Skip to main content
SpringerLink
Log in
Book cover

Coronary Artery Disease pp 75–87Cite as

Transmyocardial Laser Revascularization

  • Chapter
  • First Online:

  • 1222 Accesses

Abstract

Ischemic heart disease remains the leading cause of death in the Western Hemisphere. Despite recent advances in medical therapy and surgical and percutaneous revascularization, the number of so-called no option patients is increasing. These patients are no longer candidates for percutaneous or surgical revascularization but are symptomatic despite maximal medical therapy. A number of investigational therapeutic strategies have been developed to improve the quality of life of “no-option” patients. These, in addition to laser myocardial revascularization discussed here, include angiogenesis and myogenesis approaches, external counterpulsation, as well as spinal cord stimulation.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Mirhoseini M, Cayton MM. Revascularization of the heart by laser. J Microsurg. 1981;2(4):253–60.

    Article  PubMed  CAS  Google Scholar 

  2. Horvath KA. Transmyocardial laser revascularization. Curr Treat Options Cardiovasc Med. 2004;6(1):53–9.

    Article  PubMed  Google Scholar 

  3. Jansen ED, Frenz M, Kadipasaoglu KA, et al. Laser-tissue interaction during transmyocardial laser revascularization. Ann Thorac Surg. 1997;63(3):640–7.

    Article  PubMed  CAS  Google Scholar 

  4. Fisher PE, Khomoto T, DeRosa CM, Spotnitz HM, Smith CR, Burkhoff D. Histologic analysis of transmyocardial channels: comparison of CO2 and holmium:YAG lasers. Ann Thorac Surg. 1997;64(2):466–72.

    Article  PubMed  CAS  Google Scholar 

  5. Jones JW, Richman BW, Crigger NA, Baldwin JC. Technique of transmyocardial revascularization: avoiding complications in high-risk patients. J Cardiovasc Surg (Torino). 2001;42(3):353–7.

    CAS  Google Scholar 

  6. Jones JW, Schmidt SE, Richman BW, et al. Holmium:YAG laser transmyocardial revascularization relieves angina and improves functional status. Ann Thorac Surg. 1999;67(6):1596–601, discussion 601–2.

    Article  PubMed  CAS  Google Scholar 

  7. Izutani H, Gill IS, Svanidze O. Robotically assisted endoscopic transmyocardial laser revascularization. Can J Cardiol. 2004;20(9):907–9.

    PubMed  Google Scholar 

  8. Horvath KA. Thoracoscopic transmyocardial laser revascularization. Ann Thorac Surg. 1998;65(5):1439–41.

    Article  PubMed  CAS  Google Scholar 

  9. Frazier OH, March RJ, Horvath KA. Transmyocardial revascularization with a carbon dioxide laser in patients with end-stage coronary artery disease. N Engl J Med. 1999;341(14):1021–8.

    Article  PubMed  CAS  Google Scholar 

  10. Schofield PM, Sharples LD, Caine N, et al. Transmyocardial laser revascularisation in patients with refractory angina: a randomised controlled trial. Lancet. 1999;353(9152):519–24.

    Article  PubMed  CAS  Google Scholar 

  11. Wehberg KE, Julian JS, Todd 3rd JC, Ogburn N, Klopp E, Buchness M. Improved patient outcomes when transmyocardial revascularization is used as adjunctive revascularization. Heart Surg Forum. 2003;6(5):328–30.

    PubMed  Google Scholar 

  12. Peterson ED, Kaul P, Kaczmarek RG, et al. From controlled trials to clinical practice: monitoring transmyocardial revascularization use and outcomes. J Am Coll Cardiol. 2003;42(9):1611–6.

    Article  PubMed  Google Scholar 

  13. Gassler N, Wintzer HO, Stubbe HM, Wullbrand A, Helmchen U. Transmyocardial laser revascularization. Histological features in human nonresponder myocardium. Circulation. 1997;95(2):371–5.

    PubMed  CAS  Google Scholar 

  14. Hardy RI, Bove KE, James FW, Kaplan S, Goldman L. A histologic study of laser-induced transmyocardial channels. Lasers Surg Med. 1987;6(6):563–73.

    Article  PubMed  CAS  Google Scholar 

  15. Pelletier MP, Giaid A, Sivaraman S, et al. Angiogenesis and growth factor expression in a model of transmyocardial revascularization. Ann Thorac Surg. 1998;66(1):12–8.

    Article  PubMed  CAS  Google Scholar 

  16. Kohmoto T, DeRosa CM, Yamamoto N, et al. Evidence of vascular growth associated with laser treatment of normal canine myocardium. Ann Thorac Surg. 1998;65(5):1360–7.

    Article  PubMed  CAS  Google Scholar 

  17. Yamamoto N, Kohmoto T, Gu A, DeRosa C, Smith CR, Burkhoff D. Angiogenesis is enhanced in ischemic canine myocardium by transmyocardial laser revascularization. J Am Coll Cardiol. 1998;31(6):1426–33.

    Article  PubMed  CAS  Google Scholar 

  18. Domkowski PW, Biswas SS, Steenbergen C, Lowe JE. Histological evidence of angiogenesis 9 months after transmyocardial laser revascularization. Circulation. 2001;103(3):469–71.

    PubMed  CAS  Google Scholar 

  19. Horvath KA, Chiu E, Maun DC, et al. Up-regulation of vascular endothelial growth factor mRNA and angiogenesis after transmyocardial laser revascularization. Ann Thorac Surg. 1999;68(3):825–9.

    Article  PubMed  CAS  Google Scholar 

  20. Chu VF, Giaid A, Kuang JQ, et al. Thoracic surgery directors association award. Angiogenesis in transmyocardial revascularization: comparison of laser versus mechanical punctures. Ann Thorac Surg. 1999;68(2):301–7, discussion 7–8.

    Article  PubMed  CAS  Google Scholar 

  21. Horvath KA, Belkind N, Wu I, et al. Functional comparison of transmyocardial revascularization by mechanical and laser means. Ann Thorac Surg. 2001;72(6):1997–2002.

    Article  PubMed  CAS  Google Scholar 

  22. Donovan CL, Landolfo KP, Lowe JE, Clements F, Coleman RB, Ryan T. Improvement in inducible ischemia during dobutamine stress echocardiography after transmyocardial laser revascularization in patients with refractory angina pectoris. J Am Coll Cardiol. 1997;30(3):607–12.

    Article  PubMed  CAS  Google Scholar 

  23. Frazier OHCD, Kadipasaoglu KA, Pehlivanoglu S, Lindenmeir M, Barasch E, Conger JL, et al. Myocardial revascularization with laser. Preliminary findings. Circulation. 1995;92(9 Suppl):II58–65.

    PubMed  CAS  Google Scholar 

  24. Laham RJ, Simons M, Pearlman JD, Ho KK, Baim DS. Magnetic resonance imaging demonstrates improved regional systolic wall motion and thickening and myocardial perfusion of myocardial territories treated by laser myocardial revascularization. J Am Coll Cardiol. 2002;39(1):1–8.

    Article  PubMed  Google Scholar 

  25. Rana JS, Mannam A, Donnell-Fink L, Gervino EV, Sellke FW, Laham RJ. Longevity of the placebo effect in the therapeutic angiogenesis and laser myocardial revascularization trials in patients with coronary heart disease. Am J Cardiol. 2005;95(12):1456–9.

    Article  PubMed  Google Scholar 

  26. Kwong KF, Kanellopoulos GK, Nickols JC, et al. Transmyocardial laser treatment denervates canine myocardium. J Thorac Cardiovasc Surg. 1997;114(6):883–9, ­discussion 9–90.

    Article  PubMed  CAS  Google Scholar 

  27. Al-Sheikh T, Allen KB, Straka SP, et al. Cardiac sympathetic denervation after transmyocardial laser revascularization. Circulation. 1999;100(2):135–40.

    PubMed  CAS  Google Scholar 

  28. Minisi AJ, Topaz O, Quinn MS, Mohanty LB. Cardiac nociceptive reflexes after transmyocardial laser revascularization: implications for the neural hypothesis of angina relief. J Thorac Cardiovasc Surg. 2001;122(4):712–9.

    Article  PubMed  CAS  Google Scholar 

  29. Hughes GC, Lowe JE, Kypson AP, et al. Neovascularization after transmyocardial laser revascularization in a model of chronic ischemia. Ann Thorac Surg. 1998;66(6):2029–36.

    Article  PubMed  CAS  Google Scholar 

  30. Cherian SM, Bobryshev YV, Liang H, et al. Ultrastructural and immunohistochemical analysis of early myocardial changes following transmyocardial laser revascularization. J Card Surg. 2000;15(5):341–6.

    Article  PubMed  CAS  Google Scholar 

  31. Mack CA, Magovern CJ, Hahn RT, et al. Channel patency and neovascularization after transmyocardial revascularization using an excimer laser: results and comparisons to nonlased channels. Circulation. 1997;96(9 Suppl):II-65–9.

    Google Scholar 

  32. Allen KB, Dowling RD, Fudge TL, et al. Comparison of transmyocardial revascularization with medical therapy in patients with refractory angina. N Engl J Med. 1999;341(14):1029–36.

    Article  PubMed  CAS  Google Scholar 

  33. Burkhoff D, Schmidt S, Schulman SP, et al. Transmyocardial laser revascularisation compared with continued medical therapy for treatment of refractory angina pectoris: a prospective randomised trial. ATLANTIC investigators. Angina treatments-lasers and normal therapies in comparison. Lancet. 1999;354(9182):885–90.

    Article  PubMed  CAS  Google Scholar 

  34. Burkhoff D, Wesley MN, Resar JR, Lansing AM. Factors correlating with risk of mortality after transmyocardial revascularization. J Am Coll Cardiol. 1999;34(1):55–61.

    Article  PubMed  CAS  Google Scholar 

  35. Guleserian KJ, Maniar HS, Camillo CJ, Bailey MS, Damiano Jr RJ, Moon MR. Quality of life and survival after transmyocardial laser revascularization with the holmium:YAG laser. Ann Thorac Surg. 2003;75(6):1842–7, discussion 7–8.

    Article  PubMed  Google Scholar 

  36. Krabatsch T, Petzina R, Hausmann H, Koster A, Hetzer R. Factors influencing results and outcome after transmyocardial laser revascularization. Ann Thorac Surg. 2002;73(6):1888–92.

    Article  PubMed  Google Scholar 

  37. Mukherjee D, Bhatt DL, Roe MT, Patel V, Ellis SG. Direct myocardial revascularization and angiogenesis – how many patients might be eligible? Am J Cardiol. 1999;84(5):598–600, A8.

    Article  PubMed  CAS  Google Scholar 

  38. Allen KB, Dowling RD, Schuch DR, et al. Adjunctive transmyocardial revascularization: five-year follow-up of a prospective, randomized trial. Ann Thorac Surg. 2004;78(2):458–65, discussion 465.

    Article  PubMed  Google Scholar 

  39. Stone GW, Teirstein PS, Rubenstein R, et al. A prospective, multicenter, randomized trial of percutaneous transmyocardial laser revascularization in patients with nonrecanalizable chronic total occlusions. J Am Coll Cardiol. 2002;39(10):1581–7.

    Article  PubMed  Google Scholar 

  40. Aaberge L, Nordstrand K, Dragsund M, et al. Transmyocardial revascularization with CO2 laser in patients with refractory angina pectoris clinical results from the Norwegian randomized trial. J Am Coll Cardiol. 2000;35(5):1170–7.

    Article  PubMed  CAS  Google Scholar 

  41. Aaberge L, Rootwelt K, Blomhoff S, Saatvedt K, Abdelnoor M, Forfang K. Continued symptomatic improvement three to five years after transmyocardial revascularization with CO(2) laser: a late clinical follow-up of the Norwegian randomized trial with transmyocardial revascularization. J Am Coll Cardiol. 2002;39(10):1588–93.

    Article  PubMed  Google Scholar 

  42. Horvath KA, Aranki SF, Cohn LH, et al. Sustained angina relief 5 years after transmyocardial laser revascularization with a CO(2) laser. Circulation. 2001;104(12 Suppl 1):I81–4.

    PubMed  CAS  Google Scholar 

  43. Spertus JA, Jones PG, Coen M, et al. Transmyocardial CO(2) laser revascularization improves symptoms, function, and quality of life: 12-month results from a randomized controlled trial. Am J Med. 2001;111(5):341–8.

    Article  PubMed  CAS  Google Scholar 

  44. van der Sloot JAHM, Tukkie R, Verberne HJ, van der Meulen J, van Eck-Smit BL, van Gemert MJ, et al. Transmyocardial revascularization using an XeCl excimer laser: results of a randomized trial. Ann Thorac Surg. 2004;78(3):875–81.

    Article  PubMed  Google Scholar 

  45. Frazier OH, Tuzun E, Eichstadt H, et al. Transmyocardial laser revascularization as an adjunct to coronary artery bypass grafting: a randomized, multicenter study with 4-year follow-up. Tex Heart Inst J. 2004;31(3):231–9.

    PubMed  CAS  Google Scholar 

  46. Oesterle SN, Sanborn TA, Ali N, et al. Percutaneous transmyocardial laser revascularisation for severe angina: the PACIFIC randomised trial. Potential class improvement from intramyocardial channels. Lancet. 2000;356(9243):1705–10.

    Article  PubMed  CAS  Google Scholar 

  47. Aaberge L, Aakhus S, Nordstrand K, Abdelnoor M, Ihlen H, Forfang K. Myocardial performance after transmyocardial revascularization with CO(2)laser. A dobutamine stress echocardiographic study. Eur J Echocardiogr. 2001;2(3):187–96.

    Article  PubMed  CAS  Google Scholar 

  48. Horvath KA, Cohn LH, Cooley DA, et al. Transmyocardial laser revascularization: results of a multicenter trial with transmyocardial laser revascularization used as sole therapy for end-stage coronary artery disease. J Thorac Cardiovasc Surg. 1997;113(4):645–53, discussion 653–4.

    Article  PubMed  CAS  Google Scholar 

  49. Burns SM, Brown S, White CA, Tait S, Sharples L, Schofield PM. Quantitative analysis of myocardial perfusion changes with transmyocardial laser revascularization. Am J Cardiol. 2001;87(7):861–7.

    Article  PubMed  CAS  Google Scholar 

  50. Leon MB, Kornowski R, Downey WE, et al. A blinded, randomized, placebo-controlled trial of percutaneous laser myocardial revascularization to improve angina symptoms in patients with severe coronary disease. J Am Coll Cardiol. 2005;46(10):1812–9.

    Article  PubMed  Google Scholar 

  51. Whitlow PL, DeMaio Jr SJ, Perin EC, et al. One-year results of percutaneous myocardial revascularization for refractory angina pectoris. Am J Cardiol. 2003;91(11):1342–6.

    Article  PubMed  Google Scholar 

  52. Salem M, Rotevatn S, Stavnes S, Brekke M, Vollset SE, Nordrehaug JE. Usefulness and safety of percutaneous myocardial laser revascularization for refractory angina pectoris. Am J Cardiol. 2004;93(9):1086–91.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Cardiovascular Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA

    Jignesh S. Shah, Joanna J. Wykrzykowska & Roger J. Laham

Authors
  1. Jignesh S. Shah
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Joanna J. Wykrzykowska
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Roger J. Laham
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Roger J. Laham .

Editor information

Editors and Affiliations

  1. College of Medicine, Mayo Clinic, First Street SW., 200, Rochester, 55905, Minnesota, USA

    Gregory W. Barsness

  2. Div. Cardiovascular Diseases, St. Mary's Hospital, Rochester, 55905, Minnesota, USA

    David R. Holmes

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer-Verlag London Limited

About this chapter

Cite this chapter

Shah, J.S., Wykrzykowska, J.J., Laham, R.J. (2012). Transmyocardial Laser Revascularization. In: Barsness, G., Holmes, D. (eds) Coronary Artery Disease. Springer, London. https://doi.org/10.1007/978-1-84628-712-1_8

Download citation

  • DOI: https://doi.org/10.1007/978-1-84628-712-1_8

  • Published:

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84628-460-1

  • Online ISBN: 978-1-84628-712-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation