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The Biology of Mesenchymal Stem Cells in Health and Disease and Its Relevance to MSC-Based Cell Delivery Therapies

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Mesenchymal Stem Cell Therapy

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Mesenchymal stromal cells (MSCs) are dynamic cells that orchestrate tissue morphogenesis during development, support haematopoiesis throughout life, and are key mediators of tissue repair and disease resolution. In certain disease states, however, MSCs mediate tissue disrepair and disease exacerbation. Herein we describe the salient features of MSCs, and highlight the need for a deep understanding of the molecular mechanisms that underpin the biological function of these cells, in order to develop safe and effective MSC-based therapies for acute and chronic disorders that are currently untreatable.

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Authors and Affiliations

  1. Stem Cell Biology, Regenerative Medicine and Novel Cancer Therapies Laboratory, Mater Medical Research Institute, Mater Health Services, South Brisbane, QLD, Australia

    Catherine M. Browne, Tung-Liang Chung & Kerry Atkinson

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  1. Catherine M. Browne
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  2. Tung-Liang Chung
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  3. Kerry Atkinson
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Correspondence to Catherine M. Browne .

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    Lucas G. Chase

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    Mohan C. Vemuri

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Browne, C.M., Chung, TL., Atkinson, K. (2013). The Biology of Mesenchymal Stem Cells in Health and Disease and Its Relevance to MSC-Based Cell Delivery Therapies. In: Chase, L., Vemuri, M. (eds) Mesenchymal Stem Cell Therapy. Stem Cell Biology and Regenerative Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-200-1_4

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