische Ernährungsmedizin. Springer, Vienna. https://doi.org/10.1007/978-3-211-88900-8_5

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  • DOI: https://doi.org/10.1007/978-3-211-88900-8_5

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-88899-5

  • Online ISBN: 978-3-211-88900-8

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