Summary
Active motility and locomotion of animal tissue cells are based on the interaction of actin and myosin, which form a contractile network within the cell. We present two related stochastic multiparticle models of actin-myosin dynamics on different spatial scales: first, a model on the mesoscopic scale, focusing on some basic aspects of the behavior of small and medium-sized actin-myosin II systems in vitro and second, a model on the macroscopic scale, which relies on some results of the first model and which describes whole cell shape changes in vivo. Computer simulations show how simple rules for molecular interaction can result in a quite complex and naturally appearing behavior in both model systems. We also stress the advantage of modeling certain phenomena within the same context on different scales.
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Lenz, J., Felix, D. (2003). Multiparticle Modeling of Actin-Myosin Networks: From Molecular Interactions to Cell Motility. In: Alt, W., Chaplain, M., Griebel, M., Lenz, J. (eds) Polymer and Cell Dynamics. Mathematics and Biosciences in Interaction. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8043-5_8
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DOI: https://doi.org/10.1007/978-3-0348-8043-5_8
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