Abstract
Adipose tissue lipolysis is the process by which stored triacylglycerols in the lipid droplet of adipocytes are released as non-esterified fatty acids to be oxidized in peripheral organs when energy is needed. The hydrolysis of triacylglycerols involves different regulators, such as lipases, co-lipases, and proteins that coat the lipid droplet and, several converging signal transduction pathways. Dysfunction in fat mobilization may play a noticeable role in the development of obesity-related metabolic disorders, such as insulin resistance, dyslipidemia, and cardiovascular risk. This chapter aims at reviewing the fast-growing knowledge about the proteins and mechanisms modulating lipolysis with a focus on the ongoing pharmacological strategies targeting antilipolytic pathways. Inhibition of adipose tissue lipolysis may be viewed as a mechanism limiting lipotoxicity in non-adipose organs, thus alleviating the development of insulin resistance and obesity-induced metabolic abnormalities.
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Acknowledgments
Lipolysis studies from our laboratories are supported by Inserm, Université Paul Sabatier, Hôpitaux de Toulouse, FRM, SFD, DHOS, GlaxoSmithKlineBeecham, Région Midi-Pyrénées and the Commission of the European Communities Collaborative Project ADAPT (www.adapt-eu.net), Contract No. HEALTH-F2-2008-2011 00.
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Langin, D., Mouisel, E. (2013). Adipose Tissue Lipolysis. In: Bastard, JP., Fève, B. (eds) Physiology and Physiopathology of Adipose Tissue. Springer, Paris. https://doi.org/10.1007/978-2-8178-0343-2_10
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DOI: https://doi.org/10.1007/978-2-8178-0343-2_10
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