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Syndrome des antiphospholipides

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Maladies rares en médecine d’urgence

Part of the book series: Références en médecine d’urgence. Collection de la SFMU ((REFERMED))

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Résumé

La présence d’un syndrome des antiphospholipides (SAPL) peut amener un patient à être pris en charge aux urgences ou hospitalisé en unités de soins intensifs du fait des différentes atteintes thrombotiques, des complications obstétricales voire des complications iatrogènes (surdosage en antivitamines K). Surtout, le SAPL peut se présenter sous la forme d’un syndrome catastrophique des antiphospholipides (CAPS), parfois inaugural et dont le pronostic est mauvais en l’absence de traitement adapté. Sa reconnaissance par le médecin urgentiste est donc particulièrement importante. Dans ce chapitre, nous ferons un rappel sur le SAPL puis développerons plus particulièrement le CAPS.

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Références

  1. Miyakis S, Lockshin MD, Atsumi T et al. (2006) International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 4: 295–306

    Article  PubMed  CAS  Google Scholar 

  2. Frances C, Barete S and Soria A (2012) Manifestations dermatologiques du syndrome des antiphospholipides. Rev Med Interne 33: 200–5

    Article  PubMed  CAS  Google Scholar 

  3. Frances C, Niang S, Laffitte E et al. (2005) Dermatologic manifestations of the antiphospholipid syndrome: two hundred consecutive cases. Arthritis Rheum 52: 1785–93

    Article  PubMed  Google Scholar 

  4. Frances C, Barete S and Soria A (2011) Manifestations dermatologiques du syndrome des antiphospholipides. Rev Med Interne 33: 200–5

    Article  PubMed  Google Scholar 

  5. Reiner P, Galanaud D, Leroux G et al. (2011) Long-term outcome of 32 patients with chorea and systemic lupus erythematosus or antiphospholipid antibodies. Mov Disord 26: 2422–7

    Article  PubMed  Google Scholar 

  6. Reiner P, Piette JC, Leroux G et al. (2012) Choree, lupus et antiphospholipides. Rev Med Interne 33: 206–8

    Article  PubMed  CAS  Google Scholar 

  7. Wilson WA, Gharavi AE, Piette JC (2001) International classification criteria for antiphospholipid syndrome: synopsis of a post-conference workshop held at the Ninth International (Tours) aPL Symposium. Lupus 10: 457–60

    Article  PubMed  CAS  Google Scholar 

  8. Ruiz-Irastorza G, Crowther M, Branch W et al. (2010) Antiphospholipid syndrome. Lancet 376: 1498–509

    Article  PubMed  CAS  Google Scholar 

  9. Costedoat-Chalumeau N, Arnaud L, Saadoun D et al. (2012) Le syndrome catastrophique des antiphospholipides. Rev Med Interne 33: 194–9

    Article  PubMed  CAS  Google Scholar 

  10. Tektonidou MG, Sotsiou F, Nakopoulou L et al. (2004) Antiphospholipid syndrome nephropathy in patients with systemic lupus erythematosus and antiphospholipid antibodies: prevalence, clinical associations, and long-term outcome. Arthritis Rheum 50: 2569–79

    Article  PubMed  Google Scholar 

  11. Costedoat-Chalumeau N, Guettrot-Imbert G, Leguern V et al. (2012) Grossesse et syndrome des antiphospholipides. Rev Med Interne 33: 209–16

    Article  PubMed  CAS  Google Scholar 

  12. Le Thi Huong D, Wechsler B, Vauthier-Brouzes D et al. (2006) The second trimester Doppler ultrasound examination is the best predictor of late pregnancy outcome in systemic lupus erythematosus and/or the antiphospholipid syndrome. Rheumatology (Oxford) 45: 332–8

    Article  Google Scholar 

  13. Masliah-Planchon J and Darnige L (2012) Anticorps antiphospholipides et hemostase. Rev Med Interne 33: 181–8

    Article  PubMed  CAS  Google Scholar 

  14. M Mazodier K, Arnaud L, Mathian A, et al. (2012) The Lupus Anticoagulant-Hypoprothrombinemia Syndrome. Medicine (Baltimore) 91: 251–60

    Article  Google Scholar 

  15. Ruiz-Irastorza G, Cuadrado MJ, Ruiz-Arruza I et al. (2011) Evidence-based recommendations for the prevention and long-term management of thrombosis in antiphospholipid antibody-positive patients: report of a task force at the 13th International Congress on antiphospholipid antibodies. Lupus 20: 206–18

    Article  PubMed  CAS  Google Scholar 

  16. Pengo V, Ruffatti A, Legnani C et al. (2010) Clinical course of high-risk patients diagnosed with antiphospholipid syndrome. J Thromb Haemost 8: 237–42

    Article  PubMed  CAS  Google Scholar 

  17. Saadoun D, Piette JC, Wahl D et al. (2012) Traitement du syndrome des anticorps antiphospholipides. Rev Med Interne 33: 217–22

    Article  PubMed  CAS  Google Scholar 

  18. Pengo V, Ruiz-Irastorza G, Denas G et al. (2011) High intensity anticoagulation in the prevention of the recurrence of arterial thrombosis in antiphospholipid syndrome: ‘PROS’ and ‘CONS’. Autoimmun Rev

    Google Scholar 

  19. Snaith A, Pugh L, Simpson CR et al. (2008) The potential for interaction between warfarin and coprescribed medication: a retrospective study in primary care. Am J Cardiovasc Drugs 8: 207–12

    Article  PubMed  CAS  Google Scholar 

  20. Lane MA, Devine ST, McDonald JR (2012) High-risk antimicrobial prescriptions among ambulatory patients on warfarin. J Clin Pharm Ther 37: 157–60

    Article  PubMed  CAS  Google Scholar 

  21. Costedoat-Chalumeau N, Amoura Z, Aymard G et al. (2000) Potentiation of vitamin K antagonists by high-dose intravenous methylprednisolone. Ann Intern Med 132: 631–5

    Article  PubMed  CAS  Google Scholar 

  22. Erkan D, Leibowitz E, Berman J, Lockshin MD (2002) Perioperative medical management of antiphospholipid syndrome: hospital for special surgery experience, review of literature, and recommendations. J Rheumatol 29: 843–849

    PubMed  Google Scholar 

  23. Asherson RA, Cervera R, Piette JC et al. (1998) Catastrophic antiphospholipid syndrome. Clinical and laboratory features of 50 patients. Medicine (Baltimore) 77: 195–207

    Article  CAS  Google Scholar 

  24. Bucciarelli S, Cervera R, Espinosa G et al. (2006) Mortality in the catastrophic antiphospholipid syndrome: causes of death and prognostic factors. Autoimmun Rev 6: 72–5

    Article  PubMed  Google Scholar 

  25. Cervera R, Bucciarelli S, Plasin MA et al. (2009) Catastrophic antiphospholipid syndrome (CAPS): descriptive analysis of a series of 280 patients from the « CAPS Registry ». J Autoimmun 32: 240–5

    Article  PubMed  CAS  Google Scholar 

  26. Asherson RA, Cervera R, de Groot PG et al. (2003) Catastrophic antiphospholipid syndrome: international consensus statement on classification criteria and treatment guidelines. Lupus 12: 530–4

    Article  PubMed  CAS  Google Scholar 

  27. Cervera R, Font J, Gomez-Puerta JA et al. (2005) Validation of the preliminary criteria for the classification of catastrophic antiphospholipid syndrome. Ann Rheum Dis 64: 1205–9

    Article  PubMed  CAS  Google Scholar 

  28. Erkan D, Espinosa G and Cervera R (2010) Catastrophic antiphospholipid syndrome: Updated diagnostic algorithms. Autoimmun Rev 10: 74–9

    Article  PubMed  Google Scholar 

  29. Amoura Z, Costedoat-Chalumeau N, Veyradier A et al. (2004) Thrombotic thrombocytopenic purpura with severe ADAMTS-13 deficiency in two patients with primary antiphospholipid syndrome. Arthritis Rheum 50: 3260–4

    Article  PubMed  Google Scholar 

  30. Pauzner R, Greinacher A, Selleng K et al. (2009) False-positive tests for heparin-induced thrombocytopenia in patients with antiphospholipid syndrome and systemic lupus erythematosus. J Thromb Haemost 7: 1070–4

    Article  PubMed  CAS  Google Scholar 

  31. Gomez-Puerta JA, Cervera R, Espinosa G et al. (2007) Catastrophic antiphospholipid syndrome during pregnancy and puerperium: maternal and fetal characteristics of 15 cases. Ann Rheum Dis 66: 740–6

    Article  PubMed  CAS  Google Scholar 

  32. Pasquali JL, Sibilia J, Poindron V et al. (2012) Aspects immunologiques du syndrome des antiphospholipides. Rev Med Interne 33: 189–93

    Article  PubMed  Google Scholar 

  33. Ortega-Hernandez OD, Agmon-Levin N, Blank M et al. (2009) The physiopathology of the catastrophic antiphospholipid (Asherson’s) syndrome: compelling evidence. J Autoimmun 32: 1–6

    Article  PubMed  CAS  Google Scholar 

  34. Shoenfeld Y, Blank M, Cervera R et al. (2006) Infectious origin of the antiphospholipid syndrome. Ann Rheum Dis 65: 2–6

    Article  PubMed  CAS  Google Scholar 

  35. Sene D, Piette JC and Cacoub P (2009) Anticorps antiphospholipide, syndrome des anticorps antiphospholipides et infections virales. Rev Med Interne 30: 135–41

    Article  PubMed  CAS  Google Scholar 

  36. Espinosa G, Cervera R and Asherson RA (2007) Catastrophic antiphospholipid syndrome and sepsis. A common link? J Rheumatol 34: 923–6

    PubMed  CAS  Google Scholar 

  37. Cervera R and Group CRP (2010) Catastrophic antiphospholipid syndrome (CAPS): update from the ‘CAPS Registry’. Lupus 19: 412–8

    Article  PubMed  CAS  Google Scholar 

  38. Lacueva J, Enriquez R, Cabezuelo JB et al. (1993) Acute renal failure as first clinical manifestation of the primary antiphospholipid syndrome. Nephron 64: 479–80

    Article  PubMed  CAS  Google Scholar 

  39. Nochy D, Daugas E, Droz D et al. (1999) The intrarenal vascular lesions associated with primary antiphospholipid syndrome. J Am Soc Nephrol 10: 507–18

    PubMed  CAS  Google Scholar 

  40. Bucciarelli S, Espinosa G, Asherson RA et al. (2006) The acute respiratory distress syndrome in catastrophic antiphospholipid syndrome: analysis of a series of 47 patients. Ann Rheum Dis 65: 81–6

    Article  PubMed  CAS  Google Scholar 

  41. Leroux G, Sellam J, Costedoat-Chalumeau N et al. (2008) Posterior reversible encephalopathy syndrome during systemic lupus erythematosus: four new cases and review of the literature. Lupus 17: 139–47

    Article  PubMed  CAS  Google Scholar 

  42. Erkan D, Patel S, Nuzzo M et al. (2008) Management of the controversial aspects of the antiphospholipid syndrome pregnancies: a guide for clinicians and researchers. Rheumatology (Oxford) (47 Suppl 3): iii23–7

    Google Scholar 

  43. Dessailloud R, Papo T, Vaneecloo S et al. (1998) Acalculous ischemic gallbladder necrosis in the catastrophic antiphospholipid syndrome. Arthritis Rheum 41: 1318–20

    Article  PubMed  Google Scholar 

  44. Papo T, Le Thi Huong D, Godeau P et al. (1997) Pancréatites et maladies systémiques. Gastroenterol Clin Biol: 768–75

    Google Scholar 

  45. Espinosa G, Santos E, Cervera R et al. (2003) Adrenal involvement in the antiphospholipid syndrome: clinical and Immunologic characteristics of 86 patients. Medicine (Baltimore) 82: 106–18

    Article  Google Scholar 

  46. Cervera R, Bucciarelli S, Plasin MA et al. (2009) Catastrophic antiphospholipid syndrome (CAPS): descriptive analysis of a series of 280 patients from the « CAPS Registry ». J Autoimmun 32: 240–5

    Article  PubMed  CAS  Google Scholar 

  47. Bayraktar UD, Erkan D, Bucciarelli S et al. (2007) The clinical spectrum of catastrophic antiphospholipid syndrome in the absence and presence of lupus. J Rheumatol 34: 346–52

    PubMed  Google Scholar 

  48. Erkan D, Asherson RA, Espinosa G et al. (2003) Long term outcome of catastrophic antiphospholipid syndrome survivors. Ann Rheum Dis 62: 530–3

    Article  PubMed  CAS  Google Scholar 

  49. Cervera R (2010) Update on the diagnosis, treatment, and prognosis of the catastrophic antiphospholipid syndrome. Curr Rheumatol Rep 12: 70–6

    Article  PubMed  Google Scholar 

  50. Asherson RA, Espinosa G, Menahem S et al. (2008) Relapsing catastrophic antiphospholipid syndrome: report of three cases. Semin Arthritis Rheum 37: 366–72

    Article  PubMed  Google Scholar 

  51. Iglesias-Jimenez E, Camacho-Lovillo M, Falcon-Neyra D et al. (2010) Infant with probable catastrophic antiphospholipid syndrome successfully managed with rituximab. Pediatrics 125: e1523–8

    Article  PubMed  Google Scholar 

  52. Espinosa G, Berman H, Cervera R (2011) Management of refractory cases of catastrophic antiphospholipid syndrome. Autoimmun Rev 10: 664–8

    Article  PubMed  Google Scholar 

  53. Lonze BE, Singer AL, Montgomery RA (2010) Eculizumab and renal transplantation in a patient with CAPS. N Engl J Med 362: 1744–5

    Article  PubMed  CAS  Google Scholar 

  54. Repesse X, Freund Y, Mathian A et al. (2010) Successful extracorporeal membrane oxygenation for refractory cardiogenic shock due to the catastrophic antiphospholipid syndrome. Ann Intern Med 153: 487–8

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Centre de Référence maladies auto-immunes et systémiques rares, service de médecine interne Pôle médecine, Hôpital Cochin, AP-HP, Université Paris Descartes, 75679, Paris Cedex 14, France

    N. Costedoat-Chalumeau

  2. service de réanimation médicale, Hôpital Cochin, AP-HP, Université Paris Descartes, 75679, Paris Cedex 14, France

    G. Geri

  3. Centre de Référence national pour le lupus systémique et le syndrome des antiphospholipides, Hôpital Pitié-Salpêtrière, service de médecine interne, AP-HP et Université Marie Curie, 75013, Paris, France

    J.-C. Piette

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  1. N. Costedoat-Chalumeau
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  2. G. Geri
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  3. J.-C. Piette
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Correspondence to N. Costedoat-Chalumeau .

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Costedoat-Chalumeau, N., Geri, G., Piette, JC. (2013). Syndrome des antiphospholipides. In: Maladies rares en médecine d’urgence. Références en médecine d’urgence. Collection de la SFMU. Springer, Paris. https://doi.org/10.1007/978-2-8178-0350-0_15

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  • DOI: https://doi.org/10.1007/978-2-8178-0350-0_15

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-8178-0349-4

  • Online ISBN: 978-2-8178-0350-0

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