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Chocolate in Health and Nutrition pp 277–287Cite as

Endothelial Control of Vascular Tone by Chocolate and Other Polyphenols

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References

  1. Feletou M, Vanhoutte PM. Endothelial dysfunction: a multifaceted disorder (the Wiggers Award Lecture). Am J Physiol Heart Circ Physiol. 2006;291(3):H985–1002.

    Article  PubMed  CAS  Google Scholar 

  2. Tang EH, Vanhoutte PM. Endothelial dysfunction: a strategic target in the treatment of hypertension? Pflugers Arch. 2010;459(6):995–1004.

    Article  PubMed  CAS  Google Scholar 

  3. Griendling KK, Sorescu D, Ushio-Fukai M. NAD(P)H oxidase: role in cardiovascular biology and disease. Circ Res. 2000;86(5):494–501.

    Article  PubMed  CAS  Google Scholar 

  4. Harrison DG, Cai H, Landmesser U, Griendling KK. Interactions of angiotensin II with NAD(P)H oxidase, oxidant stress and cardiovascular disease. J Renin Angiotensin Aldosterone Syst. 2003;4(2):51–61.

    Article  PubMed  CAS  Google Scholar 

  5. Mezzano D, Leighton F, Martinez C, Marshall G, Cuevas A, Castillo O, et al. Complementary effects of Mediterranean diet and moderate red wine intake on haemostatic cardiovascular risk factors. Eur J Clin Nutr. 2001;55(6):444–51.

    Article  PubMed  CAS  Google Scholar 

  6. Naissides M, Pal S, Mamo JC, James AP, Dhaliwal S. The effect of chronic consumption of red wine polyphenols on vascular function in postmenopausal women. Eur J Clin Nutr. 2006;60(6):740–5.

    Article  PubMed  CAS  Google Scholar 

  7. Marfella R, Cacciapuoti F, Siniscalchi M, Sasso FC, Marchese F, Cinone F, et al. Effect of moderate red wine intake on cardiac prognosis after recent acute myocardial infarction of subjects with Type 2 diabetes mellitus. Diabet Med. 2006;23(9):974–81.

    Article  PubMed  CAS  Google Scholar 

  8. Duffy SJ, Keaney Jr JF, Holbrook M, Gokce N, Swerdloff PL, Frei B, et al. Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease. Circulation. 2001;104(2):151–6.

    Article  PubMed  CAS  Google Scholar 

  9. Taubert D, Roesen R, Lehmann C, Jung N, Schomig E. Effects of low habitual cocoa intake on blood pressure and bioactive nitric oxide: a randomized controlled trial. JAMA. 2007;298(1):49–60.

    Article  PubMed  CAS  Google Scholar 

  10. Frankel EN, Kanner J, German JB, Parks E, Kinsella JE. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet. 1993;341(8843):454–7.

    Article  PubMed  CAS  Google Scholar 

  11. Freedman JE, Parker III C, Li L, Perlman JA, Frei B, Ivanov V, et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation. 2001;103(23):2792–8.

    Article  PubMed  CAS  Google Scholar 

  12. Wollny T, Aiello L, Di TD, Bellavia V, Rotilio D, Donati MB, et al. Modulation of haemostatic function and prevention of experimental thrombosis by red wine in rats: a role for increased nitric oxide production. Br J Pharmacol. 1999;127(3):747–55.

    Article  PubMed  CAS  Google Scholar 

  13. Iijima K, Yoshizumi M, Hashimoto M, Akishita M, Kozaki K, Ako J, et al. Red wine polyphenols inhibit vascular smooth muscle cell migration through two distinct signaling pathways. Circulation. 2002;105(20):2404–10.

    Article  PubMed  CAS  Google Scholar 

  14. Iijima K, Yoshizumi M, Hashimoto M, Kim S, Eto M, Ako J, et al. Red wine polyphenols inhibit proliferation of vascular smooth muscle cells and downregulate expression of cyclin A gene. Circulation. 2000;101(7):805–11.

    Article  PubMed  CAS  Google Scholar 

  15. Auger C, Caporiccio B, Landrault N, Teissedre PL, Laurent C, Cros G, et al. Red wine phenolic compounds reduce plasma lipids and apolipoprotein B and prevent early aortic atherosclerosis in hypercholesterolemic golden Syrian hamsters (Mesocricetus auratus). J Nutr. 2002;132(6):1207–13.

    PubMed  CAS  Google Scholar 

  16. Auger C, Gerain P, Laurent-Bichon F, Portet K, Bornet A, Caporiccio B, et al. Phenolics from commercialized grape extracts prevent early atherosclerotic lesions in hamsters by mechanisms other than antioxidant effect. J Agric Food Chem. 2004;52(16):5297–302.

    Article  PubMed  CAS  Google Scholar 

  17. Schini-Kerth VB, Auger C, Etienne-Selloum N, Chataigneau T. Polyphenol-induced endothelium-dependent relaxations role of NO and EDHF. Adv Pharmacol. 2010;60:133–75.

    Article  PubMed  CAS  Google Scholar 

  18. Fitzpatrick DF, Hirschfield SL, Coffey RG. Endothelium-dependent vasorelaxing activity of wine and other grape products. Am J Physiol Heart Circ Physiol. 1993;265(2 Pt 2):H774–8.

    CAS  Google Scholar 

  19. Fitzpatrick DF, Bing B, Maggi DA, Fleming RC, O’Malley RM. Vasodilating procyanidins derived from grape seeds. Ann NY Acad Sci. 2002;957:78–89.

    Article  PubMed  CAS  Google Scholar 

  20. Fitzpatrick DF, Fleming RC, Bing B, Maggi DA, O’Malley RM. Isolation and characterization of endothelium-dependent vasorelaxing compounds from grape seeds. J Agric Food Chem. 2000;48(12):6384–90.

    Article  PubMed  CAS  Google Scholar 

  21. Fitzpatrick DF, Bing B, Rohdewald P. Endothelium-dependent vascular effects of Pycnogenol. J Cardiovasc Pharmacol. 1998;32(4):509–15.

    Article  PubMed  CAS  Google Scholar 

  22. Anselm E, Socorro VF, Dal-Ros S, Schott C, Bronner C, Schini-Kerth VB. Crataegus special extract WS 1442 causes endothelium-dependent relaxation via a redox-sensitive Src- and Akt-dependent activation of endothelial NO synthase but not via activation of estrogen receptors. J Cardiovasc Pharmacol. 2009;53(3):253–60.

    Article  PubMed  CAS  Google Scholar 

  23. Andriambeloson E, Kleschyov AL, Muller B, Beretz A, Stoclet JC, Andriantsitohaina R. Nitric oxide production and endothelium-dependent vasorelaxation induced by wine polyphenols in rat aorta. Br J Pharmacol. 1997;120(6):1053–8.

    Article  PubMed  CAS  Google Scholar 

  24. Andriambeloson E, Magnier C, Haan-Archipoff G, Lobstein A, Anton R, Beretz A, et al. Natural dietary polyphenolic compounds cause endothelium-dependent vasorelaxation in rat thoracic aorta. J Nutr. 1998;128(12):2324–33.

    PubMed  CAS  Google Scholar 

  25. Cishek MB, Galloway MT, Karim M, German JB, Kappagoda CT. Effect of red wine on endothelium-dependent relaxation in rabbits. Clin Sci (Lond). 1997;93(6):507–11.

    CAS  Google Scholar 

  26. Dal-Ros S, Bronner C, Schott C, Kane MO, Chataigneau M, Schini-Kerth VB, et al. Angiotensin II-induced hypertension is associated with a selective inhibition of endothelium-derived hyperpolarizing factor-mediated responses in the rat mesenteric artery. J Pharmacol Exp Ther. 2009;328(2):478–86.

    Article  PubMed  CAS  Google Scholar 

  27. Soares De Moura R, Costa Viana FS, Souza MA, Kovary K, Guedes DC, Oliveira EP, et al. Antihypertensive, vasodilator and antioxidant effects of a vinifera grape skin extract. J Pharm Pharmacol. 2002;54(11):1515–20.

    Article  PubMed  CAS  Google Scholar 

  28. Chan SL, Tabellion A, Bagrel D, Perrin-Sarrado C, Capdeville-Atkinson C, Atkinson J. Impact of chronic treatment with red wine polyphenols (RWP) on cerebral arterioles in the spontaneous hypertensive rat. J Cardiovasc Pharmacol. 2008;51(3):304–10.

    Article  PubMed  CAS  Google Scholar 

  29. Nagaoka T, Hein TW, Yoshida A, Kuo L. Resveratrol, a component of red wine, elicits dilation of isolated porcine retinal arterioles: role of nitric oxide and potassium channels. Invest Ophthalmol Vis Sci. 2007;48(9):4232–9.

    Article  PubMed  Google Scholar 

  30. Ndiaye M, Chataigneau M, Lobysheva I, Chataigneau T, Schini-Kerth VB. Red wine polyphenol-induced, endothelium-dependent NO-mediated relaxation is due to the redox-sensitive PI3-kinase/Akt-dependent phosphorylation of endothelial NO-synthase in the isolated porcine coronary artery. FASEB J. 2005;19(3):455–7.

    PubMed  CAS  Google Scholar 

  31. Flesch M, Schwarz A, Bohm M. Effects of red and white wine on endothelium-dependent vasorelaxation of rat aorta and human coronary arteries. Am J Physiol. 1998;275(4 Pt 2):H1183–90.

    PubMed  CAS  Google Scholar 

  32. Rakici O, Kiziltepe U, Coskun B, Aslamaci S, Akar F. Effects of resveratrol on vascular tone and endothelial function of human saphenous vein and internal mammary artery. Int J Cardiol. 2005;105(2):209–15.

    Article  PubMed  Google Scholar 

  33. Karim M, McCormick K, Kappagoda CT. Effects of cocoa extracts on endothelium-dependent relaxation. J Nutr. 2000;130(8S Suppl):2105S–8.

    PubMed  CAS  Google Scholar 

  34. Ndiaye M, Chataigneau T, Andriantsitohaina R, Stoclet JC, Schini-Kerth VB. Red wine polyphenols cause endothelium-dependent EDHF-mediated relaxations in porcine coronary arteries via a redox-sensitive mechanism. Biochem Biophys Res Commun. 2003;310(2):371–7.

    Article  PubMed  CAS  Google Scholar 

  35. Anselm E, Chataigneau M, Ndiaye M, Chataigneau T, Schini-Kerth VB. Grape juice causes endothelium-­dependent relaxation via a redox-sensitive Src- and Akt-dependent activation of eNOS. Cardiovasc Res. 2007;73(2):404–13.

    Article  PubMed  CAS  Google Scholar 

  36. Kwan CY, Zhang WB, Deyama T, Nishibe S. Endothelium-dependent vascular relaxation induced by Eucommia ulmoides Oliv. bark extract is mediated by NO and EDHF in small vessels. Naunyn Schmiedebergs Arch Pharmacol. 2004;369(2):206–11.

    Article  PubMed  CAS  Google Scholar 

  37. Kwan CY, Zhang WB, Sim SM, Deyama T, Nishibe S. Vascular effects of Siberian ginseng (Eleutherococcus senticosus): endothelium-dependent NO- and EDHF-mediated relaxation depending on vessel size. Naunyn Schmiedebergs Arch Pharmacol. 2004;369(5):473–80.

    Article  PubMed  CAS  Google Scholar 

  38. Rocha AP, Carvalho LC, Sousa MA, Madeira SV, Sousa PJ, Tano T, et al. Endothelium-dependent vasodilator effect of Euterpe oleracea Mart. (Acai) extracts in mesenteric vascular bed of the rat. Vascul Pharmacol. 2007;46(2):97–104.

    Article  PubMed  CAS  Google Scholar 

  39. Ndiaye M, Chataigneau T, Chataigneau M, Schini-Kerth VB. Red wine polyphenols induce EDHF-mediated relaxations in porcine coronary arteries through the redox-sensitive activation of the PI3-kinase/Akt pathway. Br J Pharmacol. 2004;142(7):1131–6.

    Article  PubMed  CAS  Google Scholar 

  40. Madeira SV, Auger C, Anselm E, Chataigneau M, Chataigneau T, Soares de Moura R, et al. eNOS activation induced by a polyphenol-rich grape skin extract in porcine coronary arteries. J Vasc Res. 2009;46(5):406–16.

    Article  PubMed  CAS  Google Scholar 

  41. Auger C, Kim JH, Chabert P, Chaabi M, Anselm E, Lanciaux X, et al. The EGCg-induced redox-sensitive activation of endothelial nitric oxide synthase and relaxation are critically dependent on hydroxyl moieties. Biochem Biophys Res Commun. 2010;393(1):162–7.

    Article  PubMed  CAS  Google Scholar 

  42. Natsume M, Osakabe N, Yamagishi M, Takizawa T, Nakamura T, Miyatake H, et al. Analyses of polyphenols in cacao liquor, cocoa, and chocolate by normal-phase and reversed-phase HPLC. Biosci Biotechnol Biochem. 2000;64(12):2581–7.

    Article  PubMed  CAS  Google Scholar 

  43. Ramirez-Sanchez I, Maya L, Ceballos G, Villarreal F. (−)-epicatechin activation of endothelial cell endothelial nitric oxide synthase, nitric oxide, and related signaling pathways. Hypertension. 2010;55(6):1398–405.

    Article  PubMed  CAS  Google Scholar 

  44. Kim JA, Formoso G, Li Y, Potenza MA, Marasciulo FL, Montagnani M, et al. Epigallocatechin gallate, a green tea polyphenol, mediates NO-dependent vasodilation using signaling pathways in vascular endothelium requiring reactive oxygen species and Fyn. J Biol Chem. 2007;282(18):13736–45.

    Article  PubMed  CAS  Google Scholar 

  45. Ramirez-Sanchez I, Maya L, Ceballos G, Villarreal F. (−)-Epicatechin induces calcium and translocation independent eNOS activation in arterial endothelial cells. Am J Physiol Cell Physiol. 2011;300(4):C880–7.

    Article  PubMed  CAS  Google Scholar 

  46. Martin S, Andriambeloson E, Takeda K, Andriantsitohaina R. Red wine polyphenols increase calcium in bovine aortic endothelial cells: a basis to elucidate signalling pathways leading to nitric oxide production. Br J Pharmacol. 2002;135(6):1579–87.

    Article  PubMed  CAS  Google Scholar 

  47. Cienfuegos-Jovellanos E, Quinones MM, Muguerza B, Moulay L, Miguel M, Aleixandre A. Antihypertensive effect of a polyphenol-rich cocoa powder industrially processed to preserve the original flavonoids of the cocoa beans. J Agric Food Chem. 2009;57(14):6156–62.

    Article  PubMed  CAS  Google Scholar 

  48. Sanchez D, Quinones M, Moulay L, Muguerza B, Miguel M, Aleixandre A. Changes in arterial blood pressure of a soluble cocoa fiber product in spontaneously hypertensive rats. J Agric Food Chem. 2010;58(3):1493–501.

    Article  PubMed  CAS  Google Scholar 

  49. Shaughnessy KS, Boswall IA, Scanlan AP, Gottschall-Pass KT, Sweeney MI. Diets containing blueberry extract lower blood pressure in spontaneously hypertensive stroke-prone rats. Nutr Res. 2009;29(2):130–8.

    Article  PubMed  CAS  Google Scholar 

  50. Negishi H, Xu JW, Ikeda K, Njelekela M, Nara Y, Yamori Y. Black and green tea polyphenols attenuate blood pressure increases in stroke-prone spontaneously hypertensive rats. J Nutr. 2004;134(1):38–42.

    PubMed  CAS  Google Scholar 

  51. Peng N, Clark JT, Prasain J, Kim H, White CR, Wyss JM. Antihypertensive and cognitive effects of grape polyphenols in estrogen-depleted, female, spontaneously hypertensive rats. Am J Physiol Regul Integr Comp Physiol. 2005;289(3):R771–5.

    Article  PubMed  CAS  Google Scholar 

  52. Lopez-Sepulveda R, Jimenez R, Romero M, Zarzuelo MJ, Sánchez M, Gómez-Guzmán M, et al. Wine polyphenols improve endothelial function in large vessels of female spontaneously hypertensive rats. Hypertension. 2008;51(4):1088–95.

    Article  PubMed  CAS  Google Scholar 

  53. Bernatova I, Pechanova O, Babal P, Kysela S, Stvrtina S, Andriantsitohaina R. Wine polyphenols improve cardiovascular remodeling and vascular function in NO-deficient hypertension. Am J Physiol Heart Circ Physiol. 2002;282(3):H942–8.

    PubMed  CAS  Google Scholar 

  54. Pechanova O, Bernatova I, Babal P, Martínez MC, Kyselá S, Stvrtina S, et al. Red wine polyphenols prevent cardiovascular alterations in L-NAME-induced hypertension. J Hypertens. 2004;22(8):1551–9.

    Article  PubMed  CAS  Google Scholar 

  55. Sarr M, Chataigneau M, Martins S, Schott C, El Bedoui J, Oak MH, et al. Red wine polyphenols prevent angiotensin II-induced hypertension and endothelial dysfunction in rats: role of NADPH oxidase. Cardiovasc Res. 2006;71(4):794–802.

    Article  PubMed  CAS  Google Scholar 

  56. Jimenez R, Lopez-Sepulveda R, Kadmiri M, Romero M, Vera R, Sánchez M, et al. Polyphenols restore endothelial function in DOCA-salt hypertension: role of endothelin-1 and NADPH oxidase. Free Radic Biol Med. 2007;43(3):462–73.

    Article  PubMed  CAS  Google Scholar 

  57. Kurosawa T, Itoh F, Nozaki A, Nakano Y, Katsuda S, Osakabe N, et al. Suppressive effect of cocoa powder on atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic rabbits. J Atheroscler Thromb. 2005;12(1):20–8.

    Article  PubMed  CAS  Google Scholar 

  58. Kurosawa T, Itoh F, Nozaki A, Nakano Y, Katsuda S, Osakabe N, et al. Suppressive effects of cacao liquor polyphenols (CLP) on LDL oxidation and the development of atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic rabbits. Atherosclerosis. 2005;179(2):237–46.

    Article  PubMed  CAS  Google Scholar 

  59. Tomaru M, Takano H, Osakabe N, Yasuda A, Inoue K, Yanagisawa R, et al. Dietary supplementation with cacao liquor proanthocyanidins prevents elevation of blood glucose levels in diabetic obese mice. Nutrition. 2007;23(4):351–5.

    Article  PubMed  CAS  Google Scholar 

  60. Ruzaidi A, Amin I, Nawalyah AG, Hamid M, Faizul HA. The effect of Malaysian cocoa extract on glucose levels and lipid profiles in diabetic rats. J Ethnopharmacol. 2005;98(1–2):55–60.

    Article  PubMed  CAS  Google Scholar 

  61. Al-Awwadi NA, Araiz C, Bornet A, Delbosc S, Cristol JP, Linck N, et al. Extracts enriched in different polyphenolic families normalize increased cardiac NADPH oxidase expression while having differential effects on insulin resistance, hypertension, and cardiac hypertrophy in high-fructose-fed rats. J Agric Food Chem. 2005;53(1):151–7.

    Article  PubMed  CAS  Google Scholar 

  62. Dal-Ros S, Zoll J, Lang AL, Auger C, Keller N, Bronner C, Geny B, Schini-Kerth VB, et al. Chronic intake of red wine polyphenols by young rats prevents aging-induced endothelial dysfunction and decline in physical performance: role of NADPH oxidase. Biochem Biophys Res Commun. 2011;404(2):743–9.

    Article  PubMed  CAS  Google Scholar 

  63. Fisher ND, Hughes M, Gerhard-Herman M, Hollenberg NK. Flavanol-rich cocoa induces nitric-oxide-dependent vasodilation in healthy humans. J Hypertens. 2003;21(12):2281–6.

    Article  PubMed  CAS  Google Scholar 

  64. Schroeter H, Heiss C, Balzer J, Kleinbongard P, Keen CL, Hollenberg NK, et al. (−)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. Proc Natl Acad Sci USA. 2006;103(4):1024–9.

    Article  PubMed  CAS  Google Scholar 

  65. Engler MB, Engler MM, Chen CY, Malloy MJ, Browne A, Chiu EY, et al. Flavonoid-rich dark chocolate improves endothelial function and increases plasma epicatechin concentrations in healthy adults. J Am Coll Nutr. 2004;23(3):197–204.

    PubMed  CAS  Google Scholar 

  66. Monahan KD, Feehan RP, Kunselman AR, Preston AG, Miller DL, Lott ME. Dose-dependent increases in flow-mediated dilation following acute cocoa ingestion in healthy older adults. J Appl Physiol. 2011;111(6):1568–74.

    Google Scholar 

  67. Shiina Y, Funabashi N, Lee K, Murayama T, Nakamura K, Wakatsuki Y, et al. Acute effect of oral flavonoid-rich dark chocolate intake on coronary circulation, as compared with non-flavonoid white chocolate, by transthoracic Doppler echocardiography in healthy adults. Int J Cardiol. 2009;131(3):424–9.

    Article  PubMed  Google Scholar 

  68. Heiss C, Dejam A, Kleinbongard P, Schewe T, Sies H, Kelm M. Vascular effects of cocoa rich in flavan-3-ols. JAMA. 2003;290(8):1030–1.

    Article  PubMed  Google Scholar 

  69. Grassi D, Desideri G, Necozione S, Lippi C, Casale R, Properzi G, et al. Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate. J Nutr. 2008;138(9):1671–6.

    PubMed  CAS  Google Scholar 

  70. Grassi D, Necozione S, Lippi C, Croce G, Valeri L, Pasqualetti P, et al. Cocoa reduces blood pressure and insulin resistance and improves endothelium-dependent vasodilation in hypertensives. Hypertension. 2005;46(2):398–405.

    Article  PubMed  CAS  Google Scholar 

  71. Taubert D, Berkels R, Roesen R, Klaus W. Chocolate and blood pressure in elderly individuals with isolated systolic hypertension. JAMA. 2003;290(8):1029–30.

    Article  PubMed  Google Scholar 

  72. Muniyappa R, Hall G, Kolodziej TL, Karne RJ, Crandon SK, Quon MJ. Cocoa consumption for 2 wk enhances insulin-mediated vasodilatation without improving blood pressure or insulin resistance in essential hypertension. Am J Clin Nutr. 2008;88(6):1685–96.

    Article  PubMed  CAS  Google Scholar 

  73. Ried K, Frank OR, Stocks NP. Dark chocolate or tomato extract for prehypertension: a randomised controlled trial. BMC Complement Altern Med. 2009;9:22.

    Article  PubMed  Google Scholar 

  74. Hermann F, Spieker LE, Ruschitzka F, Sudano I, Hermann M, Binggeli C, et al. Dark chocolate improves endothelial and platelet function. Heart. 2006;92(1):119–20.

    Article  PubMed  CAS  Google Scholar 

  75. Heiss C, Finis D, Kleinbongard P, Hoffmann A, Rassaf T, Kelm M, et al. Sustained increase in flow-mediated dilation after daily intake of high-flavanol cocoa drink over 1 week. J Cardiovasc Pharmacol. 2007;49(2):74–80.

    Article  PubMed  CAS  Google Scholar 

  76. Balzer J, Rassaf T, Heiss C, Kleinbongard P, Lauer T, Merx M, et al. Sustained benefits in vascular function through flavanol-containing cocoa in medicated diabetic patients a double-masked, randomized, controlled trial. J Am Coll Cardiol. 2008;51(22):2141–9.

    Article  PubMed  CAS  Google Scholar 

  77. Flammer AJ, Hermann F, Sudano I, Spieker L, Hermann M, Cooper KA, et al. Dark chocolate improves coronary vasomotion and reduces platelet reactivity. Circulation. 2007;116(21):2376–82.

    Article  PubMed  Google Scholar 

  78. Farouque HM, Leung M, Hope SA, Baldi M, Schechter C, Cameron JD, et al. Acute and chronic effects of flavanol-rich cocoa on vascular function in subjects with coronary artery disease: a randomized double-blind placebo-controlled study. Clin Sci (Lond). 2006;111(1):71–80.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. UMR CNRS 7213 – Laboratory of Biophotonics and Pharmacology, Strasbourg University, 74, route du Rhin, Illkirch, 67401, France

    Cyril Auger Ph.D. & Noureddine Idris-Khodja Pharm D, Ph.D.

  2. UMR CNRS 7213–Laboratory of Biophotonics and Pharmacology, Strasbourg University, 74, route du rhin, Illkirch, 67401, France

    Valérie B. Schini-Kerth Ph.D.

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  1. Cyril Auger Ph.D.
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  2. Noureddine Idris-Khodja Pharm D, Ph.D.
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  3. Valérie B. Schini-Kerth Ph.D.
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Correspondence to Valérie B. Schini-Kerth Ph.D. .

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Editors and Affiliations

  1. Health Sciences Center, Department of Health Promotion Sciences, University of Arizona, 1295 N. Martin Ave. 1295, Tucson, 85724-5155, Arizona, USA

    Ronald Ross Watson

  2. Dept. Nutrition & Dietetics, King's College, Stamford St. 150, London, SE1 9NH, United Kingdom

    Victor R. Preedy

  3. Division of Health Promotion Sciences, Mel and Enid Zuckerman, University of Arizona, 1295 N. Martin Avenue, Tucson, 85724, Arizona, USA

    Sherma Zibadi

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Auger, C., Idris-Khodja, N., Schini-Kerth, V.B. (2013). Endothelial Control of Vascular Tone by Chocolate and Other Polyphenols. In: Watson, R., Preedy, V., Zibadi, S. (eds) Chocolate in Health and Nutrition. Nutrition and Health, vol 7. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-803-0_20

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