Lupus: An introduction

Abstract

Forty years ago lupus (systemic lupus erythematosus) was widely regarded as a rare, largely untreatable disease: at best, requiring high dose steroids; at worst, ending in renal failure. However, lupus is now recognized as an important and relatively common disease affecting up to 1 in 800 women; it is more common than multiple sclerosis or leukemia. In many countries, lupus is now seen by every primary care practitioner. It is very treatable, and most patients diagnosed early can expect a normal lifespan. It is predominantly a disease of young women (most commonly affecting women between the ages of 15–45) but can affect men as well. Pregnancy, once contraindicated in lupus, is now largely successful.