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Altering the properties of the blood-brain barrier: disruption and permeabilization

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Book cover Peptide Transport and Delivery into the Central Nervous System

Part of the book series: Progress in Drug Research ((PDR,volume 61))

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Abstract

By way of its intrinsic structural and physiological properties, the blood-brain barrier (BBB) represents a formidable obstacle to the delivery of drug to the central nervous system. The treatments of many diseases affecting the central nervous system is thereby complicated by the aspect of delivery, that is, insuring that the therapeutic molecule will reach the target cell in sufficient concentration, and in a suitable timing for the treatment to be effective. Although many different etiologic conditions will be affected by this delivery impediment, in no other condition has it been as extensively documented as in malignant brain tumors. Brain tumor is the prototypical situation through which one can best exemplify the problematic of delivery across the blood-brain barrier. We will therefore frequently refer to this particular problematic, acknowledging the fact that a lot of research endeavour in this field was undertaken as alternate strategies in the treatment of brain tumors. However, by no means will we imply that these strategies should be restricted to the treatment of cerebral malignancies.

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Abbreviations

BAT:

brain adjacent to tumor

BBB:

blood-brain barrier

BBBD:

blood brain barrier disruption

BCNU:

1,3-bis(2-chloroethyl)-1-nitrosourea

BDT:

brain distant to tumor

CNS:

central nervous system

CSF:

cerebrospinal fluid

CT:

computed tomography

ICP:

intracranial pressure

i.v.:

intravenous

LH:

left hemisphere

MRI:

magnetic resonance imaging

PET:

positron emission tomographty

SPECT:

single photon emission computed tomography

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Author information

Authors and Affiliations

  1. Departments of Neurosurgery and Neuro-oncology, University of Sherbrooke Hospital, Sherbrooke, Quebec, J1H 5N4, Canada

    David Fortin

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  1. David Fortin
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Editors and Affiliations

  1. Department of Medicinal Chemistry, College of Pharmacy and The McKnight Brain Institute, University of Florida, 1600 S.W. Archer Road, Gainesville, FL, 32610-0497, USA

    Laszlo Prokai

  2. Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, 1600 S.W. Archer Road, Gainesville, FL, 32610-0267, USA

    Katalin Prokai-Tatrai

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Fortin, D. (2003). Altering the properties of the blood-brain barrier: disruption and permeabilization. In: Prokai, L., Prokai-Tatrai, K. (eds) Peptide Transport and Delivery into the Central Nervous System. Progress in Drug Research, vol 61. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8049-7_5

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  • DOI: https://doi.org/10.1007/978-3-0348-8049-7_5

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9420-3

  • Online ISBN: 978-3-0348-8049-7

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