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Centriole Duplication and Inheritance in Drosophila melanogaster

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The Centrosome

Abstract

Centrosomes are conserved microtubule-based organelles that are essential for animal development. In this chapter, we highlight key centrosomal proteins and describe the centrosome in the context of several developmental processes in Drosophila melanogaster. These processes include fertilization, during which the centrosome mediates the fusion of male and female pronuclei; development of the embryonic syncytium, where centrosomes act as microtubule-organizing centers and participate in nuclear division; and the formation of sensory and motile cilia in the adult, where the centrosome's centrioles template axoneme assembly. The study of these processes in Drosophila provides a unique experimental system where classical approaches in genetics and biochemistry can be used to dissect centrosome biology.

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Acknowledgments

This material is based upon work supported by the National Science Foundation under Grant No. MCB-1121176. Andrey Polyanovsky was supported by RFBR grant 10-04-01027

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Authors and Affiliations

  1. Department of Cell Biology, Harvard Medical School, Seeley G. Mudd Building, Room 509A, 250 Longwood Avenue, Boston, 02115, MA, USA

    Tomer Avidor-Reiss, Jayachandran Gopalakrishnan & Stephanie Blachon

  2. Sechenov Institute, Russian Academy of Sciences, St. Petersburg, Russia

    Andrey Polyanovsky

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  1. Tomer Avidor-Reiss
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  2. Jayachandran Gopalakrishnan
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  3. Stephanie Blachon
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  4. Andrey Polyanovsky
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Correspondence to Tomer Avidor-Reiss .

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  1. Dept. Veterinary Pathobiology, University of Missouri-Columbia, East Rollins Street 1600, Columbia, 65211, Missouri, USA

    Heide Schatten

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© 2012 Humana Press, a part of Springer Science+Business Media, LLC

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Avidor-Reiss, T., Gopalakrishnan, J., Blachon, S., Polyanovsky, A. (2012). Centriole Duplication and Inheritance in Drosophila melanogaster . In: Schatten, H. (eds) The Centrosome. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-035-9_1

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