Chapter

Primary Liver Cancer

Part of the series Clinical Gastroenterology pp 143-160

Date:

Hepatocellular Carcinoma in Children

  • Christiane SokollikAffiliated withDivision of Gastroenterology, Hepatology and Nutrition, Department of Paediatrics, University of Toronto, The Hospital for Sick Children
  • , Abha GuptaAffiliated withDivision of Hematology/Oncology, Department of Paediatrics, University of Toronto, The Hospital for Sick Children
  • , Simon C. LingAffiliated withDivision of Gastroenterology, Hepatology and Nutrition, Department of Paediatrics, University of Toronto, The Hospital for Sick Children Email author 

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Abstract

Hepatocellular carcinoma (HCC) is the second most common malignant liver tumor in children after hepatoblastoma (HB) and accounts for approximately 0.3% of all pediatric malignancies [1]. The age-adjusted incidence rate of HCC in the United States in children is 0.41 (0.24–0.65) per 1,000,000 population, with no gender predominance [1]. Children with HCC may present at any age, although the incidence is highest between the ages of 10–19 years [1–3].