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Topical Capsaicin Formulations in the Management of Neuropathic Pain

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Capsaicin as a Therapeutic Molecule

Part of the book series: Progress in Drug Research ((PDR,volume 68))

Abstract

This chapter reviews the scientific and clinical evidence supporting the use of topical formulations containing the pungent principle of chili peppers—capsaicin, for the treatment of peripheral neuropathic pain. Given the limitations of current oral and parenteral therapies for the management of pain arising from various forms of nerve injury, alternate therapeutic approaches that are not associated with systemic adverse events that limit quality of life, impair function, or threaten respiratory depression are critically needed. Moreover, neuropathic conditions can be complicated by progressive changes in the central and peripheral nervous system, leading to persistent reorganization of pain pathways and chronic neuropathic pain. Recent advances in the use of high-dose topical capsaicin preparations hold promise in managing a wide range of painful conditions associated with peripheral neuropathies and may in fact help reduce suffering by reversing progressive changes in the nervous system associated with chronic neuropathic pain conditions.

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Acknowledgments

Thanks to Morgen Ahearn for her editorial assistance.

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Authors and Affiliations

  1. Division of Pain Medicine, Department of Anesthesia and Perioperative Care, University of California, 513 Parnassus Ave, Box 0427, San Francisco, CA, 94143-0427, USA

    Mark Schumacher

  2. Division of Pain Medicine, Department of Anesthesia and Perioperative Care, University of California, 2255 Post St., MZ Bldg N, San Francisco, CA, 94143, USA

    George Pasvankas

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  1. Mark Schumacher
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Correspondence to Mark Schumacher .

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Editors and Affiliations

  1. Department of Toxicology and Narcotics, National Research Center, Cairo, Egypt

    Omar M. E. Abdel-Salam

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Schumacher, M., Pasvankas, G. (2014). Topical Capsaicin Formulations in the Management of Neuropathic Pain. In: Abdel-Salam, O. (eds) Capsaicin as a Therapeutic Molecule. Progress in Drug Research, vol 68. Springer, Basel. https://doi.org/10.1007/978-3-0348-0828-6_4

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