Abstract
Several studies over the years have demonstrated that sleep complaints in general, and excessive daytime sleepiness (EDS), in particular, tend to be more prevalent among women. The 2007 Sleep in America poll of women age 40–60 years old found that 20% reported sleepiness that interfered with daily life (Chasens et al., Behav Sleep Med 8(3):157–71, 2010). This chapter discusses EDS due to primary sleep disorders other than Obstructive Sleep Apnea Syndrome (OSAS) and Restless Legs Syndrome (RLS) including Narcolepsy, Recurrent Hypersomnia, Idiopathic Hypersomnia, Behaviorally Induced Insufficient Sleep Syndrome as well as Hypersomnia Due to Medical condition and Hypersomnia Due to Drug or Substance. Narcolepsy is a neurological disorder characterized by the tetrad of EDS, cataplexy, sleep paralysis, and hypnagogic/hypnapompic hallucinations. Recurrent hypersomnia is characterized by recurrent episodes of hypersomnia often associated with other symptoms that typically last weeks or months apart. Episodes usually last a few days to several weeks and appear one to ten times a year. Sleep and general behavior must be normal between episodes. Kleine-Levin Syndrome (KLS) and Menstrual-related hypersomnia are two distinct clinical subtypes of recurrent hypersomnia. Idiopathic hypersomnia is characterized by constant and severe excessive sleepiness. Naps are typically unrefreshing and post-awakening confusion (sleep drunkenness) is often reported. EDS is a very prevalent problem in developed societies. Women tend to complain more of EDS than men. This prevalence may partially be due to greater sleep deprivation, hormonal factors, and the higher incidence of some primary and secondary sleep disorders in women.
Note: In the previous edition of this book, the chapter on this subject was authored by Hrayr Attarian, MD
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Chasens ER, Twerski SR, Yang K, Umlauf MG. Sleepiness and health in midlife women: results of the National Sleep Foundation’s 2007 Sleep in America poll. Behav Sleep Med. 2010;8(3):157–71.
Liu X, Uchiyama M, Kim K, etal. Sleep loss and daytime sleepiness in the general adult population of Japan. Psychiatry Res. 2000;93(1):1–11.
Doi Y, Minowa M. Gender differences in excessive daytime sleepiness among Japanese workers. Soc Sci Med. 2003;56(4):883–94.
Theorell-Haglow J, Lindberg E, Janson C. What are the important risk factors for daytime sleepiness and fatigue in women? Sleep. 2006;29(6):751–7.
Lichstein KL, Durrence HH, Riedel BW, Taylor DJ, Bush AJ. Epidemiology of sleep. Mahwah, NJ: Lawrence Erlbaum Associates; 2004.
Johns M, Hocking B. Daytime sleepiness and sleep habits of Australian workers. Sleep. 1997;20(10):844–9.
Baldwin CM, Kapur VK, Holberg CJ, Rosen C, Nieto FJ. Associations between gender and measures of daytime somnolence in the Sleep Heart Health Study. Sleep. 2004;27(2):305–11.
Beaudreau SA, Spira AP, Stewart A, etal. Validation of the Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale in older black and white women. Sleep Med. 2011;13(1):36–42.
Liu X, Sun Z, Uchiyama M, Shibui K, Kim K, Okawa M. Prevalence and correlates of sleep problems in Chinese schoolchildren. Sleep. 2000;23(8):1053–62.
Baker FC, Colrain IM. Daytime sleepiness, psychomotor performance, waking EEG spectra and evoked potentials in women with severe premenstrual syndrome. J Sleep Res. 2010;19(1 Pt 2):214–27.
Lamarche LJ, Driver HS, Wiebe S, Crawford L. JM DEK. Nocturnal sleep, daytime sleepiness, and napping among women with significant emotional/behavioral premenstrual symptoms. J Sleep Res. 2007;16(3):262–8.
Doghramji K, Mitler MM, Sangal RB, etal. A normative study of the maintenance of wakefulness test (MWT). Electroencephalogr Clin Neurophysiol. 1997;103(5):554–62.
Mitler MM, Doghramji K, Shapiro C. The maintenance of wakefulness test: normative data by age. J Psychosom Res. 2000;49(5):363–5.
American Academy of Sleep Medicine. The international classification of sleep disorders: diagnostic and coding manual. 2nd ed. Westchester, IL: American Academy of Sleep Medicine; 2005.
Rye DB, Dihenia B, Weissman JD, Epstein CM, Bliwise DL. Presentation of narcolepsy after 40. Neurology. 1998;50(2):459–65.
Wise MS. Childhood narcolepsy. Neurology. 1998;50(2 Suppl 1):S37–42.
Black JE, Brooks SN, Nishino S. Narcolepsy and syndromes of primary excessive daytime somnolence. Semin Neurol. 2004;24(3):271–82.
Wieczorek S, Gencik M, Rujescu D, etal. TNFA promoter polymorphisms and narcolepsy. Tissue Antigens. 2003;61(6):437–42.
Kato T, Honda M, Kuwata S, etal. Novel polymorphism in the promoter region of the tumor necrosis factor alpha gene: no association with narcolepsy. Am J Med Genet. 1999;88(4):301–4.
Sakurai T, Amemiya A, Ishii M, etal. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998;92(4):573–85.
Kanbayashi T, Inoue Y, Chiba S, etal. CSF hypocretin-1 (orexin-A) concentrations in narcolepsy with and without cataplexy and idiopathic hypersomnia. J Sleep Res. 2002;11(1):91–3.
Lin L, Faraco J, Li R, etal. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell. 1999;98(3):365–76.
Chemelli RM, Willie JT, Sinton CM, etal. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell. 1999;98(4):437–51.
Thannickal TC, Moore RY, Nienhuis R, etal. Reduced number of hypocretin neurons in human narcolepsy. Neuron. 2000;27(3):469–74.
Nishino S, Ripley B, Overeem S, Lammers GJ, Mignot E. Hypocretin (orexin) deficiency in human narcolepsy. Lancet. 2000;355(9197):39–40.
Khatami R, Maret S, Werth E, etal. Monozygotic twins concordant for narcolepsy-cataplexy without any detectable abnormality in the hypocretin (orexin) pathway. Lancet. 2004;363(9416):1199–200.
Thannickal TC, Nienhuis R, Siegel JM. Localized loss of hypocretin (orexin) cells in narcolepsy without cataplexy. Sleep. 2009;32(8):993–8.
Scammell TE. The frustrating and mostly fruitless search for an autoimmune cause of narcolepsy. Sleep. 2006;29(5):601–2.
Tanaka S, Honda Y, Inoue Y, Honda M. Detection of autoantibodies against hypocretin, hcrtrl, and hcrtr2 in narcolepsy: anti-Hcrt system antibody in narcolepsy. Sleep. 2006;29(5):633–8.
Aran A, Lin L, Nevsimalova S, etal. Elevated anti-streptococcal antibodies in patients with recent narcolepsy onset. Sleep. 2009;32(8):979–83.
Morgenthaler TI, Kapur VK, Brown T, etal. Practice parameters for the treatment of narcolepsy and other hypersomnias of central origin. Sleep. 2007;30(12):1705–11.
Thorpy MJ, Schwartz JR, Kovacevic-Ristanovic R, Hayduk R. Initiating treatment with modafinil for control of excessive daytime sleepiness in patients switching from methylphenidate: an open-label safety study assessing three strategies. Psychopharmacology (Berl). 2003;167(4):380–5.
Littner M, Johnson SF, McCall WV, etal. Practice parameters for the treatment of narcolepsy: an update for 2000. Sleep. 2001;24(4):451–66.
Akaoka H, Roussel B, Lin JS, Chouvet G, Jouvet M. Effect of modafinil and amphetamine on the rat catecholaminergic neuron activity. Neurosci Lett. 1991;123(1):20–2.
Ferraro L, Antonelli T, O’Connor WT, Tanganelli S, Rambert FA, Fuxe K. Modafinil: an antinarcoleptic drug with a different neurochemical profile to d-amphetamine and dopamine uptake blockers. Biol Psychiatry. 1997;42(12):1181–3.
Engber TM, Koury EJ, Dennis SA, Miller MS, Contreras PC, Bhat RV. Differential patterns of regional c-Fos induction in the rat brain by amphetamine and the novel wakefulness-promoting agent modafinil. Neurosci Lett. 1998;241(2–3):95–8.
Lin JS, Hou Y, Jouvet M. Potential brain neuronal targets for amphetamine-, methylphenidate-, and modafinil-induced wakefulness, evidenced by c-fos immunocytochemistry in the cat. Proc Natl Acad Sci U S A. 1996;93(24):14128–33.
Scammell TE, Estabrooke IV, McCarthy MT, etal. Hypothalamic arousal regions are activated during modafinil-induced wakefulness. J Neurosci. 2000;20(22):8620–8.
Schwartz JR, Feldman NT, Bogan RK. Dose effects of modafinil in sustaining wakefulness in narcolepsy patients with residual evening sleepiness. J Neuropsychiatry Clin Neurosci. 2005;17(3):405–12.
Scrima L, Hartman PG, Johnson Jr FH, Thomas EE, Hiller FC. The effects of gamma-hydroxybutyrate on the sleep of narcolepsy patients: a double-blind study. Sleep. 1990;13(6):479–90.
Dhuria SV, Hanson LR, Frey 2nd WH. Intranasal drug targeting of hypocretin-1 (orexin-A) to the central nervous system. J Pharm Sci. 2009;98(7):2501–15.
Hallschmid M, Born J. Revealing the potential of intranasally administered orexin A (hypocretin-1). Mol Interv. 2008;8(3):133–7.
U.S. Xyrem Multicenter Study Group. Sodium oxybate demonstrates long-term efficacy for the treatment of cataplexy in patients with narcolepsy. Sleep Med. 2004;5(2):119–23.
Katz JD, Ropper AH. Familial Kleine-Levin syndrome: two siblings with unusually long hypersomnic spells. Arch Neurol. 2002;59(12):1959–61.
Janicki S, Franco K, Zarko R. A case report of Kleine-Levin syndrome in an adolescent girl. Psychosomatics. 2001;42(4):350–2.
Dauvilliers Y, Mayer G, Lecendreux M, etal. Kleine-Levin syndrome: an autoimmune hypothesis based on clinical and genetic analyses. Neurology. 2002;59(11):1739–45.
BaHammam AS, GadElRab MO, Owais SM, Alswat K, Hamam KD. Clinical characteristics and HLA typing of a family with Kleine-Levin syndrome. Sleep Med. 2008;9(5):575–8.
Billiard M, Guilleminault C, Dement WC. A menstruation-linked periodic hypersomnia. Kleine-Levin syndrome or new clinical entity? Neurology. 1975;25(5):436–43.
Papy JJ, Conte-Devolx B, Sormani J, Porto R, Guillaume V. The periodic hypersomnia and megaphagia syndrome in a young female, correlated with menstrual cycle (author’s transl). Rev Electroencephalogr Neurophysiol Clin. 1982;12(1):54–61.
Sachs C, Persson HE, Hagenfeldt K. Menstruation-related periodic hypersomnia: a case study with successful treatment. Neurology. 1982;32(12):1376–9.
Bamford CR. Menstrual-associated sleep disorder: an unusual hypersomniac variant associated with both menstruation and amenorrhea with a possible link to prolactin and metoclopramide. Sleep. 1993;16(5):484–6.
Manber R, Bootzin RR. Sleep and the menstrual cycle. Health Psychol. 1997;16(3):209–14.
Rocamora R, Gil-Nagel A, Franch O, Vela-Bueno A. Familial recurrent hypersomnia: two siblings with Kleine-Levin syndrome and menstrual-related hypersomnia. J Child Neurol. 2010;25(11):1408–10.
Huang YS, Guilleminault C, Kao PF, Liu FY. SPECT findings in the Kleine-Levin syndrome. Sleep. 2005;28(8):955–60.
Hong SB, Joo EY, Tae WS, Lee J, Han SJ, Lee HW. Episodic diencephalic hypoperfusion in Kleine-Levin syndrome. Sleep. 2006;29(8):1091–3.
Poryazova R, Schnepf B, Boesiger P, Bassetti CL. Magnetic resonance spectroscopy in a patient with Kleine-Levin syndrome. J Neurol. 2007;254(10):1445–6.
Rosenow F, Kotagal P, Cohen BH, Green C, Wyllie E. Multiple sleep latency test and polysomnography in diagnosing Kleine-Levin syndrome and periodic hypersomnia. J Clin Neurophysiol. 2000;17(5):519–22.
Huang YS, Lakkis C, Guilleminault C. Kleine-Levin syndrome: current status. Med Clin North Am. 2010;94(3):557–62.
Poppe M, Friebel D, Reuner U, Todt H, Koch R, Heubner G. The Kleine-Levin syndrome—effects of treatment with lithium. Neuropediatrics. 2003;34(3):113–9.
Billiard M. Idiopathic hypersomnia. Neurol Clin. 1996;14(3):573–82.
Billiard M, Dauvilliers Y. Idiopathic hypersomnia. Sleep Med Rev. 2001;5(5):349–58.
Dauvilliers Y, Baumann CR, Carlander B, etal. CSF hypocretin-1 levels in narcolepsy, Kleine-Levin syndrome, and other hypersomnias and neurological conditions. J Neurol Neurosurg Psychiatry. 2003;74(12):1667–73.
Bassetti C, Gugger M, Bischof M, etal. The narcoleptic borderland: a multimodal diagnostic approach including cerebrospinal fluid levels of hypocretin-1 (orexin A). Sleep Med. 2003;4(1):7–12.
Bastuji H, Jouvet M. Successful treatment of idiopathic hypersomnia and narcolepsy with modafinil. Prog Neuropsychopharmacol Biol Psychiatry. 1988;12(5):695–700.
Khan AA, Gardner CO, Prescott CA, Kendler KS. Gender differences in the symptoms of major depression in opposite-sex dizygotic twin pairs. Am J Psychiatry. 2002;159(8):1427–9.
Sadock BJ, Sadock VA. Mood disorders. In: Sadock BJ, Sadock VA, editors. Kaplan and Sadock’s synopsis of psychiatry: behavioral sciences/clinical psychiatry. 9th ed. Philadelphia: Lippincott Williams & Wilkins; 2002. p. 534–72.
Vgontzas AN, Bixler EO, Kales A, Criley C, Vela-Bueno A. Differences in nocturnal and daytime sleep between primary and psychiatric hypersomnia: diagnostic and treatment implications. Psychosom Med. 2000;62(2):220–6.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer Science+Business Media New York
About this chapter
Cite this chapter
Undevia, N.S. (2013). Women and Excessive Daytime Sleepiness. In: Attarian, H., Viola-Saltzman, M. (eds) Sleep Disorders in Women. Current Clinical Neurology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-324-4_12
Download citation
DOI: https://doi.org/10.1007/978-1-62703-324-4_12
Published:
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-62703-323-7
Online ISBN: 978-1-62703-324-4
eBook Packages: MedicineMedicine (R0)