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Adhesive Interactions in Normal and Transformed Cells pp 153–184Cite as

Topographic Cell Responses

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Abstract

Tissue cells have an ability to respond not only to biochemical ­characteristics of the ­extracellular matrix, but also to its geometric configuration, the matrix surface topography. Such topographic features as curvature, orderly grooves and ridges, discontinuities, or some other microscale or nanoscale geometries affect cell adhesion and spreading, cell shapes and orientation, direction of migration, and also proliferation and synthetic activities of the cells. The cell responses to the geometric configuration of the substratum surface, which the cells are attached to and spread on so-called “topographic cell responses,” are altered as a result of oncogenic transformation.

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Authors and Affiliations

  1. Research Center of the Russian Academy of Medical Sciences, Moscow, Russia

    Yury A. Rovensky M.D., Ph.D., D.Sci (Former Leading Researcher at Cancer)

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  1. Yury A. Rovensky M.D., Ph.D., D.Sci
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Correspondence to Yury A. Rovensky M.D., Ph.D., D.Sci .

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Rovensky, Y.A. (2011). Topographic Cell Responses. In: Adhesive Interactions in Normal and Transformed Cells. Humana Press. https://doi.org/10.1007/978-1-61779-304-2_8

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