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Cystic Fibrosis

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Book cover Vitamin D and the Lung

Part of the book series: Respiratory Medicine ((RM,volume 3))

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Abstract

The features of cystic fibrosis (CF) include chronic infection and inflammation of the lungs and malabsorption due to pancreatic insufficiency. In people with CF, the many factors contributing to vitamin D deficiency include reduced sun exposure, pancreatic insufficiency, reduced levels of vitamin D binding protein, reduced fat stores, liver disease, accelerated enterohepatic excretion and influence of CF transmembrane conductance regulator (CFTR). The clinical impact of vitamin D deficiency on bone metabolism is known; however, its effects beyond the skeletal system is less recognized. The evidence for routine vitamin D supplementation and management in the presence of vitamin D deficiency are discussed.

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Acknowledgement

Funding: AC is funded by a NHMRC practitioner fellowship (grant number 545216).

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Authors and Affiliations

  1. Queensland Children’s Respiratory Centre and Queensland Children’s Medical Research Centre, Royal Children’s Hospital, Herston Road, Brisbane, Queensland, 4029, Australia

    Helen M. Buntain

  2. Child Health Division, Department of Respiratory Medicine, Menzies School of Health Research and Queensland Children’s Medical Research Centre, Royal Children’s Hospital, Herston Road, Brisbane, Queensland, 4029, Australia

    Anne B. Chang

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  1. Helen M. Buntain
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Correspondence to Helen M. Buntain .

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Editors and Affiliations

  1. Channing Laboratory, Division of Pulmonary and Critical Care, Harvard Medical School, Brigham and Wome, 181 Longwood Avenue, Boston, 02115, Massachusetts, USA

    Augusto A. Litonjua

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Buntain, H.M., Chang, A.B. (2012). Cystic Fibrosis. In: Litonjua, A. (eds) Vitamin D and the Lung. Respiratory Medicine, vol 3. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-888-7_12

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  • DOI: https://doi.org/10.1007/978-1-61779-888-7_12

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