Abstract
International guidelines for the treatment of patients with chronic obstructive pulmonary disease (COPD) state that effective management should relieve symptoms, improve health status, prevent exacerbations, and improve exercise tolerance. In randomized placebo-controlled trials evaluating once-a-day indacaterol over 26–52 weeks, valid, reliable, and responsive instruments/methods were used to quantify the impact of treatment on patient outcomes. Compared with placebo treatment, both 150 and 300 μg doses of indacaterol provided significant and clinically meaningful improvements in dyspnea as measured by the Transition Dyspnea Index. Analyses showed that as-needed use of salbutamol, an indirect assessment of the efficacy of therapy on relief of dyspnea, was significantly lower with 150 and 300 μg doses of indacaterol than with placebo. With 150 and 300 μg doses of indacaterol, there were significant improvements in health status, as measured by the St. George’s Respiratory Questionnaire, relative to placebo therapy. In two of three randomized trials, the differences in the St. George’s Respiratory Questionnaire between indacaterol and placebo achieved the minimal important difference of −4 U. Time to first exacerbation was significantly decreased with 150 and 300 μg doses of indacaterol compared with placebo. In two randomized trials published as abstracts, the 300 μg dose of indacaterol significantly improved exercise endurance times on the cycle ergometer (by 88 and 111 s; p < 0.05) and significantly increased inspiratory capacity at end-exercise (by 280 and 317 ml; p < 0.05) compared with placebo. These overall findings demonstrate the clinical efficacy of indacaterol on patient-centered outcomes.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Alifano M, Cuvelier A, Delage A, Roche N, Lamia B, Molano LC, Couderc LJ, Marquette CH, Devillier P (2010) Treatment of COPD: from pharmacological to instrumental therapies. Eur Respir Rev 19:7–23
Cazzola M, MacNee W, Martinez FJ, Rabe KF, Franciosi LG, Barnes PJ, Brusasco V, Burge PS, Calverley PM, Celli BR, Jones PW, Mahler DA, Make B, Miravitlles M, Page CP, Palange P, Parr D, Pistolesi M, Rennard SI, Rutten-van Molken MP, Stockley R, Sullivan SD, Wedzicha JA, Wouters EF, American Thoracic Society, European Respiratory Society Task Force on outcomes of COPD (2008) Outcomes for COPD pharmacological trials: from lung function to biomarkers. Eur Respir J 31:416–469
Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Calverley P, Fukuchi Y, Jenkins C, Rodriguez-Roisin R, van Weel C, Zielinski J (2007) Global initiative for chronic obstructive lung disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 176:532–555
O’Donnell DE, Aaron S, Bourbeau J, Hernandez P, Marciniuk DD, Balter M, Ford G, Gervais A, Goldstein R, Hodder R, Kaplan A, Keenan S, Lacasse Y, Maltais F, Road J, Rocker G, Sin D, Sinuff T, Voduc N (2007) Canadian thoracic society recommendations for management of chronic obstructive pulmonary disease—2007 update. Can Respir J 14(Suppl B):5B–32B
Celli BR, MacNee W (2004) ATS/ERS Task Force. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur Respir J 23:932–946
Mahler DA (2008) Choosing the right bronchodilator. In: Rennard S, Rodriguez-Roisin R, Huchon G, Roche N (eds) Clinical management of chronic obstructive pulmonary disease. Informa Healthcare, New York, NY, pp 263–279
Dahl R, Chung KF, Buhl R, Magnussen H, Nonikov V, Jack D, Bleasdale P, Owen R, Higgins M, Kramer B, INVOLVE (INdacaterol: Value in COPD: Longer Term Validation of Efficacy and Safety) Study Investigators (2010) Efficacy of a new once-daily long-acting inhaled beta2-agonist indacaterol versus twice-daily formoterol in COPD. Thorax 65:473–479
Donohue JF, Fogarty C, Lotvall J, Mahler DA, Worth H, Yorgancioglu A, Iqbal A, Swales J, Owen R, Higgins M, Kramer B, INHANCE Study Investigators (2010) Once-daily bronchodilators for chronic obstructive pulmonary disease: indacaterol versus tiotropium. Am J Respir Crit Care Med 182:155–162
Kornmann O, Dahl R, Centanni S, Dogra A, Owen R, Lassen C, Kramer B (2011) Once-daily indacaterol vs twice-daily salmeterol for COPD: a placebo-controlled comparison. Eur Respir J 37(2):273–279
Mahler DA, Weinberg DH, Wells CK, Feinstein AR (1984) The measurement of dyspnea. contents, interobserver agreement, and physiologic correlates of two new clinical indexes. Chest 85:751–758
Mahler DA (2005) Measurement of dyspnea: clinical ratings. In: Mahler DA, O’Donnell DE (eds) Dyspnea: mechanisms, measurement, and management. Taylor & Francis, Boca Raton, FL, pp 147–165
Mahler DA, Witek TJ Jr (2005) The MCID of the transition dyspnea index is a total score of one unit. COPD 2:99–103
Hanania NA, Darken P, Horstman D, Reisner C, Lee B, Davis S, Shah T (2003) The efficacy and safety of fluticasone propionate (250 microg)/salmeterol (50 microg) combined in the diskus inhaler for the treatment of COPD. Chest 124:834–843
Casaburi R, Mahler DA, Jones PW, Wanner A, San PG, ZuWallack RL, Menjoge SS, Serby CW, Witek T Jr (2002) A long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease. Eur Respir J 19:217–224
Vincken W, van Noord JA, Greefhorst AP, Bantje TA, Kesten S, Korducki L, Cornelissen PJ (2002) Dutch/Belgian Tiotropium Study Group. Improved health outcomes in patients with COPD during 1 yr’s treatment with tiotropium. Eur Respir J 19:209–216
Mahler DA, Wire P, Horstman D, Chang CN, Yates J, Fischer T, Shah T (2002) Effectiveness of fluticasone propionate and salmeterol combination delivered via the diskus device in the treatment of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 166:1084–1091
Mahler DA, Huang S, Tabrizi M, Bell GM (2004) Efficacy and safety of a monoclonal antibody recognizing interleukin-8 in COPD: a pilot study. Chest 126:926–934
Mahler DA, Matthay RA, Snyder PE, Wells CK, Loke J (1985) Sustained-release theophylline reduces dyspnea in nonreversible obstructive airway disease. Am Rev Respir Dis 131:22–25
Fabbri LM, Calverley PM, Izquierdo-Alonso JL, Bundschuh DS, Brose M, Martinez FJ, Rabe KF, M2-127 and M2-128 study groups (2009) Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials. Lancet 374:695–703
Calverley P, Pauwels R, Vestbo J, Jones P, Pride N, Gulsvik A, Anderson J, Maden C, TRial of Inhaled STeroids ANd long-acting beta2 agonists study group (2003) Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial. Lancet 361:449–456
Jones PW, Quirk FH, Baveystock CM, Littlejohns P (1992) A self-complete measure of health status for chronic airflow limitation. The St. George’s Respiratory Questionnaire. Am Rev Respir Dis 145:1321–1327
Jones PW (2005) St. George’s Respiratory Questionnaire: MCID. COPD 2:75–79
Calverley PM, Anderson JA, Celli B, Ferguson GT, Jenkins C, Jones PW, Yates JC, Vestbo J, TORCH investigators (2007) Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease. N Engl J Med 356:775–789
Calverley PM, Boonsawat W, Cseke Z, Zhong N, Peterson S, Olsson H (2003) Maintenance therapy with budesonide and formoterol in chronic obstructive pulmonary disease. Eur Respir J 22:912–919
Tashkin DP, Celli B, Senn S, Burkhart D, Kesten S, Menjoge S, Decramer M, UPLIFT Study Investigators (2008) A 4-year trial of tiotropium in chronic obstructive pulmonary disease. N Engl J Med 359:1543–1554
Wedzicha JA, Calverley PM, Seemungal TA, Hagan G, Ansari Z, Stockley RA, INSPIRE Investigators (2008) The prevention of chronic obstructive pulmonary disease exacerbations by salmeterol/fluticasone propionate or tiotropium bromide. Am J Respir Crit Care Med 177:19–26
Beeh K, Khindri S, Eeg M, Drollmann AF (2009) Effect of indacaterol maleate on dynamic lung hyperinflation in patients with COPD. Eur Respir J 34:E4357
O’Donnell DE, Casaburi R, Swales J, Emery C, Kramer B (2010) Effect of indacaterol on exercise endurance in patients with moderate-to-severe COPD. Am J Respir Crit Care Med 181:A4431
Jones PW, Agusti AG (2006) Outcomes and markers in the assessment of chronic obstructive pulmonary disease. Eur Respir J 27:822–832
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer Basel
About this chapter
Cite this chapter
Mahler, D.A. (2014). Phase III Clinical Efficacy of Indacaterol: Patient-Centered Outcomes. In: Trifilieff, A. (eds) Indacaterol. Milestones in Drug Therapy. Springer, Basel. https://doi.org/10.1007/978-3-0348-0709-8_7
Download citation
DOI: https://doi.org/10.1007/978-3-0348-0709-8_7
Published:
Publisher Name: Springer, Basel
Print ISBN: 978-3-0348-0708-1
Online ISBN: 978-3-0348-0709-8
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)