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The Inflammasomes pp 165–182Cite as

Inflammasome and Lung Pathologies

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Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Nonregulated inflammation in the lung often leads to chronic inflammatory diseases such as asthma, chronic obstructive pulmonary disease (COPD), and pulmonary fibrosis. Interleukin-1α (IL-1α) and interleukin-1β (IL-1β) are potent mediators of innate immunity and IL-1β is processed by large multiprotein complexes called inflammasomes. Using a mice model of lung inflammatory diseases, it was shown that acute cigarette smoke exposure induces inflammasome-dependent IL-1β maturation and ASC-associated protein complex is necessary to lung emphysema. Moreover, bleomycin- or crystalline silica particle-induced pulmonary inflammation and fibrosis are Nlrp3 inflammasome dependent. Nlrp3-containing inflammasome appears to be an essential mediator for allergic lung inflammation. Pulmonary exposure to nanomaterials may lead to pulmonary inflammation and fibrosis. Inhalation of nano-TiO2 provokes lung inflammation which is strongly dependent on IL-1α.

Nlrp3 inflammasome appears as a corner stone in pulmonary inflammatory diseases, but growing evidences suggest that IL-1α plays an important role through the common IL-1 receptor.

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Acknowledgments

I thank Dr Valérie Quesniaux, the director of the UMR6218 IEM unit for comments and discussions, and Pr François Erard for critically reviewing the manuscript and for helpful discussion.

I would like to thank Jürg Tschopp, Vincent Lagente, and François Huaux for fruitfull collaborations.

The work was supported by the Key-Obs SAS, Orleans, the “Conseil Général du Loiret” (PhD fellowship) and the Agence Nationale pour la Recherche (ANR).

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Authors and Affiliations

  1. Molecular Immunology and Embryology, UMR6218, University of Orleans and CNRS, 3B rue de la Férollerie, 45071, Orleans, France

    Bernhard Ryffel, Dieudonnée Togbe & Isabelle Couillin

  2. ArtImmune SAS, Orleans, France

    Dieudonnée Togbe

  3. KeyObs SAS, Orleans, France

    Isabelle Couillin

Authors
  1. Bernhard Ryffel
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  2. Dieudonnée Togbe
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  3. Isabelle Couillin
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Correspondence to Isabelle Couillin .

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Editors and Affiliations

  1. Institut de Transgénose, Labo. d'Immunologie et, CNRS, rue de la Férollerie 3B, Orléans CX 2, 45071, France

    Isabelle Couillin

  2. CNRS UMR 5201, Labo. Génétique et Cancer, Université de Lyon I, rue Laënnec 28, Lyon, 69008, France

    Virginie Pétrilli

  3. Dept. Immunology & Infectious, Diseases, Harvard School of Public Health, Huntington Ave. 651, Boston, 02115-6017, Massachusetts, USA

    Fabio Martinon

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Ryffel, B., Togbe, D., Couillin, I. (2011). Inflammasome and Lung Pathologies. In: Couillin, I., Pétrilli, V., Martinon, F. (eds) The Inflammasomes. Progress in Inflammation Research. Springer, Basel. https://doi.org/10.1007/978-3-0348-0148-5_11

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