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Keratinocyte Stem Cells: Biology and Clinical Applications

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Regenerative Medicine and Cell Therapy

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Human epidermis represents a large reservoir of stem cells that continue to self-renew throughout life. Stem cells are essential for skin regeneration and for repair after wounding. They allow long-term culture of keratinocytes that produce large sheets of epidermis to cover extensive burns, thus being lifesaving for these patients. Furthermore, stem cells can be expanded in culture, genetically modified to correct the gene deficiency in genetic skin diseases. This chapter will describe the most recent data on stem cell biology and the potential medical applications of these cells.

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Authors and Affiliations

  1. Laboratory of Cutaneous Biology, Department of Medicine, Emergency Medicine and Medical Specialties, Institute of Dermatology, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100, Modena, Italy

    Carlo Pincelli & Alessandra Marconi

Authors
  1. Carlo Pincelli
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  2. Alessandra Marconi
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Corresponding author

Correspondence to Carlo Pincelli .

Editor information

Editors and Affiliations

  1. Royan Institute, Department of Developmental Biology, University of Science and Culture, PO Box 19395-4644, Tehran, Iran

    Hossein Baharvand

  2. , Regenerative Medicine, Royan Institute for Stem Cell Biology an, P.O. Box: 19395-4644, Tehran, Iran

    Nasser Aghdami

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Pincelli, C., Marconi, A. (2013). Keratinocyte Stem Cells: Biology and Clinical Applications. In: Baharvand, H., Aghdami, N. (eds) Regenerative Medicine and Cell Therapy. Stem Cell Biology and Regenerative Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-098-4_4

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