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T-Cell Lymphomas pp 113–135Cite as

HTLV-1-Associated T-cell Diseases

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Part of the book series: Contemporary Hematology ((CH))

Abstract

Adult T-cell leukemia-lymphoma (ATL) is a distinct peripheral T-lymphocytic malignancy etiologically associated with human T-cell lymphotropic virus type I. The diversity in clinical features and prognosis of patients with this disease has led to its subtype classification into four categories, acute, lymphoma, chronic, and smoldering types. The chronic or smoldering subtypes are considered indolent and are usually managed with watchful-waiting until disease progression. Patients with acute or lymphoma subtypes generally have a very poor prognosis due to multidrug-resistance of ATL cells, a large tumor burden with multi-organ failure, hypercalcemia, and/or frequent infectious complications due to a profound T-cell immunodeficiency. A treatment strategy based on the clinical subtypes, prognostic factors, and response to initial therapy is suggested including watchful-waiting approach, intensive chemotherapy, interferon-α zidobudine therapy, allogeneic hematopoietic stem cell transplantation, and targeted-therapies. Several new agent-trials for ATL are ongoing and in preparation, including a defucosylated humanized anti-CC chemokine receptor 4 monoclonal antibody, IL2-fused with diphtheria toxin, histone deacetylase inhibitors, a purine nucleoside phosphorylase inhibitor, a proteasome inhibitor, and lenalidomide.

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References

  1. Uchiyama T, Yodoi J, Sagawa K, et al. Adult T-cell leukemia: clinical and hematologic features of 16 cases. Blood. 1977;50:481–92.

    PubMed  CAS  Google Scholar 

  2. Poiesz BJ, Ruscetti FW, Gazdar AF, et al. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci USA. 1980;77:7415–9.

    Article  PubMed  CAS  Google Scholar 

  3. Hinuma Y, Nagata K, Hanaoka M, Nakai M, Matsumoto T, Kinoshita KI, et al. Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera. Proc Natl Acad Sci USA. 1981;78(10):6476–80.

    Article  PubMed  CAS  Google Scholar 

  4. Miyoshi I, Kubonishi I, Yoshimoto S, Akagi T, Ohtsuki Y, Shiraishi Y, et al. Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells. Nature. 1981;294(5843):770–1.

    Article  PubMed  CAS  Google Scholar 

  5. Yoshida M, Miyoshi I, Hinuma Y. Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease. Proc Natl Acad Sci USA. 1982;79:2031–5.

    Article  PubMed  CAS  Google Scholar 

  6. Gessain A, Barin F, Vernant JC, Gout O, Maurs L, Calender A, et al. Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet. 1985;2(8452):407–10.

    Article  PubMed  CAS  Google Scholar 

  7. Osame M, Usuku K, Izumo S, Ijichi N, Amitani H, Igata A, et al. HTLV-I associated myelopathy, a new clinical entity. Lancet. 1986;1(8488):1031–2.

    Article  PubMed  CAS  Google Scholar 

  8. LaGrenade L, Hanchard B, Fletcher V, Cranston B, Blattner W. Infective dermatitis of Jamaican children: a marker for HTLV-I infection. Lancet. 1990;336(8727):1345–7.

    Article  PubMed  CAS  Google Scholar 

  9. Mochizuki M, Watanabe T, Yamaguchi K, Takatsuki K, Yoshimura K, Shirao M, et al. HTLV-I uveitis: a distinct clinical entity caused by HTLV-I. Jpn J Cancer Res. 1992;83(3):236–9.

    Article  PubMed  CAS  Google Scholar 

  10. Terada K, Katamine S, Eguchi K, Moriuchi R, Kita M, Shimada H, et al. Prevalence of serum and salivary antibodies to HTLV-1 in Sjögren’s syndrome. Lancet. 1994;344(8930):1116–9.

    Article  PubMed  CAS  Google Scholar 

  11. Takatsuki K. Adult T-cell Leukemia. Oxford: Oxford University Press, New York; 1994.

    Google Scholar 

  12. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans: Human immunodeficiency viruses and human T-cell lymphotropic viruses. IARC monographs on the evaluation of carcinogenic risks to humans, Geneva: IARCPress 1996

    Google Scholar 

  13. Ohshima K, Jaffe ES, Kikuchi M. Adult T-cell leukemia/lymphoma. In: Swerdlow SH, Campo E, Harris NL, et al., editors. WHO classification of tumour of haemaopoietic and lymphoid tissues. 4th ed. Lyon: IARC Press; 2008. p. 281–4.

    Google Scholar 

  14. Shimoyama M. Diagnostic criteria and classification of clinical subtypes of adult T- cell leukaemia-lymphoma: a report from the lymphoma study group (1984–87). Br J Haematol. 1991;79:428–37.

    Article  PubMed  CAS  Google Scholar 

  15. Matsuoka M, Jeang KT. Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation. Nat Rev Cancer. 2007;7(4):270–80.

    Article  PubMed  CAS  Google Scholar 

  16. Satou Y, Matsuoka M. HTLV-1 and the host immune system: how the virus disrupts immune regulation, leading to HTLV-1 associated diseases. J Clin Exp Hematop. 2010;50(1):1–8.

    Article  PubMed  Google Scholar 

  17. Seiki M, Hattori S, Hirayama Y, Yoshida M. Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA. Proc Natl Acad Sci USA. 1983;80(12):3618–22.

    Article  PubMed  CAS  Google Scholar 

  18. Sodroski JG, Goh WC, Rosen CA, Salahuddin SZ, Aldovini A, Franchini G, et al. trans-Activation of the human T-cell leukemia virus long terminal repeat correlates with expression of the x-lor protein. J Virol. 1985;55(3):831–5.

    PubMed  CAS  Google Scholar 

  19. Kiyokawa T, Seiki M, Iwashita S, Imagawa K, Shimizu F, Yoshida M. p27x-III and p21x-III, proteins encoded by the pX sequence of human T-cell leukemia virus type I. Proc Natl Acad Sci USA. 1985;82(24):8359–63.

    Article  PubMed  CAS  Google Scholar 

  20. Gaudray G, Gachon F, Basbous J, et al. The complementary strand of the human T-cell leukemia virus type 1 RNA genome encodes a bZIP transcription factor that down-regulates viral transcription. J Virol. 2002;76:12813.

    Article  PubMed  CAS  Google Scholar 

  21. Satou Y, Yasunaga J, Yoshida M, et al. HTLV-I basic leucine zipper factor gene mRNA supports proliferation of adult T cell leukemia cells. Proc Natl Acad Sci USA. 2006;103:720.

    Article  PubMed  CAS  Google Scholar 

  22. Murata K, Hayashibara T, Sugahara K, Uemura A, Yamaguchi T, Harasawa H, et al. A novel alternative splicing isoform of human T-cell leukemia virus type 1 bZIP factor (HBZ-SI) targets distinct subnuclear localization. J Virol. 2006;80(5):2495–505.

    Article  PubMed  CAS  Google Scholar 

  23. Kline RL, Brothers T, Halsey N, Boulos R, Lairmore MD, Quinn TC. Evaluation of enzyme immunoassays for antibody to human T-lymphotropic viruses type I/II. Lancet. 1991;337(8732):30–3.

    Article  PubMed  CAS  Google Scholar 

  24. Ikeda M, Fujino R, Matsui T, Yoshida T, Komoda H, Imai J. A new agglutination test for serum antibodies to adult T-cell leukemia virus. Gann. 1984;75(10):845–8.

    PubMed  CAS  Google Scholar 

  25. Aoki T, Miyakoshi H, Koide H, Yoshida T, Ishikawa H, Sugisaki Y, et al. Seroepidemiology of human T-lymphotropic retrovirus type I (HTLV-I) in residents of Niigata Prefecture, Japan. Comparative studies by indirect immunofluorescence microscopy and enzyme-linked immunosorbent assay. Int J Cancer. 1985;35(3):301–6.

    Article  PubMed  CAS  Google Scholar 

  26. Aboulafia DM, Feigal E, Vranzian K, Bennett C, Blattner W, Moss A, et al. Human T cell leukemia virus (HTLV-I/II) serodiagnostic testing: disparate results among a cohort of intravenous drug users. AIDS Res Hum Retroviruses. 1993;9(10):1043–50.

    Article  PubMed  CAS  Google Scholar 

  27. Acquired immunodeficiency syndrome (AIDS). Proposed WHO criteria for interpreting results from western blot assays for HIV-1, HIV-2, and HTLV-I/HTLV-II. Wkly Epidemiol Rec. 1990 Sep 14;65(37):281–3.

    Google Scholar 

  28. Franchini G, Wong-Staal F, Gallo RC. Human T-cell leukemia virus (HTLV-I) transcripts in fresh and cultured cells of patients with adult T-cell leukemia. Proc Natl Acad Sci USA. 1984;81:6207.

    Article  PubMed  CAS  Google Scholar 

  29. Kinoshita T, Shimoyama M, Tobinai K, Ito M, Ito S, Ikeda S, et al. Detection of mRNA for the tax1/rex1 gene of human T-cell leukemia virus type I in fresh peripheral blood mononuclear cells of adult T-cell leukemia patients and viral carriers by using the polymerase chain reaction. Proc Natl Acad Sci USA. 1989;86(14):5620–4.

    Article  PubMed  CAS  Google Scholar 

  30. Yoshida M, Seiki M, Yamaguchi K, Takatsuki K. Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease. Proc Natl Acad Sci USA. 1984;81(8):2534–7.

    Article  PubMed  CAS  Google Scholar 

  31. Takemoto S, Matsuoka M, Yamaguchi K, Takatsuki K. A novel diagnostic method of adult T-cell leukemia: monoclonal integration of human T-cell lymphotropic virus type I provirus DNA detected by inverse polymerase chain reaction. Blood. 1994;84(9):3080–5.

    PubMed  CAS  Google Scholar 

  32. Wattel E, Vartanian JP, Pannetier C, Wain-Hobson S. Clonal expansion of human T-cell leukemia virus type I-infected cells in asymptomatic and symptomatic carriers without malignancy. J Virol. 1995;69(5):2863–8.

    PubMed  CAS  Google Scholar 

  33. Yamaguchi K, Seiki M, Yoshida M, Nishimura H, Kawano F, Takatsuki K. The detection of human T cell leukemia virus proviral DNA and its application for classification and diagnosis of T cell malignancy. Blood. 1984;63(5):1235–40.

    PubMed  CAS  Google Scholar 

  34. Tamiya S, Matsuoka M, Etoh K, Watanabe T, Kamihira S, Yamaguchi K, et al. Two types of defective human T-lymphotropic virus type I provirus in adult T-cell leukemia. Blood. 1996;88(8):3065–73.

    PubMed  CAS  Google Scholar 

  35. Tsukasaki K, Tsushima H, Yamamura M, et al. Integration patterns of HTLV-I provirus in relation to the clinical course of ATL: frequent clonal change at crisis from indolent disease. Blood. 1997;89:948–56.

    PubMed  CAS  Google Scholar 

  36. Furukawa Y, Fujisawa J, Osame M, Toita M, Sonoda S, Kubota R, et al. Frequent clonal proliferation of human T-cell leukemia virus type 1 (HTLV-1)-infected T cells in HTLV-1-associated myelopathy (HAM-TSP). Blood. 1992;80(4):1012–6.

    PubMed  CAS  Google Scholar 

  37. Ikeda S, Momita S, Kinoshita K, Kamihira S, Moriuchi Y, Tsukasaki K, et al. Clinical course of human T-lymphotropic virus type I carriers with molecularly detectable monoclonal proliferation of T lymphocytes: defining a low- and high-risk population. Blood. 1993;82(7):2017–24.

    PubMed  CAS  Google Scholar 

  38. Takahashi K, Takezaki T, Oki T, Kawakami K, Yashiki S, Fujiyoshi T, et al. Inhibitory effect of maternal antibody on mother-to-child transmission of human T-lymphotropic virus type I. The Mother-to-Child Transmission Study Group. Int J Cancer. 1991;49(5):673–7.

    Article  PubMed  CAS  Google Scholar 

  39. Kinoshita K, Hino S, Amagaski T, Ikeda S, Yamada Y, Suzuyama J, et al. Demonstration of adult T-cell leukemia virus antigen in milk from three sero-positive mothers. Gann. 1984;75(2):103–5.

    PubMed  CAS  Google Scholar 

  40. Hino S, Katamine S, Miyata H, Tsuji Y, Yamabe T, Miyamoto T. Primary prevention of HTLV-1 in Japan. Leukemia. 1997;11 Suppl 3:57–9.

    PubMed  Google Scholar 

  41. Tajima K, Tominaga S, Suchi T, Kawagoe T, Komoda H, Hinuma Y, et al. Epidemiological analysis of the distribution of antibody to adult T-cell leukemia-virus-associated antigen: possible horizontal transmission of adult T-cell leukemia virus. Gann. 1982;73(6):893–901.

    PubMed  CAS  Google Scholar 

  42. Okochi K, Sato H, Hinuma Y. A retrospective study on transmission of adult T cell leukemia virus by blood transfusion: seroconversion in recipients. Vox Sang. 1984;46(5):245–53.

    Article  PubMed  CAS  Google Scholar 

  43. Schwebke J, Calsyn D, Shriver K, Saxon A, Kleyn J, Oluoch-Mitchell E, et al. Prevalence and epidemiologic correlates of human T cell lymphotropic virus infection among intravenous drug users. J Infect Dis. 1994;169(5):962–7.

    Article  PubMed  CAS  Google Scholar 

  44. Schaffar-Deshayes L, Chavance M, Monplaisir N, Courouce AM, Gessain A, Blesonski S, et al. Antibodies to HTLV-I p24 in sera of blood donors, elderly people and patients with hemopoietic diseases in France and in French West Indies. Int J Cancer. 1984;34(5):667–70.

    Article  PubMed  CAS  Google Scholar 

  45. Hunsmann G, Bayer H, Schneider J, Schmitz H, Kern P, Dietrich M, et al. Antibodies to ATLV/HTLV-1 in Africa. Med Microbiol Immunol. 1984;173(3):167–70.

    Article  PubMed  CAS  Google Scholar 

  46. Ohtsu T, Tsugane S, Tobinai K, Shimoyama M, Nanri S, Watanabe S. Prevalence of antibodies to human T-cell leukemia/lymphoma virus type I and human immunodeficiency virus in Japanese immigrant colonies in Bolivia and Bolivian natives. Jpn J Cancer Res. 1987;78(12):1347–53.

    PubMed  CAS  Google Scholar 

  47. Achiron A, Pinhas-Hamiel O, Doll L, Djaldetti R, Chen A, Ziv I, et al. Spastic paraparesis associated with human T-lymphotropic virus type I: a clinical, serological, and genomic study in Iranian-born Mashhadi Jews. Ann Neurol. 1993;34(5):670–5.

    Article  PubMed  CAS  Google Scholar 

  48. Yanagihara R, Jenkins CL, Alexander SS, Mora CA, Garruto RM. Human T lymphotropic virus type I infection in Papua New Guinea: high prevalence among the Hagahai confirmed by western analysis. J Infect Dis. 1990;162(3):649–54.

    Article  PubMed  CAS  Google Scholar 

  49. Cruickshank JK, Rudge P, Dalgleish AG, Newton M, McLean BN, Barnard RO, et al. Tropical spastic paraparesis and human T cell lymphotropic virus type 1 in the United Kingdom. Brain. 1989;112(Pt 4):1057–90.

    Article  PubMed  Google Scholar 

  50. Tajima K, Kamura S, Ito S, Ito M, Nagatomo M, Kinoshita K, et al. Epidemiological features of HTLV-I carriers and incidence of ATL in an ATL-endemic island: a report of the community-based co-operative study in Tsushima, Japan. Int J Cancer. 1987;40(6):741–6.

    Article  PubMed  CAS  Google Scholar 

  51. Mueller N, Okayama A, Stuver S, Tachibana N. Findings from the Miyazaki Cohort Study. J Acquir Immune Defic Syndr Hum Retrovirol. 1996;13 Suppl 1:S2–7.

    Article  PubMed  Google Scholar 

  52. Iwanaga M, Chiyoda S, Kusaba E, Kamihira S. Trends in the seroprevalence of HTLV-1 in Japanese blood donors in Nagasaki Prefecture, 2000–2006. Int J Hematol. 2009;90(2):186–90.

    Article  PubMed  Google Scholar 

  53. Morgan OS, Rodgers-Johnson P, Mora C, Char G. HTLV-1 and polymyositis in Jamaica. Lancet. 1989;2(8673):1184–7.

    Article  PubMed  CAS  Google Scholar 

  54. Sugimoto M, Nakashima H, Watanabe S, Uyama E, Tanaka F, Ando M, et al. T-lymphocyte alveolitis in HTLV-I-associated myelopathy. Lancet. 1987;2(8569):1220.

    Article  PubMed  CAS  Google Scholar 

  55. Nishioka K, Maruyama I, Sato K, Kitajima I, Nakajima Y, Osame M. Chronic inflammatory arthropathy associated with HTLV-I. Lancet. 1989;1(8635):441.

    Article  PubMed  CAS  Google Scholar 

  56. Tachibana N, Okayama A, Ishizaki J, Yokota T, Shishime E, Murai K, et al. Suppression of tuberculin skin reaction in healthy HTLV-I carriers from Japan. Int J Cancer. 1988;42(6):829–31.

    Article  PubMed  CAS  Google Scholar 

  57. Tsukasaki K, Hermine O, Bazarbachi A, et al. Definition, prognostic factors, treatment, and response criteria of adult T-cell leukemia-lymphoma: a proposal from an international consensus meeting. J Clin Oncol. 2009;27:453–9.

    Article  PubMed  Google Scholar 

  58. Major prognostic factors of patients with adult T-cell leukemia- lymphoma: a cooperative study. Lymphoma Study Group (1984–1987): Leuk Res 1991;15:81–90.

    Google Scholar 

  59. Yamada Y, Hatta Y, Murata K, et al. Deletions of p15 and/or p16 genes as a poor-prognosis factor in adult T-cell leukemia. J Clin Oncol. 1997;15:1778–85.

    PubMed  CAS  Google Scholar 

  60. Utsunomiya A, Ishida T, Inagaki A, et al. Clinical significance of a blood eosinophilia in adult T-cell leukemia/lymphoma: a blood eosinophilia is a significant unfavorable prognostic factor. Leuk Res. 2007;31:915–20.

    Article  PubMed  CAS  Google Scholar 

  61. Takasaki Y, Iwanaga M, Tsukasaki K, et al. Impact of visceral involvements and blood cell count abnormalities on survival in adult T-cell leukemia/lymphoma (ATLL). Leuk Res. 2007;31:751–7.

    Article  PubMed  Google Scholar 

  62. Inagaki A, Ishida T, Ishii T, et al. Clinical significance of serum Th1-, Th2- and regulatory T cells-associated cytokines in adult T-cell leukemia/lymphoma: high interleukin-5 and −10 levels are significant unfavorable prognostic factors. Int J Cancer. 2006;118:3054–61.

    Article  PubMed  CAS  Google Scholar 

  63. Ishida T, Utsunomiya A, Iida S, et al. Clinical significance of CCR4 expression in adult T-cell leukemia/lymphoma: its close association with skin involvement and unfavorable outcome. Clin Cancer Res. 2003;9:3625–34.

    PubMed  CAS  Google Scholar 

  64. Ohno N, Tani A, Uozumi K, et al. Expression of functional lung resistance–related protein predicts poor outcome in adult T-cell leukemia. Blood. 2001;98:1160–5.

    Article  PubMed  CAS  Google Scholar 

  65. Tawara M, Hogerzeil SJ, Yamada Y, et al. Impact of p53 aberration on the progression of Adult T-cell Leukemia/Lymphoma. Cancer Lett. 2006;234:249–55.

    Article  PubMed  CAS  Google Scholar 

  66. Bittencourt AL, da Graças Vieira M, et al. Adult T-cell leukemia/lymphoma in Bahia, Brazil: analysis of prognostic factors in a group of 70 patients. Am J Clin Pathol. 2007;128:875–82.

    Article  PubMed  Google Scholar 

  67. Statistical analyses of clinico-pathological, virological and epidemiological data on lymphoid malignancies with special reference to adult T-cell leukemia/lymphoma: a report of the second nationwide study of Japan. The T- and B-Cell Malignancy Study Group. Jpn J Clin Oncol. 1985 Sep;15(3):517–35.

    Google Scholar 

  68. Bartholomew C, Charles W, Saxinger C, Blattner W, Robert-Guroff M, Raju C, et al. Racial and other characteristics of human T cell leukemia/lymphoma (HTLV-I) and AIDS (HTLV-III) in Trinidad. Br Med J (Clin Res Ed). 1985;290(6477):1243–6.

    Article  CAS  Google Scholar 

  69. Gérard Y, Lepere JF, Pradinaud R, Joly F, Lepelletier L, Joubert M, et al. Clustering and clinical diversity of adult T-cell leukemia/lymphoma associated with HTLV-I in a remote black population of French Guiana. Int J Cancer. 1995;60(6):773–6.

    Article  PubMed  Google Scholar 

  70. Tajima K, Kuroishi T. Estimation of rate of incidence of ATL among ATLV (HTLV-I) carriers in Kyushu, Japan. Jpn J Clin Oncol. 1985;15(2):423–30.

    PubMed  CAS  Google Scholar 

  71. Kondo T, Kono H, Nonaka H, Miyamoto N, Yoshida R, Bando F, et al. Risk of adult T-cell leukaemia/lymphoma in HTLV-I carriers. Lancet. 1987;2(8551):159.

    Article  PubMed  CAS  Google Scholar 

  72. Murphy EL, Hanchard B, Figueroa JP, Gibbs WN, Lofters WS, Campbell M, et al. Modelling the risk of adult T-cell leukemia/lymphoma in persons infected with human T-lymphotropic virus type I. Int J Cancer. 1989;43(2):250–3.

    Article  PubMed  CAS  Google Scholar 

  73. Wilks R, Hanchard B, Morgan O, Williams E, Cranston B, Smith ML, et al. Patterns of HTLV-I infection among family members of patients with adult T-cell leukemia/lymphoma and HTLV-I associated myelopathy/tropical spastic paraparesis. Int J Cancer. 1996;65(2):272–3.

    Article  PubMed  CAS  Google Scholar 

  74. Osame M, Janssen R, Kubota H, Nishitani H, Igata A, Nagataki S, et al. Nationwide survey of HTLV-I-associated myelopathy in Japan: association with blood transfusion. Ann Neurol. 1990;28(1):50–6.

    Article  PubMed  CAS  Google Scholar 

  75. Chen YC, Wang CH, Su IJ, Hu CY, Chou MJ, Lee TH, et al. Infection of human T-cell leukemia virus type I and development of human T-cell leukemia lymphoma in patients with hematologic neoplasms: a possible linkage to blood transfusion. Blood. 1989;74(1):388–94.

    PubMed  CAS  Google Scholar 

  76. Kanno M, Nakamura S, Matsuda T. Adult T-cell leukemia with HTLV-I-associated myelopathy after complete remission of acute myelogenous leukemia. N Engl J Med. 1998;338(5):333.

    Article  PubMed  CAS  Google Scholar 

  77. Kondo T, Kono H, Miyamoto N, Yoshida R, Toki H, Matsumoto I, et al. Age- and sex-specific cumulative rate and risk of ATLL for HTLV-I carriers. Int J Cancer. 1989;43(6):1061–4.

    Article  PubMed  CAS  Google Scholar 

  78. Kawano F, Tsuda H, Yamaguchi K, Nishimura H, Sanada I, Matsuzaki H, et al. Unusual clinical courses of adult T-cell leukemia in siblings. Cancer. 1984;54(1):131–4.

    Article  PubMed  CAS  Google Scholar 

  79. Tokudome S, Shimamoto Y, Sumida I. Smoking and adult T-cell leukemia/lymphoma. Eur J Cancer Prev. 1993;2(1):84–5.

    Article  PubMed  CAS  Google Scholar 

  80. Tsukasaki K, Yamada Y, Ikeda S, Tomonaga M. Infective dermatitis among patients with ATL in Japan. Int J Cancer. 1994;57(2):293.

    Article  PubMed  CAS  Google Scholar 

  81. Hisada M, Okayama A, Shioiri S, Spiegelman DL, Stuver SO, Mueller NE. Risk factors for adult T-cell leukemia among carriers of human T-lymphotropic virus type I. Blood. 1998;92(10):3557–61.

    PubMed  CAS  Google Scholar 

  82. Usuku K, Sonoda S, Osame M, Yashiki S, Takahashi K, Matsumoto M, et al. Igata A HLA haplotype-linked high immune responsiveness against HTLV-I in HTLV-I-associated myelopathy: comparison with adult T-cell leukemia/lymphoma. Ann Neurol. 1988;23(Suppl):S143–50.

    Article  PubMed  Google Scholar 

  83. Iwanaga M, Watanabe T, Utsunomiya A, Okayama A, Uchimaru K, Koh KR, et al. Human T-cell leukemia virus type I (HTLV-1) proviral load and disease progression in asymptomatic HTLV-1 carriers: a nationwide prospective study in Japan. Blood. 2010 [Epub ahead of print].

    Google Scholar 

  84. Amano M, Kurokawa M, Ogata K, Itoh H, Kataoka H, Setoyama M. New entity, definition and diagnostic criteria of cutaneous adult T-cell leukemia/lymphoma: human T-lymphotropic virus type 1 proviral DNA load can distinguish between cutaneous and smoldering types. J Dermatol. 2008;35(5):270–5.

    Article  PubMed  CAS  Google Scholar 

  85. Bennett JM, Catovsky D, Daniel MT, et al. Proposals for the classification of chronic (mature) B and T lymphoid leukaemias. French-American-British (FAB) Cooperative Group. J Clin Pathol. 1989;42:567–84.

    Article  PubMed  CAS  Google Scholar 

  86. Tsukasaki K, Imaizumi Y, Tawara M, et al. Diversity of leukaemic cell morphology in ATL correlates with prognostic factors, aberrant immunophenotype and defective HTLV-1 genotype. Br J Haematol. 1999;105:369–75.

    Article  PubMed  CAS  Google Scholar 

  87. Lennert K, Kikuchi M, Sato E, Suchi T, Stansfeld AG, Feller AC, et al. HTLV-positive and -negative T-cell lymphomas. Morphological and immunohistochemical differences between European and HTLV-positive Japanese T-cell lymphomas. Int J Cancer. 1985;35(1):65–72.

    Article  PubMed  CAS  Google Scholar 

  88. Watanabe T, Yamaguchi K, Takatsuki K, Osame M, Yoshida M. Constitutive expression of parathyroid hormone-related protein gene in human T cell leukemia virus type 1 (HTLV-1) carriers and adult T cell leukemia patients that can be trans-activated by HTLV-1 tax gene. J Exp Med. 1990;172(3):759–65.

    Article  PubMed  CAS  Google Scholar 

  89. Nosaka K, Miyamoto T, Sakai T, Mitsuya H, Suda T, Matsuoka M. Mechanism of hypercalcemia in adult T-cell leukemia: overexpression of receptor activator of nuclear factor kappaB ligand on adult T-cell leukemia cells. Blood. 2002;99(2):634–40.

    Article  PubMed  CAS  Google Scholar 

  90. Tsuda H, Sawada T, Sakata KM, Takatsuki K. Possible mechanisms for the elevation of serum beta 2-microglobulin levels in adult T-cell leukemia. Int J Hematol. 1992;55(2):179–87.

    PubMed  CAS  Google Scholar 

  91. Sadamori N, Ikeda S, Yamaguchi K, et al. Serum deoxythymidine kinase in adult T-cell leukemia-lymphoma and its related disorders. Leuk Res. 1991;15:99–103.

    Article  PubMed  CAS  Google Scholar 

  92. Kamihira S, Atogami S, Sohda H, et al. Significance of soluble interleukin-2 receptor levels for evaluation of the progression of adult T-cell leukemia. Cancer. 1994;73:2753–8.

    Article  PubMed  CAS  Google Scholar 

  93. Kamihira S, Sohda H, Atogami S, Toriya K, Yamada Y, Tsukazaki K, et al. Phenotypic diversity and prognosis of adult T-cell leukemia. Leuk Res. 1992;16(5):435–41.

    Article  PubMed  CAS  Google Scholar 

  94. Kohno T, Yamada Y, Akamatsu N, Kamihira S, Imaizumi Y, Tomonaga M, et al. Possible origin of adult T-cell leukemia/lymphoma cells from human T lymphotropic virus type-1-infected regulatory T cells. Cancer Sci. 2005;96(8):527–33.

    Article  PubMed  CAS  Google Scholar 

  95. Kamada N, Sakurai M, Miyamoto K, Sanada I, Sadamori N, Fukuhara S, et al. Chromosome abnormalities in adult T-cell leukemia/lymphoma: a karyotype review committee report. Cancer Res. 1992;52(6):1481–93.

    PubMed  CAS  Google Scholar 

  96. Itoyama T, Chaganti RS, Yamada Y, et al. Cytogenetic analysis and clinical significance in adult T-cell leukemia/lymphoma: a study of 50 cases from the human T-cell leukemia virus type-1 endemic area, Nagasaki. Blood. 2001;97:3612–20.

    Article  PubMed  CAS  Google Scholar 

  97. Tsukasaki K, Krebs J, Nagai K, Tomonaga M, Koeffler HP, Bartram CR, et al. Comparative genomic hybridization analysis in adult T-cell leukemia/lymphoma: correlation with clinical course. Blood. 2001;97(12):3875–81.

    Article  PubMed  CAS  Google Scholar 

  98. Oshiro A, Tagawa H, Ohshima K, Karube K, Uike N, Tashiro Y, et al. Identification of subtype-specific genomic alterations in aggressive adult T-cell leukemia/lymphoma. Blood. 2006;107(11):4500–7.

    Article  PubMed  CAS  Google Scholar 

  99. Choi YL, Tsukasaki K, O’Neill MC, Yamada Y, Onimaru Y, Matsumoto K, et al. A genomic analysis of adult T-cell leukemia. Oncogene. 2007;26(8):1245–55.

    Article  PubMed  CAS  Google Scholar 

  100. Sasaki H, Nishikata I, Shiraga T, Akamatsu E, Fukami T, Hidaka T, et al. Overexpression of a cell adhesion molecule, TSLC1, as a possible molecular marker for acute-type adult T-cell leukemia. Blood. 2005;105(3):1204–13.

    Article  PubMed  CAS  Google Scholar 

  101. Takasaki Y, Iwanaga M, Imaizumi Y, Tawara M, Joh T, Kohno T, et al. Long-term study of indolent adult T-cell leukemia-lymphoma. Blood. 2010;115(22):4337–43.

    Article  PubMed  CAS  Google Scholar 

  102. Shimoyama M, Ota K, Kikuchi M, et al. Chemotherapeutic results and prognostic factors of patients with advanced non-Hodgkins lymphoma treated with VEPA or VEPA-M. J Clin Oncol. 1988;6:128–41.

    PubMed  CAS  Google Scholar 

  103. Shimoyama M, Ota K, Kikuchi M, et al. Major prognostic factors of adult patients with advanced T-cell lymphoma/leukemia. J Clin Oncol. 1988;6:1088–97.

    PubMed  CAS  Google Scholar 

  104. Tobinai K, Shimoyama M, Minato K, et al. Japan Clinical Oncology Group phase II trial of second-­generation LSG4 protocol in aggressive T- and B-lymphoma: a new predictive model for T- and B-lymphoma (abstract). Proc Am Soc Clin Oncol. 1994;13:378a.

    Google Scholar 

  105. Tsukasaki K, Tobinai K, Shimoyama M, et al. Deoxycoformycin-containing combination chemotherapy for adult T-cell leukemia-lymphoma: Japan Clinical Oncology Group study (JCOG9109). Int J Hematol. 2003;77:164–70.

    Article  PubMed  CAS  Google Scholar 

  106. Yamada Y, Tomonaga M, Fukuda H, et al. A new G-CSF-supported combination chemotherapy, LSG15, for adult T-cell leukemia-lymphoma (ATL): Japan Clinical Oncology Group (JCOG) Study 9303. Br J Haematol. 2001;113:375–82.

    Article  PubMed  CAS  Google Scholar 

  107. Tsukasaki K, Utsunomiya A, Fukuda H, et al. VCAP-AMP-VECP compared with biweekly CHOP for adult T-cell leukemia-lymphoma: Japan Clinical Oncology Group Study JCOG9801. J Clin Oncol. 2007;25:5458–564.

    Article  PubMed  CAS  Google Scholar 

  108. Tobinai K, Shimoyama M, Inoue S, et al. Phase I study of YK-176 (2-deoxycoformycin) in patients with adult T-cell leukemia-lymphoma. Jpn J Clin Oncol. 1992;22:164–71.

    PubMed  CAS  Google Scholar 

  109. Kuwazuru Y, Hanada S, Furukawa T, et al. Expression of p-glycoprotein in adult T-cell leukemia cells. Blood. 1990;76:2065–71.

    PubMed  CAS  Google Scholar 

  110. Tsukasaki K, Ikeda S, Murata K, et al. Characteristics of chemotherapy-induced clinical remission in long survivors with aggressive adult T-cell leukemia/lymphoma. Leuk Res. 1993;17:157–66.

    Article  PubMed  CAS  Google Scholar 

  111. Ichimaru M, Kamihira S, Moriuchi Y, Kuraishi Y, Usui N, Toki H, et al. Clinical study on the effect of natural alpha-interferon (HLBI) in the treatment of adult T-cell leukemia. Gan To Kagaku Ryoho. 1988;15(10):2975–81. Japanese.

    PubMed  CAS  Google Scholar 

  112. Gill PS, Harrington W, Kaplan MH, et al. Treatment of adult T-cell leukemia-lymphoma with a combination of interferon alfa and zidovudine. N Engl J Med. 1995;332:1744–8.

    Article  PubMed  CAS  Google Scholar 

  113. Hermine O, Blouscary D, Gessain A, et al. Treatment of adult T-cell leukemia-lymphoma with zidovudine and interferon alfa. N Engl J Med. 1995;332:1749–51.

    Article  PubMed  CAS  Google Scholar 

  114. Tobinai K, Kobayashi Y, Shimoyama M, et al. Interferon alfa and zidovudine in adult T-cell leukemia-lymphoma (correspondence). N Engl J Med. 1995;333:1285–6.

    Article  PubMed  CAS  Google Scholar 

  115. White JD, Wharfe G, Stewart DM, et al. The combination of zidovudine and interferon alpha-2B in the treatment of adult T-cell leukemia/lymphoma. Leuk Lymphoma. 2001;40:287–94.

    Article  PubMed  CAS  Google Scholar 

  116. Matutes E, Taylor GP, Cavenagh J, et al. Interferon alpha and zidovudine therapy in adult T-cell leukaemia lymphoma: response and outcome in 15 patients. Br J Haematol. 2001;113:779–84.

    Article  PubMed  CAS  Google Scholar 

  117. Hermine O, Allard I, Levy V, et al. A prospective phase II clinical trial with the use of zidovudine and interferon-alpha in the acute and lymphoma forms of adult T-cell leukemia/lymphoma. Hematol J. 2002;3:276–82.

    Article  PubMed  CAS  Google Scholar 

  118. Bazarbachi A, Plumelle Y, Ramos JC, Tortevoye P, Otrock Z, Taylor G, et al. Meta-analysis on the use of zidovudine and interferon-alfa in adult T-cell leukemia/lymphoma showing improved survival in the leukemic subtypes. J Clin Oncol. 2010;28(27):4177–83.

    Article  PubMed  CAS  Google Scholar 

  119. Kchour G, Tarhini M, Kooshyar M-M, et al. Phase 2 study of the efficacy and safety of the combination of arsenic trioxide, interferon alpha, and zidovudine in newly diagnosed chronic adult T-cell leukemia/lymphoma (ATL). Blood. 2009;113:6528–32.

    Article  PubMed  CAS  Google Scholar 

  120. Hishizawa M, Kanda J, Utsunomiya A, Taniguchi S, Eto T, Moriuchi Y, et al. Transplantation of allogeneic hematopoietic stem cells for adult T-cell leukemia: a nationwide retrospective study. Blood. 2010 [Epub ahead of print].

    Google Scholar 

  121. Okamura J, Utsunomiya A, Tanosaki R, et al. Allogeneic stem-cell transplantation with reduced conditioning intensity as a novel immunotherapy and antiviral therapy for adult T-cell leukemia/lymphoma. Blood. 2005;105:4143–5.

    Article  PubMed  CAS  Google Scholar 

  122. Tanosaki R, Uike N, Utsunomiya A, Saburi Y, Masuda M, Tomonaga M, et al. Allogeneic hematopoietic stem cell transplantation using reduced-intensity conditioning for adult T cell leukemia/lymphoma: impact of antithymocyte globulin on clinical outcome. Biol Blood Marrow Transplant. 2008;14(6):702–8.

    Article  PubMed  CAS  Google Scholar 

  123. Cheson BD, Horning SJ, Coiffier B, et al. Report of an international workshop to standardize response criteria for non-Hodgkin’s lymphomas. NCI Sponsored International Working Group. J Clin Oncol. 1999;17:1244.

    PubMed  CAS  Google Scholar 

  124. Cheson BD, Bennett JM, Grever M, et al. National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood. 1996;87:4990–7.

    PubMed  CAS  Google Scholar 

  125. Cheson BD, Pfistner B, Juweid ME, et al. The International Harmonization Project on Lymphoma. Revised response criteria for malignant lymphoma. J Clin Oncol. 2007;25:579–86.

    Article  PubMed  Google Scholar 

  126. Ohno R, Masaoka T, Shirakawa S, Sakamoto S, Hirano M, Hanada S, et al. Treatment of adult T-cell leukemia/lymphoma with MST-16, a new oral antitumor drug and a derivative of bis(2,6-dioxopiperazine). The MST-16 Study Group. Cancer. 1993;71(7):2217–21.

    Article  PubMed  CAS  Google Scholar 

  127. Tsuda H, Takatsuki K, Ohno R, et al. A late phase II trial of a potent topoisomerase inhibitor, CPT-11, in malignant lymphoma [abstract]. Proc Am Soc Clin Oncol. 1992;11:316.

    Google Scholar 

  128. Arima N, Mizoguchi H, Shirakawa S, Tomonaga M, Takatsuki K, Ohno R. Phase I clinical study of SH L573 (fludarabine phosphate) in patients with chronic lymphocytic leukemia and adult T-cell leukemia/lymphoma. Gan To Kagaku Ryoho. 1999;26(5):619–29 [Article in Japanese].

    PubMed  CAS  Google Scholar 

  129. Tobinai K, Uike N, Saburi Y, Chou T, Etoh T, Masuda M, et al. Cladribine/ATL Study Group, Japan. Phase II study of cladribine (2-chlorodeoxyadenosine) in relapsed or refractory adult T-cell leukemia-lymphoma. Int J Hematol. 2003;77(5):512–7.

    Article  PubMed  CAS  Google Scholar 

  130. Duvic M, Forero-Torres A, Foss F, et al: Long-term treatment of CTCL with the oral PNP inhibitor, forodesine. ASCO annual meeting, Jun 2009; No. 8552.

    Google Scholar 

  131. O’Connor OA, Heaney ML, Schwartz L, et al. Clinical experience with intravenous and oral formulations of the novel histone deacetylase inhibitor suberoylanilide hydroxamic acid in patients with advanced hematologic malignancies. J Clin Oncol. 2006;24(1):166–73.

    Article  PubMed  CAS  Google Scholar 

  132. Hasegawa H, Yamada Y, Tsukasaki K, et al. LBH589, a deacetylase inhibitor, induces apoptosis in adult T-cell leukemia/lymphoma cells via activation of a novel RAIDD-caspase-2 pathway. Leukemia. 2011;25(4):575–87.

    Article  PubMed  CAS  Google Scholar 

  133. Waldmann TA. Multichain interleukin-2 receptor: a target for immunotherapy in lymphoma. J Natl Cancer Inst. 1989;81:914–23.

    Article  PubMed  CAS  Google Scholar 

  134. Waldmann TA, White JD, Carrasquillo JA, et al. Radioimmunotherapy of interleukin-2Ra-expressing adult T-cell leukemia with yttrium-90-labeled anti-Tac. Blood. 1985;86:4063–75.

    Google Scholar 

  135. Berkowitz JL, Janik JE, Stewart DM, Fioravanti S, Jaffe ES, Fleisher TA, et al. Phase II trial of daclizumab in human T-cell lymphotropic virus type-1 (HTLV-1)-associated adult T-cell leukemia/lymphoma (ATL). J Clin Oncol. 2010;28:7s (suppl; abstr 8043).

    Article  Google Scholar 

  136. Kreitman RJ, Wilson WH, White JD, Stetler-Stevenson M, Jaffe ES, Giardina S, et al. Phase I trial of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) in patients with hematologic malignancies. J Clin Oncol. 2000;18(8):1622–36.

    PubMed  CAS  Google Scholar 

  137. Dang NH, Pro B, Hagemeister FB, et al. Phase II trial of denileukin diftitox for relapsed/refractory T-cell non-Hodgkin lymphoma. Br J Haematol. 2007;136(3):439–47.

    Article  PubMed  CAS  Google Scholar 

  138. Foss FM, Sjak-Shie NN, Goy A, Advani R, Jacobsen ED. Phase II study of denileukin diftitox with CHOP chemotherapy in newly-diagnosed PTCL: CONCEPT trial. J Clin Oncol. 2010;28:15s (suppl; abstr 8045).

    Google Scholar 

  139. Di Venuti G, Nawgiri R, Foss F. Denileukin diftitox and hyper-CVAD in the treatment of human T-cell lymphotropic virus 1-associated acute T-cell leukemia/lymphoma. Clin Lymphoma. 2003;4(3):176–8.

    Article  PubMed  Google Scholar 

  140. Rodig SJ, Abramson JS, Pinkus GS, Treon SP, Dorfman DM, Dong HY, et al. Heterogeneous CD52 expression among hematologic neoplasms: implications for the use of alemtuzumab (CAMPATH-1H). Clin Cancer Res. 2006;12(23):7174–9.

    Article  PubMed  CAS  Google Scholar 

  141. Jiang L, Yuan CM, Hubacheck J, Janik JE, Wilson W, Morris JC, et al. Variable CD52 expression in mature T cell and NK cell malignancies: implications for alemtuzumab therapy. Br J Haematol. 2009;145(2):173–9.

    Article  PubMed  CAS  Google Scholar 

  142. Gallamini A, Zaja F, Patti C, Billio A, Specchia MR, Tucci A, Levis A, Manna A, Secondo V, Rigacci L, Pinto A, Iannitto E, Zoli V, Torchio P, Pileri S, Tarella C. Alemtuzumab (Campath-1H) and CHOP chemotherapy as first-line treatment of peripheral T-cell lymphoma: results of a GITIL (Gruppo Italiano Terapie Innovative nei Linfomi) prospective multicenter trial. Blood. 2007 Oct 1;110(7):2316–23. Clin Cancer Res. 2006 Dec 1;12(23):7174–9.

    Google Scholar 

  143. Zhang Z, Zhang M, Goldman CK, Ravetch JV, Waldmann TA. Effective therapy for a murine model of adult T-cell leukemia with the humanized anti-CD52 monoclonal antibody, Campath-1H. Cancer Res. 2003;63(19):6453–7.

    PubMed  CAS  Google Scholar 

  144. Mone A, Puhalla S, Whitman S, Baiocchi RA, Cruz J, Vukosavljevic T, et al. Durable hematologic complete response and suppression of HTLV-1 viral load following alemtuzumab in zidovudine/IFN-[alpha]-refractory adult T-cell leukemia. Blood. 2005;106(10):3380–2.

    Article  PubMed  CAS  Google Scholar 

  145. Ravandi F, Faderl S. Complete response in a patient with adult T-cell leukemia (ATL) treated with combination of alemtuzumab and pentostatin. Leuk Res. 2006;30(1):103–5.

    Article  PubMed  CAS  Google Scholar 

  146. O’Mahony D, Morris JC, Stetler-Stevenson M, Matthews H, Brown MR, Fleisher T, et al. EBV-related lymphoproliferative disease complicating therapy with the anti-CD2 monoclonal antibody, siplizumab, in patients with T-cell malignancies. Clin Cancer Res. 2009;15(7):2514–22.

    Article  PubMed  CAS  Google Scholar 

  147. Niwa R, Shoji-Hosaka E, Sakurada M, Shinkawa T, Uchida K, Nakamura K, Matsushima K, Ueda R, Hanai N, Shitara K.: Defucosylated chimeric anti-CC chemokine receptor 4 IgG1 with enhanced antibody-dependent cellular cytotoxicity shows potent therapeutic activity to T-cell leukemia and lymphoma. Cancer Res. 2004 Mar 15;64(6):2127–33. Cancer Res. 2004 Mar 15;64(6):2127–33.

    Google Scholar 

  148. Yamamoto K, Utsunomiya A, Tobinai K, et al. Phase I study of KW-0761, a defucosylated humanized anti-CCR4 antibody, in relapsed patients with adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma. J Clin Oncol. 2010;28(9):1591–8.

    Article  PubMed  CAS  Google Scholar 

  149. Ishida T, Joh T, Uike N, et al. Defucosylated anti-CCR4 monoclonal antibody (KW-0761) for relapsed adult T-cell leukemia-lymphoma: a multicenter phase II study. J Clin Oncol. 2012 [Epub ahead of print].

    Google Scholar 

  150. O’Connor OA, Horwitz S, Hamlin P, et al. Phase II-I-II study of two different doses and schedules of pralatrexate, a high-affinity substrate for the reduced folate carrier, in patients with relapsed or refractory lymphoma reveals marked activity in T-cell malignancies. J Clin Oncol. 2009;27(26):4357–64.

    Article  PubMed  CAS  Google Scholar 

  151. O’Connor OA, Pro B, Pinter-Brown L, et al. PROPEL: a multi-center phase 2 open-label study of pralatrexate (PDX) with vitamin B12 and folic acid supplementation in patients with replapsed or refractory peripheral T-cell lymphoma. Blood (ASH Annual Meeting Abstracts). 2008;112:261.

    Google Scholar 

  152. Marneros AG, Grossman ME, Silvers DN, Husain S, Nuovo GJ, MacGregor-Cortelli B, et al. Pralatrexate-induced tumor cell apoptosis in the epidermis of a patient with HTLV-1 adult T-cell lymphoma/leukemia causing skin erosions. Blood. 2009;113(25):6338–41.

    Article  PubMed  CAS  Google Scholar 

  153. Lee J, Suh C, Kang HJ, Ryoo BY, et al. Phase I study of proteasome inhibitor bortezomib plus CHOP in patients with advanced, aggressive T-cell or NK/T-cell lymphoma. Ann Oncol. 2008;19(12):2079–83.

    Article  PubMed  CAS  Google Scholar 

  154. Satou Y, Nosaka K, Koya Y, et al. Proteasome inhibitor, bortezomib, potently inhibits the growth of adult T-cell leukemia cells both in vivo and in vitro. Leukemia. 2004;18:1357–63.

    Article  PubMed  CAS  Google Scholar 

  155. Dueck GS, Chua N, Prasad A, et al. Activity of lenalidomide in a phase II trial for T-cell lymphoma: report on the first 24 cases. J Clin Oncol. 2009;27:15s (suppl; abstr 8524).

    Article  Google Scholar 

  156. Vose J, Armitage J, Weisenburger D. International peripheral T-cell and natural killer/T-cell lymphoma study: pathology findings and clinical outcomes. J Clin Oncol. 2008;26(25):4124–30.

    Article  PubMed  Google Scholar 

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  1. Department of Hematology, National Cancer Centre Hospital East, Chiba, Japan

    Kunihiro Tsukasaki M.D., Ph.D.

  2. Department of Hematology, National Cancer Center Hospital, Tokyo, Japan

    Kensei Tobinai M.D., Ph.D.

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  1. Kunihiro Tsukasaki M.D., Ph.D.
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Correspondence to Kunihiro Tsukasaki M.D., Ph.D. .

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  1. Yale University School of Medicine, Dept. of Medical Oncology/Hematology, Cedar Street 333, New Haven, 06520, Connecticut, USA

    Francine Foss

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Tsukasaki, K., Tobinai, K. (2013). HTLV-1-Associated T-cell Diseases. In: Foss, F. (eds) T-Cell Lymphomas. Contemporary Hematology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-170-7_8

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