Abstract
Orchestration of host responses to infection or injury depends upon communication between cells by soluble molecules given the generic term cytokines. These are low molecular weight secreted proteins that regulate both the amplitude and duration of a huge range of responses. They have multiple effects on growth and differentiation in many cell types, with considerable redundancy of action. Interaction may occur in a network or cascade system in which one cytokine induces another, through modulation of the receptor of another cytokine, and through either synergism or antagonism of two cytokines acting on the same cell. Specific actions depend on the stimulus, the cell type, and the presence of other mediators and receptors.
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Galley, H.F., Webster, N.R. (2008). Cytokines. In: Fink, M., Hayes, M., Soni, N. (eds) Classic Papers in Critical Care. Springer, London. https://doi.org/10.1007/978-1-84800-145-9_20
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DOI: https://doi.org/10.1007/978-1-84800-145-9_20
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