Abstract
Cancers of the anal margin (AM) are cutaneous cancers (peri-anal skin cancers) occurring on the peri-anal area outside the anal verge. This funnel-shaped skin area is defined by a circle measuring 10 cm in diameter centred on the anal orifice. For some authors, the lower part of the anal canal, a non-keratinizing squamous epithelium area below the pectinate line, is part of the anal margin. Frequently AM tumours are included in series on “anal or anal canal” cancers (AC). In the prospective trial of the UKCCCR 1997 [25] on “anal cancers”, comparing radiotherapy (RT) alone vs RT + chemotherapy, 134 (23 %) of 587 cases were AM tumours; unfortunately, their results were not separated from the anal canal group.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Refrences
Bauer P, Etienney I (2002) Therapeutiques du cancer épidermoïde de l’anus: particularité chez les sujets infectés par le VIH. Gastroenterol Clin Biol 26: 147–9
Bieri S, Allal AS, Kurtz JM (2001) Sphincter conserving treatment of carcinomas of the anal margin. Acta Oncol 40: 29–33
Cleator S, Fife K, Nelson M et al. (2000) Treatment of HIV associated invasive anal cancer with combined chemoradiation. Eur J Cancer 36: 754–8
Créhange G, Bosset M, Lorchel F (2006) Combining Cisplatin and mitomycin with radiotherapy in anal carcinoma. Dis Colon Rectum 50: 43–9
Cummings BJ, Keane TJ, Hawkins NV et al. (1986) Treatment of peri-anal carcinoma by radiation plus chemotherapy (RTCT). Int J Radiat Oncol Biol Phys 12(suppl 1): 152
Cummings BJ, Brierley JD, Anal c and Tanal. Chapter 55, In: Principles and Practice of Radiation Oncology. Ca Perez, LW Brady, EC Halperin, RK Schmidt-Ulrich (eds.) Lippincott Williams & Wilkins. Philadelphia 4th Edition 2004; 1630–48
Cutuli B, Fenton J, Labib A et al. (1988) Anal margin carcinoma: 21 cases treated at Institut Curie by exclusive conservative radiotherapy. Radiother Oncol 11: 1–6
Dillard BM, Spratt JS, Ackerman LV et al. (1963) Epidermoid cancer of anal margin and canal. Review of 79 cases. Arch Surg 86: 100–5
Grabenbauer CG, Kessler H, Matzel KE (2005) Tumor site predicts outcome after radiochemotherapy in squamous cell carcinoma of the anal region: long term results in 101 patients. Dis Colon Rectum 48:1742–51
Greenall MJ, Quan SHQ, Stearns MW et al. (1985) Epidermoid cancer of the anal margin. Pathologic features, treatment, and clinical results. Am J Surg 149: 95–101
Hoffman R, Welton ML, Klencke B et al. (1999) The significance of pre-treatment CD4 count on the outcome and treatment tolerance of HIV-positive patients with anal cancer. Int J Radiat Oncol Biol Phys 44: 127–31
Jensen SL, Hagen K, Harling H et al. (1988) Long term prognosis after radical treatment for squamous-cell carcinoma of the anal canal and anal margin. Dis Colon Rectum 31: 273–8
NCI (2007) Cisplatin, fluorouracil, cetuximab and radiation therapy in treating patients with HIV and Stage I, Stage II or Stage III anal cancer. Clinical Trials.gov.NCT 00324415
Nigro N, Vaitkevicius VK, Considine BJ (1974) Combined therapy for cancer of the anal canal. A preliminary report. Dis Colon Rectum 17: 354
Papillon J, Renard L, Pipard G (1985) Le cancer de la marge de l’anus. J Eur Radiother 6: 23–34
Papillon J, Chassard JL (1992) Respective roles of radiotherapy and surgery in the management of epidermoid carcinoma of the anal margin. Series of 57 patients. Dis Colon Rectum 35: 422–9
Parthasarathy A, Glaubiger DL, Grant KM (2006) Treatment of anal carcinoma in HIV positive males. A single institution experience. Int J Radiat Oncol Biol Phys 3 suppl: 2139
Peiffert D, Bey P, Pernot M et al. (1997) Conservative treatment by irradiation of epidermoid carcinomas of the anal margin. Int J Radiat Oncol Biol Phys 39: 57–66
Pinna Pintor M, Northover JMA, Nicholls RJ (1989) Squamous-cell carcinoma of the anus, 1948 to 1984. Br J Surg 76: 806–10
Place RJ, Gregorcyk SG, Huber PL et al. (2001) Outcome analysis of HIV positive patients with anal squamous cell carcinoma. Dis Colon Rectum 44: 506–12
RTOG/EORTC (1995) Late effects working group.LENT SOMA tables. Radiother Oncol 35: 19–60
Schraut WH, Wang C, Dawson PJ et al. (1983) Depth of invasion, location, and size of cancer of the anus dictate operative treatment. Cancer 51: 1291–6
Sobin LH,Wittekind CH (eds) (1997) TNM classification of malignant tumors. UICC 5th edit New York AJ Wiley 70–3
Touboul E, Schlienger M, Buffat L et al. (1995) Epidermoid carcinoma of the anal margin: 17 cases treated with curative-intent radiation therapy. Radiother Oncol 34:195–202
UKCCCR (1996) Anal cancer trial working party: Epidermoid anal cancer: results from the UKCCCR randomized trial of radiotherapy alone versus radiotherapy, fluorouracil and mitomycin. Lancet 348: 1049–54
Vatra B, Sobhani I, Aparicio T et al. (2002) Charactéristiques cliniques, thérapeutiques et pronostiques des carcinomes épidermoides du canal anal chez les malades VIH positifs. Gastroenterol Clin Biol 26: 150–6
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Springer-Verlag France, Paris
About this chapter
Cite this chapter
Schlienger, M., Touboul, E. (2009). Anal margin tumours. In: Belkacémi, Y., Mirimanoff, RO., Ozsahin, M. (eds) Management of Rare Adult Tumours. Springer, Paris. https://doi.org/10.1007/978-2-287-92246-6_20
Download citation
DOI: https://doi.org/10.1007/978-2-287-92246-6_20
Publisher Name: Springer, Paris
Print ISBN: 978-2-287-92245-9
Online ISBN: 978-2-287-92246-6
eBook Packages: MedicineMedicine (R0)