Skip to main content

Dentin and Bone: Similar Collagenous Mineralized Tissues

  • Chapter
  • First Online:

Part of the book series: Topics in Bone Biology ((TBB,volume 6))

Abstract

Teeth are individual organs that consist of an exposed crown structure and an internally embedded root structure. Each tooth is an individual organ that, through location and function, is coordinated to form a highly ordered and symmetrical patterned unit known as the dentition. Humans have two successive sets of teeth, the primary dentition or baby teeth, which are replaced by the permanent dentition. The tooth forms three distinct mineralized extracellular matrices, enamel, dentin, and cementum, which are temporally and spatially integrated to form the hardest structure in the human body. The tooth crown is covered by an outer layer of enamel with an inner, more resilient mineralized dentin layer in juxtaposition, followed by an unmineralized predentin matrix adjacent to the dental pulp chamber. The root is covered by a thin outer layer of cementum over the inner layers of dentin and predentin. Therefore, the most abundant matrix of the tooth is dentin that covers both the crown and root structures. This chapter will discuss dentin, the mineralized connective tissue of the teeth, and compare and contrast its formation and structure with that of bone.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Arany S, Nakata A, Kameda T, Koyota S, Ueno Y, Sugiyama T (2006) Phenotype properties of a novel spontaneously immortalized odontoblast lineage cell line. Biochem Biophys Res Commun 342:718-724

    Article  CAS  PubMed  Google Scholar 

  2. Banerjee C, McCabe LR, Choi JY, Hiebert SW, Stein JL, Stein GS, Lian JB (1997) Runt homology domain proteins in osteoblast differentiation: AML3/CBFA1 is a major component of a bone-specific complex. J Cell Biochem 66(1):1-8

    Article  CAS  PubMed  Google Scholar 

  3. Bialek P, Kern B, Yang X, Schrock M, Sosic D, Hong N, Wu H, Yu K, Ornitz DM, Olson EN, Justice MJ, Karsenty G (2004) A twist code determines the onset of osteoblast differentiation. Dev Cell 6:423-435

    Article  CAS  PubMed  Google Scholar 

  4. Bonewald LF, Johnson ML (2008) Osteocytes, mechanosensing and Wnt signaling. Bone 42(4):606-615

    Article  CAS  PubMed  Google Scholar 

  5. Bonucci E (1967) Fine structure of early cartilage calcification. J Ultrastruct Res 20:33

    Article  CAS  PubMed  Google Scholar 

  6. Boskey AL, Young MF, Kilts T, Verdelis K (2005) Variation in mineral properties in normal and mutant bones and teeth. Cells Tissues Organs 181(3-4):144-153

    Article  PubMed  Google Scholar 

  7. Butler WT (1998) Dentin matrix proteins. Eur J Oral Sci 106(suppl 1): 204-210

    CAS  PubMed  Google Scholar 

  8. Butler WT, Brunn JC, Qin C (2003) Dentin extracellular matrix (ECM) proteins: comparison to bone ECM and contribution to dynamics of dentinogenesis. Connect Tissue Res 44(suppl 1):171-178

    CAS  PubMed  Google Scholar 

  9. Catón J, Bringas P Jr, Zeichner-David M (2007) Establishment and characterization of an immortomouse-derived odontoblast-like cell line to evaluate the effect of insulin-like growth factors on odontoblast differentiation. J Cellular Biochem 100:450-463

    Article  CAS  Google Scholar 

  10. Caviedes-Bucheli J, Angel-Londoño P, Díaz-Perez A, Orozco MP, Alvarez JL, Lombana N, Díaz E, Muñoz HR (2007) Variation in the expression of insulin-like growth factor-1 in human pulp tissue according to the root-development stage. J Endod 33(11):1293-1295

    Article  PubMed  Google Scholar 

  11. Celil AB, Campbell PG (2005) BMP-2 and insulin-like growth factor-I mediate Osterix (Osx) expression in human mesenchymal stem cells via the MAPK and protein kinase D signaling pathways. J Biol Chem 280(36):31353-31359

    Article  CAS  PubMed  Google Scholar 

  12. Chen S, Chen L, Jahangiri A, Chen B, Wu Y, Chuang HH, Qin C, MacDougall M (2008) Expression and processing of small intergrin-binding ligand N-linked glycoproteins in mouse odontoblastic cells. Arch Oral Biol 53(9):879-889

    Article  PubMed  CAS  Google Scholar 

  13. Chen S, Gluhak-Heinrich J, Martinez M, Li T, Wu Y, Chuang HH, Chen L, Dong J, Gay I, MacDougall M (2008) Bone morphogenetic protein 2 mediates dentin sialophosphoprotein expression and odontoblast differentiation via NF-Y signaling. J Biol Chem 283(28):19359-19370

    Article  CAS  PubMed  Google Scholar 

  14. Chen S, Gu TT, Sreenath T, Kulkarni AB, Karsenty G, MacDougall M (2002) Spatial expression of Cbfa1/Runx2 isoforms in teeth and characterization of binding sites in the DSPP gene. Connect Tissue Res 43(2-3): 338-344

    Article  CAS  PubMed  Google Scholar 

  15. Choi JY, Pratap J, Javed A, Zaidi SK, Xing L, Balint E, Dalamangas S, Boyce B, van Wijnen AJ, Lian JB, Stein JL, Jones SN, Stein GS (2001) Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development. Proc Natl Acad Sci U S A 98(15):8650-8655

    Article  CAS  PubMed  Google Scholar 

  16. Danielson KG, Baribault H, Holmes DF, Graham H, Kadler KE, Iozzo RV (1997) Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility. J Cell Biol 136:729-743

    Article  CAS  PubMed  Google Scholar 

  17. Delany AM, Amling M, Priemel M, Howe C, Baron R, Canalis E (2000) Osteopenia and decreased bone formation in osteonectin-deficient mice. J Clin Invest 105(7):915-923

    Article  CAS  PubMed  Google Scholar 

  18. D’Souza RN, Aberg T, Gaikwad J, Cavender A, Owen M, Karsenty G, Thesleff I (1999) Cbfa1 is required for epithelial-mesenchymal interactions regulating tooth development in mice. Development 126(13):2911-2920

    PubMed  Google Scholar 

  19. Dobreva G, Chahrour M, Dautzenberg M, Chirivella L, Kanzler B, Fariñas I, Karsenty G, Grosschedl R (2006) SATB2 is amultifunctional determinant of craniofacial patterning and osteoblast differentiation. Cell 125:971-986

    Article  CAS  PubMed  Google Scholar 

  20. Domon T, Sugaya k, Yawaka Y, Osanai M, Hanaizumi Y, Takaahashi S, Wakita M (1994) Electron microscopic and histochemical studies of the mononuclear odontoblasts of the human. Ant Rec 240:42-51

    Article  CAS  Google Scholar 

  21. Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G (1997) Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89:747-754

    Article  CAS  PubMed  Google Scholar 

  22. Ducy P, Desbois C, Boyce B, Pinero G, Story B, Dunstan C, Smith E, Bonadio J, Goldstein S, Gundberg C, Bradley A, Karsenty G (1996) Increased bone formation in osteocalcin-deficient mice. Nature 382(6590):448-452

    Article  CAS  PubMed  Google Scholar 

  23. Erlebacher A, Filvaroff EH, Gitelman SE, Derynck R (1995) Toward a molecular understanding of skeletal development. Cell 80:371-378

    Article  CAS  PubMed  Google Scholar 

  24. Farges JC, Couble ML, Magloire H, Hartmann DJ, Bleicher F (1995) Ultrastructural characterization of mesenchymal and epithelial cells co-cultured from human dental root apical explants. Connect Tissue Res 33(1-3):37-46

    Article  CAS  PubMed  Google Scholar 

  25. Feng JQ, Ward LM, Liu S, Lu Y, Xie Y, Yuan B, Yu X, Rauch F, Davis SI, Zhang S, Rios H, Drezner MK, Quarles LD, Bonewald LF, White KE (2006) Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. Nat Genet 38(11):1310-1315

    Article  CAS  Google Scholar 

  26. Fisher LW, Fedarko NS (2003) Six genes expressed in bones and teeth encode the current members of the SIBLING family of proteins. Connect Tissue Res 44(suppl 1): 33-40

    CAS  PubMed  Google Scholar 

  27. Fogh J, Wright WC, Loveless JD (1977) Absence of HeLa cell contamination in 169 cell lines derived from human tumors. J Natl Cancer Inst 58(2):209-214

    CAS  PubMed  Google Scholar 

  28. Frost HM (1969) Tetracycline-based histological analysis of bone remodeling. Calcif Tissue Res 3(3):211-237

    Article  CAS  PubMed  Google Scholar 

  29. Furseth R (1968) The resorption oprocesses of human deciduous teeth studied by light mcriscopy, microadiography and electron microscopy. Arch Oral Biol 13:417

    Article  CAS  PubMed  Google Scholar 

  30. Galler K, Schweikl H, Thonemann B, D’Souza RN, Schmalz G (2006) Human pulp-derived cells immortalized with Simian Virus 40 T-antigen. Eur J Oral Sci 114:138-146

    Article  CAS  PubMed  Google Scholar 

  31. George EL, Georges-Labouesse EN, Patel-King RS, Rayburn H, Hynes RO (1993) Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin. Development 119(4):1079-1091

    CAS  PubMed  Google Scholar 

  32. Gluhak-Heinrich J, Pavlin D, Yang W, MacDougall M, Harris SE (2007) MEPE expression in osteocytes during orthodontic tooth movement. Arch Oral Biol 52(7):684-690

    Article  CAS  PubMed  Google Scholar 

  33. Gluhak-Heinrich J, Ye L, Bonewald LF, Feng JQ, MacDougall M, Harris SE, Pavlin D (2003) Mechanical loading stimulates dentin matrix protein 1 (DMP1) expression in osteocytes in vivo. J Bone Miner Res 18(5):807-817

    Article  CAS  PubMed  Google Scholar 

  34. Goldberg M, Septier D, Oldberg A, Young MF, Ameye LG (2006) Fibromodulin-deficient mice display impaired collagen fibrillogenesis in predentin as well as altered dentin mineralization and enamel formation. J Histochem Cytochem 54(5):525-537

    Article  CAS  PubMed  Google Scholar 

  35. Goldberg M, Smith AJ (2004) Cells and extracellular matrices of dentin and pulp: a biological basis for repair and tissue engineering. Crit Rev Oral Biol Med 15(1):13-27

    Article  PubMed  Google Scholar 

  36. Goldstein SA (1987) The mechanical properties of trabecular bone: dependence on anatomic location and function. J Biomech 20(11-12):1055-1061

    Article  CAS  PubMed  Google Scholar 

  37. Gotlive B, Veis A (2007) Peritubular dentin, a vertebrate apatitic mineralized tissue without collagen: role of a phospholipid-proteolipid complex. Calcif Tissue Int 81:191-205

    Article  CAS  Google Scholar 

  38. Gowen LC, Petersen DN, Mansolf AL, Qi H, Stock JL, Tkalcevic GT, Simmons HA, Crawford DT, Chidsey-Frink KL, Ke HZ, McNeish JD, Brown TA (2003) Targeted disruption of the osteoblast/osteocyte factor 45 gene (OF45) results in increased bone formation and bone mass. J Biol Chem 278(3):1998-2007

    Article  CAS  PubMed  Google Scholar 

  39. Gutierrez S, Javed A, Tennant DK, van Rees M, Montecino M, Stein GS, Stein JL, Lian JB (2002) CCAAT/enhancer-binding proteins (C/EBP) beta and delta activate osteocalcin gene transcription and synergize with Runx2 at the C/EBP element to regulate bone-specific expression. J Biol Chem 277(2):1316-1323

    Article  CAS  PubMed  Google Scholar 

  40. Hall BK, Miyake T (1992) The membranous skeleton: the role of cell condensations in vertebrate skeletogenesis. Anat Embryol 186:107-124

    Article  CAS  PubMed  Google Scholar 

  41. Hanks CT, Fang D, Sun Z, Edwards CA, Butler WT (1998) Dentin-specific proteins in MDPC-23 cell line. Eur J Oral Sci 106:260-266

    CAS  PubMed  Google Scholar 

  42. Hao J, Narayanan K, Ramachandran A, He G, Almushayt A, Evans C, George A (2002) Odontoblast cells immortalized by telomerase produce mineralized dentin-like tissue both in vitro and in vivo. J Biol Chem 277:19976-19981

    Article  CAS  PubMed  Google Scholar 

  43. Harris SE, Gluhak-Heinrich J, Harris MA, Yang W, Bonewald LF, Riha D, Rowe PS, Robling AG, Turner CH, Feng JQ, McKee MD, Nicollela D (2007) DMP1 and MEPE expression are elevated in osteocytes after mechanical loading in vivo: theoretical role in controlling mineral quality in the perilacunar matrix. J Musculoskelet Neuronal Interact 7(4):313-315

    CAS  PubMed  Google Scholar 

  44. Hart PS, Hart TC (2007) Disorders of human dentin. Cells Tissues Organs 186(1):70-77

    Article  CAS  PubMed  Google Scholar 

  45. Hassan MQ, Javed A, Morasso MI, Karlin J, Montecino M, van Wijnen AJ, Stein GS, Stein JL, Lian JB (2004) Dlx3 transcriptional regulation of osteoblast differentiation: temporal recruitment of Msx2, Dlx3, and Dlx5 homeodomain proteins to chromatin of the osteocalcin gene. Mol Cell Biol. 24(20):9248-9261

    Article  CAS  PubMed  Google Scholar 

  46. Hofstetter W, Wetterwald A, Cecchini MG, Mueller C, Felix R (1995) Detection of transcripts and binding sites for colony-stimulating factor-1 during bone development. Bone 17:145-151

    Article  CAS  PubMed  Google Scholar 

  47. Horton WA (1993) Morphology of connective tissue: cartilage. In: Connective tissue and its heritable disorders. Wiley, New York, NY, pp 73-84

    Google Scholar 

  48. Hu H, Hilton MJ, Tu X, Yu K, Ornitz DM, Long F (2005) Sequential roles of Hedgehog and Wnt signaling in osteoblast development. Development 132:49-60

    Article  CAS  PubMed  Google Scholar 

  49. Jabs EW, Müller U, Li X, Ma L, Luo W, Haworth IS, Klisak I, Sparkes R, Warman ML, Mulliken JB, Sneadf ML, Maxson R (1993) A mutation in the homeodomain of the human MSX2 gene in a family affected with autosomal dominant craniosynostosis. Cell 75(3):443-450

    Article  CAS  PubMed  Google Scholar 

  50. Javed A, Bae JS, Afzal F, Gutierrez S, Pratap J, Zaidi SK, Lou Y, van Wijnen AJ, Stein JL, Stein GS, Lian JB (2008) Structural coupling of Smad and Runx2 for execution of the BMP2 osteogenic signal. J Biol Chem 283(13):8412-8422

    Article  CAS  PubMed  Google Scholar 

  51. Javed A, Guo B, Hiebert S, Choi JY, Green J, Zhao SC, Osborne MA, Stifani S, Stein JL, Lian JB, van Wijnen AJ, Stein GS (2000) Groucho/TLE/R-esp proteins associate with the nuclear matrix and repress RUNX (CBF(alpha)/AML/PEBP2(alpha)) dependent activation of tissue-specific gene transcription. J Cell Sci 113(pt 12):2221-2231

    CAS  PubMed  Google Scholar 

  52. Javed A, Gutierrez S, Montecino M, van Wijnen AJ, Stein JL, Stein GS, Lian JB (1999) Multiple Cbfa/AML sites in the rat osteocalcin promoter are required for basal and vitamin D-responsive transcription and contribute to chromatin organization. Mol Cell Biol 19(11):7491-7500

    CAS  PubMed  Google Scholar 

  53. Jensen ED, Schroeder TM, Bailey J, Gopalakrishnan R, Westendorf JJ (2008) Histone deacetylase 7 associates with Runx2 and represses its activity during osteoblast maturation in a deacetylation-independent manner. J Bone Miner Res 23(3):361-372

    Article  CAS  PubMed  Google Scholar 

  54. Jilka RL (2007) Molecular and cellular mechanisms of the anabolic effect of intermittent PTH. Bone 40(6):1434-1446

    Article  CAS  PubMed  Google Scholar 

  55. Jones DC, Wein MN, Oukka M, Hofstaetter JG, Glimcher MJ, Glimcher LH (2006) Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3. Science 312:1223-1227

    Article  CAS  PubMed  Google Scholar 

  56. Joseph BK, Savage NW, Daley TJ, Young WG (1996) In situ hybridization evidence for a paracrine/autocrine role for insulin-like growth factor-I in tooth development. Growth Factors 13(1-2): 11-17

    Article  CAS  PubMed  Google Scholar 

  57. Kaipatur NR, Murshed M, McKee MD (2008) Matrix Gla protein inhibition of tooth mineralization. J Dent Res 87(9):839-844

    Article  CAS  PubMed  Google Scholar 

  58. Kasugai S, Adachi M, Ogura H (1988) Establishment and characterization of a clonal cell line (RPC-C2A) from dental pulp of the rat incisor. Arch Oral Biol 33:887-891

    Article  CAS  PubMed  Google Scholar 

  59. Kato Y, Windle JJ, Koop BA, Mundy GR, Bonewald LF (1997) Establishment of an osteocyte-like cell line, MLO-Y4. J Bone Miner Res 12(12):2014-2023

    Article  CAS  PubMed  Google Scholar 

  60. Kawase T, Orikasa M, Suzuki A (1990) A clonal prostaglandinresponsive cell line (RDP 4-1) derived from rat dental pulp. Bone Miner 11:163-175

    Article  CAS  PubMed  Google Scholar 

  61. Kerebel B, Daculsi G, Menenteau J, Kerebel LM (1981) The inorganic phase in dentinogenesis imperfecta. J Dent Res 60(9):1655-1660

    CAS  PubMed  Google Scholar 

  62. Kettunen P, Laurikkala J, Itäranta P, Vainio S, Itoh N, Thesleff I (2000) Association of FGF-3 and FGF-10 with signaling networks regulation tooth morphogenesis. Dev Dyn 219(3):322-332

    Article  CAS  PubMed  Google Scholar 

  63. Kim S, Koga T, Isobe M, Kern BE, Yokochi T, Chin YE, Karsenty G, Taniguchi T, Takayanagi H (2003) Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation. Genes Dev 17:1979-1991

    Article  CAS  PubMed  Google Scholar 

  64. Kim SH, Roth KA, Coopersmith CM, Pipas JP, Gordon JI (1994) Expression of wild-type and mutant simian virus 40 large tumor antigens in villus-associated enterocytes of transgenic mice. Proc Natl Acad Sci U S A 91:6914-6918

    Article  CAS  PubMed  Google Scholar 

  65. Kitagawa M, Ueda H, Iizuka S, Sakamoto K, Oka H, Kudo Y, Ogawa I, Miyauchi M, Tahara H, Takata T (2007) Immortalization and characterization of human dental pulp cells with odontoblastic differentiation. Arch Oral Biol 52(8):727-731

    Article  CAS  PubMed  Google Scholar 

  66. Kodama H, Amagai Y, Sudo H, Kasai S, Yamamoto S (1981) Establishment of a clonal osteogenic cell line from newborn mouse calvaria. Jpn J Oral Biol 23:899-901

    Google Scholar 

  67. Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K, Shimizu Y, Bronson RT, Gao YH, Inada M, Sato M, Okamoto R, Kitamura Y, Yoshiki S, Kishimoto T (1997) Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89:755-764

    Article  CAS  PubMed  Google Scholar 

  68. Kyriakides TR, Zhu YH, Smith LT, Bain SD, Yang Z, Lin MT, Danielson KG, Iozzo RV, LaMarca M, McKinney CE, Ginns EI, Bornstein P (1998) Mice that lack thrombospondin 2display connective tissue abnormalities that are associated with disordered collagen fibrillogenesis, an increased vascular density, and a bleeding diathesis. J Cell Biol 140:419-430

    Article  CAS  PubMed  Google Scholar 

  69. Lian JB, Javed A, Zaidi SK, Lengner C, Montecino M, van Wijnen AJ, Stein JL, Stein GS (2004) Regulatory controls for osteoblast growth and differentiation: role of Runx/Cbfa/AML factors. Crit Rev Eukaryot Gene Expr 14(1-2):1-41

    Article  CAS  PubMed  Google Scholar 

  70. Lian JB, Stein GS, Stein JL, van Wijnen AJ (1998) Osteocalcin gene promoter: unlocking the secrets for regulation of osteoblast growth and differentiation. J Cell Biochem Suppl 30-31:62-72

    Article  CAS  PubMed  Google Scholar 

  71. Linde A, Goldberg M (1993) Dentinogenesis. Crit Rev Oral Biol Med 4(5):679-728

    CAS  Google Scholar 

  72. Linde A (1984) Dentin and dentinogenesis, vol 1-2. CRC Press, Boca Raton, FL, pp 55-92

    Google Scholar 

  73. Lorenz-Depiereux B, Bastepe M, Benet-Pagès A, Amyere M, Wagenstaller J, Müller-Barth U, Badenhoop K, Kaiser SM, Rittmaster RS, Shlossberg AH, Olivares JL, Loris C, Ramos FJ, Glorieux F, Vikkula M, Jüppner H, Strom TM (2006) DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis. Nat Genet 38(11):1248-1250

    Article  CAS  PubMed  Google Scholar 

  74. Luo G, Ducy P, McKee MD, Pinero GJ, Loyer E, Behringer RR, Karsenty G (1997) Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature 386:78-81

    Article  CAS  PubMed  Google Scholar 

  75. Lupu F, Terwilliger JD, Lee K, Segre GV, Efstratiadis A (2001) Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth. Dev Biol 229:141-162

    Article  CAS  PubMed  Google Scholar 

  76. MacDougall M, Dong J, Acevedo AC (2006) Molecular basis of human dentin disease. Am J Hum Genet 140(23):2536-2546

    Google Scholar 

  77. MacDougall M, Unterbrink A, Carnes D, Rani S, Luan X, Chen S (2001) Utilization of MO6-G3 immortalized odontoblast cells in studies regarding dentinogenesis. Adv Dent Res 15:25-29

    Article  CAS  PubMed  Google Scholar 

  78. MacDougall M, Selden JK, Nydegger J, Carnes DL (1998) Immortalized mouse odontoblast cell line M06-G3 application for in vitro biocompatibility testing. Am J Dent 11:511-516

    Google Scholar 

  79. MacDougall M, Simmons D, Luan X, Nydegger J, Feng J, Gu TT (1997) Dentin phosphoprotein and dentin sialoprotein are cleavage products expressed from a single transcript coded by a gene on human chromosome 4: dentin phosphoprotein DNA sequence determination. J Biol Chem 272:835-842

    Article  CAS  PubMed  Google Scholar 

  80. MacDougall M, Thiemann F, Ta H, Hsu P, Chen LS, Snead ML (1995) Temperature sensitive simian Virus 40 large T Antigen immortalization of murine odontoblast cell cultures: establishment of clonal odontoblast cell line. Conn Tiss Res 33:97-103

    Article  CAS  Google Scholar 

  81. MacDougall M (1992) Dentin excellular matrix protein expression by odontoblastic cell cultures. In Slavkin H, Price P (eds) The fourth international conference on the chemistry and biology of mineralized tissues. Elsevier, New York, pp 117-124

    Google Scholar 

  82. Magloire H, Hartmann DJ, Couble ML, Grimaud J, Herage D, Ville G (1984) Tooth morphogenesis and differentiation, vol 125. INSERM, Paris, pp 119-126

    Google Scholar 

  83. Malaval L, Wade-Guéye NM, Boudiffa M, Fei J, Zirngibl R, Chen F, Laroche N, Roux JP, Burt-Pichat B, Duboeuf F, Boivin G, Jurdic P, Lafage-Proust MH, Amédée J, Vico L, Rossant J, Aubin JE (2008) Bone sialoprotein plays a functional role in bone formation and osteoclastogenesis. J Exp Med 205(5):1145-1153

    Article  CAS  PubMed  Google Scholar 

  84. Martin TJ, Ingleton PM, Underwood JC, Michelangeli VP, Hunt NH, Melick RA (1976) Parathyroid hormone-responsive adenylate cyclase in induced transplantable osteogenic rat sarcoma. Nature 260(5550):436-438

    Article  CAS  PubMed  Google Scholar 

  85. Melnick M, Levin LS, Brady J (1980) Dentin dysplasia type I: a scanning electron microscopic analysis of the primary dentition. Oral Surg 50:335-339

    Article  CAS  PubMed  Google Scholar 

  86. Melnick M, Eastman JR, Goldblatt LI, Michaud M, Bixler D (1977) Dentin dysplasia, type II: a rare autosomal dominant disorder. Oral Surg 44:592-599

    Article  CAS  PubMed  Google Scholar 

  87. Mesgouez C, Oboef M, Mauro N, Colon P, MacDougall M, Machtou P, Sautier JM, Berdal A (2006) Ultrastructural and immunohistochemical characterization of immortalized odontoblasts M06-G3. Intern Endodont J 38:1-11

    Google Scholar 

  88. Mitsiadis TA, Rahiotis C (2004) Parallels between tooth development and repair: conserved molecular mechanisms following carious and dental injury. J Dent Res 83(12):896-902

    Article  CAS  PubMed  Google Scholar 

  89. Miyazaki T, Kanatani N, Rokutanda S, Yoshida C, Toyosawa S, Nakamura R, Takada S, Komori T (2008) Inhibition of the terminal differentiation of odontoblasts and their transdifferentation into osteoblasts in Runx2 transgenic mice. Arch Histol Cytol 71(2):131-146

    Article  CAS  PubMed  Google Scholar 

  90. Muenke M, Schell U, Hehr A, Robin NH, Losken HW, Schinzel A, Pulleyn LJ, Rutland P, Reardon W, Malcolm S, Winter RM (1994) A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome. Nat Genet 8(3):269-274

    Article  CAS  PubMed  Google Scholar 

  91. Mundlos S, Otto F, Mundlos C, Mulliken JB, Aylsworth AS, Albright S, Lindhout D, Cole WG, Henn W, Knoll JH, Owen MJ, Mertelsmann R, Zabel BU, Olsen BR (1997) Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia. Cell 89:773-779

    Article  CAS  PubMed  Google Scholar 

  92. Nakashima K, Zhou X, Kunkel G, Zhang Z, Deng JM, Behringer RR, de Crombrugghe B (2002) The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108:17-29

    Article  CAS  PubMed  Google Scholar 

  93. Nakashima M (1990) The induction of reparative dentine in the amputated dental pulp of the dog by bone morphogenetic protein. Archs Oral Biol 35(7):493-497

    Article  CAS  Google Scholar 

  94. Naski MC, Ornitz DM (1998) FGF signaling in skeletal development. Front Biosci 3 781-794

    Google Scholar 

  95. Niizima M (1956) Dental papilla in tissue culture. Am J Anat 99:351-389

    Article  CAS  PubMed  Google Scholar 

  96. Nomiyama K, Kitamura C, Tsujisawa T, Nagayoshi M, Morotomi T, Terashita M, Nishihara T (2007) Effects of lipopolysaccharide on newly established dental pulp-derived cell line with odontoblastic properties. J Endod 33:1187-1191

    Article  PubMed  Google Scholar 

  97. Ogbureke KU, Fisher LW (2004) Expression of SIBLINGs and their partner MMPs in salivary glands. J Dent Res 83(9):664-670

    Article  CAS  PubMed  Google Scholar 

  98. Ornitz DM, Marie PJ (2002) FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease. Genes Dev 16(12):1446-1465

    Article  CAS  PubMed  Google Scholar 

  99. Otto F, Thornell AP, Crompton T, Denzel A, Gilmour KC, Rosewell IR, Stamp GW, Beddington RS, Mundlos S, Olsen BR, Selby PB, Owen MJ (1997) Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89:765-771

    Article  CAS  PubMed  Google Scholar 

  100. Panagakos FS (1998) Transformation and preliminary characterization of primary human pulp cells. J Endodon 24:171-175

    Article  CAS  Google Scholar 

  101. Parfitt AM (1987) Bone remodeling and bone loss: understanding the pathophysiology of osteoporosis. Clin Obstet Gynecol 30(4):789-811

    Article  CAS  PubMed  Google Scholar 

  102. Parfitt AM, Mathews CH, Villanueva AR, Kleerekoper M, Frame B, Rao DS (1983) Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis. Implications for the microanatomic and cellular mechanisms of bone loss. J Clin Invest 72(4):1396-1409

    Article  CAS  PubMed  Google Scholar 

  103. Puzas JE (1996) Osteoblast cell biology, lineage and functions In: Favus MJ (eds) Primer on the metabolic bone diseases and disorders of mineral metabolism. Lippincott-Raven, Philadelphia, PA, pp 11-16

    Google Scholar 

  104. Qin C, Baba O, Butler WT (2004) Post-translational modifications of sibling proteins and their roles in osteogenesis and dentinogenesis. Crit Rev Oral Biol Med 15(3):126-136

    Article  CAS  PubMed  Google Scholar 

  105. Qin C, Brunn JC, Cadena E, Ridall A, Butler WT (2003) Dentin sialoprotein in bone and dentin sialophosphoprotein gene expressed by osteoblasts. Connect Tissue Res 44(suppl 1):179-183

    CAS  PubMed  Google Scholar 

  106. Qin C, Brunn JC, Jones J, George A, Ramachandran A, Gorski JP, Butler WT (2001) A comparative study of sialic acid-rich proteins in rat bone and dentin. Eur J Oral Sci 109:133-141

    Article  CAS  PubMed  Google Scholar 

  107. Reardon W, Winter RM, Rutland P, Pulleyn LJ, Jones BM, Malcolm S (1994) Mutations in the fibroblast growth factor receptor 2 gene cause Crouzon syndrome. Nat Genet 8(1):98-103

    Article  CAS  PubMed  Google Scholar 

  108. Reznikoff CA, Brankow DW, Heidelberger C (1973) Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division. Cancer Res 33(12):3231-328

    CAS  PubMed  Google Scholar 

  109. Rittling SR, Matsumoto HN, McKee MD, Nanci A, An XR, Novick KE, Kowalski AJ, Noda M, Denhardt DT (1998) Mice lacking osteopontin show normal development and bone structure but display altered osteoclast formation in vitro. J Bone Miner Res 13(7):1101-1111

    Article  CAS  PubMed  Google Scholar 

  110. Rodan SB, Fischer MK, Egan JJ, Epstein PM, Rodan GA (1984) The effect of dexamethasone on parathyroid hormone stimulation of adenylate cyclase in ROS 17/2.8 cells. Endocrinology 115(3):951-958

    Article  CAS  PubMed  Google Scholar 

  111. Ruch JV, Lesot H, Begue-Kirn C (1995) Odontoblast differentiation. Int J Dev BioI 39:51-68

    CAS  Google Scholar 

  112. Rutherford RB, Wahle J, Tucker M, Sampath K, Rueger D, Charette M (1993) Induction of reparative dentine formation in monkeys by recombinant humanosteogenic protein-1. Arch Oral Biol 38:571-576

    Article  CAS  PubMed  Google Scholar 

  113. Rutherford RB, Wahle J, Tucker M, Rueger D, Charette M (1994) The time-course of the induction of reparative dentine formation in monkeys by recombinant human osteogenic protein-1. Arch Oral Biol 39:833-838

    Article  CAS  PubMed  Google Scholar 

  114. Sabatakos G, Sims NA, Chen J, Aoki K, Kelz MB, Amling M, Bouali Y, Mukhopadhyay K, Ford K, Nestler EJ, Baron R (2000) Overexpression of ΔFosB transcription factor(s) increases bone formation and inhibits adipogenesis. Nat Med 6:985-990

    Article  CAS  PubMed  Google Scholar 

  115. Satokata I, Ma L, Ohshima H, Bei M, Woo I, Nishizawa K, Maeda T, Takano Y, Uchiyama M, Heaney S, Peters H, Tang Z, Maxson R, Maas R (2000) Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation. Nat Genet 24:391-395

    Article  CAS  PubMed  Google Scholar 

  116. Shields ED, Bixler D, El-Kafrawy AM (1973) A proposed classification for heritable human dentine defect with a description of a new entity. Arch Oral Biol 18:543-553

    Article  CAS  PubMed  Google Scholar 

  117. Sierra J, Villagra A, Paredes R, Cruzat F, Gutierrez S, Javed A, Arriagada G, Olate J, Imschenetzky M, Van Wijnen AJ, Lian JB, Stein GS, Stein JL, Montecino M (2003) Regulation of the bone-specific osteocalcin gene by p300 requires Runx2/Cbfa1 and the vitamin D3 receptor but not p300 intrinsic histone acetyltransferase activity. Mol Cell Biol 23:3339-3351

    Article  CAS  PubMed  Google Scholar 

  118. Slinskey A, Barnes D, Pipas JM (1999) Simian virus 40 large T antigen J domain and Rb-binding motif are sufficient to block apoptosis induced by growth factor withdrawal in a neural stem cell line. J Virol 73(8):6791-6799

    CAS  PubMed  Google Scholar 

  119. Smith AJ, Robias RS, Cassidy N, Plant G, Browne RM, Begue-Kirn C, Ruch JV, Lesot H (1994) Odontoblast stimulation in ferrets by dentine matrix components. Archs Oral Biol 39:13-22

    Article  CAS  Google Scholar 

  120. Sreenath T; Thyagarajan T; Hall B, Longenecker G, D’Souza R, Hong S, Wright JT, MacDougall M, Sauk J, Kulkarni AB (2003) Dentin sialophosphoprotein knockout mouse teeth display widened predentin zone and develop defective dentin mineralization similar to human dentinogenesis imperfecta type III. J Biol Chem 278:24874-24880

    Article  CAS  PubMed  Google Scholar 

  121. St-Arnaud R (2008) The direct role of vitamin D on bone homeostasis. Arch Biochem Biophys 473(2):225-230

    Article  CAS  PubMed  Google Scholar 

  122. Stein GS, Lian JB, Owen TA (1990) Relationship of cell growth to the regulation of tissue-specific gene expression during osteoblast differentiation. FASEB J 4:3111-3123

    CAS  PubMed  Google Scholar 

  123. Svensson L, Aszódi A, Reinholt FP, Fässler R, Heinegård D, Oldberg A (1999) Fibromodulin-null mice have abnormal collagen fibrils, tissue organization, and altered lumican deposition in tendon. J Biol Chem 274(14):9636

    Article  CAS  PubMed  Google Scholar 

  124. Tatsumi S, Ishii K, Amizuka N, Li M, Kobayashi T, Kohno K, Ito M, Takeshita S, Ikeda K (2007) Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction. Cell Metab 5:464-475

    Article  CAS  PubMed  Google Scholar 

  125. Thesleff I (2003) Epithelial-mesenchymal signalling regulating tooth morphogenesis. J Cell Sci 116:1647-1648

    Article  CAS  PubMed  Google Scholar 

  126. Thonemann B, Schmalz G (2000) Bovine dental papilla-derived cells immortalized with HPV 18 E6/E7. Eur J Oral Sci 108:432-441

    Article  CAS  PubMed  Google Scholar 

  127. Tribioli C, Lufkin T (1999) The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen. Development 126:5699-5711

    CAS  PubMed  Google Scholar 

  128. Tsukamoto Y, Fukutani S, Shinike T, Kubota T, Sato S, Suzuki Y, Mori M (1993) Mineralized nodule formation by cultures of human dental pulp-derived fibroblasts. Arch Oral Biol 37:1045-1055

    Article  Google Scholar 

  129. Tsukamoto Y, Fukutani S, Takeuchi S, Tanaka Y, Mori M (1988) Cultivation of fibroblast-like cells derived from human dental pulp, demonstrated 1,25(OH)2D3 sensitive alkaline phosphatase. Jpn J of Oral Biol 30:851-854

    CAS  Google Scholar 

  130. Tucker A, Sharpe P (2004) The cutting-edge of mammalian development; how the embryo makes teeth. Nat Rev 5:499-508

    CAS  Google Scholar 

  131. Tziafas D (2004) The future role of a molecular approach to pulp-dentinal regeneration. Caries Res 38:314-320

    Article  CAS  PubMed  Google Scholar 

  132. Tziafas D, Hurmerinta K (1990) Inductive influences of demineralized dentin and bone matrix on pulp cells: an approach of secondary dentinogenesis. J Dent Res 69:75-81

    CAS  PubMed  Google Scholar 

  133. Vanderschueren D, Gaytant J, Boonen S, Venken K (2008) Androgens and bone. Curr Opin Endocrinol Diabetes Obes 15(3):250-254

    CAS  PubMed  Google Scholar 

  134. Vastardis H, Karimbus N, Guthua SW, Seidman JG, Seidman CE (1996) A human MSX1 homeodomain missense mutation causes selective tooth agenesis. Nat Genet 13:417-421

    Article  CAS  PubMed  Google Scholar 

  135. Verdelis K, Ling Y, Sreenath T, Haruyama N, MacDougall M, van der Meulen MC, Lukashova L, Spevak L, Kulkarni AB, Boskey AL (2008) DSPP effects on in vivo bone mineralization. Bone 43(6): 983-990

    Article  CAS  PubMed  Google Scholar 

  136. Watanabe H, Yamada Y (1999) Mice lacking link protein develop dwarfism and craniofacial abnormalities. Nat Genet 21(2):225-229

    Article  CAS  PubMed  Google Scholar 

  137. Watanabe H, Kimata K, Line S, Strong D, Gao LY, Kozak CA, Yamada Y (1994) Mouse cartilage matrix deficiency (cmd) caused by a 7 bp deletion in the aggrecan gene. Nat Genet 7(2):154-157

    Article  CAS  PubMed  Google Scholar 

  138. Weiner A, Veis A, Beniash Em Arad T, Dillon JW, Sabsay B, Siddiqui F (1999) Peritubular dentin formation: crystal organization and the macromolecular constituents in human teeth. J Struct Biol 126:27-41

    Article  CAS  PubMed  Google Scholar 

  139. Wilkie AO, Tang Z, Elanko N, Walsh S, Twigg SR, Hurst JA, Wall SA, Chrzanowska KH, Maxson RE Jr (2000) Functional haploinsufficiency of the human homeobox gene MSX2 causes defects in skull ossification. Nat Genet 24(4):387-390

    Article  CAS  PubMed  Google Scholar 

  140. Witkop CJ (1957) Hereditary defects in enamel and dentin. Acta Genet 7:236-239

    CAS  PubMed  Google Scholar 

  141. Xiao S, Yu C, Chou X, Yuan W, Wang Y, Bu L, Fu G, Qian M, Yang J, Shi Y, Hu L, Han B, Wang Z, Huang W, Liu J, Chen Z, Zhao G, Kong X (2001) Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP. Nat Genet 27(2):201-204

    Article  CAS  PubMed  Google Scholar 

  142. Xu T, Bianco P, Fisher LW, Longenecker G, Smith E, Goldstein S, Bonadio J, Boskey A, Heegaard AM, Sommer B, Satomura K, Dominguez P, Zhao C, Kulkarni AB, Robey PG, Young MF (1998) Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice. Nat Genet. 20(1):78-82

    Article  CAS  PubMed  Google Scholar 

  143. Yamashiro T, Zheng L, Shitaku Y, Saito M, Tsubakimoto T, Takada K, Takano-Yamomoto T, Thesleff I (2007) Wnt10a regulates dentin sialophosphoprotein mRNA expression and possibly links odontoblast differentiation and tooth morphogenesis. Differentiation 75(5): 452-462

    Article  CAS  PubMed  Google Scholar 

  144. Yamakoshi Y, Hu JCC, Fukae M, Zhang H, Simmer JP (2006) Dentin glycoprotein: the protein in the middle of the dentin sialophophoprotien chimera. J Biol Chem 280(17):17472-17479

    Article  CAS  Google Scholar 

  145. Yamamoto N, Akiyama S, Katagiri T, Namiki M, Kurokawa T, Suda T (1997) Smad1 and smad5 act downstream of intracellular signalings of BMP-2 that inhibits myogenic differentiation and induces osteoblast differentiation in C2C12 myoblasts. Biochem Biophys Res Commun 238:574-580

    Article  CAS  PubMed  Google Scholar 

  146. Yang X, Matsuda K, Bialek P, Jacquot S, Masuoka HC, Schinke T, Li L, Brancorsini S, Sassone-Corsi P, Townes TM, Hanauer A, Karsenty G (2004) ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry syndrome. Cell 117(3):387-398

    Article  CAS  PubMed  Google Scholar 

  147. Ye L, MacDougall M, Zhang S, Xie Y, Zhang J, Li Z, Lu Y, Mishina Y, Feng JQ (2004) Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during ­postnatal tooth development. J Biol Chem 279(18):19141-19148

    Article  CAS  PubMed  Google Scholar 

  148. Zhang M, Xuan S, Bouxsein ML, von Stechow D, Akeno N, Faugere MC, Malluche H, Zhao G, Rosen CJ, Efstratiadis A, Clemens TL (2002) Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization. J Biol Chem 277(46):44005-44012

    Article  CAS  PubMed  Google Scholar 

  149. Zheng L, Iohara K, Ishikawa M, Into T, Takano-Yamamoto T, Matsushita K, Nakashima M (2007) Runx3 negatively regulates osterix expression in dental pulp cells. Biochem J 405(1):69-75

    CAS  PubMed  Google Scholar 

  150. Zhang X, Rahemtulla FG, MacDougall MJ, Thomas HF (2007) Vitamin D receptor deficiency affects dentin maturation in mice. Arch Oral Biol 52(12): 1172-1179

    Article  CAS  PubMed  Google Scholar 

  151. Zhang X, Zhao J, Li C, Gao S, Qiu C, Liu P, Wu G, Qiang B, Lo WHY, Shen Y (2001) DSPP mutation in dentinogenesis imperfecta Shields type II. Nat Genet 27:151-152

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag London

About this chapter

Cite this chapter

MacDougall, M.J., Javed, A. (2010). Dentin and Bone: Similar Collagenous Mineralized Tissues. In: Bronner, F., Farach-Carson, M., Roach, H. (eds) Bone and Development. Topics in Bone Biology, vol 6. Springer, London. https://doi.org/10.1007/978-1-84882-822-3_11

Download citation

  • DOI: https://doi.org/10.1007/978-1-84882-822-3_11

  • Published:

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84882-821-6

  • Online ISBN: 978-1-84882-822-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics