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The Golgi Apparatus pp 87–105Cite as

COPI: mechanisms and transport roles

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Abstract

Coat protein I (COPI) is considered one of the best characterized coat complexes, which represent the core machinery by which vesicle formation and cargo sorting are coupled to initiate vesicular transport (Bonifacino and Lippincott-Schwartz 2003; McMahon and Mills 2004). Our understanding of the molecular mechanisms by which COPI acts and the transport path- ways in which it operates has evolved significantly over the years, and with considerable accompanying controversy. These aspects of COPI research will be reviewed. See also Fig. 1 for a timeline that summarizes its key discoveries.

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Authors and Affiliations

  1. Harvard Medical School Brigham and Women’s Hospital, One Jimmy Fund Way, Smith 538, Boston, MA, 02115, USA

    Victor W. Hsu

  2. Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, One Jimmy Fund Way, Smith 528, Boston, MA, 02115, USA

    Jia- Shu Yang & Stella Y. Lee

  3. Department of Medicine, Harvard Medical School, One Jimmy Fund Way, Smith 528, Boston, MA, 02115, USA

    Jia- Shu Yang

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  1. Victor W. Hsu
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  2. Jia- Shu Yang
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  3. Stella Y. Lee
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Editors and Affiliations

  1. Department of Cell Biology and Oncology, Consorzio Mario Negri Sud Laboratory of Intracellular Traffic, S. Maria Imbaro (Chieti), Italy

    Alexander A. Mironov

  2. Department of Cell Biology and Ultrastructure Research Institute of Histology and Embryology Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria

    Margit Pavelka

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© 2008 Springer-Verlag/Wien

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Hsu, V.W., Yang, J.S., Lee, S.Y. (2008). COPI: mechanisms and transport roles. In: Mironov, A.A., Pavelka, M. (eds) The Golgi Apparatus. Springer, Vienna. https://doi.org/10.1007/978-3-211-76310-0_7

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