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Molecular Regulation of Vasculogenesis and Angiogenesis: Recent Advances and Future Directions

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Molecular and Translational Vascular Medicine

Part of the book series: Molecular and Translational Medicine ((MOLEMED))

Abstract

Major advances have occurred over the past two decades in our understanding of the development of the vasculature as well as its response to injurious stimuli in the context of disease. This chapter emphasizes the molecular regulation of vascular morphogenesis, the process that leads to interconnecting networks of endothelial cell (EC)-lined tubes in three-dimensional (3D) tissues. Importantly, the process of vascular morphogenesis depends on the interaction of ECs with extracellular matrices (ECMs) in a 3D matrix-specific manner. Recent studies indicate that specific combinations of signaling molecules control vascular morphogenesis in a 3D matrix-specific manner. In addition to ECM, other critical regulators of vascular morphogenesis include growth factors and cytokines, which stimulate and modulate morphogenic responses such as proliferation, motility, invasion, sprouting, and tube formation. In addition, these factors regulate the proliferation and recruitment of pericytes and vascular smooth muscle cells to developing vessels. The advances in our understanding of these events have been facilitated by technical advances and development of models of vascular morphogenesis in vitro and in vivo. Emphasis is placed on utilizing in vitro experimental approaches as a primary discovery tool to more rapidly elucidate fundamental molecule and signaling requirements controlling vascular morphogenesis during development, postnatal life, and under disease conditions.

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Acknowledgments

This work was supported by NIH grants HL59373, HL79460, HL87308, and HL105606 to GED.

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  1. Department of Medical Pharmacology and Physiology, Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Dalton Cardiovascular Sciences Center, MA415 Medical Sciences Building, Columbia, MO, 65212, USA

    George E. Davis MD, PhD

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Correspondence to George E. Davis MD, PhD .

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  1. , The University of North Carolina, McAllister Heart Institute, 101 Manning Drive, Chapel Hill, 27599-7525, USA

    Jonathon W. Homeister

  2. , The University of North Carolina, McAllister Heart Institute, 103 Mason Farm Road, Chapel Hill, 27599-7525, USA

    Monte S. Willis

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Davis, G.E. (2012). Molecular Regulation of Vasculogenesis and Angiogenesis: Recent Advances and Future Directions. In: Homeister, J., Willis, M. (eds) Molecular and Translational Vascular Medicine. Molecular and Translational Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-906-8_6

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