Abstract
Adipogenesis involves a cross talk between cell cycle regulators and metabolic factors. We discuss here how E2F1, cdk4, cyc D3, and other cell cycle regulators are important for adipocyte differentiation and function under normal or pathological conditions.
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Abella A, Dubus P, Malumbres M et al (2005) Cdk4 promotes adipogenesis through PPARgamma activation. Cell Metab 2:239–249
Aguilar V, Annicotte JS, Escote X et al (2010) Cyclin G2 Regulates Adipogenesis through PPAR{gamma} Coactivation. Endocrinology 151:5247–5254
Annicotte JS, Blanchet E, Chavey C et al (2009) The CDK4-pRB-E2F1 pathway controls insulin secretion. Nat Cell Biol 11:1017–1023
Blanchet E, Annicotte JS, Lagarrigue S et al (2011) E2F transcription factor-1 regulates oxidative metabolism. Nat Cell Biol 13:1146–1152
Brehm A, Miska EA, Mccance DJ et al (1998) Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature 391:597–601
Chen HZ, Tsai SyLeone G (2009) Emerging roles of E2Fs in cancer: an exit from cell cycle control. Nat Rev Cancer 9:785–797
Chen P, Riley DJ, Chen Y et al (1996) Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs. Genes & Development 10:2794–2804
Choi JH, Banks AS, Estall JL et al (2010) Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5. Nature 466:451–456
Choi JH, Banks AS, Kamenecka TM et al (2011) Antidiabetic actions of a non-agonist PPARgamma ligand blocking Cdk5-mediated phosphorylation. Nature 477:477–481
Chung L, Lau SK, Jiang Z et al (2009) Overlapping features between dedifferentiated liposarcoma and undifferentiated high-grade pleomorphic sarcoma. Am J Surg Pathol 33:1594–1600
Dali-Youcef N, Mataki C, Coste A et al (2007) Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure. Proc Natl Acad Sci U S A 104:10703–10708
Fabbrizio E, El Messaoudi S, Polanowska J et al (2002) Negative regulation of transcription by the type II arginine methyltransferase PRMT5. EMBO Rep 3:641–645
Fajas L (2003) Adipogenesis: a cross-talk between cell proliferation and cell differentiation. Annals of Medicine 35:79–85
Fajas L, Landsberg RL, Huss-Garcia Y et al (2002a) E2Fs regulate adipocyte differentiation. Dev Cell 3:39–49
Fajas L, Egler V, Reiter R et al (2002b) The retinoblastoma-histone deacetylase 3 complex inhibits the peroxisome proliferator-activated receptor gamma and adipocyte differentiation. Developmental Cell 3:903–910
Fu M, Rao M, Bouras T et al (2005) Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment. J Biol Chem 280:16934–16941
Hansen JB, Jorgensen C, Petersen RK et al (2004) Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation. Proc Natl Acad Sci U S A 101:4112–4117
Helenius K, Yang Y, Alasaari J et al (2009) Mat1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipocyte differentiation. Mol Cell Biol 29:315–323
Helias-Rodzewicz Z, Pedeutour F, Coindre JM et al (2009) Selective elimination of amplified CDK4 sequences correlates with spontaneous adipocytic differentiation in liposarcoma. Genes Chromosomes Cancer 48:943–952
Iankova I, Rk Petersen, Annicotte JS et al (2006) PPAR{gamma} Recruits the P-TEFb Complex to Activate Transcription and Promote Adipogenesis. Mol Endocrinol 20:1494–1505
Inoue N, Yahagi N, Yamamoto T et al (2008) Cyclin-dependent kinase inhibitor, p21WAF1/CIP1, is involved in adipocyte differentiation and hypertrophy, linking to obesity, and insulin resistance. J Biol Chem 283:21220–21229
Kurat CF, Wolinski H, Petschnigg J et al (2009) Cdk1/Cdc28-dependent activation of the major triacylglycerol lipase Tgl4 in yeast links lipolysis to cell-cycle progression. Mol Cell 33:53–63
Lalioti V, Muruais G, Dinarina A et al (2009) The atypical kinase Cdk5 is activated by insulin, regulates the association between GLUT4 and E-Syt1, and modulates glucose transport in 3T3-L1 adipocytes. Proc Natl Acad Sci U S A 106:4249–4253
Landsberg RL, Sero JE, Danielian PS et al (2003) The role of E2F4 in adipogenesis is independent of its cell cycle regulatory activity. Proc Natl Acad Sci U S A 100:2456–2461
Lin J, Della-Fera MA, Li C et al (2003) P27 knockout mice: reduced myostatin in muscle and altered adipogenesis. Biochem Biophys Res Commun 300:938–942
Magnaghi-Jaulin L, Groisman R, Naguibneva I et al (1998) Retinoblastoma protein represses transcription by recruiting a histone deacetylase. Nature 391:601–605
Malumbres M, Barbacid M (2005) Mammalian cyclin-dependent kinases. Trends Biochem Sci 30:630–641
Muruais G, Lalioti V, Sandoval IV (2009) The Cdk5 inhibitor roscovitine strongly inhibits glucose uptake in 3T3-L1 adipocytes without altering GLUT4 translocation from internal pools to the cell surface. J Cell Physiol 220:238–244
Naaz A, Holsberger DR, Iwamoto GA et al (2004) Loss of cyclin-dependent kinase inhibitors produces adipocyte hyperplasia and obesity. Faseb J 18:1925–1927
Nohara A, Okada S, Ohshima K et al (2011) Cyclin-dependent kinase-5 is a key molecule in tumor necrosis factor-alpha-induced insulin resistance. J Biol Chem 286:33457–33465
Rane SG, Dubus P, Mettus RV et al (1999) Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia. Nat Genet 22:44–52
Richon VM, Lyle RE, McGehee RE Jr (1997) Regulation and expression of retinoblastoma proteins p107 and p130 during 3T3-L1 adipocyte differentiation. J Biol Chem 272:10117–10124
Sarruf DA, Iankova I, Abella A et al (2005) Cyclin D3 promotes adipogenesis through activation of peroxisome proliferator-activated receptor gamma. Mol Cell Biol 25:9985–9995
Scime A, Grenier G, Huh MS et al (2005) Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1alpha. Cell Metab 2:283–295
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Chavey, C., Lagarrigue, S., Annicotte, JS., Fajas, L. (2013). Emerging Roles of Cell Cycle Regulators in Adipocyte Metabolism. In: Bastard, JP., Fève, B. (eds) Physiology and Physiopathology of Adipose Tissue. Springer, Paris. https://doi.org/10.1007/978-2-8178-0343-2_2
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DOI: https://doi.org/10.1007/978-2-8178-0343-2_2
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