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The Impact of Infection During Pregnancy on the Mother and Baby

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Infection continues to account for a major proportion of maternal, fetal, and neonatal mortality and morbidity worldwide.

In the developing world, maternal systemic infections, such as pneumonia, malaria, tuberculosis, typhoid fever, and pyelonephritis, which are often functions of poverty, crowding, and malnutrition, impose health costs to the mother and risks to the fetus. These risks include spontaneous abortion, stillbirth, preterm labor and preterm birth, low birth weight, intrauterine growth restriction (IUGR), and infection. This is in addition to the rapidly escalating rates of a number of sexually transmitted diseases, in particular, human immunodeficiency virus (HIV) infection with its associated comorbidities.

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References

  • Ahmad N (2005) The vertical transmission of human immunodeficiency virus type 1: molecular and biological properties of the virus. Crit Rev Clin Lab Sci 42:1–34.

    Article  PubMed  CAS  Google Scholar 

  • American Academy of Pediatrics (2003a) Cytomegalo-virus infection. In: Pickering LK (ed) Red Book Online 2003: Report of the Committee on Infectious Diseases, 26th ed. American Academy of Pediatrics, Elk Grove Village, IL, pp. 259–262. http:// aapredbook.aappublications.org/.

    Google Scholar 

  • American Academy of Pediatrics (2003b) Herpes simplex. In: Pickering LK (ed) Red Book Online 2003: Report of the Committee on Infectious Diseases, 26th ed. American Academy of Pediatrics, Elk Grove Village, IL, pp. 344–353. http://aapredbook. aappublications.org/.

    Google Scholar 

  • American Academy of Pediatrics (2003c) Human Immunodeficiency Virus. In: Pickering LK (ed) Red Book Online 2003: Report of the Committee on Infectious Diseases, 26th ed. American Academy of Pediatrics, Elk Grove Village, IL, pp. 360–382. http:// aapredbook.aappublications.org/.

    Google Scholar 

  • American Academy of Pediatrics (2003d) Varicella-zoster infection. In: Pickering LK (ed) Red Book Online 2003: Report of the Committee on Infectious Diseases, 26th ed. American Academy of Pediatrics, Elk Grove Village, IL, pp. 672–686. http:// aapredbook.aappublications.org/.

    Google Scholar 

  • Anderson MJ, Higgins PG, Davis LR, et al. (1985) Experimental parvoviral infection in humans. J Infect Dis 152:257–65

    PubMed  CAS  Google Scholar 

  • Arias F, Tomich P (1982) Etiology and outcomes of low birth weight and preterm infants. Obstet Gynecol 60:277–281.

    PubMed  CAS  Google Scholar 

  • Arvin AM (1996) Varicella-zoster virus. Clin Microbiol Rev 9:361–381.

    PubMed  CAS  Google Scholar 

  • Arvin AM, Hensliegh PA, Prober CG, et al. (1986) Failure of antepartum maternal cultures to predict the infant's risk of exposure to herpes simplex at delivery. N Engl J Med 315:796–800.

    PubMed  CAS  Google Scholar 

  • Austin N, Darlow B (2003) Prophylactic oral antifungal agents to prevent systematic Candida infection in preterm infants. Cochrane Database of Systematic Reviews 4:CD003478.

    Google Scholar 

  • Bachman J, Heise R, Naessons J, et al. (1993) A study of various tests to detect asymptomatic urinary tract infections in an obstetric population. JAMA 270: 1971–1974.

    Article  PubMed  CAS  Google Scholar 

  • Baker C, Edwards M (2003) Group B streptococcal conjugate vaccines. Arch Dis Child 88:375–378.

    Article  PubMed  CAS  Google Scholar 

  • Banatvala JE, Brown DWG (2004) Rubella. Lancet 363:1127–1137.

    Article  PubMed  CAS  Google Scholar 

  • Benitz W, Gould J, Druzin M (1999) Risk factors for early-onset group B streptococcal sepsis: estimation of odds ratios by critical literature review. Pediatrics 103. URL: http://www.pediatrics.org/cgi/content/full/ 103/6/e77.

  • Berkowitz K, LaSala A (1990) Risk factors associated with the increasing prevalence of pneumonia during pregnancy. Am J Obstet Gynecol 163:981–985.

    PubMed  CAS  Google Scholar 

  • Berman S (2004) Maternal syphilis: pathophysiology and treatment. Bull WHO 82:433–438.

    PubMed  Google Scholar 

  • Bignell CJ (2001) European guidelines for the management of gonorrhea. Int J STD AIDS 12(suppl 12): 27–29.

    Article  PubMed  Google Scholar 

  • Bisharat N, Crook D, Leigh J, et al. (2004) Hyperinvasive neonatal group B streptococcus has arisen from a bovine ancestor. J Clin Microbiol 42:2161–2167.

    Article  PubMed  Google Scholar 

  • Blackwell AL (1999) Vaginal bacterial phaginosis? Sex Transm Inf 75:352–353.

    Article  CAS  Google Scholar 

  • Boyer K, Gotoff S (1986) Prevention of early-onset neonatal group B streptococcal disease with selective intrapartum chemoprophylaxis. N Engl J Med 314: 1665–1669.

    PubMed  CAS  Google Scholar 

  • Brabin B, Romagosa C, Abdelgalil S, et al. (2004) The sick placenta—the role of malaria. Placenta 25:359– 378.

    Article  PubMed  CAS  Google Scholar 

  • Bradshaw C, Morton A, Garland S, et al. (2005) Higher-risk behavioural practices associated with bacterial vaginosis compared with vaginal candidiasis. Obstet Gynecol 106:105–114.

    PubMed  Google Scholar 

  • Brocklehurst P (1999) Update on the treatment of sexually transmitted infections in pregnancy-1. Int J STD AIDS 10:571–580.

    Article  PubMed  CAS  Google Scholar 

  • Brocklehurst P (2002) Antibiotics for gonorrhoea in pregnancy. Cochrane Database of Systematic Reviews 2:CD000098.

    Google Scholar 

  • Brown KE, Anderson SM, Young NS (1993) Erythrocyte P antigen: cellular receptor for B19 parvovirus. Science 262:114–117.

    Article  PubMed  CAS  Google Scholar 

  • Brown KE, Green SW, Antunez de Mayolo J, et al. (1994) Congenital anemia after transplacental parvovirus B19 infection. Lancet 343:895–896.

    Article  PubMed  CAS  Google Scholar 

  • Brown ZA, Benedetti J, Ashley R, et al. (1986) Neonatal herpes simplex virus infection in relation to asymptomatic maternal infection at the time of labor. N Engl J Med 315:796–800.

    Google Scholar 

  • Brown ZA, Wald A, Morrow RA, et al. (2003) Effect of serologic status and cesarean delivery on transmission rates of herpes simplex virus from mother to infant. JAMA 289:203–209.

    Article  PubMed  Google Scholar 

  • Bryce J, Boshi-Pinto C, Shibuya K, et al. (2005) WHO estimates of the causes of death in children. Lancet 365:1147–1152.

    Article  PubMed  Google Scholar 

  • Carr P, Felsenstein D, Friedman R (1998) Evaluation and management of vaginitis. J Gen Intern Med 13:335–346.

    Article  PubMed  CAS  Google Scholar 

  • Carrol S, Papaioannou S, Ntumazah I, et al. (1996) Lower genital tract swabs in the prediction of intra-uterine infection in preterm prelabour rupture of the membranes. Br J Obstet Gynaecol 103:54–59.

    Google Scholar 

  • Cassell G, Davis R, Waites K, et al. (1983) Isolation of Mycoplasma hominis and ureaplasma urealyticum from amniotic fluid at 16–20 weeks of gestation: potential effect on outcome of pregnancy. Sex Transm Dis 10(4 suppl):294–302.

    PubMed  CAS  Google Scholar 

  • Centers for Disease Control and Prevention (1995) Guidelines for prophylaxis against Pneumocystis carinii pneumonia for children infected with or peri-natally exposed to human immunodeficiency virus. MMWR 44(RR-4).

    Google Scholar 

  • Centers for Disease Control and Prevention (1996) Prevention of varicella: recommendations of Advisory Committee on Immunization Practices (ACIP). MMWR 45(RR-11).

    Google Scholar 

  • Centers for Disease Control and Prevention (1997) Case definitions for Infectious conditions under public health surveillance. MMWR 46(RR-10):30.

    Google Scholar 

  • Centers for Disease Control and Prevention (2001) Control and prevention of rubella; evaluation and management of suspected outbreaks, rubella in pregnant women, and surveillance for congenital rubella syndrome. MMWR 50(RR-12).

    Google Scholar 

  • Centers for Disease Control and Prevention (2002a) Prevention of perinatal group B streptococcal disease. MMWR 51(RR-11):1–22.

    Google Scholar 

  • Centers for Disease Control and Prevention (2002b) Sexually transmitted diseases treatment guidelines 2002. MMWR 51(RR-6):1–84.

    Google Scholar 

  • Centers for Disease Control and Prevention (2004) Trends in Reportable Sexually Transmitted Diseases in the United States, 2004. National Data on Chla-mydia, Gonorrhea and Syphilis. Atlanta, GA: U.S. Department of Health and Human Services.

    Google Scholar 

  • Centers for Disease Control and Prevention (2005a) Achievements in public health: elimination of rubella and congenital rubella syndrome in the United States, 1969–2004. MMWR 54;279–282.

    Google Scholar 

  • Centers for Disease Control and Prevention (2005b) Controlling tuberculosis in the United States. MMWR 54(RR-12):1–81.

    Google Scholar 

  • Centers for Disease Control and Prevention (2005c) Cytomegalovirus (CMV) infection. http://www.cdc. gov/ncidod/diseases/cmv.htm.

  • Centers for Disease Control and Prevention (2005d) Early-onset and late-onset neonatal group B strepto-coccal disease- United States, 1996–2004. MMWR 54(RR-47):1205–1208.

    Google Scholar 

  • Centers for Disease Control and Prevention (2005e) Genital herpes fact sheet. http://www.cdc.gov/std/ Herpes/STDFact-Herpes.htm.

  • Centers for Disease Control and Prevention (2005f) Human immunodeficiency type 2. http://www.cdc. gov/hiv/pubs/facts/hiv2.htm.

  • Centers for Disease Control and Prevention (2005g) Parvovirus B19 infection and pregnancy. http://www. cdc.gov/ncidod/dvrd/revb/respiratory/B19&preg. htm.

  • Centers for Disease Control and Prevention (2005h) Reported Tuberculosis in the United States, 2004. Atlanta, GA: U.S. Department of Health and Human Services.

    Google Scholar 

  • Centers for Disease Control and Prevention (2005i) STDs and Pregnancy—CDC Fact Sheet. http:// www.cdc.gov/std/STDFact-STDs&Pregnancy.htm (accessed December 6, 2005).

  • Chaim W, Mazor M, Wiznitzer A (1992) The prevalence and clinical significance of intraamniotic infection with Candida species in women with preterm labour. Arch Gynecol Obstet 251:9–15.

    Article  PubMed  CAS  Google Scholar 

  • Colditz G, Brewer T, Berkley C, et al. (1994) Efficacy of BCG vaccine in the prevention of tuberculosis: meta-analysis of the published literature. JAMA 271: 698–702.

    Article  PubMed  CAS  Google Scholar 

  • Cooper LZ, Krugman S (1967) Clinical manifestations of postnatal and congenital rubella. Arch Ophthal-mol 77:343–349.

    Google Scholar 

  • Corcoran A, Doyle S (2004) Advances in the biology, diagnosis and host-pathogen interactions of parvovi-rus B19. J Med Microbiol 53:459–75.

    Article  PubMed  CAS  Google Scholar 

  • Cossart YE, Field AM, Cant B, Widdows D (1975) Parvovirus-like particles in human sera. Lancet 1:72–73.

    Article  PubMed  CAS  Google Scholar 

  • Cotch M, Pastorek J, Nugent R (1991) Demographic and behavioural predictors of Trichomonas vaginalis infection among pregnant women. The vaginal infections and prematurity study group. Obstet Gynecol 78:1087–92.

    CAS  Google Scholar 

  • Cotch M, Pastorek J, Nugent R (1997) Trichomonas vaginalis associated with low birth weight and preterm delivery. Sex Transm Dis 24:353–360.

    Article  PubMed  CAS  Google Scholar 

  • Danesh I, Stephen J, Gorbach J (1995) Neonatal Tricho-monas vaginalis infection. J Emerg Med 13:51–54.

    Article  PubMed  CAS  Google Scholar 

  • Dear K, Andrews R, Holden J, et al. (2003) Vaccines for preventing pneumococcal infection in adults. Cochrane Database of Systematic Reviews 4: CD000422.

    Google Scholar 

  • Demmler GJ (1991) Infectious Diseases Society of America and Centers for Disease Control: summary of a workshop on surveillance for congenital cyto-megalovirus disease. Rev Infect Dis 13;315–29.

    PubMed  CAS  Google Scholar 

  • DeVillard E, Burton J, Reid G (2005) Complexity of vaginal microflora as analysed by PCR denaturing gradient gel electrophoresis in a patient with recurrent bacterial vaginosis. Infect Dis Obstet Gynecol 13:25–30.

    PubMed  CAS  Google Scholar 

  • Donovan B (2004) Sexually transmissible infections other than HIV. Lancet 363:545–556.

    Article  PubMed  Google Scholar 

  • Duffy PE (2003) Maternal immunization and malaria in pregnancy. Vaccine 21:3358–3361.

    Article  PubMed  Google Scholar 

  • Dunn D, Wallon M, Peyron F, et al. (1999) Mother-to-child transmission of toxoplasmosis: risk estimated for clinical counselling. Lancet 353:1829–1833.

    Article  PubMed  CAS  Google Scholar 

  • Edwards J, Apicella M (2004) The molecular mechanisms used by Neisseria gonorrhoeae to initiate infection differ between men and women. Clin Micro Rev 17:965–981.

    Article  PubMed  CAS  Google Scholar 

  • Enders G, Bader U, Lindemann L, et al. (2001) Prenatal diagnosis of congenital cytomegalovirus infection in 189 pregnancies with known outcome. Prenat Diagn 21:362–377.

    Article  PubMed  CAS  Google Scholar 

  • Enders G, Miller E, Craddock-Watson J, et al. (1994) Consequences of varicella and herpes zoster in pregnancy: prospective study of 1739 cases. Lancet 343:1548–1552.

    Article  PubMed  CAS  Google Scholar 

  • Enright AM, Prober CG (2004) Herpesviridae infections in newborns: varicella zoster virus, herpes simplex virus, and cytomegalovirus. Pediatr Clin North Am 51:889–908.

    Article  PubMed  Google Scholar 

  • Fischer PB (2003) Malaria and newborns. J Trop Pediatr 49:132–134.

    Article  PubMed  Google Scholar 

  • Fleming DT, McQuillan GM, Johnson RE, et al. (1997) Herpes simplex virus type 2 in the United States, 1976–1994. N Engl J Med 337:1105–1111.

    Article  PubMed  CAS  Google Scholar 

  • Fletcher M (2001) Vaccine candidates in STD. Int J STD AIDS 12:419–422.

    Article  PubMed  CAS  Google Scholar 

  • Forrest JM, Turnbull FM, Sholler GF, et al. (2002) Gregg's congenital rubella patients 60 years later. Med J Aust 177:664–667.

    PubMed  Google Scholar 

  • Foulon W, Pinon J-M, Stray-Pedersen B, et al. (1999) Prenatal diagnosis of congenital toxoplasmosis: a multicenter evaluation of different diagnostic parameters. Am J Obstet Gynecol 181:843–847.

    Article  PubMed  CAS  Google Scholar 

  • Foxman B (2003) Epidemiology of urinary tract infections: incidence, morbidity, and economic costs. Dis Mon 49:53–70.

    Article  PubMed  Google Scholar 

  • Fraser C, Norris S, Weinstock G (1998) Complete genome sequence of Treponema pallidum, the syphilis spirochete. Science 281:375–388.

    Article  PubMed  CAS  Google Scholar 

  • Freedman E, Mindel A, Jones CA (2004) Epidemiologi-cal, clinical and laboratory aids for the diagnosis of neonatal herpes—an Australian perspective. Herpes 11:38–40.

    PubMed  Google Scholar 

  • Frieden T, Sterling T, Munsiff S, et al. (2003) Tuberculosis. Lancet 362:887–899.

    Article  PubMed  Google Scholar 

  • Garner P, Gülmezoglu AM (2002) Drugs for preventing malaria-related illness in pregnant women and death in the newborn. Cochrane Database of Systematic Reviews 4:CD000169.

    Google Scholar 

  • Gibbs R, Schrag S, Schuchat A (2004) Perinatal infections due to group B streptococci. Obstet Gynecol 104:1062–1076.

    PubMed  Google Scholar 

  • Goldenberg R, Andrews W, Mercer B, et al. (2000a) The preterm prediction study: granulocyte colony-stimulating factor and spontaneous preterm birth. Am J Obstet Gynecol 182:625–630.

    Article  CAS  Google Scholar 

  • Goldenberg R, Hauth J, Andrews W (2000b) Intrauter-ine infection and preterm delivery. N Engl J Med 342:1500–1507.

    Article  CAS  Google Scholar 

  • Grant AD, De Cock KM (2001) ABC of AIDS. HIV infection and AIDS in the developing world. Br Med J 322:1475–1478.

    CAS  Google Scholar 

  • Gregg NM (1941) Congenital cataract following German measles in the mother. Trans Ophthalmol Soc Aust 3:35–46.

    Google Scholar 

  • Griffiths P, Baboonian C, Ashby D (1985) The demographic characteristics of pregnant women infected with cytomegalovirus. Int J Epidemiol 14:447–552.

    Article  PubMed  CAS  Google Scholar 

  • Guerin P, Olliaro P, Nosten F, et al. (2002) Malaria: current status of control, diagnosis, treatment, and a proposed agenda for research and development. Lancet Infect Dis 2:564–573.

    Article  PubMed  Google Scholar 

  • Gülmezoglu AM (2002) Interventions for trichomonia-sis in pregnancy. Cochrane Database of Systematic Reviews 3:CD000220.

    Google Scholar 

  • Guyatt H, Snow R (2001) Malaria in pregnancy as an indirect cause of infant mortality in sub-Saharan Africa. Trans Royal Soc Trop Med Hygiene 95: 569–576.

    Article  CAS  Google Scholar 

  • Guyatt H, Snow R (2004) Impact of malaria during pregnancy on low birth weight in sub-Saharan Africa. Clin Micro Rev 17:760–769.

    Article  PubMed  Google Scholar 

  • Haberland C, Benitz W, Sanders G, et al. (2002) Perinatal screening for group B streptococci: cost-benefit analysis of rapid polymerase chain reaction. Pediatrics 110:471–480.

    Article  PubMed  Google Scholar 

  • Haile M, Kallenius G (2005) Recent developments in tuberculosis vaccines. Curr Opin Infect Dis 18:211– 215.

    Article  PubMed  CAS  Google Scholar 

  • Hedges S, Mayo M, Mestecky J, et al. (1999) Limited local and systemic antibody response to Neisseria gonorrhoeae during uncomplicated genital infections. Infect Immun 67:3937–3946.

    PubMed  CAS  Google Scholar 

  • Heegaard ED, Laub Peterson B (2000) Parvovirus B19 transmitted by bone marrow. Br J Haematol 111:659– 661

    Article  PubMed  CAS  Google Scholar 

  • Heine P, McGregor J (1993) Trichomonas vaginalis: a remerging pathogen. Clin Obstet Gynecol 36:137– 144.

    Article  PubMed  CAS  Google Scholar 

  • Hightower M, Kallas EG (2003) Diagnosis, antiretrovi-ral therapy, and emergence of resistance to antiret-roviral agents in HIV-2 infection: a review. Brazi J Inf Dis 7(1):7–15.

    CAS  Google Scholar 

  • Hill J, Roberts S (2005) Herpes simplex virus in pregnancy: New concepts in prevention and management. Clin Perinatol 32:657–670.

    Article  PubMed  Google Scholar 

  • Hollier LM, Grissom H (2005) Human herpes viruses in pregnancy: cytomegalovirus, Epstein-Barr virus, and varicella zoster virus. Clin Perinatol 32:671– 696.

    Article  PubMed  Google Scholar 

  • Holmes K, Levine R, Weaver M (2004) Effectiveness of condoms in preventing sexually transmitted infections. Bull World Health Organ 82:454–457.

    PubMed  Google Scholar 

  • Jaffar S, Grant AD, Whitworth J, et al. (2004) The natural history of HIV-1 and HIV-2 infections in adults in Africa: a literature review. Bull WHO 82:462–469.

    PubMed  Google Scholar 

  • Jeffery HE (1996) Perinatal group B streptococcal infection: a significant public health problem. Semin Neonatal 1:77–89.

    Article  Google Scholar 

  • Jeffery HE, Lahra M (1998) Eight-year outcome of universal screening and intrapartum antibiotics for maternal group B streptococcal carriers. Pediatrics 101e2. URL: http://www.pediatrics.org/cgi/content/ full/101/1/e2.

  • Jones J, Kruszon-Moran D, Wilson M, et al. (2001) Toxoplasma gondii infection in the United States: seroprevalence and risk factors. Am J Epidemiol 154:357–365.

    Article  PubMed  CAS  Google Scholar 

  • Jordon JA (1996) Identification of human parvovirus infection in idiopathic nonimmune hydrops fetalis. Am J Obstet Gynecol 174;37–42.

    Article  Google Scholar 

  • Jumaan AO, Yu O, Jackson LA, et al. (2005) Incidence of herpes-zoster, before and after varicella-vaccination-associated incidence decreases in the incidence of varicella 1992–2002. J Infect Dis 191: 2002–2007.

    Article  PubMed  Google Scholar 

  • Kimberlin DW, Lin C-Y, Jacobs RF, et al. (2001) Natural history of neonatal herpes simplex virus infections in the Acyclovir era. Pediatrics 108:223–229.

    Article  PubMed  CAS  Google Scholar 

  • Kimberlin DW, Lin Cy, Sanchez PJ, et al. (2003) Effect of ganciclovir therapy on hearing impairment in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trial. J Pediatr 143:16–25.

    Article  PubMed  CAS  Google Scholar 

  • Kiss H, Petricevic L, Husslein P (2004) Prospective randomized controlled trial of an infection screening programme to reduce the rate of preterm delivery. Br Med J 329:371–375.

    Article  Google Scholar 

  • Klebanoff M, Carey C, Hauth J, et al. (2001) Failure of metronidazole to prevent preterm delivery among women with asymptomatic Trichomonas vaginalis infection. N Engl J Med 345:487–493.

    Article  PubMed  CAS  Google Scholar 

  • Koch WC (2001) Fifth (human parvovirus) and sixth (herpes virus 6) diseases. Curr Opin Inf Dis 14: 343–356.

    CAS  Google Scholar 

  • Koch WC, Harger JH, Barnstein B, et al. (1998) Sero-logic and virologic evidence for frequent intrauterine transmission of human parvovirus B19 with a primary maternal infection during pregnancy. Pediatr Infect Dis J 17:489–494.

    Article  PubMed  CAS  Google Scholar 

  • Kotiw M, Zhang G, Daggard G, et al. (2003) Late-onset and recurrent neonatal group B streptococcal disease associated with breast-milk transmission. Pediatr Dev Pathol 6:251–265.

    Article  PubMed  Google Scholar 

  • Kravetz J, Federman D (2005) Toxoplasmosis in pregnancy. Am J Med 118:212–216.

    Article  PubMed  Google Scholar 

  • Lahra M, Jeffery HE (2004) A fetal response to chorio-amnionitis is associated with early survival after preterm birth. Am J Obstet Gynecol 190:147–151.

    Article  PubMed  Google Scholar 

  • Laibl V, Sheffield J (2005a) Tuberculosis in pregnancy. Clin Perinatol 32:739–747.

    Article  Google Scholar 

  • Laibl V, Sheffield J (2005b) Influenza and pneumonia in pregnancy. Clin Perinatol 32:727–738.

    Article  Google Scholar 

  • Lamont R, Duncan S, Mandal D, et al. (2003) Intravagi-nal clindamycin to reduce preterm birth in women with abnormal genital tract flora. Obstet Gynecol 101:516–22.

    Article  PubMed  CAS  Google Scholar 

  • Lamont RF (2005) Vaginal markers of preterm birth. Acta Obstet Gynecol Scand 84:537–538.

    Article  PubMed  Google Scholar 

  • Le J, Briggs G, McKeown A, et al. (2004) Urinary tract infections during pregnancy. Ann Pharmacotherapy 38:1692–1701.

    Article  Google Scholar 

  • Lengeler C (2004) Insecticide-treated bed nets and curtains for preventing malaria. Cochrane Database of Systematic Reviews 2:CD000363.

    Google Scholar 

  • Leviton A, Paneth N, Reuss L, et al. (1999) Maternal infection, fetal inflammatory response, and brain damage in very low birth weight infants. Pediatr Res 46:566.

    Article  PubMed  CAS  Google Scholar 

  • Lim W, Macfarlane J, Colthorpe C (2001) Pneumonia and pregnancy. Thorax 56:398–405.

    Article  PubMed  CAS  Google Scholar 

  • Lindsay S, Ansell J, Selman C, et al. (2000) Effect of pregnancy on exposure to malaria mosquitoes. Lancet 355:1972.

    Article  PubMed  CAS  Google Scholar 

  • Lockwood CJ (2002) Predicting premature delivery— no easy task. N Engl J Med 346:282–284.

    Article  PubMed  Google Scholar 

  • Lopez A, Dieta V, Wilson M, et al. (2000) Preventing congenital toxoplasmosis. MMWR 49 RR-2:59–69.

    Google Scholar 

  • Maldonado YA (2003) Rubella virus. In: Long SS (ed) Principles and Practice of Pediatric Infectious Diseases, 2nd ed. Churchill Livingstone, New York.

    Google Scholar 

  • Martin C (2005) The dream of a vaccine against tuberculosis; new vaccines improving or replacing BCG? Eur Respir J 26:162–167.

    Article  PubMed  CAS  Google Scholar 

  • McDonald H, Brocklehurst P, Parsons J (2005) Antibiotics for treating bacterial vaginosis in pregnancy. Cochrane Database of Systematic Reviews 1: CD000262.

    Google Scholar 

  • Mertz GJ, Benedetti JK, Selke Sa, et al. (1992) Risk factors for the sexual transmission of genital herpes. Ann Intern Med 116:197–202.

    PubMed  CAS  Google Scholar 

  • Miller E, Cradock-Watson JE, Pollock TM (1982) Consequences of confirmed maternal rubella at successive stages of pregnancy. Lancet 2:781–794.

    Article  PubMed  CAS  Google Scholar 

  • Miller E, Cradock-Watson JE, Ridehalgh MK (1989) Outcome of newborn babies given anti-varicella-zoster immunoglobulin after perinatal infection with varicella- zoster virus. Lancet 2:371–373.

    Article  PubMed  CAS  Google Scholar 

  • Miller E, Fairley CK, Cohen BJ, Seng C (1998) Immediate and long term outcome of human parvovirus B19 infection in pregnancy. Br J Obstet Gynaecol 105:174–178.

    PubMed  CAS  Google Scholar 

  • Mittal P, Wing D (2005) Urinary tract infections in pregnancy. Clin Perinat 32:749–764.

    Article  Google Scholar 

  • Montoya J (2002) Laboratory diagnosis of Toxoplasma gondii infection and toxoplasmosis. Infect Dis 185(suppl 1):s73–82.

    Article  Google Scholar 

  • Montoya J, Rosso F (2005) Diagnosis and management of toxoplasmosis. Clin Perinatol 32:705–726.

    Article  PubMed  Google Scholar 

  • Moodley J, Moodley D (2005) Management of human immunodeficiency virus infection in pregnancy. Best Pract Res Clin Obstet Gynaecol 19:169– 183.

    Article  PubMed  CAS  Google Scholar 

  • Moore M, Schrag S, Schuchat A (2003) Effects of intra-partum antimicrobial prophylaxis for prevention of group-B-streptococcal disease on the incidence and ecology of early-onset neonatal sepsis. Lancet Infect Dis 3:201–13.

    Article  PubMed  Google Scholar 

  • Morel C, Lauer J, Evans D (2005) Cost effectiveness analysis of strategies to combat malaria in developing countries. Br Med J 331:1299.

    Article  Google Scholar 

  • Mylonakis E, Paliou M, Hohmann E, et al. (2002) Liste-riosis during pregnancy: a case series and review of 222 cases. Medicine 81:260–69.

    Article  PubMed  Google Scholar 

  • Nahmias AJ (2004) Neonatal HSV infection. Part 1: continuing challenges. Herpes 11:33–37.

    PubMed  Google Scholar 

  • Nahmias AJ, Lee FK, Beckman-Nahmias S (1990) Sero-epidemiological and sociological patterns of herpes simplex virus infection in the world. Scand J Infect Dis S69:19–36.

    Google Scholar 

  • National Institutes of Health (2005) Guidelines for the use of antiretroviral agents in pediatric HIV therapy. http://aidsinfo.nih.gov/ContentFiles/PediatricGuide-lines_PDA.pdf.

  • Neralla S, Glassroth J (2003) Mycobacterium tuberculosis: the treatment of active disease. Semin Respir Infect 18:292–306.

    Article  PubMed  Google Scholar 

  • Newman RD, Hailemariam A, Jimma D, et al. (2003) Burden of malaria during pregnancy in areas of stable and unstable transmission in Ethiopia during a nonepidemic year. J Infect Dis 187:1765– 1772.

    Article  PubMed  Google Scholar 

  • Newnham J, Shub A, Jobe A, et al. (2005) The effects of intra-amniotic injection of periodontopathic lipo-polysaccharides in sheep. Am J Obstet Gynecol 193:313–321.

    Article  PubMed  CAS  Google Scholar 

  • Nicolle L, Bradley S, Colgan R, et al. (2005) Infectious disease society of America guidelines for the diagnosis and treatment of asymptomatic bacteruria in adults. Clin Infect Dis 40:643–654.

    Article  PubMed  Google Scholar 

  • Nigro G, Bastianon V, Colloridi V, et al. (2004) Human parvovirus B19 infection in infancy associated with acute and chronic lymphocytic myocarditis and high cytokine levels: report of three cases and review. Clin Infect Dis 31:65–69.

    Article  Google Scholar 

  • Offenbacher S, Katz V, Fertik G, et al. (1996) Periodon-tal infections as a possible risk factor for preterm low birth weight. J Periodontal 67:1103–1113.

    CAS  Google Scholar 

  • Ogunmodede F, Jones JL, Scheftel J, Kirkland E, Schul-kin J, Lynfield R (2005) Listeriosis prevention knowledge among pregnant women in the USA. Infect Dis Obstet Gynecol 13:11–5.

    PubMed  Google Scholar 

  • Olliaro P (2004) Congenital toxoplasmosis. Clin Evidence 12:1058–1061.

    Google Scholar 

  • Ormerod P (2001) Tuberculosis in pregnancy and the puerperium. Thorax 56:494–499.

    Article  PubMed  CAS  Google Scholar 

  • Orton L, Garner P (2005) Drugs for treating uncomplicated malaria in pregnant women. Cochrane Database of Systematic Reviews 3:CD004912.

    Google Scholar 

  • Pacora P, Chaiworapongsa T, Maymon E, et al. (2002) Funisitis and chorionic vasculitis: the histological counterpart of the fetal inflammatory response syndrome. J Matern Fetal Neonatal Med 11:18– 25.

    Article  PubMed  CAS  Google Scholar 

  • Pastore L, Savitz D, Thorp J (1999) Predictors of urinary tract infection at the first prenatal visit. Epidemiology 10:282–287.

    Article  PubMed  CAS  Google Scholar 

  • Peeling R, Ye H (2004) Diagnostic tools for preventing and managing maternal and congenital syphilis: an overview. Bull WHO 82:439–446.

    PubMed  Google Scholar 

  • Peipert JF (2003) Genital chlamydial infections. N Engl J Med 349:2424–2430.

    Article  PubMed  CAS  Google Scholar 

  • Petersen E (2004) Malaria chemoprophylaxis: when should we use it and what are the options? Expert Rev Antiinfect Ther 2:119–32.

    Article  CAS  Google Scholar 

  • Peyron F, Wallon M (2001) Options for the pharmaco-therapy of toxoplasmosis during pregnancy. Exp Opin Pharmacol 2:1269–1274.

    Article  CAS  Google Scholar 

  • Peyron F, Wallon M, Liou C, et al. (1999) Treatments for toxoplasmosis in pregnancy. Cochrane Database of Systematic Reviews 3:CD001684.

    Google Scholar 

  • Planche T, Krishna S (2005) The relevance of malaria pathophysiology to strategies of clinical management. Curr Opin Infect Dis 18:369–375.

    Article  PubMed  Google Scholar 

  • Plotkin SA (2001) Rubella eradication. Vaccine 19: 3311–3319.

    Article  PubMed  CAS  Google Scholar 

  • Polizzotto M (2005) Prevention of sexually transmitted diseases. Clin Fam Prac 7:1–12.

    Article  Google Scholar 

  • Preblud SR, Bregman DJ, Vernon LL (1985) Deaths from varicella in infants. Pediatr Infect Dis J 4:503– 507.

    Article  CAS  Google Scholar 

  • Puopolo K, Madoff L, Eichenwald E (2005) Early-onset group B streptococcal disease in the era of maternal screening. Pediatrics 115:1240–1246.

    Article  PubMed  Google Scholar 

  • Reef SE, Plotkin S, Cordero JF, et al. (2000) Preparing for elimination of congenital rubella syndrome (CRS): summary of a workshop on CRS elimination in the United States. Clin Infect Dis 31:85–95.

    Article  PubMed  CAS  Google Scholar 

  • Reynolds DW, Stagno S, Stubbs KG, et al. (1974) Inap-parent congenital cytomegalovirus infection with elevated cord IgM levels; causal relationship with auditory and mental deficiency. N Engl J Med 290:291–296.

    PubMed  CAS  Google Scholar 

  • Risser W, Bortot A, Benjamins L, et al. (2005) The epidemiology of sexually transmitted infections in adolescents. Semin Pediatr Infect Dis 16:160–167.

    Article  PubMed  Google Scholar 

  • Robertson SE, Featherstone DA, Gacic-Dobo M (2003) Rubella and congenital rubella syndrome: global update. Pan Am J Public Health 14:306–315.

    Google Scholar 

  • Rodis JF, Quinn DL, Gary GW Jr, et al. (1990) Management and outcomes of pregnancies complicated by human parvovirus B19 infection: a prospective study. Am J Obst Gynecol 163:1168–1171.

    CAS  Google Scholar 

  • Romero R, Chaiworapongsa T, Espinoza J (2003) Micro-nutrients and intrauterine infection, preterm birth and the fetal inflammatory response syndrome. J Nutr 133:1668s–1673s.

    PubMed  CAS  Google Scholar 

  • Romero R, Gomez R, Chaiworapongsa T, et al. (2001) The role of infection in preterm labour and delivery. Paediatr Perinatal Epidemiol 15(suppl 2):41–56.

    Article  Google Scholar 

  • Rouse D, Andrews W, Goldenberg R, et al. (1995) Screening and treatment of asymptomatic bacteruria of pregnancy to prevent pyelonephritis: a cost-effectiveness and cost-benefit analysis. Obstet Gynecol 86:119–123.

    Article  PubMed  CAS  Google Scholar 

  • Rupp R, Stanberry L, Rosenthal S (2004) New biomedi-cal approaches for sexually transmitted infection prevention: vaccines and microbicides. Adolesc Med Clin 15:393–407.

    Article  PubMed  Google Scholar 

  • Russell P (1979) Inflammatory lesions of the human placenta: I, clinical significance of acute chorioamnionitis. Am J Diagn Gynecol Obstet 1:127–137.

    Google Scholar 

  • Sachs J, Malaney P (2002) The economic and social burden of malaria. Nature 415:680–685.

    Article  PubMed  CAS  Google Scholar 

  • Saloojee H, Velaphi S, Goga Y, et al. (2004) The prevention and management of congenital syphilis: an overview and recommendations. Bull WHO 82: 424–430.

    PubMed  Google Scholar 

  • Schild RL, Bald R, Plath H, et al. (1999) Intrauterine management of fetal parvovirus B19 infection. Ultrasound Obstet Gynecol 13:161–166.

    Article  PubMed  CAS  Google Scholar 

  • Schleiss MR (2005) Cytomegalovirus infection. www.emedicine.com/MED/topic504.htm.

  • Schmid G (2004) Policy and practice. Economic and programmatic aspects of congenital syphilis prevention. Bull WHO 82:402–409.

    Google Scholar 

  • Silver HM (1998) Listeriosis during pregnancy. Obstet Gynecol Surv 53:737–740.

    Article  PubMed  CAS  Google Scholar 

  • Skjoldebrand-Sparre L, Tolfvenstam T, Papadogianna-kis N, et al. (2000) Parvovirus B19 infection: association with third-trimester intrauterine death. Br J Obstet Gynaecol 107:476–480.

    CAS  Google Scholar 

  • Smaill F (1996) Intrapartum antibiotics for group B streptococcal colonization. Cochrane Database of Systematic Reviews 1:CD000115.

    Google Scholar 

  • Smaill F (2001) Antibiotics for asymptomatic bacter-uria in pregnancy. Cochrane Database of Systematic Reviews 2:CD000490.

    Google Scholar 

  • Smith K (2002) Congenital tuberculosis: a rare manifestation of a common infection. Curr Opin Infect Dis 15:269–274.

    PubMed  Google Scholar 

  • Soper D (2004) Trichomoniasis: Under control or undercontrolled? Am J Obstet Gynecol 190:281–90.

    Article  PubMed  Google Scholar 

  • Southwick F, Purich D (1996) Mechanisms of disease, Intracellular pathogenesis of listeriosis. N Engl J Med 334:770–776.

    Article  PubMed  CAS  Google Scholar 

  • Spigarelli M, Biro F (2004) Sexually transmitted disease testing: evaluation of diagnostic tests and methods. Adolesc Med Clin 15:287–299.

    Article  PubMed  Google Scholar 

  • Stagno S, Pass R, Cloud G, et al. (1986) Primary cyto-megalovirus infection in pregnancy: incidence, transmission to fetus, and clinical outcome. JAMA 256:1904–1908.

    Article  PubMed  CAS  Google Scholar 

  • Steketee R, Nahlen B, Parise M, et al. (2001) The burden of malaria in pregnancy in malaria-endemic areas. Am J Trop Med Hyg 64S:28–35.

    Google Scholar 

  • Steketee RW (2003) Pregnancy, nutrition and parasitic diseases. J Nutr 133:1661S–1667S.

    PubMed  CAS  Google Scholar 

  • Stevens-Simon C, Sheeder J (2005) Chlamydia tracho-matis: common misperceptions and misunderstandings. J Pediatr Adolesc Gynecol 18:231–243.

    Article  PubMed  Google Scholar 

  • Stringer JR, Beard CB, Miller RF, Wakefield AE (2002) A new name (Pneumocystis jiroveci) for pneumocys-tis from humans. Emerg Infect Dis 8. http://www.cdc. gov/ncidod/EID/vol8no9/02–0096.htm.

    Google Scholar 

  • ter Kuile F, Parise M, Verhoeff F, et al. (2004) The burden of co-infection with human immunodefi-ciency virus type 1 and malaria in pregnant women in sub-Saharan Africa. Am J Trop Med Hyg 71(suppl 2):41–54.

    PubMed  Google Scholar 

  • Thomsen AC, Morup L, Brogaard Hansen K (1987) Antibiotic elimination of group B streptococci in urine in prevention of preterm labour. Lancet 1: 591–593.

    Article  PubMed  CAS  Google Scholar 

  • Trincado DE, Rawlinson WD (2001) Congenital and perinatal infections with cytomegalovirus. J Paediatr Child Health 37:187–192.

    Article  PubMed  CAS  Google Scholar 

  • U.S. Department of Health and Human Services (2000) Blueprint for action on breastfeeding. http://www. womenshealth.gov/Breastfeeding/bluprntbk2.pdf.

  • van Geertruyden J-P, Thomas F, Erhart A, et al. (2004) The contribution of malaria in pregnancy to perinatal mortality. Ann Trop Med Hyg 71(suppl 2):35– 40.

    Google Scholar 

  • Vazquez JC, Villar J (2003) Treatments for symptomatic urinary tract infections during pregnancy. Cochrane Database of Systematic Reviews 4:CD002256.

    Google Scholar 

  • Villar J, Widmer M, Lyon-Rochelle MT, et al. (2000) Duration of treatment for asymptomatic bacteruria during pregnancy. Cochrane Database of Systematic Reviews 2:CD000491.

    Google Scholar 

  • Volmink J, Garner P (2003) Directly observed therapy for treating tuberculosis. Cochrane Database of Systematic Reviews 1:CD003343.

    Google Scholar 

  • Wagner HU, Van Dyck E, Roggan E, et al. (1994) Sero-prevalence and incidence of sexually transmitted diseases in a rural Ugandan population. Int J STD AIDS 5:322–327.

    Google Scholar 

  • Weiss HA, Buve A, Robinson NJ, et al. (2001) Study group on the heterogeneity of HIV epidemics in African Cities. The epidemiology of HSV-2 infection and its association with HIV infection in four urban African populations. AIDS 15(suppl 4):S97–S108.

    Article  PubMed  Google Scholar 

  • White DO, Fenner FJ (1994a) Cytomegalovirus in Her-pesviridae In: Medical Virology, 4th ed. Academic Press, San Diego, pp. 334–341.

    Google Scholar 

  • White DO, Fenner FJ (1994b) Herpes simplex viruses in Herpesviridae. In: Medical Virology, 4th ed. Academic Press, San Diego, pp. 323–330.

    Google Scholar 

  • White DO, Fenner FJ (1994c) Human immunodefi-ciency virus in Retroviridae In: Medical Virology, 4th ed. Academic Press, San Diego, pp. 538–561.

    Google Scholar 

  • White DO, Fenner FJ (1994d) Parvoviridae In: Medical Virology, 4th ed. Academic Press, San Diego, pp. 285–293.

    Google Scholar 

  • White DO, Fenner FJ (1994e) Varicella-Zoster virus in Herpesviridae In: Medical Virology, 4th ed. Academic Press, San Diego, pp. 333–334.

    Google Scholar 

  • Whitely RJ (2000) Varicella-zoster virus. In: Mandell GL, Bennett JE, Dolin R (eds) Principles and Practice of Infectious Diseases, 5th ed. Churchill Livingstone, New York, pp. 1580–1586.

    Google Scholar 

  • Whitely RJ, Corey L, Arvin A, et al. (1988) Changing presentation of herpes simplex virus infection in neonates. J Infect Dis 158:109–116.

    Google Scholar 

  • Workowski K, Levine W, Wasserheit J (2002) U.S. Centers for disease control and prevention guidelines for the treatment of sexually transmitted diseases: an opportunity to unify clinical and public health practice. Ann Intern Med 137:e255–262.

    Google Scholar 

  • World Health Organization (2004a) AIDS Epidemic update. http://.whqlibdoc.who.int/unaids/2004/a 62410.

  • World Health Organization (2004b) A strategic Framework for Malaria Prevention and Control During Pregnancy in the African Region. Brazzawille: WHO Regional Office for Africa.

    Google Scholar 

  • WHO/UNAIDS/LSHTM (2001) Herpes simplex virus type 2 programmatic and research priorities in developing countries. Report of a WHO/UNAIDS/LSHTM Workshop 2001. http://www.who.int/docstore/hiv/ herpes meeting/.

  • Yaegashi N, Niinuma T, Chisaka H, et al. (1999) Sero-logic study of human parvovirus B19 in pregnancy in Japan. J Infect 38:30–35.

    Article  PubMed  CAS  Google Scholar 

  • Yaegashi N, Okamura K, Yajima A, et al. (1994) The frequency of human parvovirus B19 infection in nonimmune hydrops fetalis. J Perinat Med 22:159– 163.

    Article  PubMed  CAS  Google Scholar 

  • Yoon B, Romero R, Park J, et al. (2000) The relationship among inflammatory lesions of the umbilical cord (funisitis), umbilical cord plasma interleukin 6 concentration, amniotic fluid infection, and neonatal sepsis. Am J Obstet Gynecol 183:1124–1129.

    Article  PubMed  CAS  Google Scholar 

  • Yost N, Bloom S, Richey S, et al. (2000) An appraisal of treatment guidelines for antepartum community-acquired pneumonia. Am J Obstet Gynecol 183: 131–135.

    PubMed  CAS  Google Scholar 

  • Young G, Jewell D (2001) Topical treatment for vaginal candidiasis (thrush) in pregnancy. Cochrane Database of Systematic Reviews 4:CD000225.

    Google Scholar 

  • Young NS, Brown KE (2004) Mechanisms of disease: parvovirus B19. N Engl J Med 350:586–597.

    Article  PubMed  CAS  Google Scholar 

  • Yudin MH (2005) Bacterial vaginosis in pregnancy: diagnosis, screening and management. Clin Perinatol 32:617–627.

    Article  PubMed  Google Scholar 

  • Zeltser R, Kurban A (2004) Syphilis. Clin Dermatol 22:461–468.

    Article  PubMed  Google Scholar 

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Jeffery, H.E., Lahra, M.M. (2007). The Impact of Infection During Pregnancy on the Mother and Baby. In: Keeling, J.W., Khong, T.Y. (eds) Fetal and Neonatal Pathology. Springer, London. https://doi.org/10.1007/978-1-84628-743-5_16

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