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Surgical Treatment of Colorectal Liver Metastases in Elderly Patients

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References

  1. World Health Organisation. World Health statistics. Anonymous. WHO Library Cataloguing-in-Publication Data, 2007.

    Google Scholar 

  2. Franceschi S, La Vecchia C. Cancer epidemiology in the elderly. Crit Rev Oncol Hematol. 2001; 39(3): 219–226.

    Article  PubMed  CAS  Google Scholar 

  3. Quaglia R, Capocaccia A, Micheli E, et al. A wide difference in cancer survival between middle aged and elderly patients in Europe. Int J Cancer. 2007; 120(10): 2196–2201.

    Article  PubMed  CAS  Google Scholar 

  4. Petrowsky H, Clavien PA. Should we deny surgery for malignant hepato- pancreatico-biliary tumors to elderly patients? World J Surg. 2005; 29(9): 1093–1100.

    Article  PubMed  Google Scholar 

  5. Mitry E, Bouvier AM, Esteve J, Faivre J. Improvement in colorectal cancer survival: a population-based study. Eur J Cancer. 2005; 41(15): 2297–2303.

    Article  PubMed  Google Scholar 

  6. Gatta G, Capocaccia R, Coleman MP, et al. Toward a comparison of survival in American and European cancer patients. Cancer. 2000; 89(4): 893–900.

    Article  PubMed  CAS  Google Scholar 

  7. Temple LK, Hsieh L, Wong WD, et al. Use of surgery among elderly patients with stage IV colorectal cancer. J Clin Oncol. 2004; 22(17): 3475–3484.

    Article  PubMed  Google Scholar 

  8. Vercelli M, Lillini R, Capocaccia R, et al. Cancer survival in the elderly: effects of socio-economic factors and health care system features (ELDCARE project). Eur J Cancer. 2006; 42(2): 234–242.

    Article  PubMed  Google Scholar 

  9. Yun HR, Lee WY, Lee OS, et al. The prognostic factors of stage IV colorectal cancer and assessment of proper treatment according to the patient’s status. Int J Colorectal Dis. 2007; 22(11): 1301–10.

    Article  PubMed  Google Scholar 

  10. Manfredi S, Lepage C, Hatem C, O. et al. Epidemiology and management of liver metastases from colorectal cancer. Ann Surg. 2006; 244(2): 254–259.

    Article  PubMed  Google Scholar 

  11. Leporrier J, Maurel L, Chiche S, et al. A population-based study of the incidence, management and prognosis of hepatic metastases from colorectal cancer. Ann Surg. 2006; 93(4): 465–474.

    CAS  Google Scholar 

  12. Tocchi A, Mazzoni G, Brozzetti S, et al. Hepatic resection in stage IV colorectal cancer: prognostic predictors of outcome. Int J Colorectal Dis. 2004; 19(6): 580–585.

    Article  PubMed  Google Scholar 

  13. Okuno K. Surgical treatment for digestive cancer. Current issues—colon cancer. Dig Surg. 2006; 24(2): 108–114.

    Article  Google Scholar 

  14. Cunningham S, Pyrhonen R D, James C J, et al. Randomised trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer. Lancet. 1998; 352(9138): 1413–1418.

    Article  PubMed  CAS  Google Scholar 

  15. Scheithauer W, Kornek GV, Raderer M, et al. Randomized multicenter phase II trial of oxaliplatin plus irinotecan versus raltitrexed as first-line treatment in advanced colorectal cancer. J Clin Oncol. 2002; 20(1): 165–172.

    Article  PubMed  CAS  Google Scholar 

  16. Falcone S, Ricci S, Brunetti I, et al. Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: the Gruppo Oncologico Nord Ovest. J Clin Oncol. 2007; 25(13): 1670–1676.

    Article  PubMed  CAS  Google Scholar 

  17. Simmonds PC, Primrose JN, Colquitt JL, et al. Surgical resection of hepatic metastases from colorectal cancer: a systematic review of published studies. Br J Cancer. 2006; 94(7) 982–999.

    Article  PubMed  CAS  Google Scholar 

  18. Cummings LC, Payes JD, Cooper GS. Survival after hepatic resection in metastatic colorectal cancer: a population-based study. Cancer. 2007; 109(4): 718–726.

    Article  PubMed  Google Scholar 

  19. US Department of Health and Human Services. Health, United States, 2006. Centers for Disease Control and Prevention and National Center for Health Statistics. 2006.

    Google Scholar 

  20. Fortner JG, Lincer RM. Hepatic resection in the elderly. Ann Surg. 1990; 211(2): 141–145.

    Article  PubMed  CAS  Google Scholar 

  21. Koperna T, Kisser M, Schulz F. Hepatic resection in the elderly. World J Surg. 1998; 22(4): 406–412.

    Article  PubMed  CAS  Google Scholar 

  22. Menon KV, Al Mukhtar A, Aldouri A, et al. Outcomes after major hepatectomy in elderly patients. J Am Coll Surg. 2006; 203(5): 677–683.

    Article  PubMed  Google Scholar 

  23. Ferrero A, Vigano L, Polastri R, et al. Hepatectomy as treatment of choice for hepatocellular carcinoma in elderly cirrhotic patients. World J Surg. 2005; 29(9): 1101–1105.

    Article  PubMed  Google Scholar 

  24. Aldrighetti L, Arru M, Caterini R, et al. Impact of advanced age on the outcome of liver resection. World J Surg. 2003; 27(10): 1149–1154.

    Article  PubMed  Google Scholar 

  25. Aldrighetti L, Arru M, Catena M, et al. Liver resections in over-75-year-old patients: surgical hazard or current practice? J Surg Oncol. 2006; 93(3): 186–193.

    Article  PubMed  Google Scholar 

  26. Cescon M, Grazi GL, Del Gaudio M, et al. Outcome of right hepatectomies in patients older than 70 years. 2003; 138(5): 547–552.

    Google Scholar 

  27. Cosenza CA, Hoffman AL, Podesta LG, et al. Hepatic resection for malignancy in the elderly. Am Surg 1995; 61(10): 889–895.

    PubMed  CAS  Google Scholar 

  28. Aalami OO, Fang TD, Song HM, Nacamuli RP. Physiological features of aging persons. Arch Surg. 2003; 138(10): 1068–1076.

    Article  PubMed  Google Scholar 

  29. Kimura F, Miyazaki M, Suwa T, Kakizaki S. Reduction of hepatic acute phase response after partial hepatectomy in elderly patients. Res Exp Med (Berl). 1996; 196(5): 281–290.

    Article  CAS  Google Scholar 

  30. Ettorre GM, Sommacale D, Farges O, et al. Postoperative liver function after elective right hepatectomy in elderly patients. Br J Surg. 2001; 88(1): 73–76.

    Article  PubMed  CAS  Google Scholar 

  31. Grande L, Rull A, Rimola A, et al. Outcome of patients undergoing orthotopic liver transplantation with elderly donors (over 60 years). Transplant Proc. 1997; 29(8): 3289–3290.

    Article  PubMed  CAS  Google Scholar 

  32. Tisone G, Manzia TM, Zazza S, et al. Marginal donors in liver transplantation. Transplant Proc. 2004; 36(3): 525–526.

    Article  PubMed  CAS  Google Scholar 

  33. Balducci L. Aging, frailty, and chemotherapy. Cancer Control. 2006; 14(1): 7–12.

    Google Scholar 

  34. Pope D, Ramesh H, Gennari R, et al. Pre-operative assessment of cancer in the elderly (PACE): A comprehensive assessment of underlying characteristics of elderly cancer patients prior to elective surgery. Surg Oncol. 2006; 15(4): 189–197.

    Article  PubMed  CAS  Google Scholar 

  35. Audisio RA, Zbar AP, Jaklitsch MT. Surgical management of oncogeriatric patients. J Clin Oncol. 2007; 25(14): 1924–1929.

    Article  PubMed  Google Scholar 

  36. Gruttadauria Doria C, Vitale CH, et al. Preliminary report on surgical technique in hepatic parenchymal transection for liver tumors in the elderly: a lesson learned from living-related liver transplantation. J Surg Oncol. 2004; 88(4): 229–233.

    Google Scholar 

  37. Mazzoni G, Tocchi A, Miccini M, et al. Surgical treatment of liver metastases from colorectal cancer in elderly patients. Int J Colorectal Dis. 2007; 22(1): 77–83.

    Article  PubMed  Google Scholar 

  38. Zhou L, Rui JA, Wang SB, et al. Clinicopathological features, post-surgical survival and prognostic indicators of elderly patients with hepatocellular carcinoma. Eur J Surg Oncol. 2006;32(7): 767–772.

    Article  PubMed  CAS  Google Scholar 

  39. Audisio RA, Veronesi P, Ferrario L, et al. Elective surgery for gastrointestinal tumours in the elderly. Ann Oncol. 1997; 8(4): 317–326.

    Article  PubMed  CAS  Google Scholar 

  40. Gayowski TJ, Iwatsuki S, Madariaga JR, et al. Experience in hepatic resection for metastatic colorectal cancer: analysis of clinical and pathologic risk factors. Surgery. 1994; 116(4): 703–710.

    PubMed  CAS  Google Scholar 

  41. Zieren HU, Muller JM, Zieren J. Resection of colorectal liver metastases in old patients. Hepatogastroenterology. 1994; 41(1): 34–37.

    PubMed  CAS  Google Scholar 

  42. Zieren HU, Muller JM, Zieren J, Pichlmaier H. The impact of patient’s age on surgical therapy of colorectal liver metastases. Int Surg. 1993; 78(4): 288–291.

    PubMed  CAS  Google Scholar 

  43. Fong Y, Blumgart LH, Fortner JG, Brennan MF. Pancreatic or liver resection for malignancy is safe and effective for the elderly. Ann Surg. 1995; 222(4): 426–434.

    PubMed  CAS  Google Scholar 

  44. Brunken C, Rogiers X, Malago M, et al. [Is resection of colorectal liver metastases still justified in very elderly patients?]. Chirurg. 1998; 69(12): 1334–1339.

    Article  PubMed  CAS  Google Scholar 

  45. Brand MI, Saclarides TJ, Dobson HD, Millikan KW. Liver resection for colorectal cancer: liver metastases in the aged. Am Surg. 2000; 66(4): 412–415.

    PubMed  CAS  Google Scholar 

  46. Zacharias T, Jaeck D, Oussoultzoglou E, et al. First and repeat resection of colorectal liver metastases in elderly patients. Ann Surg. 2004; 240(5): 858–865.

    Article  PubMed  Google Scholar 

  47. Adam R, Laurent C, Poston G, et al. Liver resection of colorectal metastases in elderly patients: is it worthwhile and is there an age limit? Annual Meeting European Surgical Association, 2007.

    Google Scholar 

  48. Fong Y, Fortner J, Sun RL, et al. Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases. Ann Surg. 1999; 230(3): 309–318.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Surgery, University Medical Center Groningen, Groningen, The Netherlands

    Barbara L. van Leeuwen

Authors
  1. Barbara L. van Leeuwen
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  2. N. de Liguori Carino
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  3. G.J. Poston
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  4. R.A. Audisio
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Editor information

Editors and Affiliations

  1. M.D. Anderson Cancer Center, Dept. Surgical Oncology, University of Texas, Holcombe Blvd. 1515, Houston, 77030, Texas, USA

    Jean-Nicolas Vauthey

  2. São Paulo, Faculdade de Medicina da, Universidade de São Paulo,, Instituto do Cancer do Estado de, Ave Dr Arnaldo 251, São Paulo, 01246-000, São Paulo, Brazil

    Paulo M. Hoff

  3. University of Liverpool, St Helens Teach, Marshalls Cross Road, St Helens, WA9 3DA, United Kingdom

    Riccardo A. Audisio

  4. Center for Digestive Diseases, University Hospital Aintree, Lower Lane, Liverpool, L9 7AL, United Kingdom

    Graeme J. Poston

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© 2009 Springer-Verlag London

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van Leeuwen, B.L., de Liguori Carino, N., Poston, G., Audisio, R. (2009). Surgical Treatment of Colorectal Liver Metastases in Elderly Patients. In: Vauthey, JN., Hoff, P., Audisio, R., Poston, G. (eds) Liver Metastases. Springer, London. https://doi.org/10.1007/978-1-84628-947-7_11

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  • DOI: https://doi.org/10.1007/978-1-84628-947-7_11

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