Skip to main content
SpringerLink
Log in
Book cover

Biomaterials for Surgical Operation pp 91–130Cite as

Barriers to Prevent Tissue Adhesion

  • Chapter
  • First Online:

Abstract

Adhesion often occurs after surgery, especially in abdominal, gynecological, and thoracic surgeries. It can cause serious postsurgical complications such as infertility, chronic pelvic pain, and difficulties of extensive adhesiolysis in future ­surgery. Antiadhesive barriers have been developed to provide physical separation between the injured site and the adjacent tissues. Since physical separation is only required during the critical time of wound healing of the damaged area, bioabsorbable polymers have been found to be appropriate. A range of adhesion barriers are commercially available in the forms of solutions, gels, and sheets. Their characteristics and limitations are discussed in this chapter. Recent investigations are also described on newly developed devices that show promising performance such as ease of handling and more effective reduction of adhesion.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Ray NF, Denton WG, Thamer M, Henderson SC, Perry S (1998) Abdominal adhesiolysis: inpatient care and expenditures in the United States in 1994. J Am Coll Surg 186(1):1–9

    Article  PubMed  CAS  Google Scholar 

  2. Imai A, Takagi H, Matsunami K, Suzuki N (2010) Non-barrier agents for postoperative adhesion prevention: clinical and preclinical aspects. Arch Gynecol Obstet 282(3):269–75

    Article  PubMed  Google Scholar 

  3. Tanaka A, Abe T, Matsuura A (2000) Prevention of postoperative intrapleural adhesion of the thoracotomy incision by a bioresorbable membrane in the rat adhesion model. Ann Thorac Cardiovasc Surg 6(3):151–60

    PubMed  CAS  Google Scholar 

  4. Kamel RM (2010) Prevention of postoperative peritoneal adhesions. Eur J Obstet Gynecol Reprod Biol 150(2):111–8

    Article  PubMed  Google Scholar 

  5. Malinak LR, Young A (1997) Peritoneal closure: when and why. Contemp Obstet Gynecol 42:102–12

    Google Scholar 

  6. Tulandi T, Al-Jaroudi D (2003) Nonclosure of peritoneum: a reappraisal. Am J Obstet Gynecol 189(2):609–12

    Article  PubMed  Google Scholar 

  7. Tulandi T, Hum HS, Gelfand MM (1988) Closure of laparotomy incisions with or without peritoneal suturing and second-look laparoscopy. Am J Obstet Gynecol 158(3 Pt 1):536–7

    PubMed  CAS  Google Scholar 

  8. Johns A (2001) Evidence-based prevention of post-operative adhesions. Hum Reprod Update 7(6):577–9

    Article  PubMed  CAS  Google Scholar 

  9. Cheong YC, Bajekal N, Li TC (2001) Peritoneal closure—to close or not to close. Hum Reprod 16(8):1548–52

    Article  PubMed  CAS  Google Scholar 

  10. Novitsky YW, Harrell AG, Cristiano JA, Paton BL, Norton HJ, Peindl RD, Kercher KW, Heniford BT (2007) Comparative evaluation of adhesion formation, strength of ingrowth, and textile properties of prosthetic meshes after long-term intra-abdominal implantation in a rabbit. J Surg Res 140(1):6–11

    Article  PubMed  CAS  Google Scholar 

  11. Harris ES, Morgan RF, Rodeheaver GT (1995) Analysis of the kinetics of peritoneal adhesion formation in the rat and evaluation of potential antiadhesive agents. Surgery 117:663–9

    Article  PubMed  CAS  Google Scholar 

  12. Buckman RF, Woods M, Sargent L, Gervin AS (1976) A unifying pathogenetic mechanism in the etiology of intraperitoneal adhesions. J Surg Res 20(1):1–5

    Article  PubMed  CAS  Google Scholar 

  13. Matsuda S, Se N, Iwata H, Ikada Y (2002) Evaluation of the antiadhesion potential of UV cross-linked gelatin films in a rat abdominal model. Biomaterials 23:2901–8

    Article  PubMed  CAS  Google Scholar 

  14. Larsson B, Lalos O, Marsk L, Tronstad SE, Bygdeman M, Pehrson S, Joelsson I (1985) Effect of intraperitoneal instillation of 32% dextran 70 on postoperative adhesion formation after tubal surgery. Acta Obstet Gynecol Scand 64(5):437–41

    Article  PubMed  CAS  Google Scholar 

  15. Weinans MJ, Kauer FM, Klompmaker IJ, Wijma J (1990) Transient liver function disturbances after the intraperitoneal use of 32% dextran 70 as adhesion prophylaxis in infertility surgery. Fertil Steril 53(1):159–61

    PubMed  CAS  Google Scholar 

  16. Tulandi T (1987) Transient edema after intraperitoneal instillation of 32% dextran 70. A report of five cases. J Reprod Med 32(6):472–4

    PubMed  CAS  Google Scholar 

  17. Sites CK, Jensen BA, Glock JL, Blackman JA, Badger GJ, Johnson JV, Brumsted JR (1997) Transvaginal ultrasonographic assessment of Hyskon or lactated Ringer’s solution instillation after laparoscopy: randomized, controlled study. J Ultrasound Med 16(3):195–9

    PubMed  CAS  Google Scholar 

  18. Holtz G, Baker E, Tsai C (1980) Effect of thirty-two per cent dextran 70 on peritoneal adhesion formation and re-formation after lysis. Fertil Steril 33(6):660–2

    PubMed  CAS  Google Scholar 

  19. Rose B (1987) Safety of Hyskon for routine gynecologic surgery. A case report. J Reprod Med 32(2):134–6

    Google Scholar 

  20. Ruiz JM, Neuwirth RF (1992) The incidence of complications associated with the use of Hyskon during hysteroscopy: experience in 1793 consecutive patients. J Gynecol Surg 8(4):219–24

    Article  Google Scholar 

  21. Kossi J, Gronlund S, Uotila-Nieminen M, Crowe A, Knight A, Keranen U (2008) The effect of 4% icodextrin solution on adhesiolysis surgery time at the Hartmann’s reversal: a pilot, multicentre, randomized control trial vs lactated Ringer’s solution. Colorect Dis 11:168–72

    Article  Google Scholar 

  22. Johns DB, Keyport GM, Hoehler F, Johns DB, Keyport GM, Hoehler F, Zerega GS (2001) Reduction of postsurgical adhesions with intergel® adhesion prevention solution: a multicenter study of safety and efficacy after conservative gynecologic surgery. Fertil Steril 76(3):595–604

    Article  PubMed  CAS  Google Scholar 

  23. FDA 2003 Safety Alert INTERGEL adhesion prevention solution. Available from: http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm170010.htm

  24. Rice VM, Shanti A, Moghissi KS, Leach RE (1993) A comparative evaluation of Poloxamer 407 and oxidized regenerated cellulose (Interceed [TC7]) to reduce postoperative adhesion formation in the rat uterine horn model. Fertil Steril 59(4):901–6

    PubMed  CAS  Google Scholar 

  25. Weis C, Odermatt E (2006) A-part gel - an efficient adhesion prevention barrier. J Biomed Mater Res Part B: Appl Biomater 82B:174–82

    Article  Google Scholar 

  26. Weis C, Odermatt EK, Kressler J, Unke Z, Wehner T, Freytag D (2004) Poly(vinyl alcohol) membrane for adhesion prevention. J Biomed Mater Res 70B:191–202

    Article  CAS  Google Scholar 

  27. Janigen B, Weis C, Odermatt EK, Obermaier R, Hopt UT (2009) The new adhesion prophylaxis membrane A-Part from in vitro testing to first in vivo results. J Biomed Mater Res 89B:293–9

    Article  Google Scholar 

  28. Young P, Johns A, Templeman C, Witz C, Webster B, Ferland R, Diamond MP, Block K, di Zerega G (2005) Reduction of postoperative adhesions after laparoscopic gynecological surgery with Oxiplex/AP Gel: a pilot study. Fertil Steril 84(5):1450–6

    Article  PubMed  Google Scholar 

  29. Dunn R, Lyman MD, Edelman PG, Campbell PK (2001) Evaluation of the SprayGelTM adhesion barrier in the rat cecum abrasion and rabbit uterine horn adhesion models. Fertil Steril 75(2):411–6

    Article  PubMed  CAS  Google Scholar 

  30. Trew G (2006) Postoperative adhesions and their prevention. Rev Gynaecol Perinat Pract 6(1):47–56

    Article  Google Scholar 

  31. Ferland R, Mulani D, Campbell PK (2001) Evaluation of a sprayable polyethylene glycol adhesion barrier in a porcine efficacy model. Hum Reprod 16(12):2718–23

    Article  PubMed  CAS  Google Scholar 

  32. Mettler L, Audebert A, Lehmann-Willenbrock E, Jacobs VR, Schive K (2003) New adhesion prevention concept in gynecological surgery. JSLS 7(3):207–9

    PubMed  CAS  Google Scholar 

  33. Mettler L, Audebert A, Lehmann-Willenbrock E, Schive K, Jacobs VR (2003) Prospective clinical trial of SprayGel as a barrier to adhesion formation: an interim analysis. J Am Assoc Gynecol Laparosc 10(3):339–44

    Article  PubMed  CAS  Google Scholar 

  34. Tjandra JJ, Chan MK (2008) A sprayable hydrogel adhesion barrier facilitates closure of defunctioning loop ileostomy: a randomized trial. Dis Colon Rectum 51(6):956–60

    Article  PubMed  Google Scholar 

  35. Ferland R, Campbell PK (2008) Evaluation of SprayShield adhesion barrier system in a porcine model of gynecological surgery Covidien 2008. Available from: http://www.surgipeer.com/sprayshield/publications.php

  36. Angiotech presents positive AdhibitTM data at the 19th annual European Congress of Obstetrics and Gynecology: surgical adhesion scores were threefold less in patients treated with AdhibitTM. Vancouver: Angiotech Pharmaceuticals; 2006; Available from: http://www.bcbiotech.ca/News/Member_Press_Releaeses/pr04070602.asp.

  37. Salminen JT, Mattila IP, Puntila JT, Sairanen HI (2010) Prevention of postoperative pericardial adhesions in children with hypoplastic left heart syndrome. Interact CardioVasc Thorac Surg 12:270–272

    Article  PubMed  Google Scholar 

  38. An expanded polytetrafluoroethylene barrier (Gore-Tex Surgical Membrane) reduces post-myomectomy adhesion formation. The Myomectomy Adhesion Multicenter Study Group (1995). Fertil Steril 3(3):491–3.

    Google Scholar 

  39. Haney AF, Hesla J, Hurst BS, Kettel LM, Murphy AA, Rock JA, Rowe G, Schlaff WD (1995) Expanded polytetrafluoroethylene (Gore-Tex Surgical Membrane) is superior to oxidized regenerated cellulose (Interceed TC7+) in preventing adhesions. Fertil Steril 63(5):1021–6

    PubMed  CAS  Google Scholar 

  40. Hurst BS (1999) Permanent implantation of expanded polytetrafluoroethylene is safe for pelvic surgery. Human Reprod 14(4):925–7

    Article  CAS  Google Scholar 

  41. Kawamura H, Yokota R, Yokota K, Watarai H, Tsunoda Y, Yamagami H, Hata T, Tanaka K, Masuko H, Ishizu H, Okada K, Adachi T, Kondo Y (2010) A sodium hyaluronate carboxymethylcellulose bioresorbable membrane prevents postoperative small-bowel adhesive obstruction after distal gastrectomy. Surg Today 40:223–7

    Article  PubMed  CAS  Google Scholar 

  42. Medina M, Paddock HN, Connolly RJ, Schwaitzberg SD (1995) Novel antiadhesion barrier does not prevent anastomotic healing in a rabbit model. J Invest Surg 8(3):179–86

    Article  PubMed  CAS  Google Scholar 

  43. Burns JW, Colt MJ, Burgees LS, Skinner KC (1997) Preclinical evaluation of Seprafilm bioresorbable membrane. Eur J Surg Suppl 577:40–8

    PubMed  Google Scholar 

  44. Rajab TK, Wallwiener M, Planck C, Brochhausen C, Kraemer B, Wallwiener CW (2010) A direct comparison of seprafilm, adept, intercoat, and spraygel for adhesion prophylaxis. J Surg Res 161:246–9

    Article  PubMed  CAS  Google Scholar 

  45. Becker JM, Dayton MT, Fazio VW, Beck DE, Stryker SJ, Wexner SD, Wolff BG, Roberts PL, Smith LE, Sweeney SA, Moore M (1996) Prevention of postoperative abdominal adhesions by a sodium hyaluronate-based bioresorbable membrane: a prospective, randomized, double-blind multicenter study. J Am Coll Surg 183(4):297–306

    PubMed  CAS  Google Scholar 

  46. Kusunoki M, Ikeuchi H, Yanagi H, Noda M, Tonouchi H, Mohri Y, Uchida K, Inoue Y, Kobayashi M, Miki C, Yamamura T (2005) Bioresorbable hyaluronate-carboxymethylcellulose membrane (Seprafilm) in surgery for rectal carcinoma: a prospective randomized clinical trial. Surg Today 35(11):940–5

    Article  PubMed  Google Scholar 

  47. Hayashi S, Takayama T, Masuda H, Kochi M, Ishii Y, Matsuda M, Yamagata M, Fujii M (2008) Bioresorbable membrane to reduce postoperative small bowel obstruction in patients with gastric cancer: a randomized clinical trial. Ann Surg 247(5):766–70

    Article  PubMed  Google Scholar 

  48. Beck DE, Cohen Z, Fleshman JW, Kaufman HS, van Goor H, Wolff BG, Adhesion Study Group Steering Committee (2003) A prospective, randomized, multicenter, controlled study of the safety of Seprafilm adhesion barrier in abdominopelvic surgery of the intestine. Dis Colon Rectum 46(10):1310–9

    Article  PubMed  Google Scholar 

  49. Fazio VW, Cohen Z, Fleshman JW, van Goor H, Bauer JJ, Wolff BG, Corman M, Beart RW Jr, Wexner SD, Becker JM, Monson JR, Kaufman HS, Beck DE, Bailey HR, Ludwig KA, Stamos MJ, Darzi A, Bleday R, Dorazio R, Madoff RD, Smith LE, Gearhart S, Lillemoe K, Gohl J (2006) Reduction in adhesive small-bowel obstruction by Seprafilm adhesion barrier after intestinal resection. Dis Colon Rectum 49(1):1–11

    Article  PubMed  Google Scholar 

  50. Walther T, Rastan A, Dähnert I, Falk V, Jacobs S, Mohr FW, Kostelka M (2005) A novel adhesion barrier facilitates reoperations in complex congenital cardiac surgery. J Thorac Cardiovasc Surg 129(2):359–63

    Article  PubMed  Google Scholar 

  51. Naito Y, Shin’oka T, Hibino N, Matsumura G, Kurosawa H (2008) A novel method to reduce pericardial adhesion: a combination technique with hyaluronic acid biocompatible membrane. J Thorac Cardiovasc Surg 135(4)):850–6

    Article  PubMed  Google Scholar 

  52. Wiseman DM, Trout JR, Franklin RR, Diamond MP (1999) Metaanalysis of the safety and efficacy of an adhesion barrier (Interceed TC7) in laparotomy. J Reprod Med 44(4):325–31

    PubMed  CAS  Google Scholar 

  53. Prevention of postsurgical adhesions by INTERCEED(TC7), an absorbable adhesion barrier: a prospective randomized multicenter clinical study. INTERCEED(TC7) Adhesion Barrier Study Group (1989). Fertil Steril 51(6):933–8

    Google Scholar 

  54. Iliopoulos J, Cornwall GB, Evans RO, Manganas C, Thomas KA, Newman DC, Walsh WR (2004) Evaluation of a bioabsorable polylactide film in a large animal model for the reduction of retrosternal adhesions. J Surg Res 118(2):144–53

    Article  PubMed  CAS  Google Scholar 

  55. Faerden A, Reiertsen O, Marx A (2006) The effectiveness of a bioresorbable polymer sheet (SurgiWrap®) in minimizing Soft Tissue Attachments (STA) after major colorectal surgery: a randomized controlled pilot study. MAST Biosurgery from manufactures website.

    Google Scholar 

  56. Okuyama N, Wang CY, Rose EA, Rodgers KE, Pines E, Zerega GS, Oz MC (1999) Reduction of retrosternal and pericardial adhesions with rapidly resorbable polymer films. Ann Thorac Surg 68((3):913–8

    Article  Google Scholar 

  57. Lodge AJ, Wells WJ, Backer CL, O’Brien JE, Austin EH, Bacha EA, Decampli WM, Lavin PT, Weinstein S (2008) A novel bioresorbable film reduces postoperative adhesions after infant cardiac surgery. Ann Thorac Surg 86(2):614–21

    Article  PubMed  Google Scholar 

  58. Gagnieu CH, Forest PO (2007) In vivo biodegradability and biocompatibility of porcine type I atelocollagen newly crosslinked by oxidized glycogen. Biomed Mater Eng 17(1):9–18

    PubMed  CAS  Google Scholar 

  59. Bel A, Kachatryan L, Bruneval P, Peyrard S, Gagnieu C, Fabiani JN, Menasché P (2010) A new absorbable collagen membrane to reduce adhesions in cardiac surgery. Interact Cardiovasc Thorac Surg 10(2):213–6

    Article  PubMed  Google Scholar 

  60. Gruber-Blum S, Petter-Puchner AH, Brand J, Fortelny RH, Walder N, Oehlinger W, Koenig F, Redl H (2011) Comparison of three separate antiadhesive barriers for intraperitoneal onlay mesh hernia repair in an experimental model. Br J Surg 98(3):442–9

    Article  PubMed  CAS  Google Scholar 

  61. Diamond MP, Kruger M, Saed GM (2004) Effect of Tisseel on expression of tissue plasminogen activator and plasminogen activator inhibitor-1. Fertil Steril 81:1657–64

    Article  PubMed  CAS  Google Scholar 

  62. Lindenberg S, Lauritsen JG (1984) Prevention of peritoneal adhesion formation by fibrin sealant. Ann Chirurgiae et Gynaecologiae 73:11–3

    CAS  Google Scholar 

  63. Prieto-Díaz-Chávez E, Medina-Chávez JL, Ramírez-Barba EJ, Trujillo-Hernández B, Millán-Guerrero RO, Vásquez C (2008) Reduction of peritoneal adhesion to polypropylene mesh with the application of fibrin glue. Acta chir Belg 108:433–7

    PubMed  Google Scholar 

  64. Martín-Cartes JA, Morales-Conde S, Suárez-Grau JM, Bustos-Jiménez M, Cadet-Dussort JM, López-Bernal F, Morcillo-Azcárate J, Tutosaus-Gómez JD, Morales-Méndez S (2008) Role of fibrin glue in the prevention of peritoneal adhesions in ventral hernia repair. Surg Today 38(2):135–40

    Article  PubMed  Google Scholar 

  65. Petter-Puchner AH, Walder N, Redl H, Schwab R, Ohlinger W, Gruber-Blum S, Fortelny RH (2008) Fibrin sealant (Tissucol) enhances tissue integration of condensed polytetrafluoroethylene meshes and reduces early adhesion formation in experimental intraabdominal peritoneal onlay mesh repair. J Surg Res 150(2):190–5

    Article  PubMed  CAS  Google Scholar 

  66. Frykman E, Jacobsson S, Widenfalk B (1993) Fibrin sealant in prevention of flexor tendon adhesions: an experimental study in the rabbit. J Hand Surg 18A:68–75

    Google Scholar 

  67. Tulandi T, Al-Jaroudi D (2007) Averting adhesions: surgical techniques and tools. OBG Management 19(05):86–94

    Google Scholar 

  68. Suzuki S, Ikada Y (in press) Sealing effects of cross-linked gelatin. J Biomater Appl

    Google Scholar 

  69. Yoshioka I, Saiki Y, Sakuma K, Iguchi A, Moriya T, Ikada Y, Tabayashi K (2007) Bioabsorbable gelatin sheets latticed with polyglycolic acid can eliminate pericardial adhesion. Ann Thorac Surg 84:864–870

    Article  PubMed  Google Scholar 

  70. Sakuma K, Iguchi A, Ikada Y, Tabayashi K (2005) Closure of the pericardium using synthetic bioabsorbable polymers. Ann Thorac Surg 80:1835–40

    Article  PubMed  Google Scholar 

  71. Young RL, Cota J, Zund G, Mason BA, Wheeler JM (1991) The use of an amniotic membrane graft to prevent postoperative adhesions. Fertil Steril 55(3):624–8

    PubMed  CAS  Google Scholar 

  72. Miyata T, Fususe M, Yamane Y, Noishiki Y (1988) A biodegradable antiadhesion collagen membrane with slow release heparin. ASAIO Trans 34(3):687–91

    PubMed  CAS  Google Scholar 

  73. Badawy SZ, Baggish MS, ElBakry MM, Baltoyannis P (1989) Evaluation of tissue healing and adhesion formation after an intraabdominal amniotic membrane graft in the rat. J Reprod Med 34((3):198–202

    PubMed  CAS  Google Scholar 

  74. Edwards GA, Glattauer V, Nash TJ, White JF, Brock KA, Werkmeister JA, Ramshaw JA (1997) In vivo evaluation of a collagenous membrane as an absorbable adhesion barrier. J Biomed Mater Res 34(3):291–7

    Article  PubMed  CAS  Google Scholar 

  75. Arnold PB, Green CW, Foresman PA, Rodeheaver GT (2000) Evaluation of resorbable barriers for preventing surgical adhesions. Fertil Steril 73(1):157–61

    Article  PubMed  CAS  Google Scholar 

  76. Liu S, Boutrand JP, Tadie M (2001) Use of a collagen-based sealant to prevent in vivo epidural adhesions in an adult rat laminectomy model. J Neurosurg 94(1 Suppl)):61–7

    PubMed  CAS  Google Scholar 

  77. Liu S, Boutrand JP, Bittoun J, Tadie M (2002) A collagen-based sealant to prevent in vivo reformation of epidural scar adhesions in an adult rat laminectomy model. J Neurosurg 97(1 Suppl)):69–74

    PubMed  Google Scholar 

  78. Longaker MT, Chiu ES, Adzick NS, Stern M, Harrison MR, Stern R (1991) Studies in fetal wound healing. V. A prolonged presence of hyaluronic acid characterizes fetal wound fluid. Ann Surg 213(4):292–6

    Article  PubMed  CAS  Google Scholar 

  79. Mast BA, Diegelmann RF, Krummel TM, Cohen IK (1992) Scarless wound healing in the mammalian fetus. Surg Gynecol Obstet 174(5):441–51

    PubMed  CAS  Google Scholar 

  80. Huang-Lee LL, Wu JH, Nimni ME (1994) Effects of hyaluronan on collagen fibrillar matrix contraction by fibroblasts. J Biomed Mater Res 28(1):123–32

    Article  PubMed  CAS  Google Scholar 

  81. Mensitieri M, Ambrosio L, Nicolais L, Bellini D, O’Regan M (1996) Viscoelastic properties modulation of a novel autocrosslinked hyaluronic acid polymer. J Mater Sci Mater Med 7(11):695–8

    Article  CAS  Google Scholar 

  82. Renier D, Bellato P, Bellini D, Pavesio A, Pressato D, Borrione A (2005) Pharmacokinetic behaviour of ACP gel, an autocrosslinked hyaluronan derivative, after intraperitoneal administration. Biomaterials 26(26):5368–74

    Article  PubMed  CAS  Google Scholar 

  83. Belluco C, Meggiolaro F, Pressato D, Pavesio A, Bigon E, Donà M, Forlin M, Nitti D, Lise M (2001) Prevention of postsurgical adhesions with an autocrosslinked hyaluronan derivative gel. J Surg Res 100(2):217–21

    Article  PubMed  CAS  Google Scholar 

  84. De Iaco PA, Muzzupapa G, Bigon E, Pressato D, Donà M, Pavesio A, Bovicelli L (2001) Efficacy of a hyaluronan derivative gel in postsurgical adhesion prevention in the presence of inadequate hemostasis. Surgery 130(1):60–4

    Article  PubMed  Google Scholar 

  85. Vorvolakos K, Isayeva IS, Luu H-MD, Patwardhan DV, Pollack SK (2010) Ionically cross-linked hyaluronic acid: wetting, lubrication, and viscoelasticity of a modified adhesion barrier gel. Med Dev Evid Res 2011(4):1–10

    Article  Google Scholar 

  86. Shih HN, Fang JF, Chen JH, Yang CL, Chen YH, Sung TH, Shih LY (2004) Reduction in experimental peridural adhesion with the use of a crosslinked hyaluronate/collagen membrane. J Biomed Mater Res B Appl Biomater 71(2):421–8

    Article  PubMed  Google Scholar 

  87. Yeo Y, Highley CB, Bellas E, Ito T, Marini R, Langer R, Kohane DS (2006) In situ cross-linkable hyaluronic acid hydrogels prevent post-operative abdominal adhesions in a rabbit model. Biomaterials 27(27):4698–705

    Article  PubMed  CAS  Google Scholar 

  88. Ito T, Yeo Y, Highley CB, Bellas E, Benitez CA, Kohane DS (2007) The prevention of peritoneal adhesions by in-situ cross-linking hydrogels of hyaluronic acid and cellulose derivatives. Biomaterials 28(6):975–83

    Article  PubMed  CAS  Google Scholar 

  89. Ito T, Fraser IP, Yeo Y, Highley CB, Bellas E, Kohane DS (2007) Anti-inflammatory function of an in situ cross-linkable conjugate hydrogel of hyaluronic acid and dexamethasone. Biomaterials 28(10):1778–86

    Article  PubMed  CAS  Google Scholar 

  90. Yeo Y, Ito T, Bellas E, Highley CB, Marini R, Kohane DS (2007) In situ cross-linkable hyaluronan hydrogels containing polymeric nanoparticles for preventing postsurgical adhesions. Ann Surg 245(5):819–24

    Article  PubMed  Google Scholar 

  91. Yeo Y, Bellas E, Highley CB, Langer R, Kohane DS (2007) Peritoneal adhesion prevention with an in situ cross-linkable hyaluronan gel containing tissue-type plasminogen activator in a rabbit repeated-injury model. Biomaterials 28(25):3704–13

    Article  PubMed  CAS  Google Scholar 

  92. Nilsson E, Björn C, Sjöstrand V, Lindgren K, Münnich M, Mattsby-Baltzer I, Ivarsson ML, Olmarker K, Mahlapuu M (2009) A novel polypeptide derived from human lactoferrin in sodium hyaluronate prevents postsurgical adhesion formation in the rat. Ann Surg 250(6):1021–8

    Article  PubMed  Google Scholar 

  93. Kennedy R, Costain DJ, McAlister VC, Lee TD (1996) Prevention of experimental postoperative peritoneal adhesions by N,O-carboxymethyl chitosan. Surgery 120(5):866–70

    Article  PubMed  CAS  Google Scholar 

  94. Lauder CI, Garcea G, Strickland A, Maddern GJ (2011) Use of a modified chitosan-dextran gel to prevent peritoneal adhesions in a rat model. J Surg Res 171(2):877–82

    Google Scholar 

  95. Falabella CA, Melendez MM, Weng L, Chen W (2010) Novel macromolecular crosslinking hydrogel to reduce intra-abdominal adhesions. J Surg Res 159(2):772–8

    Article  PubMed  CAS  Google Scholar 

  96. Pätilä T, Jokinen JJ, Salminen J, Kankuri E, Harjula A (2008) Polyglycolic acid glue does not prevent intrapericardial adhesions in a short-term follow-up. J Surg Res 148(2):181–4

    Article  Google Scholar 

  97. Lee J-H, Nho Y-C, Lim Y-M, Son T-I (2005) Prevention of surgical adhesions with barriers of carboxymethylcellulose and poly(ethylene glycol) hydrogels synthesized by irradiation. J Appl Polym Sci 96(4):1138–45

    Article  CAS  Google Scholar 

  98. Yang B, Gong CY, Qian ZY, Zhao X, Li ZY, Zhou ST, Qi XR, Zhong Q, Luo F, Wei YQ (2011) Prevention of abdominal adhesion formation by thermosensitive PECE-hydrogel in a rat uterine horn model. J Biomed Mater Res B Appl Biomater 96(1):57–66

    PubMed  Google Scholar 

  99. Zhang Z, Ni J, Chen L, Yu L, Xu J, Ding J (2011) Biodegradable and thermoreversible PCLA-PEG-PCLA hydrogel as a barrier for prevention of post-operative adhesion. Biomaterials 32(11):4725–36

    Article  PubMed  CAS  Google Scholar 

  100. Pryor HI, O’Doherty E, Hart A, Owens G, Hoganson D, Vacanti JP, Masiakos PT, Sundback CA (2009) Poly(glycerol sebacate) films prevent postoperative adhesions and allow laparoscopic placement. Surgery 146:490–7

    Article  PubMed  Google Scholar 

  101. Izumi Y, Yamamoto M, Kawamura M, Adachi T, Kobayashi K (2006) Cross-linked poly(gamma-glutamic acid) attenuates peritoneal adhesion in a rat model. Surgery 141(5):678–81

    Article  Google Scholar 

  102. Wallwiener M, Brucker S, Hierlemann H, Brochhausen C, Solomayer E, Wallwiener C (2006) Innovative barriers for peritoneal adhesion prevention: liquid or solid? A rat uterine horn model. Fertil Steril 86(4 Suppl):1266–76

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Graduate School Department of Medical Engineering, Nara Medical University, Shijo-cho 840, Kashihara-shi, 634-8521, Nara, Japan

    Shuko Suzuki & Yoshito Ikada

Authors
  1. Shuko Suzuki
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yoshito Ikada
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Shuko Suzuki .

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Suzuki, S., Ikada, Y. (2012). Barriers to Prevent Tissue Adhesion. In: Biomaterials for Surgical Operation. Humana Press. https://doi.org/10.1007/978-1-61779-570-1_5

Download citation

  • DOI: https://doi.org/10.1007/978-1-61779-570-1_5

  • Published:

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-61779-569-5

  • Online ISBN: 978-1-61779-570-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation