Abstract
Pluripotent stem cells have been thought to be useful sources for regenerative medicine. Although embryonic stem (ES) cells have abilities to differentiate into several kinds of somatic cells and grow infinitely in vitro, there are several problems with using ES cells for clinical application such as ethical issues and rejection after transplantation. To overcome these problems, pluripotent stem cells were generated from somatic cells by introduction of defined factors. These have been termed induced pluripotent stem (iPS) cells. iPS cells have raised hopes for a new era of regenerative medicine because they can avoid the ethical problems and innate immune rejection associated with ES cells. In this chapter, I look back at the story of generation of iPS cells and discuss recent understanding of iPS cells with our latest data.
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Nakagawa, M. (2011). Generation of Induced Pluripotent Stem Cells from Somatic Cells. In: Ainscough, J., Yamanaka, S., Tada, T. (eds) Nuclear Reprogramming and Stem Cells. Stem Cell Biology and Regenerative Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-225-0_7
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DOI: https://doi.org/10.1007/978-1-61779-225-0_7
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