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Molecular Imaging of Cardiovascular Disease

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Book cover Translational Cardiology

Part of the book series: Molecular and Translational Medicine ((MOLEMED))

Abstract

Cardiovascular disease remains a leading killer in the United States. Although much progress has been made in diagnosing and treating this deadly disease, many questions remain. By studying disease pathogenesis at the genomic and proteomic levels, researchers have developed new strategies for managing disease, but only few have successfully translated these methods into routine clinical implementation. Molecular imaging enables the visualization of biological processes in vivo, providing valuable information that will likely improve clinical translation of these novel therapies. Molecular imaging utilizes imaging probes that interact with specific molecular targets which are then detected by an imaging system, such as single photon emission computed tomography (CT), positron emission tomography (PET), ultrasound, and magnetic resonance imaging (MRI). Patients can then be followed serially using noninvasive methodologies to evaluate disease progression and the effects of therapeutic interventions. Using these specialized probes, researchers have evaluated the role of the following biological processes in atherosclerosis and heart failure: inflammation, thrombosis, apoptosis, vascular remodeling, and angiogenesis. This chapter presents the state of the art in molecular imaging and its role in the management of cardiovascular disease.

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  1. Department of Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA, 94305, USA

    Patricia K. Nguyen & Joseph C. Wu

  2. Department of Radiology, Stanford University School of Medicine, Stanford, CA, USA

    Divya Nag

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  1. , The University of North Carolina, McAllister Heart Institute, 6022 - Burnett Womack Building, Chapel Hill, 27599-7075, North Carolina, USA

    Cam Patterson

  2. , The University of North Carolina, McAllister Heart Institute, 103 Mason Farm Road, Chapel Hill, 27599-7525, USA

    Monte S. Willis

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Nguyen, P.K., Nag, D., Wu, J.C. (2012). Molecular Imaging of Cardiovascular Disease. In: Patterson, C., Willis, M. (eds) Translational Cardiology. Molecular and Translational Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-891-7_14

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