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Ghrelin in Health and Disease pp 149–170Cite as

Ghrelin Regulation of Sleep, Circadian Clock, and Body Temperature

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Part of the book series: Contemporary Endocrinology ((COE,volume 10))

Abstract

The regulation of sleep, body temperature, and metabolism is intertwined on functional, structural, and behavioral levels. The hypothalamus emerges as a key brain region that coordinates these functions by integrating central and peripheral signals. Increasing evidence suggests that products of the preproghrelin gene provide important contribution to this integrative function. In this review, we present evidence from human and animal studies supporting the role of ghrelin in the regulation of (1) sleep–wake activity, (2) circadian rhythms, and (3) metabolism and body temperature. Central ghrelinergic mechanisms—as part of the hypothalamic ghrelin–orexin–neuropeptide Y circuit—play a role in promoting wakefulness and feeding. Ghrelin modulates the activity of the suprachiasmatic nucleus but it is not a crucial component of or a key input signal to the food-entrainable oscillator. Products of the preproghrelin gene, particularly obestatin, are involved in maintaining normal body temperature and metabolism under conditions when increased metabolic heat production is required. Our understanding of the physiological role of the preproghrelin gene products expanded remarkably in the last decade, yet, full comprehension of their role in the regulation of vigilance, circadian clocks, and body temperature remains incomplete.

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Authors and Affiliations

  1. WWAMI Medical Education Program, Washington State University, 412 E. Spokane Falls Blvd, Spokane, WA, 99202, USA

    Éva Szentirmai M.D., Ph.D. & Levente Kapás M.D., Ph.D.

  2. Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, WA, 99202, USA

    Éva Szentirmai M.D., Ph.D. & Levente Kapás M.D., Ph.D.

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  1. Éva Szentirmai M.D., Ph.D.
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  2. Levente Kapás M.D., Ph.D.
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Correspondence to Éva Szentirmai M.D., Ph.D. .

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  1. , Department of Metabolism and Aging, The Scripps Research Institute Florida, Scripps Way 3B3 130, Jupiter, 33458, Florida, USA

    Roy G. Smith

  2. , Department of Medicine, University of Virginia, Ray C Hunt Drive 450, Charlottesville, 22908, Virginia, USA

    Michael O. Thorner

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© 2012 Springer Science+Business Media New York

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Szentirmai, É., Kapás, L. (2012). Ghrelin Regulation of Sleep, Circadian Clock, and Body Temperature. In: Smith, R., Thorner, M. (eds) Ghrelin in Health and Disease. Contemporary Endocrinology, vol 10. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-903-7_8

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  • DOI: https://doi.org/10.1007/978-1-61779-903-7_8

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