Skip to main content

Infection of the Upper Urinary Tract

  • Chapter
  • First Online:
Urological Emergencies

Part of the book series: Current Clinical Urology ((CCU))

  • 1481 Accesses

Abstract

Infection of the upper urinary tract is relatively common and associated with potentially serious sequelae. Both uncomplicated pyelonephritis and purulent renal infections can be difficult to diagnose and require a high index of suspicion. Accurate identification of the causative organism allows the tailored use of antibiotic therapy, and careful follow-up and subsequent specimen culture help ensure adequate treatment of the infection.

Radiographic studies, primarily computed tomography, are warranted when the clinical picture is either unclear or deteriorates. Aggressive resuscitation and management may be necessary when systemic manifestation or sepsis results. The early identification of more severe complications of renal infection is crucial for prompt intervention, which is indicated by the severity of infection and size of abscess. The evolution of minimally invasive techniques of drainage for renal and perinephric abscess has reduced patient morbidity; however, inadequate drainage may result in significant morbidity and mortality and open surgical drainage and/or nephrectomy may still be required.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Patton JP, Nash DB, Abrutyn E. Urinary tract infection: economic considerations. Med Clin North Am. 1991; 75:495–513.

    PubMed  CAS  Google Scholar 

  2. Foxman B. Epidemiology of urinary tract infections: incidence, morbidity, and economic costs. Am J Med. 2002;113(Suppl 1A):5S–13.

    Article  PubMed  Google Scholar 

  3. Schaeffer A. Infections of the urinary tract. In: Walsh PC, Wein AJ, Vaughan Jr ED, Retik AB, editors. Campbell’s urology. 8th ed. Philadelphia: WB Saunders; 2002. p. 515.

    Google Scholar 

  4. Ronald A. The etiology of urinary tract infection: traditional and emerging pathogens. Am J Med. 2002; 113:14s–9.

    Article  PubMed  Google Scholar 

  5. Rubenstein JN, Schaeffer AJ. Managing complicated urinary tract infections: the urologic view. Infect Dis Clin North Am. 2003;17:333–51.

    Article  PubMed  Google Scholar 

  6. Foxman B, Brown P. Epidemiology of urinary tract infections: transmission and risk factors, incidence, and costs. Infect Dis Clin North Am. 2003;17:227–41.

    Article  PubMed  Google Scholar 

  7. Zhang L, Foxman B. Molecular epidemiology of Escherichia coli mediated urinary tract infection. Front Biosci. 2003;8:e235–44.

    Article  PubMed  CAS  Google Scholar 

  8. Marrs CF, Zhang L, Tallman P, et al. Variations in ten putative uropathogen virulence genes among urinary, fecal and periurethral Escherichia coli. J Med Microbiol. 2002;51:138–42.

    PubMed  CAS  Google Scholar 

  9. Elo J, Tallgren LG, Vaisanen V, Korhonen TK, Svenson SB, Makela PH. Association of P and other fibriae with clinical pyelonephritis in children. Scand J Urol Nephrol. 1985;19:281–4.

    Article  PubMed  CAS  Google Scholar 

  10. Latham R, Stamm W. Role of fibriated Escherichia coli in urinary tract infections in adult women: correlation with localization studies. J Infect Dis. 1984; 149:835–40.

    Article  PubMed  CAS  Google Scholar 

  11. Roberts JA, Marklund B-I, Ilver D, et al. The Gal (1–4)Gal-specific tip adhesion of Escherichia coli P-fibriae is needed for pyelonephritis to occur in the normal urinary tract. Proc Natl Acad Sci U S A. 1994;91:11889–93.

    Article  PubMed  CAS  Google Scholar 

  12. Svenson SB, Kallenius G. Density and localization of P-fibriae-specific receptors of mammalian cells: fluorescence-activated cell analysis. Infection. 1983; 1:6–12.

    Article  Google Scholar 

  13. Jacobson SH, Hylander B, Wretlind B, Brauner A. Interleukin-6 and interleukin-8 in serum and urine in patients with acute pyelonephritis in relation to bacterial-virulence-associated traits and renal function. Nephron. 1994;67:172–9.

    Article  PubMed  CAS  Google Scholar 

  14. Svanborg C, Godaly G. Bacterial virulence in urinary tract infections in adults. Infect Dis Clin North Am. 1997;11:513–29.

    Article  PubMed  CAS  Google Scholar 

  15. Roberts JA. Management of pyelonephritis and upper urinary tract infections. Urol Clin North Am. 1999; 26:753–63.

    Article  PubMed  CAS  Google Scholar 

  16. Pinson AG, Philbrick JT, Lindbeck GH, Schorling JB. ED management of acute pyelonephritis in women: a cohort study. Am J Emerg Med. 1994;12:271–8.

    Article  PubMed  CAS  Google Scholar 

  17. Safrin S, Siegal D, Black D. Pyelonephritis in adult women: inpatient versus outpatient therapy. Am J Med. 1988;85:793–8.

    Article  PubMed  CAS  Google Scholar 

  18. Nicolle LE, Friesen D, Harding GKM, Roos LL. Hospitalization for acute pyelonephritis in Manitoba, Canada, during the period from 1989 to 1992: impact of diabetes, pregnancy, and aboriginal origin. Clin Infect Dis. 1996;22:1051–6.

    Article  PubMed  CAS  Google Scholar 

  19. Foxman B, Klemstine KL, Brown PD. Acute pyelonephritis in US hospitals in 1997: hospitalization and in-hospital mortality. Ann Epidemiol. 2003;13: 144–50.

    Article  PubMed  Google Scholar 

  20. Czaja CA, Scholes D, Hooton TM, Stamm WE. Population-based epidemiologic analysis of acute pyelonephritis. Clin Infect Dis. 2007;45:280–3.

    Google Scholar 

  21. Stamm WE, Hooton TM. Management of urinary tract infections in adults. N Engl J Med. 1983;329:1328–34.

    Google Scholar 

  22. Rubin RH, Beam TR, Stamm WE. An approach to evaluating antibacterial agents in the treatment of ­urinary tract infections. Clin Infect Dis. 1992; 14:S246–51.

    Article  PubMed  Google Scholar 

  23. Stamey TA. Pathogenesis and treatment of urinary tract infections. Baltimore: Williams & Wilkins; 1980.

    Google Scholar 

  24. Fairley KF, Bond AG, Brown RB, Habersberge EB. Simple test to determine one site of urinary tract infection. Lancet. 1967;2:427–8.

    Article  PubMed  CAS  Google Scholar 

  25. Hooton TM. The current management strategies for community-acquired urinary tract infection. Infect Dis Clin North Am. 2003;17:303–32.

    Article  PubMed  Google Scholar 

  26. Gupta K, Hooton TM, Naber KG, et al. International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: a 2010 update by the Infectious Diseases Society of American and the European Society for Microbiology and Infectious Diseases. Clin Infect Dis. 2011; 52:e103–20.

    Article  PubMed  Google Scholar 

  27. Stamm WE, McKevitt M, Counts GW. Acute renal infection in women: treatment with trimethoprim-sulfamethoxazole or ampicillin for two or six weeks. A randomized trial. Ann Intern Med. 1987; 106: 341–5.

    Article  PubMed  CAS  Google Scholar 

  28. Hooton TM, Stamm WE. Diagnosis and treatment of uncomplicated urinary tract infection. Infect Dis Clin North Am. 1997;11:551–81.

    Article  PubMed  CAS  Google Scholar 

  29. Talan DA, Stamm WE, Hooton TM, et al. Comparison of ciprofloxacin (7 days) and trimethoprim-sulfamethoxazole (14 days) for acute uncomplicated pyelonephritis in women: a randomized trial. JAMA. 2000;283:1583–90.

    Article  PubMed  CAS  Google Scholar 

  30. van Nieuwkoop C, van’t Wout J, Assendelft WJJ, et al. Treatment duration of febrile urinary traction infection (FUTIRST trial): a randomized placebo-controlled multicenter trial comparing short (7 days) antibiotic treatment with conventional treatment (14 days). BMC Infect Dis. 2009;9:131.

    Article  PubMed  Google Scholar 

  31. Tolkoff-Rubin NE, Wilson ME, Zuromskis BP, Jacoby I, Martin AR, Rubin RH. Single dose amoxicillin therapy of acute uncomplicated urinary tract infections in women. Antimicrob Agents Chemother. 1984;25:626–9.

    Article  PubMed  CAS  Google Scholar 

  32. Johnson JR, Stamm WE. Diagnosis and treatment of acute urinary tract infections. Infect Dis Clin North Am. 1987;1:773.

    PubMed  CAS  Google Scholar 

  33. van Nieuwkoop C, Hoppe BPC, Bonten TN, et al. Predicting the need for radiologic imaging in adults with febrile urinary tract infection. Clin Infect Dis. 2030;51:1266–72.

    Article  Google Scholar 

  34. Peters KD, Kochanek KD, Murphy SL. Deatus: final data for 1996. Natl Vital Stat Rep. 1998;47:1–100.

    PubMed  CAS  Google Scholar 

  35. Bone R. Gram-negative sepsis: a dilemma of modern medicine. Clin Microbiol Rev. 1993;6:57–68.

    PubMed  CAS  Google Scholar 

  36. Bone R, Balk RA, Cerra FB, et al. Definition for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Chest. 1992;101: 1644–55.

    Article  PubMed  CAS  Google Scholar 

  37. Glauser MP, Heumann D, Baumgartner JD, Cohen J. Pathogenesis and potential strategies for prevention and treatment of septic shock: an update. Clin Infect Dis. 1994;18:S205–16.

    Article  PubMed  Google Scholar 

  38. Kanel KT, Kroboth FJ, Schwentker FN, Lecky JW. The intravenous pyelogram in acute pyelonephritis. Arch Intern Med. 1988;148:2144–8.

    Article  PubMed  CAS  Google Scholar 

  39. Kawashima A, LeRoy AJ. Radiologic evaluation of patients with renal infections. Infect Dis Clin North Am. 2003;17:433–56.

    Article  PubMed  Google Scholar 

  40. Chen KC, Hung SW, Seow VK, et al. The role of emergency ultrasound for evaluating acute pyelonephritis in the ED. Am J Emerg Med. 2011;29:721–4.

    Article  PubMed  Google Scholar 

  41. Dembry L-M, Andriole VT. Renal and perirenal abscesses. Infect Dis Clin North Am. 1997;11: 663–80.

    Article  PubMed  CAS  Google Scholar 

  42. Ko MC, Liu CC, Woung LC, Chen HF, Su HF, Li CY. Incidence of renal and perinephric abscess in diabetic patients: a population-based national study. Epidemiol Infect. 2011;139:229–35.

    Article  PubMed  Google Scholar 

  43. Coelho RF, Schneider-Monteiro ED, Mesquita JL, Mazzucchi E, Marmo Lucon A, Srougi M. Renal and perinephric abscesses: analysis of 65 consecutive cases. World J Surg. 2007;31:431–6.

    Article  PubMed  Google Scholar 

  44. Hoddick W, Jeffrey RB, Goldberg HI, Federle MP, Laing FC. CT and sonography of severe renal and perirenal infections. Am J Roentgenol. 1983; 140:517–20.

    Article  CAS  Google Scholar 

  45. Soulen MC, Fishman EK, Goldman SM, Gatewood OM. Bacterial renal infection: role of CT. Radiology. 1989;171:703–7.

    PubMed  CAS  Google Scholar 

  46. Hoverman IV, Gentry LO, Jones DW, Guerriero WG. Intrarenal abscess: report of 14 cases. Arch Intern Med. 1980;140:914–6.

    Article  PubMed  CAS  Google Scholar 

  47. Siegel JF, Smith A, Moldwin R. Minimally invasive treatment of renal abscess. J Urol. 1996;155:52–5.

    Article  PubMed  CAS  Google Scholar 

  48. Fowler JE, Perkins T. Presentation, diagnosis and treatment of renal abscesses: 1972–1988. J Urol. 1994;151:847–51.

    PubMed  Google Scholar 

  49. Dalla Palma L, Pozzi-Mucelli F, Ene V. Medical treatment of renal and perirenal abscesses: CT evaluation. Clin Radiol. 1999;54:792–7.

    Article  PubMed  CAS  Google Scholar 

  50. Edelstein H, McCabe RE. Perinephric abscess. Medicine. 1994;67:118–31.

    Google Scholar 

  51. Meng MV, Mario LA, McAninch JW. Current treatment and outcomes of perinephric abscesses. J Urol. 2002;168:1337–40.

    Article  PubMed  Google Scholar 

  52. Salvatierra Jr O, Bucklew WB, Morrow JW. Perinephric abscess: a report of 71 cases. J Urol. 1967; 98:296–302.

    PubMed  Google Scholar 

  53. Thorley JD, Jones SR, Sanford JP. Perinephric abscess. Medicine. 1974;53:44–451.

    Article  Google Scholar 

  54. Lee SH, Jung HJ, Mah SY, Chung BH. Renal abscesses measuring 5 cm or less: outcome of medical treatment without therapeutic drainage. Yonsei Med J. 2010; 51:569–73.

    Article  PubMed  Google Scholar 

  55. Watson RA, Esposito M, Richter F, Irwin Jr RJ, Lang EK. Percutaneous nephrostomy as adjunct management in advanced upper urinary tract infection. Urology. 1999;54:234–9.

    Article  PubMed  CAS  Google Scholar 

  56. Ahlering TE, Boyd SD, Hamilton CL, et al. Emphysematous pyelonephritis: a 5-year experience with 13 patients. J Urol. 1985;134:1086–8.

    PubMed  CAS  Google Scholar 

  57. Huang J-J, Tseng C-C. Emphysematous pyelonephritis: clinicoradiological classification, management, prognosis, and pathogenesis. Arch Intern Med. 2000;160:797–805.

    Article  PubMed  CAS  Google Scholar 

  58. Michaeli J, Mogle P, Perlberg S, Hemiman S, Caine M. Emphysematous pyelonephritis. J Urol. 1984; 131:203–8.

    PubMed  CAS  Google Scholar 

  59. Chen MT, Huang CN, Chou YH, Huang CH, Chiang CP, Liu GC. Percutaneous drainage in the treatment of emphysematous pyelonephritis: 10-year experience. J Urol. 1997;157:1569–73.

    Article  PubMed  CAS  Google Scholar 

  60. Best CD, Terris MK, Tacker JR, Reese JH. Clinical and radiological findings in patients with gas forming renal abscess treated conservatively. J Urol. 1999; 162:1273–6.

    Article  PubMed  CAS  Google Scholar 

  61. Malek RS. Xanthogranulomatous pyelonephritis: a great imitator. In: Stamey TA, editor. Journal of continuing education in urology. Northfield: Medical Digest; 1978. p. 17.

    Google Scholar 

  62. Ghosh H. Chronic pyelonephritis with xanthogranulomatous change: a report of three cases. Am J Clin Pathol. 1955;25:1043–9.

    PubMed  CAS  Google Scholar 

  63. Korkes F, Favoretto RL, Broglio M, Silva CA, Castro MG, Perez MD. Xanthogranulomatous pyelonephritis: clinical experience with 41 cases. Urology. 2008;71:178–80.

    Article  PubMed  Google Scholar 

  64. Malek RS, Elder JS. Xanthogranulomatous pyelonephritis: a critical analysis of 26 cases and of the literature. J Urol. 1978;119:589–93.

    PubMed  CAS  Google Scholar 

  65. Ballesteros JJ, Faus R, Gironella J. Preoperative diagnosis of renal xanthogranulomatosis by serial urine cytology: preliminary report. J Urol. 1980; 124:9–11.

    PubMed  CAS  Google Scholar 

  66. Goldman SM, Hartman DS, Fishman EK, Finizio JP, Gatewood OM, Siegelman SS. CT of xanthogranulomatous pyelonephritis: radiologic-pathologic correlation. Am J Roentgenol. 1984; 141:963–9.

    Article  Google Scholar 

  67. Shekarriz B, Meng MV, Lu H-F, Yamada H, Duh Q-Y, Stoller ML. Laparoscopic nephrectomy for inflammatory renal conditions. J Urol. 2001;166:2091–4.

    Article  PubMed  CAS  Google Scholar 

  68. Guzzo TJ, Bivalacqua TJ, Pierorazio PM, Varkarakis J, Schaeffer EM, Allaf ME. Xanthogranulomatous pyelonephritis: presentation and management in the era of laparoscopy. BJU Int. 2009;104:1265–8.

    Article  PubMed  Google Scholar 

Download references

Acknowledgment

All imaging studies courtesy of Drs. Benjamin Yeh and Fergus Coakley, Department of Radiology, University of California, San Francisco.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Maxwell V. Meng .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media New York

About this chapter

Cite this chapter

Meng, M.V. (2013). Infection of the Upper Urinary Tract. In: Wessells, H. (eds) Urological Emergencies. Current Clinical Urology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-423-4_8

Download citation

  • DOI: https://doi.org/10.1007/978-1-62703-423-4_8

  • Published:

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-422-7

  • Online ISBN: 978-1-62703-423-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics