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Neuroimaging of Movement Disorders pp 25–47Cite as

Morphometric Analyses in Movement Disorders

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Part of the book series: Current Clinical Neurology ((CCNEU,volume 44))

Abstract

Computational neuroanatomy based on magnetic resonance imaging (MRI) provides a framework for in vivo assessment of brain structure in movement disorders, demonstrating diagnostic potential in early clinical stages next to ability to monitor therapy effects, and/or disease progression. Recent methodological developments in MR physics and data analysis have brought further insight into the pathophysiology of neurological disorders. Volume-, shape-, and surface-based computational neuroanatomy techniques allow for sensitive and reliable differentiation of phenotype–genotype-related traits and their interaction even at presymptomatic stages of disease. Analysis of multiparameter MR data sheds light on specific brain tissue property changes linking noninvasive imaging with the pathophysiology of a particular movement disorder. Given the steadily growing number of MRI-based computational neuroanatomy studies in movement disorders, this chapter can only focus on major themes within the published literature. The first section of this chapter outlines recent advances in MR data acquisition, processing, and analysis touching on general principles of computational neuroanatomy followed by a section on morphometry in specific movement disorders.

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Authors and Affiliations

  1. Max Planck Institute for Human Cognitive and Brain Sciences, Centre Hospitalier Universitaire Vaudois (CHUV), Leipzig, Germany

    Prof. Bogdan Draganski MD

  2. Mind Brain Institute, Charité and Humboldt University, Berlin, Germany

    Prof. Bogdan Draganski MD

  3. LREN, Département des Neurosciences Cliniques, Centre Hospitalier Universitaire Vaudois (CHUV), Université de Lausanne, Rue du Bugnon 46, 1011, Lausanne, VD, Switzerland

    Prof. Bogdan Draganski MD & Ettore A. Accolla MD

  4. Campus Virchow Klinikum, Charité University Medicine Berlin, Berlin, Germany

    Ettore A. Accolla MD

  5. Department of Neurology, Campus Virchow Klinikum, Charité – University Medicine Berlin, Augustenburger Platz 1, 13353, Berlin, Germany

    Ettore A. Accolla MD

Authors
  1. Prof. Bogdan Draganski MD
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  2. Ettore A. Accolla MD
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Correspondence to Ettore A. Accolla MD .

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Editors and Affiliations

  1. , Department of Neuroscience, University of California at San Diego, Gilman Dr 9500, La Jolla, 92093, California, USA

    Fatta B. Nahab

  2. , Neurorehabilitation Research Institute, Morinomiya Hospital, Morinomiya 2-1-88, Joto-ku,Osaka-shi, 536-0025, Osaka, Japan

    Noriaki Hattori

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Draganski, B., Accolla, E. (2013). Morphometric Analyses in Movement Disorders. In: Nahab, F., Hattori, N. (eds) Neuroimaging of Movement Disorders. Current Clinical Neurology, vol 44. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-471-5_2

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