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Twenty Years of G-CSF pp 293–317Cite as

Investigational Studies of rHuG-CSF to Promote the Regeneration of Nonhematopoietic Tissues

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Part of the book series: Milestones in Drug Therapy ((MDT))

Abstract

Granulocyte colony-stimulating factor (G-CSF) is a 19.6-kDa glycoprotein hormone secreted by monocytes, macrophages, fibroblasts, and endothelial cells and is the primary physiologic regulator of neutrophilic granulocyte production. It exerts its earliest actions on myeloid-restricted hematopoietic progenitor cells that reside in the bone marrow, stimulating their proliferation and differentiation through several developmental stages (myeloblasts, promyelocytes, myelocytes, and metamyelocytes), culminating in the release of terminally differentiated neutrophils into the peripheral blood. G-CSF also promotes the survival of mature neutrophils and enhances their effector functions required for a successful immune response against bacterial infection [1].

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  1. Amgen Inc., One Amgen Center Drive, MS 15-2-A, Thousand Oaks, CA, 91320, USA

    Stephen J. Szilvassy

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Correspondence to Stephen J. Szilvassy .

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    Graham Molineux

  2. MA Foote Associates, Par Five Court 4284, Westlake Village, 91362, California, USA

    MaryAnn Foote

  3. Amgen, Inc., One Amgen Center Dr. 1, Thousand Oaks, 91320, California, USA

    Tara Arvedson

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Szilvassy, S.J. (2012). Investigational Studies of rHuG-CSF to Promote the Regeneration of Nonhematopoietic Tissues. In: Molineux, G., Foote, M., Arvedson, T. (eds) Twenty Years of G-CSF. Milestones in Drug Therapy. Springer, Basel. https://doi.org/10.1007/978-3-0348-0218-5_16

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