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Double Umbilical Cord Blood Transplantation in Adults

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References

  1. Knudtzon S. In vitro growth of granulocytic colonies from circulating cells in human cord blood. Blood 1974; 43:357–61.

    PubMed  CAS  Google Scholar 

  2. Broxmeyer HE, Kurtzberg J, Gluckman E, et al. Umbilical cord blood hematopoietic stem and repopulating cells in human clinical transplantation. Blood Cells 1991; 17:313–29.

    PubMed  CAS  Google Scholar 

  3. Gluckman E, Broxmeyer HA, Auerbach AD, et al. Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical sibling. N Engl J Med 1989; 321:1174–8.

    Article  PubMed  CAS  Google Scholar 

  4. Lansdorp PM, Dragowska W, Mayani H. Ontogeny-related changes in proliferative potential of human hematopoietic cells. J Exp Med 1993; 178:787–91.

    Article  PubMed  CAS  Google Scholar 

  5. Vaziri H, Dragowska W, Allsopp RC, Thomas TE, Harley CB, Lansdorp PM. Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age. Proc Natl Acad Sci USA 1994; 91:9857–60.

    Article  PubMed  CAS  Google Scholar 

  6. Cairo MS, Wagner JE. Placental and/or umbilical cord blood: an alternative source of hematopoietic stem cells for transplantation. Blood 1997; 90:4665–78.

    PubMed  CAS  Google Scholar 

  7. Wagner JE, Kernan NA, Steinbuch M, Broxmeyer HE, Gluckman E. Allogeneic sibling umbilical-cord-blood transplantation in children with malignant and non-malignant disease. Lancet 1995; 346:214–9.

    Article  PubMed  CAS  Google Scholar 

  8. Szabolcs P, Park KD, Reese M, Marti L, Broadwater G, Kurtzberg J. Coexistent naive phenotype and higher cycling rate of cord blood T cells as compared to adult peripheral blood. Exp Hematol 2003; 31:708–14.

    Article  PubMed  Google Scholar 

  9. Loetscher P, Uguccioni M, Bordoli L, et al. CCR5 is characteristic of Th1 lymphocytes. Nature 1998; 391:344–5.

    Article  PubMed  CAS  Google Scholar 

  10. Alfani E, Migliaccio AR, Sanchez M, Passarelli AM, Migliaccio G. Characterization of the T cell receptor repertoire of neonatal T cells by RT-PCR and single strand conformation polymorphism analysis. Bone Marrow Transplant 2000; 26:83–9.

    Article  PubMed  CAS  Google Scholar 

  11. Bone Marrow Donors Worldwide, Annual Report. 2006.

    Google Scholar 

  12. National Marrow Donor Program, Facts and Figures, 2007

    Google Scholar 

  13. Hurley CK, Setterholm M, Lau M, et al. Hematopoietic stem cell donor registry strategies for assigning search determinants and matching relationships. Bone Marrow Transplant 2004; 33:443–50.

    Article  PubMed  CAS  Google Scholar 

  14. Barker JN, Krepski TP, DeFor TE, Davies SM, Wagner JE, Weisdorf DJ. Searching for unrelated donor hematopoietic stem cells: availability and speed of umbilical cord blood versus bone marrow. Biol Blood Marrow Transplant 2002; 8:257–60.

    Article  PubMed  Google Scholar 

  15. Ballen KK, Hicks J, Dharan B, et al. Racial and ethnic composition of volunteer cord blood donors: comparison with volunteer unrelated marrow donors. Transfusion 2002; 42: 1279–84.

    Article  PubMed  Google Scholar 

  16. Ballen KK, Kurtzberg J, Lane TA, et al. Racial diversity with high nucleated cell counts and CD34 counts achieved in a national network of cord blood banks. Biol Blood Marrow Transplant 2004; 10:269–75.

    Article  PubMed  Google Scholar 

  17. Cairo MS, Wagner EL, Fraser J, et al. Characterization of banked umbilical cord blood hematopoietic progenitor cells and lymphocyte subsets and correlation with ethnicity, birth weight, sex, and type of delivery: a Cord Blood Transplantation (COBLT) Study report. Transfusion 2005; 45:856–66.

    Article  PubMed  Google Scholar 

  18. Ballen KK. New trends in umbilical cord blood transplantation. Blood 2005; 105:3786–92.

    Article  PubMed  CAS  Google Scholar 

  19. Ballen KK. Advances in Umbilical Cord Blood Transplantation. Curr Stem Cell Res Ther 2006; 1:317–24.

    Google Scholar 

  20. Locatelli F, Rocha V, Chastang C, et al. Factors associated with outcome after cord blood transplantation in children with acute leukemia. Eurocord-Cord Blood Transplant Group. Blood 1999; 93:3662–71.

    PubMed  CAS  Google Scholar 

  21. Locatelli F, Rocha V, Reed W, et al. Related umbilical cord blood transplantation in patients with thalassemia and sickle cell disease. Blood 2003; 101:2137–43.

    Article  PubMed  CAS  Google Scholar 

  22. Rocha V, Wagner JE, Jr., Sobocinski KA, et al. Graft-versus-host disease in children who have received a cord-blood or bone marrow transplant from an HLA-identical sibling. Eurocord and International Bone Marrow Transplant Registry Working Committee on Alternative Donor and Stem Cell Sources. N Engl J Med 2000; 342:1846–54.

    Article  PubMed  CAS  Google Scholar 

  23. Kurtzberg J, Laughlin M, Graham ML, et al. Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients. N Engl J Med 1996; 335:157–66.

    Article  PubMed  CAS  Google Scholar 

  24. Wagner JE, Barker JN, DeFor TE, et al. Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival. Blood 2002; 100:1611–8.

    PubMed  CAS  Google Scholar 

  25. Staba SL, Escolar ML, Poe M, et al. Cord-blood transplants from unrelated donors in patients with Hurler's syndrome. N Engl J Med 2004; 350:1960–9.

    Article  PubMed  CAS  Google Scholar 

  26. Laughlin MJ, Barker J, Bambach B, et al. Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors. N Engl J Med 2001; 344:1815–22.

    Article  PubMed  CAS  Google Scholar 

  27. Long GD, Laughlin M, Madan B, et al. Unrelated umbilical cord blood transplantation in adult patients. Biol Blood Marrow Transplant 2003; 9:772–80.

    Article  PubMed  Google Scholar 

  28. Cornetta K, Laughlin M, Carter S, et al. Umbilical cord blood transplantation in adults: results of the prospective Cord Blood Transplantation (COBLT). Biol Blood Marrow Transplant 2005; 11:149–60.

    Article  PubMed  Google Scholar 

  29. Laughlin MJ, Eapen M, Rubinstein P, et al. Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia. N Engl J Med 2004; 351: 2265–75.

    Article  PubMed  CAS  Google Scholar 

  30. Rocha V, Labopin M, Sanz G, et al. Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia. N Engl J Med 2004; 351:2276–85.

    Article  PubMed  CAS  Google Scholar 

  31. Takahashi S, Iseki T, Ooi J, et al. Single-institute comparative analysis of unrelated bone marrow transplantation and cord blood transplantation for adult patients with hematologic malignancies. Blood 2004; 104:3813–20.

    Article  PubMed  CAS  Google Scholar 

  32. Khouri IF, Saliba RM, Giralt SA, et al. Nonablative allogeneic hematopoietic transplantation as adoptive immunotherapy for indolent lymphoma: low incidence of toxicity, acute graft-versus-host disease, and treatment-related mortality. Blood 2001; 98:3595–9.

    Article  PubMed  CAS  Google Scholar 

  33. Daly A, McAfee S, Dey B, et al. Nonmyeloablative bone marrow transplantation: Infectious complications in 65 recipients of HLA-identical and mismatched transplants. Bio Blood Marrow Transplant 2003; 9:373–82.

    Article  Google Scholar 

  34. Yuji K, Miyakoshi S, Kato D, et al. Reduced-intensity unrelated cord blood transplantation for patients with advanced lymphoma. Biol Blood Marrow Transplant 2005; 11: 314–18.

    Article  PubMed  Google Scholar 

  35. Miyakoshi S, Yuji K, Kami M, et al. Successful engraftment after reduced-intensity umbilical cord blood transplantation for adult patients with advanced hematological diseases. Clin Cancer Res 2004; 10:3586–92.

    Article  PubMed  Google Scholar 

  36. Narimatsu H, Kami M, Miyakoshi S, et al. Graft failure following reduced- intensity cord blood transplantation for adult patients. Br J Hematol 2005; 132:36–41.

    Article  Google Scholar 

  37. Chao NJ, Koh LP, Long GD, et al. Adult recipients of umbilical cord blood transplants after nonmyeloablative preparative regimens. Biol Blood Marrow Transplant 2004; 10:569–75.

    Article  PubMed  Google Scholar 

  38. Weinreb S, Delgado JC, Clavijo OP, et al. Transplantation of unrelated cord blood cells. Bone Marrow Transplant 1998; 22:193–6.

    Article  PubMed  CAS  Google Scholar 

  39. Barker JN, Weisdorf DJ, DeFor TE, et al. Transplantation of 2 partially matached HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy. Blood 2005; 105:1343–7.

    Article  PubMed  CAS  Google Scholar 

  40. Mao P, Wang S, Zhu Z, et al. Umbilical cord blood transplant for adult patients with severe aplastic anemia using anti-lymphocyte globulin and cyclophosphamide as conditioning therapy. Bone Marrow Transplant 2004; 33:33–8.

    Article  PubMed  CAS  Google Scholar 

  41. Barker JN, Weisdorf DF, Defor TE, et al. Rapid and complete donor chimerism in adult recipients of unrelated donor umbilical cord blood transplantation after reduced-intensity conditioning. Blood 2003; 102:1915–19.

    Article  PubMed  CAS  Google Scholar 

  42. Brunstein C, Barker J, DeFor T, et al. Non-myeloablative (NMA) umbilical cord blood transplantation (UCBT): promising disease-free survival in 95 consecutive patients. Blood 2005; 106:166a.

    Google Scholar 

  43. Verneris, M.R., Brunstein, C., DeFor, T.E., et al. Risk of relapse (REL) after umbilical cord blood transplantation (UCBT) in patients with acute leukemia: marked reduction in recipients of two units. Blood 2005; 106:93a.

    Google Scholar 

  44. Majhail NS, Weisdorf DJ, Wagner JE, et al. Comparable results of umbilical cord blood and HLA-matched sibling donor hematopoietic stem cell transplantation after reduced-intensity preparative regimen for advanced Hodgkin lymphoma. Blood 2006; 107:3804–7.

    Article  PubMed  CAS  Google Scholar 

  45. Ballen KK, Spitzer TR, Yeap BY, et al: Double unrelated reduced intensity umbilical cord blood transplantation in adults. Biol Blood Marrow Transplant 2007; 13:82–9.

    Google Scholar 

  46. Haspel R, Ballen KK: Double Cord Blood Transplants: filling a Niche? Stem Cell Rev 2006; 2:81–6.

    Google Scholar 

  47. DeLima M, St. John LS, Wieder ED, et al. Double-chimerism after transplantation of two human leucocyte antigen mismatched, unrelated cord blood units. Br J Hematol 2002; 119:773–76.

    Article  Google Scholar 

  48. Haspel RL, Kao GS, Yeap BY, et al: Pre-infusion variables predict the predominant cord blood unit in the setting of reduced intensity double cord blood transplant. Bone Marrow Transplant, 2008, in press.

    Google Scholar 

  49. Fernandez MN, Regidor C, Cabrera R, et al. Unrelated umbilical cord blood transplants in adults: early recovery of neutrophils by supportive co-transplantation of a low number of highly purified peripheral blood CD34 cells from an HLA-haploidentical donor. Exp Hematol 2003; 31:535–44.

    Article  PubMed  Google Scholar 

  50. Kim DW, Chung YJ, Kim TG, Kim YL, Oh IH. Cotransplantation of third-party mesenchymal stromal cells can alleviate single-donor predominance and increase engraftment from double cord transplantation. Blood 2004; 103:1941–8.

    Article  PubMed  CAS  Google Scholar 

  51. Ramirez M, Regidor C, Marugan I, Garcia-Conde J, Bueren JA, Fernandez MN. Engraftment kinetics of human CD34 cells from cord blood and mobilized peripheral blood co-transplanted into NOD/SCID mice. Bone Marrow Transplant 2005; 35:271–5.

    Article  PubMed  CAS  Google Scholar 

  52. Nash RA, Bowen D, McSweeney PA, et al. High-dose immunosuppressive therapy and autologous peripheral blood stem cell transplantation for severe multiple sclerosis. Blood 2003; 102:2364–72.

    Article  PubMed  CAS  Google Scholar 

  53. Burt RK, Traynor A, Oyama Y, Craig R. High-dose immune suppression and autologous hematopoietic stem cell transplantation in refractory Crohn’s disease. Blood 2003; 101: 2064–6.

    Article  PubMed  CAS  Google Scholar 

  54. Goodwin HS, Bicknese AR, Chien SN, Bogucki BD, Quinn CO, Wall DA. Multilineage differentiation activity by cells isolated from umbilical cord blood: expression of bone, fat, and neural markers. Biol Blood Marrow Transplant 2001; 7:581–8.

    Article  PubMed  CAS  Google Scholar 

  55. Ma N, Stamm C, Kaminski A, et al. Human cord blood cells induce angiogenesis following myocardial infarction in NOD/scid-mice. Cardiovasc Res 2005; 66:45–54.

    Article  PubMed  CAS  Google Scholar 

  56. Vendrame M, Cassady J, Newcomb J, et al. Infusion of human umbilical cord blood cells in a rat model of stroke dose-dependently rescues behavioral deficits and reduces infarct volume. Stroke 2004; 35:2390–5.

    Article  PubMed  Google Scholar 

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Correspondence to Karen K. Ballen .

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Phillip Stubblefield Niranjan Bhattacharya

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Ballen, K.K. (2009). Double Umbilical Cord Blood Transplantation in Adults. In: Stubblefield, P., Bhattacharya, N. (eds) Frontiers of Cord Blood Science. Springer, London. https://doi.org/10.1007/978-1-84800-167-1_9

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  • DOI: https://doi.org/10.1007/978-1-84800-167-1_9

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