Summary
Composite tissue allograft (CTA) is one of the tissue reconstruction options in plastic and reconstructive surgery. Surgical techniques in CTA are well established; however, the immunologic characters of the components of CTA still require extensive research to protect allografts from rejection. CTA are histologically heterogeneous and composed of tissues such as skin, muscle, bone with bone marrow, lymph nodes, nerves, and vessels, which represent variable levels of immunogenicity and may generate different types of immunologic responses.
This chapter introduces the immunological status of CTA components, the role of immu-nomodulatory and inflammatory mediators for allograft acceptance, immune response to foreign antigens, and the hierarchy of anti-genicity of individual components of CTA compared with the whole CTA transplant.
Keywords
- Schwann Cell
- Major Histocompatibility Complex Class
- Hair Follicle
- Biliary Atresia
- Vessel Endothelial Cell
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Abbreviations
- APC:
-
Antigen-presenting cells
- CGRP:
-
Calcitonin gene-related peptide
- CLA:
-
Cutaneous lymphocyte-associated antigen
- CTA:
-
Composite tissue allografts
- DDC:
-
Dermal dendritic cells
- FDC:
-
Follicular dendritic cells
- ICAM-1:
-
Intercellular adhesion molecule-1
- LC:
-
Langerhans cells
- MAd-CAM-1:
-
Mucosal addressin cellular adhesion molecule-1
- MHC:
-
Major histocompatibility complex
- OPN:
-
Osteopontin
- SALT:
-
Skin-associated lymphoid tissues
- SIS:
-
Skin immune system
- Tc:
-
T cytotoxic
- Th:
-
T-helper
- VCAM-1:
-
Vascular cell adhesion molecule-1
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Klimczak, A., Siemionow, M. (2010). Immunology of Tissue Transplantation. In: Siemionow, M.Z., Eisenmann-Klein, M. (eds) Plastic and Reconstructive Surgery. Springer Specialist Surgery Series. Springer, London. https://doi.org/10.1007/978-1-84882-513-0_2
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