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Physiology of erythropoiesis

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Book cover Recombinant Human Erythropoietin (rhEPO) in Clinical Oncology

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Abstract

The hematopoietic system in vertebrates requires the presence of cells that ensure a continuous production of new cells needed to replace mature blood elements endowed with only a limited life span. This continual blood cell production is ensured by pluripotent stem cells which have the unique property of both self-renewal and differentiation through progressive commitment to multipotent progenitors, then to committed progenitors and, finally, to progressively maturing precursors of the different hemopoietic lineages. Commitment of stem cells to the specific cell lineages appears not to be regulated by exogenous growth factors. Rather, stem cells develop into differentiated cell types through incompletely defined molecular events that are intrinsic to the stem cell itself. Following lineage commitment, hematopoietic progenitors and precursors come increasingly under the regulatory influence of growth factors and hormones.

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  1. Department of Hematology and Oncology, Istituto Superiore di Sanitá, Viale Regina Elena 299, 00161, Roma, Italy

    Dr. Ugo Testa

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  1. Department of Internal Medicine (Cancer Research), West German Cancer Center, University Hospital of Essen, Essen, Germany

    Mohammad Resa Nowrousian

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Testa, U. (2008). Physiology of erythropoiesis. In: Nowrousian, M.R. (eds) Recombinant Human Erythropoietin (rhEPO) in Clinical Oncology. Springer, Vienna. https://doi.org/10.1007/978-3-211-69459-6_1

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  • DOI: https://doi.org/10.1007/978-3-211-69459-6_1

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