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Medical Mimics of Neurodegenerative Diseases

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Neurodegenerative Disorders
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Abstract

Mimic syndromes may differ from a neurodegenerative condition not only in natural history with periods of stability or even spontaneous improvement, but also because the mimic may be treatable. Careful attention to history and clinical examination are required to ensure that important clues to a mimic syndrome are not overlooked. Atypical features, failure to progress, or the development of new or atypical signs should trigger a full reevaluation and a search for a mimic syndrome.

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Further Reading

  • Blexrud MD, Windebank AJ, Daube JR. Long-term follow-up of 121 patients with benign fasciculations. Ann Neurol 1993;34: 622–5.

    Article  PubMed  CAS  Google Scholar 

  • Bosco DA, Morfini G, Karabacak NM, Song Y, Gros-Louis F, Pasinelli P, Goolsby H, Fontaine BA, Lemay N, McKenna-Yasek D, Frosch MP, Agar JN, Julien JP, Brady ST, Brown RH Jr. Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS. Nat Neurosci. 2010 Nov;13(11):1396–403. Epub 2010 Oct 17.

    Article  PubMed  CAS  Google Scholar 

  • Bowler JV, Hachinski V. Subcortical vascular cognitive impairment. Medlink, September 16, 2009, online.

    Google Scholar 

  • Bruyn RP, Koelman JH, Troost D, de Jong JM. Motor neuron disease (amyotrophic lateral sclerosis) arising from longstanding primary lateral sclerosis. J Neurol Neurosurg Psychiatry. 1995 Jun;58(6):742–4.

    Article  PubMed  CAS  Google Scholar 

  • Caselli RJ, Boeve BF, Schellhauser BW, O’Duffy JD, Hunder GG. Nonvasculitic autoimmune inflammatory meningoencephalitis (NAIM): a reversible form of encephalopathy. Neurology 1999; 53: 1579–81.

    PubMed  CAS  Google Scholar 

  • de Carvalho M, Swash M. Cramps, muscle pain, and fasciculations: not always benign? Neurology. 2004 Aug 24;63(4):721–3.

    PubMed  Google Scholar 

  • Eisen A, Stewart H. Not-so-benign fasciculation. Ann Neurol 1994; 35: 375.

    Article  PubMed  CAS  Google Scholar 

  • Graus F, Saiz A, Dalmau J. Antibodies and neuronal autoimmune disorders of the CNS. J Neurol 2010 257:509–17

    Article  PubMed  CAS  Google Scholar 

  • Iqbal S, Clower JH, Boehmer TK, Yip FY, Garbe P. Carbon monoxide-related hospitalizations in the U.S.: evaluation of a web-based query system for public health surveillance. Public Health Rep. 2010 May-Jun;125(3):423–32.

    PubMed  Google Scholar 

  • Lorincz MT. Wilson disease. Medlink online, June 24,2009.

    Google Scholar 

  • Meuth SG, Kleinschnitz. Multifocal motor neuropathy: update on clinical characteristics, pathophysiological concepts and therapeutic options. Eur Neurol 2010;63: 193-  =  204.

    Article  PubMed  Google Scholar 

  • Mills KR. Characteristics of fasciculations in amyotrophic lateral sclerosis and the benign fasciculation syndrome. Brain 2010; Oct 19. (He reports differences in EMG characteristics of fasciculations.)

    Google Scholar 

  • Mills KR. Characteristics of fasciculations in amyotrophic lateral sclerosis and the benign fasciculation syndrome. Brain 2010; Oct 19 (epub ahead of print)

    Google Scholar 

  • Parry GJ, Clarke S. Multifocal acquired demyelinating neuropathy masquerading as motor neuron disease. Muscle Nerve 1988;11: 103–7.

    Article  PubMed  CAS  Google Scholar 

  • Pfeiffer RF. Wilson’s disease. Semin Neurol 2007; 27:123–32.

    Article  PubMed  Google Scholar 

  • Possin KL, Kaufer DI. Parkinsonian dementias. In Dementia, Continuum 2010;16(2): 57–79.

    Google Scholar 

  • Sáez-Fonseca JA, Lee L, Walker Z. Long-term outcome ofDepressive pseudodementia in the elderly. J Affect Disord. 2007 Aug;101(1–3):123–9.

    Article  PubMed  Google Scholar 

  • Singh V, Gibson J, McLean B, Boggild M, Silver N, White R. Fasciculations and cramps: how benign? Report of four cases progressing to ALS. J Neurol 22 Oct 2010 published online.

    Google Scholar 

  • Toothaker TB, Rubin M. Paraneoplastic neurological syndromes: a review. Neurologist. 2009 Jan;15(1):21–33.

    Article  PubMed  Google Scholar 

  • Traynor BJ, Codd MB, Corr B, Forde C, Frost E, Hardiman O. Amyotrophic lateral sclerosis mimic syndromes: a population-based study. Arch Neurol. 2000 Jan;57(1):109–13

    Article  PubMed  CAS  Google Scholar 

  • Tucker T, Layzer RB, Miller RG, Chad D Subacute, reversible motor neuron disease. Neurology. 1991 Oct;41(10):1541–4.

    PubMed  CAS  Google Scholar 

  • Tullberg M, Ziegelitz D, Ribbelin S, Ekholm S. White matter diffusion is higher in Binswanger disease than in normal pressure hydrocephalus. Acta Neurol Scand 2009; 120: 226–34.

    Article  PubMed  CAS  Google Scholar 

  • Verma A, Berger JR. ALS syndrome in patients with HIV-1 infection. J Neurol Sci 2006; 240: 59–64.

    Article  PubMed  CAS  Google Scholar 

  • Winnikates J, Jankovic J. Clinical correlates of vascular parkinsonism. Arch Neurol 1999;56:98–102.

    Article  Google Scholar 

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Correspondence to Orla Hardiman .

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© 2011 Springer-Verlag London Limited

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Rowland, L.P., Hardiman, O. (2011). Medical Mimics of Neurodegenerative Diseases. In: Hardiman, O., Doherty, C. (eds) Neurodegenerative Disorders. Springer, London. https://doi.org/10.1007/978-1-84996-011-3_11

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  • DOI: https://doi.org/10.1007/978-1-84996-011-3_11

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