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Ion Channels as Novel Pancreatic Cancer Biomarkers and Targets

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New Advances on Disease Biomarkers and Molecular Targets in Biomedicine

Abstract

Transient receptor potential (TRP) ion channels act as molecular sensors and transducers of diverse stimuli into cellular and physiological responses. Accumulating evidence has implicated the regulatory roles of TRP ion channels in various human diseases including malignancies. The requirement of the TRP melastatin-subfamily members, TRPM7 and TRPM8, in pancreatic development and cancer has been brought to light in recent discovery. Investigation of the mechanisms that mediate the functional roles of these TRP channels is expected to generate new insights into the pathogenesis of pancreatic neoplasia, and facilitate development of clinical biomarkers and therapeutic targets toward the goal of personalized therapy in pancreatic cancer.

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Acknowledgements

N.S.Y. is supported by the Physician Scientist Stimulus Package from The Pennsylvania State University College of Medicine. The research work in the laboratory of N.S.Y. has been funded by Penn State Hershey Cancer Institute, The University of Iowa Carver College of Medicine, Holden Comprehensive Cancer Center at The University of Iowa, National Institutes of Health (NIDDK and NCI), American Cancer Society, and Fraternal Orders of Eagles.

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Authors and Affiliations

  1. Division of Hematology-Oncology, Department of Medicine, Penn State College of Medicine, Penn State Hershey Cancer Institute, Penn State Milton S. Hershey Medical Center, Pennsylvania State University, 500 University Drive, Hershey, PA, 17033-0850, USA

    Nelson S. Yee M.D., Ph.D.

  2. Penn State Harrisburg School of Humanities, Pennsylvania State University, Middletown, PA, 17057, USA

    Rosemary K. Yee

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  1. Nelson S. Yee M.D., Ph.D.
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  2. Rosemary K. Yee
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Correspondence to Nelson S. Yee M.D., Ph.D. .

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Editors and Affiliations

  1. Faculty of Medicine Building, Department of Surgery, University of Hong Kong, Sassoon Road 21, Hong Kong, Hong Kong SAR

    Nikki P. Lee

  2. Center for Biomedical Research, Population Council, York Ave. 1230, NEW YORK, 10021, New York, USA

    C.Y. Cheng

  3. Yong Loo Lin School of Medicine, Department of Pharmacology and Departmen, National University of Singapore, Medical Drive 10, Singapore, 117597, Singapore

    John M. Luk

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Yee, N.S., Yee, R.K. (2013). Ion Channels as Novel Pancreatic Cancer Biomarkers and Targets. In: Lee, N., Cheng, C., Luk, J. (eds) New Advances on Disease Biomarkers and Molecular Targets in Biomedicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-456-2_5

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