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Environment, Immune Dysfunction, and Systemic Lupus Erythematosus

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Immunotoxicity, Immune Dysfunction, and Chronic Disease

Part of the book series: Molecular and Integrative Toxicology ((MOLECUL))

Abstract

In recent years, there is accumulating evidence for the role of various external environmental factors in the pathogenesis of systemic lupus erythematosus (SLE). The main environmental factors that were found to be associated with SLE include chemicals, such as silica, mercury, phthalate, trichloroethylene, and pesticides; cigarette smoking, infectious agents, drugs, vaccines, and ultraviolet radiation. In this chapter we review these associations and the possible mechanisms underlying the immune dysregulation they trigger.

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Author information

Authors and Affiliations

  1. The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, 52621, Israel

    Moran Landau Rabbi, Ilan Ben-Zvi, Nancy Agmon-Levin & Yehuda Shoenfeld

  2. Rheumatology Unit, Department of Internal Medicine F, Chaim Sheba Medical Center, Tel-Hashomer, Israel

    Ilan Ben-Zvi

  3. Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases, Tel-Aviv University, Tel-Aviv, Israel

    Yehuda Shoenfeld

Authors
  1. Moran Landau Rabbi
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  2. Ilan Ben-Zvi
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  3. Nancy Agmon-Levin
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  4. Yehuda Shoenfeld
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Corresponding author

Correspondence to Yehuda Shoenfeld .

Editor information

Editors and Affiliations

  1. College of Veterinary Medicine, Dept. Microbiology & Immunology, Cornell University, Ithaca, 14853, New York, USA

    Rodney R. Dietert

  2. National Health and Environmental Effects, Research Laboratories, US Environmental Protection Agency, Research Triangle Park, 27711, USA

    Robert W. Luebke

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Rabbi, M.L., Ben-Zvi, I., Agmon-Levin, N., Shoenfeld, Y. (2012). Environment, Immune Dysfunction, and Systemic Lupus Erythematosus. In: Dietert, R., Luebke, R. (eds) Immunotoxicity, Immune Dysfunction, and Chronic Disease. Molecular and Integrative Toxicology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-812-2_8

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