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Docosahexaenoic Acid Signalolipidomics in the Homeostatic Modulation of Photoreceptor/Retinal Pigment Epithelial Cell Integrity During Oxidative Stress

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Studies on Retinal and Choroidal Disorders

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Abstract

Vision is sustained by the relationship between photoreceptor cells and retinal pigment epithelial (RPE) cells. This relationship results in life-long cell survival in spite of the fact that they reside in a part of the eye that is constantly exposed to potentially damaging factors such as light, high O2 consumption, and high fluxes of polyunsaturated fatty acids. One goal of vision research is to uncover the endogenous cell survival signals that counteract excessive oxidative stress in the retina. Docosahexaenoic acid (DHA) is a member of the omega-3 essential fatty acid family that is derived from linolenic acid, 18:3, n-3. DHA and vitamin A from the opsin chromophore of rod photoreceptor outer segments are recycled back from the RPE to inner segments through the interphotoreceptor matrix (IPM). In this chapter, we expound upon these concepts and discuss the intimate, harmonious relationship between photoreceptor and RPE cells.

Supported by National Institutes of Health, National Eye Institute grant EY005121, and National Center for Research Resources grant P20 RR016816, American Health Assistance Foundation grant M2010091, the Eye, Ear, Nose, and Throat Foundation; the Edward G. Schlieder Educational Foundation; and by the Ernest C. and Yvette C. Villere Endowed Chair.

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  1. Neuroscience Center of Excellence and Department of Ophthalmology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA

    Nicolas G. Bazan & Anasheh Halabi

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  1. Nicolas G. Bazan
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  2. Anasheh Halabi
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Correspondence to Nicolas G. Bazan .

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    Robert D. Stratton

  2. Department of Ophthalmology, University of Florida, SW Archer Road 1600, Gainesville, 32610, Florida, USA

    William W. Hauswirth

  3. Molecular and Integrative Physiology, Ophthalmology and Visual Sciences, Kellogg Eye Center, Wall Street 1000, Ann Arbor, 17033-2390, Michigan, USA

    Thomas W. Gardner

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Bazan, N.G., Halabi, A. (2012). Docosahexaenoic Acid Signalolipidomics in the Homeostatic Modulation of Photoreceptor/Retinal Pigment Epithelial Cell Integrity During Oxidative Stress. In: Stratton, R., Hauswirth, W., Gardner, T. (eds) Studies on Retinal and Choroidal Disorders. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press. https://doi.org/10.1007/978-1-61779-606-7_7

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