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Mesenchymal Stem Cell Therapy pp 241–270Cite as

Mesenchymal Stem Cell Therapy for Heart Disease

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Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

Mesenchymal stem cells (MSC) are adult stem cells with capacity for self-renewal and multi-lineage differentiation. Initially described in bone marrow, MSC are also present in other organs and tissues. From a therapeutic perspective, facilitated by the ease of preparation and immunologic privilege, MSC are emerging as an extremely promising therapeutic agent for tissue regeneration and repair. Studies in animal models of myocardial infarction have demonstrated the ability of transplanted MSC to engraft and differentiate into cardiomyocytes and vasculature cells. Most importantly, engrafted MSC secrete a wide array of soluble factors that mediate beneficial paracrine effects and greatly contribute to cardiac repair. Together, these properties can be harnessed to both prevent and reverse remodeling in the ischemically injured ventricle. In proof-of-concept and phase I clinical trials, MSC therapy improved left ventricular function, induced reverse remodeling, and decreased scar size. This chapter reviews the current understanding of MSC biology and mechanism of action in cardiac repair of MSC therapy for cardiac disease.

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Acknowledgments

Massimiliano Gnecchi is supported by the Ministero Italiano della Sanità (GR-2008-1142871 and RF-IAI-2008-1216776), the Ministero italiano degli Affari Esteri and the Fondazione Cariplo (2007–5984).

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Authors and Affiliations

  1. Department of Molecular Medicine, University of Pavia, Pavia, Italy

    Massimiliano Gnecchi

  2. Cardiothoracic and Vascular Department, Laboratory of Experimental Cardiology for Cell and Molecular Therapy, Fondazione I.R.C.C.S. Policlinico San Matteo, Pavia, Italy

    Massimiliano Gnecchi & Elisabetta Cervio

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  1. Massimiliano Gnecchi
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  2. Elisabetta Cervio
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Correspondence to Massimiliano Gnecchi .

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  1. Cellular Dynamics International, Inc., Science Drive 525, Madison, 53711, Wisconsin, USA

    Lucas G. Chase

  2. , Stem Cells and Regenerative Medicine, Life Technologies, Executive Way 7335, Frederick, 21704, Maryland, USA

    Mohan C. Vemuri

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Gnecchi, M., Cervio, E. (2013). Mesenchymal Stem Cell Therapy for Heart Disease. In: Chase, L., Vemuri, M. (eds) Mesenchymal Stem Cell Therapy. Stem Cell Biology and Regenerative Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-200-1_13

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