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Immunosuppressive Properties of Mesenchymal Stromal Cells

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Advances in Stem Cell Research

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

The main interest in mesenchymal stromal cells (MSCs) is correlated with their ability to suppress the proliferation of T lymphocytes induced by mitogenic agents and alloantigens which regulate the transplantation rejection. Moreover, MSCs are resistant to the CD8+ T lymphocyte cytotoxicity, they are able to inhibit the differentiation of dendritic cells responsible for the antigen presentation, the proliferation, and antibody production of B lymphocytes and they stimulate the formation of regulatory T cells. The mechanisms at the basis of MSCs activity need cell–cell interaction and the secretion of soluble molecules induced by the micro-environment. The inhibitory functions of MSCs involve several soluble molecules as hepatocyte growth factor, transforming growth factor-beta, interleukin-10 and -2, tumor necrosis factor-alpha, prostaglandin E2, indoleamine 2,3-dioxygenase (IDO), and soluble HLA-G antigens. A large consensus has been obtained on the immuno-modulatory role of IDO and HLA-G molecules.

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Authors and Affiliations

  1. Hematology and Stem Cell Unit, Cremona, Italy

    Francesco Lanza, Endri Mauro & Annalisa Pasini

  2. Hematology Section, University of Ferrara, Ferrara, Italy

    Diana Campioni

  3. Microbiology Section, University of Ferrara, Ferrara, Italy

    Roberta Rizzo

Authors
  1. Francesco Lanza
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  2. Diana Campioni
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  3. Endri Mauro
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  4. Annalisa Pasini
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  5. Roberta Rizzo
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Correspondence to Francesco Lanza .

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Editors and Affiliations

  1. Royan Institute, Department of Developmental Biology, University of Science and Culture, PO Box 19395-4644, Tehran, Iran

    Hossein Baharvand

  2. , Regenerative Medicine, Royan Institute for Stem Cell Biology an, P.O. Box: 19395-4644, Tehran, Iran

    Nasser Aghdami

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Lanza, F., Campioni, D., Mauro, E., Pasini, A., Rizzo, R. (2012). Immunosuppressive Properties of Mesenchymal Stromal Cells. In: Baharvand, H., Aghdami, N. (eds) Advances in Stem Cell Research. Stem Cell Biology and Regenerative Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-940-2_15

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