Abstract
Since the publication of the landmark meta-analysis from the Oxford group in 19881 it has been known that the use of subcutaneous heparin reduces the rate of deep vein thrombosis (DVT) and pulmonary embolism (PE) in surgical patients. It is generally accepted that DVT and PE have a common cause with an event ratio of about 10:1. For the purpose of an evidence base from which to make recommendations for prophylaxis, DVT and PE are considered together as venous thrombo-embolism (VTE). A strategy which results in a demonstrable reduction in the incidence of DVT can be expected to reduce PE and fatal PE commensurately.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Collins R, Scrimgeour A, Yusuf S, Peto R. Reduction in fatal pulmonary embolism and venous thrombosis by perioperative administration of subcutaneous heparin. Overview of results of randomized trials in general, orthopedic, and urologic surgery. N Engl J Med. 1988;318:1162–1173.
Sharrock NE, Gonzalez D, V, Go G, Lyman S, Salvati EA. Potent anticoagulants are associated with a higher all-cause mortality rate after hip and knee arthroplasty. Clin Orthop Relat Res. 2008;466:714–721.
Venous thromboembolism: reducing the risk of venous thromboembolism (deep vein thrombosis and pulmonary embolism) in inpatients undergoing surgery. National Institute for Health and Clinical Excellence (NICE). 2010. http://www.nice.org.uk/guidance/index.jsp?action=byID&o=12695, Accessed 5 April 2010.
Geerts WH, Bergqvist D, Pineo GF, Heit JA, Samama CM, Lassen MR et al. Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines, 8th ed. Chest. 2008;133(6 suppl):381S–453S.
Jackaman FR, Perry BJ, Siddons H. Deep vein thrombosis after thoracotomy. Thorax. 1978;33:761–763.
Le Brigand H, Morille P, Garnier B, Bogaty-Yver J, Samama M, Spriet A. [Prevention of postoperative thrombo-embolic accidents following thoracic surgery by low-dose calcium heparinate: a comparative study (author’s transl)]. Sem Hop. 1981;57:972–977.
Bjerkeset O, Larsen S, Reiertsen O. Evaluation of enoxaparin given before and after operation to prevent venous thromboembolism during digestive surgery: play-the-winner designed study. World J Surg. 1997;21:584–588.
Lausen I, Jensen R, Jorgensen LN, Rasmussen MS, Lyng KM, Andersen M et al. Incidence and prevention of deep venous thrombosis occurring late after general surgery: randomised controlled study of prolonged thromboprophylaxis. Eur J Surg. 1998;164:657–663.
Bergqvist D, Agnelli G, Cohen AT, Eldor A, Nilsson PE, Le Moigne-Amrani A et al. Duration of prophylaxis against venous thromboembolism with enoxaparin after surgery for cancer. N Engl J Med. 2002;346:975–980.
Rasmussen MS. Preventing thromboembolic complications in cancer patients after surgery: a role for prolonged thromboprophylaxis. Cancer Treat Rev. 2002;28:141–144.
Cardillo G, Carleo F, Carbone L, De Massimi A, Keinan F, Foncella D et al. How long should venous thrombophylaxis be given following pulmonary lobectomy for cancer? ICVTS 2009;9(Supplement 2):S83
Nagahiro I, Andou A, Aoe M, Sano Y, Date H, Shimizu N. Intermittent pneumatic compression is effective in preventing symptomatic pulmonary embolism after thoracic surgery. Surg Today. 2004;34:6–10.
Mason DP, Quader MA, Blackstone EH, Rajeswaran J, DeCamp MM, Murthy SC et al. Thromboembolism after pneumonectomy for malignancy: an independent marker of poor outcome. J Thorac Cardiovasc Surg. 2006;131:711–718.
Choudhry NK, Anderson GM, Laupacis A, Ross-Degnan D, Normand SL, Soumerai SB. Impact of adverse events on prescribing warfarin in patients with atrial fibrillation: matched pair analysis. BMJ. 2006;332(7534):141–145.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer-Verlag London Limited
About this chapter
Cite this chapter
Treasure, T., Chong, LY., Sharpin, C.E. (2011). Perioperative Prophylaxis Against Venous Thrombo-Embolism in Major Lung Resection. In: Ferguson, M. (eds) Difficult Decisions in Thoracic Surgery. Springer, London. https://doi.org/10.1007/978-1-84996-492-0_18
Download citation
DOI: https://doi.org/10.1007/978-1-84996-492-0_18
Published:
Publisher Name: Springer, London
Print ISBN: 978-1-84996-364-0
Online ISBN: 978-1-84996-492-0
eBook Packages: MedicineMedicine (R0)