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The Centrosome pp 49–58Cite as

Centrosomal Functions and Dysfunctions in Cat Spermatozoa

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Abstract

The cat sperm centrosome is a paternally inherited organelle essential to successful fertilization and early embryo development. While there are structural and functional commonalities with other mammals, we have discovered original traits in the cat sperm centrosome that have offered new insights into sperm maturation as well as possible treatments for certain types of infertility. In contrast to ejaculated counterparts, cat testicular spermatozoa contain an immature centrosome preventing the formation of a large sperm aster post fertilization, which increases the incidence of early arrest in embryonic development. Emerging techniques that involve cellular desiccation or preservation in a liquid environment can adversely impact centrosomal properties of normal, mature spermatozoa. Most importantly, our investigations of the sperm centrosome in the cat model (1) re-emphasize the significance of this organelle in achieving successful reproduction and (2) are laying groundwork for overcoming centrosomal immaturity or dysfunctions using gamete micromanipulations or alternative, new in vitro sperm maturation systems.

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Competing Interests

The authors declare that they have no competing interests.

Authors’ Contributions

PC and DW equally contributed to the conception and writing of the review article.

Both authors read and approved the final manuscript.

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Authors and Affiliations

  1. Center for Species Survival, Smithsonian Conservation Biology Institute, National Zoological Park, 3001 Connecticut Ave NW, Washington, DC, 20008, USA

    Pierre Comizzoli & David E. Wildt

Authors
  1. Pierre Comizzoli
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  2. David E. Wildt
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Corresponding author

Correspondence to Pierre Comizzoli .

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Editors and Affiliations

  1. Dept. Veterinary Pathobiology, University of Missouri-Columbia, East Rollins Street 1600, Columbia, 65211, Missouri, USA

    Heide Schatten

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© 2012 Humana Press, a part of Springer Science+Business Media, LLC

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Comizzoli, P., Wildt, D.E. (2012). Centrosomal Functions and Dysfunctions in Cat Spermatozoa. In: Schatten, H. (eds) The Centrosome. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-035-9_3

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