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Pediatric Neoplasia pp 169–197Cite as

Soft Tissue “Small Round Blue Cell Tumors” of Childhood

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Part of the book series: Molecular and Translational Medicine ((MOLEMED))

Abstract

The group of small round blue cell tumors of childhood represents a descriptive category of malignant pediatric neoplasms characterized by the presence of morphologically poorly differentiated cells containing large hyperchromatic nuclei and scant cytoplasm. Frequently, clinical and morphological clues can be identified, which may orient in the correct histopathological diagnosis of these tumors; in many occasions, however, the correct diagnosis will be accomplished only through the implementation of immunohistochemical, ultrastructural, and/or molecular analysis of neoplastic cells. Significant advances have been achieved in recent years, which have proved crucial in the diagnostic work up of these frequently challenging cases, as well as in providing markers of prognostic relevance and in uncovering potential therapeutic targets.

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  1. Department of Pathology, Great Lakes Pathologists, S.C., Aurora Baycare Medical Center, 8900, Green Bay, WI, 54308-8900, USA

    Matthew P. Walters MD

  2. Department of Pathology, Froedtert Hospital/Medical College of Wisconsin, 9200 W. Wisconsin Avenue, Milwaukee, WI, 53226, USA

    Eduardo V. Zambrano MD, MS

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    Alexander Craig Mackinnon Jr

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Walters, M.P., Zambrano, E.V. (2012). Soft Tissue “Small Round Blue Cell Tumors” of Childhood. In: Mackinnon Jr, A. (eds) Pediatric Neoplasia. Molecular and Translational Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-116-5_8

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